Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
BChE/HDAC6-IN-1
CAS :BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.Formule :C34H43N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :601.74CLB-016
CAS :CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.Formule :C17H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.38SMYD3-IN-1
CAS :SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formule :C28H31ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.02Nezulcitinib
CAS :Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66AMPK activator 7
CAS :AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Formule :C23H22F3N3O5Couleur et forme :SolidMasse moléculaire :477.43CBP/p300-IN-19 hydrochloride
CAS :CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.Formule :C30H28ClN3O3Couleur et forme :SolidMasse moléculaire :514.02KDM5-IN-1
CAS :KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.Formule :C17H20N6ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :324.38Ref: TM-T15649
1mg60,00€5mg177,00€10mg269,00€25mg427,00€50mg610,00€100mg820,00€500mgÀ demander1mL*10mM (DMSO)130,00€CBB1007 hydrochloride
CAS :CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.Formule :C27H39Cl5N8O4Couleur et forme :SoildMasse moléculaire :716.91MS67
CAS :MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14RK-701
CAS :RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54HA-1004 dihydrochloride
CAS :HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel proteinFormule :C12H16ClN5O2SDegré de pureté :98%Couleur et forme :White Crystalline SolidMasse moléculaire :329.81ZINC08792229
CAS :ZINC08792229 is a novel inhibitor of SIRT1.Formule :C30H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.52L-Moses
CAS :L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Formule :C21H24N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46KH-3
CAS :KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.Formule :C21H22N2O4S2Couleur et forme :SolidMasse moléculaire :430.54I-BET762 carboxylic acid
CAS :I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).Formule :C20H17ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.83PARPYnD
CAS :PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.Formule :C34H31N9O3Couleur et forme :SolidMasse moléculaire :613.67CBB1007
CAS :CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formule :C27H34N8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.61Luteolin 7-sulfate
CAS :Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.Formule :C15H10O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.3JAK-IN-25
CAS :JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formule :C19H17N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.37PIN1 inhibitor 2
CAS :PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.Formule :C16H21N3S2Couleur et forme :SolidMasse moléculaire :319.49RTS-V5
CAS :RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).Formule :C27H35N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.6ZINC08792355
CAS :ZINC08792355 is a novel inhibitor of SIRT1.Formule :C31H24N4O3Couleur et forme :SolidMasse moléculaire :500.55SIRT6-IN-3
CAS :SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormule :C21H30Br3ClN6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.73TNKS1/2-IN-1
CAS :TNKS1/2-IN-1: potent inhibitor for cancer, fibrosis research; pIC50 7.1-8.2.Formule :C26H23F4N3O4Couleur et forme :SolidMasse moléculaire :517.47ZLN024
CAS :ZLN024 is an activator of AMPK allosteric.Formule :C13H13BrN2OSDegré de pureté :99.751%Couleur et forme :SolidMasse moléculaire :325.22Ref: TM-T13411
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)178,00€BATCP
CAS :BATCP is an inhibitor of histone deacetylases (HDAC) [1].Formule :C23H28F3N3O6Couleur et forme :SolidMasse moléculaire :499.487NHWD-870
CAS :NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.Formule :C29H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.59CBP/p300-IN-17
CAS :CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).Formule :C25H28N4O3Couleur et forme :SolidMasse moléculaire :432.51(-)-Indolactam V
CAS :(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formule :C17H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.38(Iso)-MS4322
CAS :(Iso)-MS4322 ((Iso)-YS43-22) is a protein arginine methyltransferase 5 (PRMT5 ) degrader with potential anticancer activity.Formule :C55H76N10O12SDegré de pureté :99.05% - 99.79%Couleur et forme :SolidMasse moléculaire :1101.32CM-675
CAS :CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential toFormule :C31H32N6O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :536.62Ref: TM-T10841
