Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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AB3067
AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)Formule :C74H91ClFN11O17S2Couleur et forme :SolidMasse moléculaire :1525.16PROTAC BET Degrader-1
CAS :PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formule :C44H45N11O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :871.9PROTAC BRD4 Degrader-9
CAS :PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5ZXH-3-26
CAS :ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27PRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formule :C27H30F3N7O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :669.7ACBI2
CAS :ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Formule :C56H68BrFN8O5SCouleur et forme :SolidMasse moléculaire :1064.16HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56TDI-012804
TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.Couleur et forme :Odour SolidTAT-cyclo-CLLFVY
CAS :Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1Sirtuin modulator 5
CAS :Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36SirReal1-O-propargyl
CAS :SirReal1-O-propargyl is a selective Sirtuin 2 inhibitor (IC50=2.4 μM) and PROTAC ligand. Its propargyl group enables click chemistry reactions such as CuAAc.Formule :C21H20N4O2S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :424.54MZP-55
CAS :MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)Formule :C57H70ClN7O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1080.73PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Formule :C38H47N9O5SCouleur et forme :SolidMasse moléculaire :741.9PIM-IN-1
CAS :PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).Formule :C15H18ClFN4OCouleur et forme :SolidMasse moléculaire :324.78JPS035
CAS :JPS035: potent benzamide-based VHL E3 ligase PROTAC, degrades HDAC1/2, increases gene expression and apoptosis in HCT116 cells.Formule :C49H65N7O7SCouleur et forme :SolidMasse moléculaire :896.15PROTAC BRD4 Degrader-35
CAS :PROTACBRD4 Degrader-35 (Compound 17) is a PROTAC degrader targeting BRD4. It is utilized in cancer research.Formule :C47H53ClN10O4SCouleur et forme :SolidMasse moléculaire :889.51Tet1 peptide
CAS :Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Formule :C73H114N20O17Couleur et forme :SolidMasse moléculaire :1543.81MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Couleur et forme :SolidGSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62PROTAC BRD4 Degrader-13
CAS :PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55PRMT5-IN-4
CAS :PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formule :C11H13N3O4SCouleur et forme :SolidMasse moléculaire :283.3MZP-54
CAS :MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67VPC-70063
CAS :VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formule :C16H12F6N2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :378.34Ref: TM-T60019
1mg49,00€5mg101,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€1mL*10mM (DMSO)130,00€HDAC1/2-IN-3
CAS :HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.Formule :C24H25N5OSCouleur et forme :SolidMasse moléculaire :431.56PROTAC TYK2 degradation agent1
CAS :PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.Formule :C55H69N13O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.28JQ1-TCO
CAS :JQ1-TCO, a BET inhibitor derivative, enables click chemistry for molecular probing in vivo and in vitro.Formule :C31H37ClN6O3SCouleur et forme :SolidMasse moléculaire :609.18MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28PKC β pseudosubstrate
CAS :Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formule :C177H294N62O38S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3994.84Aurora-A ligand 1
CAS :Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.439Okicenone
CAS :Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
Formule :C15H14O4Couleur et forme :SolidMasse moléculaire :258.27BAY-184
CAS :BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Formule :C23H20N2O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :420.48GSK232
CAS :GSK232 is a highly selective and cellularly penetrant inhibitor of CECR2 with outstanding physicochemical properties.Formule :C21H27ClN6O3SCouleur et forme :SolidMasse moléculaire :479.0HDAC-IN-26
CAS :HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.Formule :C24H28FN5O3Couleur et forme :SolidMasse moléculaire :453.518CPI-1328
CAS :CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12AS2553627
CAS :AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formule :C18H19N5OCouleur et forme :SolidMasse moléculaire :321.38Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS :Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Formule :C34H43N3O7Couleur et forme :SolidMasse moléculaire :605.72R8-T198wt
CAS :Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formule :C111H211N59O26SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2820.33PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formule :C53H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1045.22PF-04577806
CAS :PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.Formule :C26H37N7O3Couleur et forme :SolidMasse moléculaire :495.628Lyngbyatoxin A
CAS :Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.