1mg60,00€2mg90,00€5mg138,00€10mg215,00€25mg358,00€50mg510,00€100mg692,00€1mL*10mM (DMSO)152,00€CARM1-IN-3
CAS :CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormule :C24H32N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.54Prolyl Hydroxylase inhibitor 1
CAS :Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).Formule :C19H18ClN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.83CBP/p300-IN-19
CAS :CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.Formule :C30H27N3O3Couleur et forme :SolidMasse moléculaire :477.55PARP7-probe-1
CAS :PARP7-probe-1: biotinylated, chemiluminescent PARP7 active site probe for research use.Formule :C36H49F3N8O5SCouleur et forme :SolidMasse moléculaire :762.89FD1024
CAS :FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Formule :C21H20F2N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47MS023 trihydrochloride
CAS :MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78PRMT5-IN-16
CAS :PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.Formule :C25H34N8O2Couleur et forme :SolidMasse moléculaire :478.59Oxamflatin
CAS :Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).Formule :C17H14N2O4SDegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :342.37Ref: TM-T16415
1mg58,00€5mg145,00€10mg215,00€25mg477,00€50mg670,00€100mg879,00€200mg1.161,00€1mL*10mM (DMSO)114,00€ZL0420
CAS :ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.Formule :C16H16N4O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :296.32GSK-2807 free base
CAS :GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formule :C19H32N8O5Couleur et forme :SolidMasse moléculaire :452.511,2-Didecanoyl-sn-glycerol
CAS :GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Formule :C23H44O5Couleur et forme :SolidMasse moléculaire :400.6PRT543
CAS :PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Formule :C17H17ClN4O4Couleur et forme :SolidMasse moléculaire :376.79BRCA1-IN-2
CAS :BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.Formule :C26H33N4O7PDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :544.54Lin281632
CAS :Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.Formule :C15H15N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :281.31Ref: TM-T27835
1mg34,00€5mg71,00€10mg101,00€25mg212,00€50mg340,00€100mg535,00€500mg1.144,00€1mL*10mM (DMSO)79,00€OM-1700
CAS :OM-1700 inhibits tankyrase 1 (IC50=127 nM) and 2 (IC50=14 nM); hinders colon cancer cell growth, COLO 320DM (GI50=650 nM).Formule :C25H23FN6O2Couleur et forme :SolidMasse moléculaire :458.49JAK-IN-24
CAS :JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44NSC756093
CAS :NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.Formule :C20H19NO4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :337.37Ref: TM-T24557
1mg47,00€5mg92,00€10mg157,00€25mg329,00€50mg490,00€100mg700,00€500mg1.406,00€1mL*10mM (DMSO)117,00€JAK-IN-17
"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."Formule :C33H38F2N6O8Couleur et forme :SolidMasse moléculaire :684.69TCJL37
CAS :TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.Formule :C17H11ClF2N4O2Couleur et forme :SolidMasse moléculaire :376.74EPZ011989 HCl(1598383-40-4 Free base)
CAS :EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.Formule :C35H51N5O4·HClCouleur et forme :SolidMasse moléculaire :642.27MPI_5a
CAS :MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).Formule :C16H17N3O3Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :299.32Ref: TM-T16129
1mg250,00€2mg400,00€5mg755,00€10mg1.018,00€25mg1.504,00€50mg2.035,00€100mg2.673,00€1mL*10mM (DMSO)650,00€(S)-Ro 32-0432
CAS :(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].Formule :C28H29ClN4O2Couleur et forme :SolidMasse moléculaire :489.01EPZ031686
CAS :EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
Formule :C26H34ClF3N4O4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :591.09PARP-1-IN-4
CAS :PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.Formule :C22H15Cl2N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :424.28Piflufolastat
CAS :Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA.Formule :C18H23FN4O8Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :442.4Ref: TM-T31224
1mg54,00€5mg114,00€10mg178,00€25mg409,00€50mg708,00€100mg1.224,00€1mL*10mM (DMSO)138,00€CCT129202
CAS :CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02AU-15330
CAS :AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. Cost-effective and quality-assured.Formule :C39H49N9O5SDegré de pureté :98.21% - 99.62%Couleur et forme :SolidMasse moléculaire :755.93HS94
CAS :HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.
Formule :C15H15N5O2SDegré de pureté :95.04%Couleur et forme :SolidMasse moléculaire :329.38JWG-071
CAS :JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Formule :C34H44N8O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :612.77JAK-IN-3
CAS :JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.Formule :C18H20N4O3Degré de pureté :98.04% - 98.19%Couleur et forme :SolidMasse moléculaire :340.38Ref: TM-T11704
1mg126,00€2mg178,00€5mg304,00€10mg492,00€25mg982,00€50mg1.558,00€100mg2.538,00€200mg3.402,00€1mL*10mM (DMSO)334,00€LY3295668
CAS :LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95KDM4-IN-4
CAS :KDM4-IN-4 is a KDM4 inhibitor with anticancer activity that inhibits the KDM4A-Tudor structural domain for cancer research.Formule :C16H23NODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :245.36FHT-1015
CAS :FHT-1205 is a potent inhibitor (IC50 ≤ 10 nM) of SMARCA4/SMARCA2 ATPase (BRG1 and BRM).Formule :C25H25N5O4S3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :555.69Ref: TM-T63925
1mg54,00€5mg114,00€10mg178,00€25mg356,00€50mg580,00€100mg888,00€1mL*10mM (DMSO)138,00€E7016
CAS :E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
Formule :C20H19N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :349.38hRIO2 kinase ligand-1
CAS :hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM).Formule :C17H14N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :262.31NPAS3-IN-1
CAS :NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.Formule :C10H5N3O2S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :295.36CPI-0610 carboxylic acid
CAS :CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.Formule :C20H15ClN2O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :366.8PKC-IN-1
CAS :PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formule :C25H37FN8O2Degré de pureté :98% - 98.79%Couleur et forme :SolidMasse moléculaire :500.61Y06137
CAS :Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.Formule :C27H32N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :444.57CeMMEC1
CAS :CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Formule :C19H16N2O4Degré de pureté :98.9% - 99.92%Couleur et forme :SolidMasse moléculaire :336.34(1-Nitroethene-1,2-diyl)dibenzene
CAS :(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formule :C14H11NO2Couleur et forme :SolidMasse moléculaire :225.24GNE-886
CAS :GNE-886 has a wide range of applications in life science related research.Formule :C28H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.59BRD4 D1-IN-1
BRD4 D1-IN-1 selectively inhibits BRD4 D1 (IC50 <0.092 μM, Kd 18 nM) with >500-fold specificity versus D2.Formule :C32H37F3N6OCouleur et forme :SolidMasse moléculaire :578.67LSD1-IN-13 hydrochloride
CAS :LSD1-IN-13 hydrochloride (7e) is an oral LSD1 inhibitor (IC50: 24.43 nM), promoting differentiation in AML cell lines.Formule :C23H30ClN3O2SCouleur et forme :SolidMasse moléculaire :448.02PRMT5-IN-18
CAS :PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formule :C32H42N4O4Couleur et forme :SolidMasse moléculaire :546.70BRD4-IN-7
CAS :BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.Formule :C29H24F2N4O3Couleur et forme :SolidMasse moléculaire :514.52Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formule :C16H20N6OCouleur et forme :SolidMasse moléculaire :312.37WW437
WW437 is a histone deacetylase (HDAC) inhibitor that exhibits potent anti-breast cancer activity both in vitro and in vivo.Formule :C23H27N5O4Couleur et forme :SolidMasse moléculaire :437.49HuR degrader 2
CAS :HuRdegrader 2 (Compound 3) is a molecular glue that targets and degrades the RNA-binding protein Hu antigen R (HuR), achieving 30% degradation at 0.1 μM. It inhibits the proliferation of Colo-205 cancer cells with an IC50 of ≤200 nM. HuRdegrader 2 also shows high affinity for cereblon with an HTRF ratio < 0.02.Formule :C20H15N3O3Masse moléculaire :345.35MRK-740-NC
CAS :MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Formule :C25H31N5O3Couleur et forme :SolidMasse moléculaire :449.55AMI-408
CAS :AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formule :C20H13Cl2N6NaO5SCouleur et forme :SolidMasse moléculaire :543.32ROPA
CAS :ROPA, a potent PKCalpha and PKCgamma activator, promotes tumor growth through PKC-activation.Formule :C28H32O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.55MC2652
MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41BRD4 Inhibitor-33
CAS :BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].Formule :C24H20N4O2Couleur et forme :SolidMasse moléculaire :396.44HIF-2α-IN-7
CAS :HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor.Formule :C18H9F6NO2Couleur et forme :SolidMasse moléculaire :385.265-Ph-IAA-AM
5-Ph-IAA-AM, eggshell-permeable analog of 5-Ph-IAA, boosts protein degradation in embryos, useful for studying proteins in C. elegans.Formule :C19H17NO4Couleur et forme :SolidMasse moléculaire :323.3415:0 PG sodium
CAS :15:0 PG sodium serves as an activator for the Protein Kinase C family and is an anionic phospholipid located in the membranes of mitochondria and microsomes. It plays a crucial role in the composition of pulmonary surfactants, especially within the membrane of the pulmonary lamellar bodies.Formule :C36H70NaO10PCouleur et forme :SolidMasse moléculaire :716.90PARP7-IN-23
CAS :PARP7-IN-23 (compound 56) is a potent PARP7 inhibitor with an EC50 of 0.915 nM for pSTAT1 in NCI-H1373 cells, indicating its potential for cancer research.