Formule :C27H39N3O2Couleur et forme :SolidMasse moléculaire :437.62DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Couleur et forme :Odour SolidPumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCouleur et forme :Odour SolidRef: TM-L2200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderAS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Formule :C36H41ClN6O3S2Couleur et forme :SolidMasse moléculaire :705.332EPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :450.57AZ'9567
AZ9567 is a potent MAT2A inhibitor. It demonstrates antiproliferative activity against MTAPKO HCT116 cells, with a pIC50 of 8.9.Formule :C24H19F2N5O2Masse moléculaire :447.15068dBET23
CAS :dBET23 is a BRD4 degrader.Formule :C43H45ClN8O9SCouleur et forme :SolidMasse moléculaire :885.38MS33
CAS :MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5MS115
MS115 is a selective PRMT5/MEP50 PROTAC degrader with DC50 values of 17.4 nM for PRMT5 and 11.3 nM for PRMT5 in MDAMB468 cells after 24 hours. MS115 also inhibits the proliferation of breast cancer cells.Couleur et forme :Odour SolidJB300
CAS :JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formule :C43H45ClFN7O10SCouleur et forme :SolidMasse moléculaire :906.375N-Desmethyltamoxifen
CAS :N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.Formule :C25H27NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.49XF067-68
CAS :XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).Formule :C56H67F2N9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1096.31(rel)-Tranylcypromine D5 hydrochloride
CAS :(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Formule :C9H12ClNDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :174.682PRO-HD3
PRO-HD3 is a cell-specific, PROTAC-based degrader targeting HDAC6 [1].Degré de pureté :98%Couleur et forme :Odour SolidKB02-JQ1
CAS :KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Formule :C38H43Cl2N7O6SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :796.77MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Couleur et forme :Odour SolidNSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43ZL0590
CAS :ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55Ref: TM-T60072
1mg71,00€5mg152,00€10mg222,00€25mg401,00€50mg602,00€100mg887,00€1mL*10mM (DMSO)167,00€PAD2-IN-1
CAS :PAD2-IN-1 is a selective benzimidazole-derived inhibitor with a 95-fold and 79-fold higher affinity for PAD2 over PAD4 and PAD3, respectively.Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.544PARP/HDAC-IN-1
PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.Formule :C36H32F2N6O3Degré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :634.67Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFormule :C14H19ClO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.75mTOR/HDAC-IN-1
CAS :mTOR/HDAC-IN-1, a dual inhibitor for mTOR & HDAC1 with IC50s 0.49 & 0.91 nM, potential anti-cancer agent.Formule :C23H23N11O3Couleur et forme :SolidMasse moléculaire :501.5SNIPER(BRD)-1
CAS :SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formule :C53H66ClN9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.73NP213
CAS :NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formule :C42H84N28O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.3Namoline
CAS :Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formule :C10H3ClF3NO4Couleur et forme :SolidMasse moléculaire :293.58GSK J5
CAS :GSK J5: schistosome, helminth inhibitor; trematode insecticide; boosts schistosome death dose/time-wise.Formule :C24H27N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :417.5Ref: TM-T22821
1mg47,00€5mg126,00€10mg202,00€25mg449,00€50mg655,00€100mg934,00€500mg1.872,00€1mL*10mM (DMSO)117,00€Vanicoside A
CAS :Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formule :C51H50O21Couleur et forme :SolidMasse moléculaire :998.93HIF-1 α (556-574)
CAS :HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6BRD4 Inhibitor-16
BRD4 Inhibitor-16 (Compound 4) is a potent suppressor of BRD4 linked to cancer, aiding in research of BRD4-related treatments.Formule :C42H43N7O8SCouleur et forme :SolidMasse moléculaire :805.9Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Couleur et forme :Odour SolidRef: TM-L3510
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderHDAC6-IN-42
HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor with an IC50 of 0.009 μM, demonstrating significant anti-leukemia activity and synergistic effects with Decitabine, indicating its potential use in the research of Acute Myeloid Leukemia (AML).Formule :C24H28FN3O4Masse moléculaire :441.20638GSK040
CAS :GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formule :C29H34N4O4Couleur et forme :SolidMasse moléculaire :502.6SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Degré de pureté :98%Couleur et forme :Odour SolidMAT2A-IN-14
MAT2A-IN-14 (compound H3) is a MAT2A inhibitor that generates reactive oxygen species (ROS) following ultrasound treatment, leading to the specific degradation of MAT2A in cells through rapid oxidation reactions. When combined with ultrasound, MAT2A-IN-14 induces an 87% reduction of MAT2A in human colon cancer cells.Formule :C27H24F2N4O4Masse moléculaire :506.17656PROTAC BRD4 Degrader-19
CAS :PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormule :C44H38N8O5S2Couleur et forme :SolidMasse moléculaire :822.95GSK8573
CAS :GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formule :C20H21NO3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :323.39BRD7-IN-1 free base
CAS :BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formule :C22H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.47HD-TAC7
CAS :HD-TAC7 is a PROTAC degrader targeting HDAC, with IC50 values of 3.6/4.2/1.1 μM for HDAC1/HDAC2/HDAC3. It can reduce the expression of NF-κB p65.Formule :C33H32FN7O7Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :657.65[Ala113]MBP(104-118)
CAS :Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).Formule :C67H104N20O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1493.68BRD3067
CAS :BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.Formule :C21H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.43Biguanide
CAS :Biguanide can reduce oxidative stress in rats with hyperglycemia.Formule :C2H7N5Couleur et forme :SolidMasse moléculaire :101.11PRMT5-IN-14
CAS :PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.Formule :C18H18Cl2N4O4Couleur et forme :SolidMasse moléculaire :425.27MMH1
MMH1, a novel molecular glue degrader of BRD4, operates by enlisting the CUL4 and DCAF16 ligases to target the second bromodomain (BRD4 BD2) [1].Couleur et forme :Odour SolidEp300/CREBBP-IN-4
CAS :Ep300/CREBBP-IN-4, an Ep300 & CREBBP inhibitor; IC50: 0.024μM & 0.064μM. For cancer research.Formule :C23H22F3N5O3Couleur et forme :SolidMasse moléculaire :473.45Sphingosine (d14:1)
CAS :Sphingosine (d14:1) boosts N. rileyi fungus growth, inhibits PKC, and reduces CHO cell proliferation; found in various sea creatures.Formule :C14H29NO2Couleur et forme :SolidMasse moléculaire :243.39JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCBP/p300-IN-8
CAS :CBP/p300-IN-8 strongly inhibits CBP/P300 bromodomains; CBP IC50=0.01-0.1μM, BRD4 IC50=1-1000μM.Formule :C27H31N3O4Couleur et forme :SolidMasse moléculaire :461.562PROTAC BRD4 Degrader-5
CAS :PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67OARV-771
CAS :OARV-771: VHL-based PROTAC targeting BET; DC50: Brd4-6nM, Brd2-1nM, Brd3-4nM; enhanced cell permeability.Formule :C49H59ClN8O8S2Couleur et forme :SolidMasse moléculaire :987.623β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS :3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formule :C30H52O4Couleur et forme :SolidMasse moléculaire :476.742HIF-1 inhibitor-5
HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1Formule :C28H35NO5Couleur et forme :SolidMasse moléculaire :465.58INCB059872
CAS :INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.Formule :C23H34N2O3Couleur et forme :SolidMasse moléculaire :386.536[Ala107]MBP(104-118)
CAS :Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Formule :C67H104N20O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1493.68HDAC6-IN-61
HDAC6-IN-61 (Compound 4e) is an HDAC6 inhibitor with an IC50 of 73 nM, demonstrating greater selectivity compared to other HDAC isomers. It also acts as an activator of GPR40. HDAC6-IN-61 can increase the acetylation of tubulin and phosphorylation levels of ERK. This compound is relevant for studying neuroinflammation, including Alzheimer's disease.Couleur et forme :Odour SolidHyp-dBET1
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.Couleur et forme :Odour SolidHDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Couleur et forme :Odour SolidSAMS