Formule :C27H22F7N5O3Couleur et forme :SolidMasse moléculaire :597.484KDOAM-25 trihydrochloride
KDOAM-25 trihydrochloride selectively inhibits KDM5 enzymes, boosts H3K4 methylation, and suppresses MM1S cell growth.Formule :C15H28Cl3N5O2Couleur et forme :SolidMasse moléculaire :416.77PRMT5-IN-21
PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.Formule :C18H18F2N6O3Couleur et forme :SolidMasse moléculaire :404.37SCR-7952
CAS :SCR-7952, a MAT2A inhibitor, is utilized in cancer research.Formule :C19H15ClN4OCouleur et forme :SolidMasse moléculaire :350.80PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formule :C25H24N4OCouleur et forme :SolidMasse moléculaire :396.48LSD1/HDAC-IN-1
CAS :LSD1/HDAC-IN-1 (compound 2) serves as an effective inhibitor of both HDAC and LSD1, demonstrating IC50 values of 0.125 nM, 0.373 nM, 0.0118 nM, 0.103 nM, and 0.571 μM for HDAC1, HDAC2, HDAC6, HDAC8, and LSD1 respectively. This compound plays a crucial role in cancer research.Formule :C18H18N2O4SCouleur et forme :SolidMasse moléculaire :358.41cis-4-Br-2,5-F2-PCPA
cis-4-Br-2,5-F2-PCPA (S1024) blocks LSD1/LSD2 (Ki: 94 nM/8.4 μM), hinders cancer stem cell growth, raises H3K4me2 in CCRF-CEM cells.Formule :C9H8BrF2NCouleur et forme :SolidMasse moléculaire :248.07PARP1-IN-5
PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research.Formule :C25H24N2O5SCouleur et forme :SolidMasse moléculaire :464.53HDAC8-IN-2
HDAC8-IN-2 (5o) inhibits both smHDAC8 and hHDAC8 with IC50s of 0.27 μM, 0.32 μM, kills schistosome larvae, and lowers egg laying.Formule :C21H16N2O5Couleur et forme :SolidMasse moléculaire :376.36Cenacitinib
CAS :Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Formule :C19H19F2N7O3Couleur et forme :SolidMasse moléculaire :431.40CREB-IN-1 TFA
CREB-IN-1 TFA: Potent oral CREB inhibitor, IC50 of 0.18 μM, suppresses breast cancer cell growth.Couleur et forme :SolidPAD2-IN-1 hydrochloride
PAD2-IN-1 hydrochloride: potent, selective PAD2 inhibitor; 95x less on PAD4, 79x less on PAD3; benzimidazole derivative.Formule :C25H30ClFN6O3Couleur et forme :SolidMasse moléculaire :517YLIU-4-105-1
CAS :YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formule :C32H34F3N7O2Couleur et forme :SolidMasse moléculaire :605.65MC3138
CAS :MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :435.47Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78PFI-6-COOH
CAS :PFI-6-COOH (Compound 18) is a ligand for the eleven-nineteen leukemia (ENL) protein, and is utilized in the synthesis of the ENL PROTAC degrader MS41.Formule :C23H21N3O6Couleur et forme :SolidMasse moléculaire :435.43JAK1/TYK2-IN-3
JAK1/TYK2-IN-3, orally active, selectively inhibits TYK2 (IC50: 6 nM), JAK1 (37 nM), JAK2 (140 nM), JAK3 (362 nM), and has anti-inflammatory effects.Couleur et forme :SolidHLCL-61
CAS :HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45KAT6A-IN-1
CAS :KAT6A-IN-1 (compound 5) is an inhibitor of KAT6A.Formule :C23H27N5O5SCouleur et forme :SolidMasse moléculaire :485.56KAT6A-IN-2
CAS :KAT6A-IN-2 (compound 7) is an inhibitor of KAT6A.Formule :C23H29N5O5SCouleur et forme :SolidMasse moléculaire :487.57PARP14 inhibitor 2
CAS :PARP14 inhibitor2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of less than 30 nM. It effectively inhibits the mono ADP-ribosyltransferase activity of PARP14 and modulates IFN-γ and IL-4 signaling, thereby reversing pro-tumor macrophage polarization and suppressing anti-tumor inflammatory responses. PARP14 inhibitor2 holds potential for research in PARP14-related conditions such as tumors, atopic dermatitis, and autoimmune diseases.Formule :C25H32FN3O4SCouleur et forme :SolidMasse moléculaire :489.60Purinostat
CAS :Purinostat is a selective inhibitor of HDACI/IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI/IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.Formule :C23H26N10O3Couleur et forme :SolidMasse moléculaire :490.518LSD1-IN-15
LSD1-IN-15 inhibits LSD1, MAO-A/B with IC50s: 0.149, 0.028, 0.327 μM; arrests LNCaP cancer cell growth, IC50 9.9 μM.Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41BRD4 D1-IN-2
BRD4 D1-IN-2 (compound 26), a BRD4 D1 inhibitor, IC50 <0.092 μM, 15 nM affinity, >500x selectivity over BRD2 D1/BRD4 D2.Formule :C33H39F3N6OCouleur et forme :SolidMasse moléculaire :592.7Trichostatin A S-isomer
CAS :Trichostatin A S-isomer, a HDAC 1, 3, 4, 6, 10 inhibitor with IC50 ~20 nM, has wide-ranging epigenetic effects.Formule :C17H22N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.37BET-IN-1
BET-IN-1 is a potent inhibitor of BET, exhibiting good brain permeability and a reasonable metabolic stability.Formule :C23H24ClFN4O3SCouleur et forme :SolidMasse moléculaire :490.98FT001
CAS :FT001: Oral BET Bromodomain inhibitor, IC50=0.46μM, suppresses MYC, anti-cancer, effective in vitro/vivo.Formule :C25H29N3O4SDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :467.58Ref: TM-T27392
1mg109,00€2mg163,00€5mg241,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€500mg2.035,00€1mL*10mM (DMSO)284,00€SIRT6 activator 2
CAS :SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45Menin-MLL inhibitor 26
CAS :Menin-MLL inhibitor 26: Active reference, inhibits cell growth, used in leukemia research.Formule :C27H29F3N6O3SCouleur et forme :SolidMasse moléculaire :574.62WDR5-IN-5
CAS :WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.Formule :C29H29F3N6OCouleur et forme :SolidMasse moléculaire :534.58HDAC-IN-32
HDAC-IN-32, potent inhibitor: IC50—HDAC1 (5.2 nM), HDAC2 (11 nM), HDAC6 (28 nM). Effective anti-tumor and immunity-boosting traits.Formule :C20H23N3O3Couleur et forme :SolidMasse moléculaire :353.41TYK2 ligand 2
CAS :TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.Formule :C24H20FN7O4Couleur et forme :SolidMasse moléculaire :489.458Itareparib
CAS :Itareparib is a PARP inhibitor with demonstrated antitumor activity.Formule :C20H26FN3O2Couleur et forme :SolidMasse moléculaire :359.438PRMT5-MTA-IN-3
CAS :PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.Formule :C19H17F3N6O3Couleur et forme :SolidMasse moléculaire :434.372GSK3368715
CAS :GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFormule :C20H38N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.54Pociredir
CAS :Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.41PRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.Formule :C19H20Cl2N4O5Couleur et forme :SolidMasse moléculaire :455.29Enzomenib
CAS :Enzomenib (DSP5336), a menin protein inhibitor encoded by the multiple endocrine neoplasia (MEN) gene, blocks the interaction between menin protein and mixed lineage leukemia (MLL) fusion proteins. This compound is utilized in researching hematological malignancies.Formule :C33H43FN6O3Couleur et forme :SolidMasse moléculaire :590.73JAK3-IN-7
CAS :JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFormule :C17H20N6ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :324.38GDC-0339
CAS :GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Formule :C20H22F3N7OSCouleur et forme :SolidMasse moléculaire :465.5P300-IN-4
P300-IN-4 (compound 6) is a histone acetyltransferase p300 inhibitor with an IC50 value of 12.2 μM.Formule :C29H28ClIN4O5Couleur et forme :SolidMasse moléculaire :674.91(2S,3R)-LP99
CAS :(2S,3R)-LP99 is a less active enantiomer of LP99.Formule :C26H30ClN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :516.05PKCiota-IN-1
CAS :PKCiota-IN-1: Strong PKC-ι inhibitor (IC50=2.7 nM); also blocks PKC-α/ε (IC50s=45/450 nM).Formule :C25H22FN5OCouleur et forme :SolidMasse moléculaire :427.47PAD-IN-2
CAS :PAD-IN-2, potent PAD4 inhibitor, IC50 <1 μM; targets autoimmune/cancer disorders.Formule :C27H28ClN5O2Couleur et forme :SolidMasse moléculaire :490CCW 28-3
CAS :CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activityFormule :C44H42Cl2N6O4SCouleur et forme :SolidMasse moléculaire :821.81PRMT5-IN-50