CAS :SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Formule :C74H131N29O18S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1779.15HSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Couleur et forme :Odour SolidIzilendustat
CAS :Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.Formule :C22H28ClN3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :433.93Ref: TM-T64336
5mg43,00€10mg60,00€25mg103,00€50mg166,00€100mg259,00€200mg378,00€1mL*10mM (DMSO)47,00€TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Couleur et forme :Odour SolidCD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidPim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Couleur et forme :Odour SolidPRMT5-IN-13
CAS :PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.81SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormule :C43H45N13O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.96UNC10142
UNC10142 (Compound 44) is a small-molecule antagonist of CHD1, with a binding IC50 value of 1.7 μM. It induces a dose-dependent reduction in the viability of PTEN-deficient prostate cancer cells.Formule :C33H52N6O3Couleur et forme :SolidMasse moléculaire :580.8EPZ-025654
CAS :EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08Pep2m, myristoylated
CAS :Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formule :C63H118N18O14SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1383.8PKCδ Peptide Substrate
CAS :PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFormule :C109H191N35O29SCouleur et forme :SolidMasse moléculaire :2487.97DW71177
CAS :DW71177 is a BET inhibitor with potent anti-leukemic activity for the study of leukemia.Formule :C20H28N6O2Degré de pureté :98.13%Couleur et forme :SoildMasse moléculaire :384.48XYD198
XYD198 (Compound 14h) is an orally active degrader of CBP/p300. It inhibits the CBP/p300 bromodomain with an IC50 of 213.5 nM and exhibits antitumor activity against acute myeloid leukemia.Formule :C54H49F2N11O7Masse moléculaire :1001.37845GSK023
GSK023 (compound 31) is a selective chemical probe that targets the BET BD1 domain.Formule :C29H39N5O2Masse moléculaire :489.31038TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Couleur et forme :Odour SolidPROTAC BRD4 Degrader-32
PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.Formule :C42H42ClN5O5Couleur et forme :SolidMasse moléculaire :731.28745JAK2-IN-10
CAS :JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.Formule :C33H33D3FN9O2Couleur et forme :SolidMasse moléculaire :612.71SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37BRD4 degrader AT1
CAS :BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.Formule :C48H58ClN9O5S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :972.682-Methylquinazolin-4-ol
CAS :Compound 1769-24-0 is a natural product for research related to life sciences. The catalog number is TPL0186 and the CAS number is 1769-24-0.Formule :C9H8N2ODegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :160.17HDAC8-IN-10
HDAC8-IN-10 (compound 15) serves as a potent inhibitor of HDAC8, exhibiting an IC50 value of 7.6 nM. It also acts as a ligand for the HDAC8 target protein, utilized in the synthesis of PROTAC YX862.Couleur et forme :Odour SolidMS645
CAS :MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.Formule :C48H54Cl2N10O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :938.04MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Formule :C28H42ClN5O3Degré de pureté :98.9% - 98.96%Couleur et forme :SolidMasse moléculaire :532.12PROTAC CBP/P300 Degrader-1
CAS :PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Formule :C46H53F2N11O6Couleur et forme :SolidMasse moléculaire :893.998Uzansertib
CAS :Uzansertib (INCB053914) is a potent pan-PIM kinase inhibitor with low IC50s: 0.24, 30, 0.12 nM for PIM1, 2, 3; hinders hematologic tumor growth.Formule :C26H26F3N5O3Couleur et forme :SolidMasse moléculaire :513.51RX-37
CAS :RX-37, a potent BET inhibitor (Ki: 3.2-24.7 nM for BRD2/3/4), selectively hinders growth in leukemia cells with MLL1 gene rearrangement.Formule :C24H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :413.47PROTAC BRD4 Degrader-10
CAS :Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5BETd-246
CAS :BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formule :C48H55N11O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :946.02PARP1-IN-38