CAS :PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12Dioleyl phosphatidylserine
CAS :Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.Formule :C42H78NO10PCouleur et forme :SolidMasse moléculaire :788.04Conophyllidine
CAS :Conophyllidine is a bisindole alkaloid and functions as a selective inhibitor of M2 polarization. It inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. The IC50 of Conophyllidine for IL-4-induced arginase inhibition is 0.31 μM. This compound effectively induces tumor-associated macrophages (TAMs) to shift from an anti-inflammatory to an inflammatory state, thereby enhancing the recruitment and function of cytotoxic CD8+ T cells in the tumor microenvironment. Conophyllidine is useful for studying tumor-associated macrophages.Formule :C44H50N4O9Couleur et forme :SolidMasse moléculaire :778.89KMT9-IN-1
CAS :KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and an ethyl ester prodrug of compound 7b. Inside cells, KMT9-IN-1 releases the active form 7b through the action of esterases. It specifically associates with the KMT9 target within cells, leading to a reduction in H4K12me1 levels. KMT9-IN-1 exhibits antitumor activity against colon cancer and can be employed in research on prostate cancer and hepatocellular carcinoma.Formule :C36H47ClFN7O5Couleur et forme :SolidMasse moléculaire :712.25Bromodomain inhibitor-13
CAS :Bromodomain Inhibitor-13 (Compound 1), an analog of PFI-3, is a bromodomain-containing protein (BCP) inhibitor. It specifically targets the bromodomains of SMARCA2, SMARCA4, and the first and second bromodomains of PB1 [PB1(5) and PB1(2)], with dissociation constants (KD) of 37, 53, 30, and 190 nM, respectively.Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.43EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41Protein kinase inhibitor 7
CAS :Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Formule :C12H15N3O2SMasse moléculaire :265.33MDH1/2-IN-1
CAS :MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.Formule :C25H33NO4Couleur et forme :SolidMasse moléculaire :411.534BET-IN-6
CAS :BET-IN-6: Potent BRD2/4 inhibitor and ligand for PROTAC BRD2/BRD4 degrader-1 synthesis.Formule :C22H20N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.47Basroparib
CAS :Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.Formule :C18H21F2N7O3Couleur et forme :SolidMasse moléculaire :421.4PF-06263276
CAS :PF-06263276 selectively inhibits pan-JAK with IC50: JAK1 (2.2 nM), JAK2 (23.1 nM), JAK3 (59.9 nM), TYK2 (29.7 nM).Formule :C31H31FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.63Azaphilone-9
CAS :AZA-9 inhibits cancer growth by blocking HuR-ARE RNA binding; IC50=1.2μM.Formule :C21H23BrO5Couleur et forme :SolidMasse moléculaire :435.31TDI-015051
CAS :TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505PARP-1/HDAC-IN-1
CAS :PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Formule :C22H18N4O4Degré de pureté :95.94%Couleur et forme :SolidMasse moléculaire :402.4L-Moses dihydrochloride
L-Moses (L-45) dihydrochloride is the first, potent, selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor (Kd: 126 nM).Formule :C21H26Cl2N6Couleur et forme :SolidMasse moléculaire :433.38HDAC6-IN-59
CAS :HDAC6-IN-59 (Compound 38k) is a highly selective inhibitor of histone deacetylase 6 (HDAC6), with an IC50 of 3.12 nM and a 352-fold selectivity over HDAC1. It holds potential for research in esophageal cancer.Formule :C22H18ClN5O2Couleur et forme :SolidMasse moléculaire :419.86IOR-160
CAS :IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.Formule :C23H25F3N4O6Couleur et forme :SolidMasse moléculaire :510.46HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formule :C18H19N3O3Couleur et forme :SolidMasse moléculaire :325.36PRMT5-IN-49
CAS :PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39NSD2-PWWP1-IN-2
CAS :NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48(Rac)-RG108
CAS :(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326Balanol
CAS :Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor.Formule :C28H26N2O10Couleur et forme :SolidMasse moléculaire :550.51NVS-BPTF-1
CAS :NVS-BPTF-1 is a specific inhibitor of bromodomain and PHD finger containing transcription factor (BPTF), exhibiting a dissociation constant (K_D) of 71 nM [1].Formule :C26H28FN7O3SCouleur et forme :SolidMasse moléculaire :537.61XY153
XY153 (8l) is a BD2 selective BET inhibitor targeting BRD4, 3 & 2 with IC50s: 0.79, 5.31 & 5.09 nM, useful in acute myeloid leukemia & cancer research.Formule :C33H34FN3O4Couleur et forme :SolidMasse moléculaire :555.64Dot1L-IN-1
CAS :The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.Formule :C32H36ClN9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.21GSK3368715 3HCl
CAS :GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formule :C20H41Cl3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.92BRD-7880
CAS :BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67G-631
CAS :G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.Formule :C19H22F2N6O3Couleur et forme :SolidMasse moléculaire :420.41RU-0415529
CAS :RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538SRI-43265
CAS :SRI-43265 (compound 40) inhibits the dimerization of human antigen R protein (HuR), which is involved in cancer and inflammation pathogenesis [1].Formule :C19H20N6OCouleur et forme :SolidMasse moléculaire :348.4CP-352664
CAS :CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.Formule :C18H18N4Couleur et forme :SolidMasse moléculaire :290.36(3S,4R)-Tofacitinib
CAS :(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).Formule :C16H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37AJI-214
CAS :AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formule :C17H13ClFN5OCouleur et forme :SolidMasse moléculaire :357.77SGC-BRDVIII-NC
CAS :SGC-BRDVIII-NC (Compound 35) serves as a negative control for the SMARCA2/4 and PB1 bromodomain (BRD) inhibitors. The binding ability of the protein-ligand is completely eliminated in SGC-BRDVIII-NC through the methylation of the phenolic hydroxyl group. This compound is applicable for research in adipogenesis.Formule :C20H27N5O3Couleur et forme :SolidMasse moléculaire :385.46rel-A-395 hydrochloride
CAS :rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formule :C26H36ClFN4O2SCouleur et forme :SolidMasse moléculaire :523.11SMARCA2-IN-2
CAS :Compound I-25, also known as SMARCA2-IN-2, is a SMARCA2 inhibitor (IC 50: 101-500 μM) with applications in cancer research.Formule :C16H17N3Couleur et forme :SolidMasse moléculaire :251.33GSK789
CAS :GSK789 is a selective inhibitor of the first bromodomains (BD1) of the bromo and extra terminal domain (BET) proteins.Formule :C26H33N5O3Couleur et forme :SolidMasse moléculaire :463.57SGC6870N
CAS :SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.Formule :C23H21BrN2O2SMasse moléculaire :469.39I-BET282E
I-BET282E inhibits eight BET bromodomains (pIC50 6.4-7.7) with selectivity for other bromodomain proteins.Formule :C26H34N4O7SCouleur et forme :SolidMasse moléculaire :546.64QCA570
CAS :QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).Formule :C39H33N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :695.79XP5
XP5 is an oral HDAC6 inhibitor, potent against cancer cells, including YCC3/7 (IC50=31 nM to 2.31 μM).Formule :C19H25N3O5SCouleur et forme :SolidMasse moléculaire :407.48TD034
CAS :TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.Formule :C45H64N4O6Couleur et forme :SolidMasse moléculaire :757.01PARP14 inhibitor 1
CAS :PARP14 inhibitor1 (compound Q22) is a selective inhibitor of PARP14 with an IC50 of 5.52 nM. It also exhibits anti-inflammatory properties and has a half-life of 182 minutes in mouse liver microsomes. This compound is applicable for atopic dermatitis research.
Formule :C23H27FN4O3Couleur et forme :SolidMasse moléculaire :426.484HDAC1-IN-3
HDAC1-IN-3 is a potent inhibitor of Pf HDAC1.Formule :C22H24ClN7O2Couleur et forme :SolidMasse moléculaire :453.92AJI-100
CAS :AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).Formule :C17H14FN5OCouleur et forme :SolidMasse moléculaire :323.32HDAC6-IN-12
HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer researchFormule :C24H39F2N3O5Couleur et forme :SolidMasse moléculaire :487.58SMARCA2/4-ligand-5
CAS :SMARCA2/4-ligand-5 is the target protein ligand of PROTAC SMARCA2/4 degrader-37 (Example 4). PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC degrader of SMARCA2/4, with an IC50 value of ≤0.1 μM.Formule :C20H13ClN4O3Couleur et forme :SolidMasse moléculaire :392.795SCH-1473759
CAS :SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.54HYDAMTIQ
CAS :HYDAMTIQ, a PARP-1/2 inhibitor (IC 50 : 29-38 nM), exhibits a range of pharmacological effects including anticancer, anti-inflammatory, and ischemic protective properties. It effectively reduces pulmonary PARP activity and alleviates symptoms such as allergen-induced cough and dyspnea while also diminishing bronchial hyperresponsiveness to methacholine. Moreover, HYDAMTIQ shows potent tumor suppressor activity in various cancers such as ovarian, breast, prostate, pancreatic, and glioblastoma multiforme. Demonstrating in vivo efficacy, HYDAMTIQ has been tested in animal models for conditions like cerebral ischemia, asthma, and cancer [1].Formule :C14H14N2O2SCouleur et forme :SolidMasse moléculaire :274.34PRMT5-IN-37
CAS :PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37JAK3 covalent inhibitor-1
CAS :JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM andFormule :C22H17FN6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.47TY-011
CAS :TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Formule :C18H16ClN5Couleur et forme :SolidMasse moléculaire :337.81Ad-JQ1
CAS :Ad-JQ1 (Compound 16) is a Target Protein Ligand-Linker Conjugate incorporating a BRD4 ligand and a PROTAC linker capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACβ-NF-JQ1.Formule :C37H47ClN6O4SCouleur et forme :SolidMasse moléculaire :707.33Galegine hemisulfate
CAS :Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Formule :C6H15N3O4SCouleur et forme :SolidMasse moléculaire :225.27PROTAC BRD4 ligand-4
CAS :PROTACBRD4 ligand-4 is a BRD4 ligand used in the synthesis of [PROTACBRD4 Degrader-37].Formule :C17H15NO4Couleur et forme :SolidMasse moléculaire :297.31BET-IN-8
BET-IN-8 (Compound 27) is a potent inhibitor of BET (Ki: 0.83 μM, Kd: 0.571 μM), which ameliorates LPS-induced sepsis in vivo.BET-IN-8 has shown potential inFormule :C22H21N3O4SCouleur et forme :SolidMasse moléculaire :423.48PROTAC BRD4 Degrader-25
CAS :PROTAC BRD4 Degrader-25 (Compound 1-f), a targeted BRD4 degrader, is utilized in the study of cancer and additional diseases related to bromodomains [1].Formule :C34H30FN9O2SCouleur et forme :SolidMasse moléculaire :647.72DS17701585
DS17701585: Oral EP300/CBP inhibitor; potent on CBP, EP300, H3K27, & SOX2; useful for cancer research.Formule :C24H26N4O5SCouleur et forme :SolidMasse moléculaire :482.55STR-V-53
CAS :STR-V-53, an HDAC inhibitor (IC50 in nM), increases histone acetylation in tumor cells by inhibiting these enzymes, thereby regulating gene expression. STR-V-53 inhibits tumor growth and induces apoptosis [1].Formule :C21H30N4O8Couleur et forme :SolidMasse moléculaire :466.48Octyl-α-hydroxyglutarate
CAS :Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.Formule :C13H24O5Masse moléculaire :260.33M-525
CAS :M-525, a potent first-in-class menin-MLL inhibitor, binds at 3 nM IC50 and curbs MLL leukemia cell growth & gene expression.Formule :C39H51FN6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.92JAK1-IN-9
CAS :JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM.Formule :C16H13IN6Couleur et forme :SolidMasse moléculaire :416.22CBP/p300-IN-16
CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM).Formule :C26H31N3O4Couleur et forme :SolidMasse moléculaire :449.54NI-Pano
NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor capable of O2-dependent release of the compound panobinostat.Formule :C26H28N6O4Couleur et forme :SolidMasse moléculaire :488.54BRD4-BD1/2-IN-2
CAS :BRD4-BD1/2-IN-2 inhibits BRD4 BD1/BD2 with IC50 <300 nM/<0.5 nM (WO2021233371A1).Formule :C30H33N5O4Couleur et forme :SolidMasse moléculaire :527.61