PARP1-IN-38 (compound ent-6_P) is a potent PARP1 inhibitor with an IC50 value of 10 μM. It exhibits selective cytotoxic activity in BRCA-mutant cancer cells.Formule :C16H10FN3OCouleur et forme :SolidMasse moléculaire :279.08079Protein kinase C α peptide TFA
CAS :Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.Formule :C68H115F3N24O26SCouleur et forme :SolidMasse moléculaire :1773.85EEDi-5285
CAS :EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formule :C24H22FN5O3SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :479.53Myelin Basic Protein
CAS :Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formule :C60H103N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1390.59HDAC6 ligand-2
HDAC6 ligand-2 (Compound 15) is a ligand of HDAC6 and can be used in the synthesis of PROTAC HDAC6 degrader2.Formule :C23H20F2N6O3Couleur et forme :SolidMasse moléculaire :466.44LSD1-IN-38
LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 1.2 nM. It effectively inhibits the proliferation of cancer cells MV4-11, Kasumi-1, and NCI-H526 with IC50 values of 5, 4, and 11 nM, respectively. Furthermore, LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM and induces differentiation in MV4-11 cells. In mouse models, this compound demonstrates antitumor activity.Formule :C30H29F4N5Couleur et forme :SolidMasse moléculaire :535.578ISM012-042
ISM012-042 is an orally active inhibitor of PHD1 and PHD2, with IC50 values of 1.9 and 2.5 nM, respectively. At a concentration of 2.5 μM, ISM012-042 protects Caco-2 cells from DSS-induced barrier damage. Additionally, in LPS-induced bone marrow-derived dendritic cells (BMDC) from mice, ISM012-042 exhibits anti-inflammatory properties by dose-dependently reducing the expression of IL-12 subunit IL-12p35 and TNF. It also restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 is useful for studying intestinal mucosal repair and immune disorders.Formule :C26H28N6O4Couleur et forme :SolidMasse moléculaire :488.538HLB-0532259
CAS :HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Formule :C40H44N8O7Couleur et forme :SolidMasse moléculaire :748.827LSQ-28
LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, demonstrating significant anticancer, antiproliferative, anti-migration, anti-invasion, and anti-wound healing activities. LSQ-28 is suitable for cancer research.Formule :C31H27N5OCouleur et forme :SolidMasse moléculaire :485.579PROTAC PARP1 degrader-4
PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.Formule :C51H62FN7O6SCouleur et forme :SolidMasse moléculaire :920.145FKBP12 PROTAC dTAG-7
CAS :dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Formule :C63H79N5O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1210.32SIRT5 inhibitor 8
CAS :SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formule :C22H25ClN8O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :501EZH2-IN-5
CAS :EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Formule :C26H37BrN4O2Couleur et forme :SolidMasse moléculaire :517.512SIRT5 inhibitor 9
CAS :SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formule :C24H29ClN8O4SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :561.06SIRT1-IN-1
CAS :SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29Ref: TM-T9648
1mg92,00€5mg192,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€1mL*10mM (DMSO)195,00€3',4'-Dimethoxyflavone
CAS :3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.Formule :C17H14O4Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :282.29cis-VZ 185
CAS :cis-VZ 185 is a negative control for VZ 185.Formule :C53H67FN8O8SCouleur et forme :SolidMasse moléculaire :995.23Echinomycin
CAS :Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Formule :C51H64N12O12S2Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :1101.26Axltide
CAS :Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formule :C63H107N19O20S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1514.77EZH2-IN-15
CAS :A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Formule :C32H44N4O4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :548.72Ref: TM-T67883
1mg130,00€5mg258,00€10mg339,00€25mg578,00€50mg879,00€100mg1.314,00€200mg1.918,00€1mL*10mM (DMSO)311,00€Antidiabetic agent 7
Antidiabetic agent 7 (Compound 5m) functions as a potent hyperglycemia inhibitor. It effectively stimulates GLUT4 translocation in skeletal muscle cells by activating the AMPK-dependent pathway. Additionally, this compound is capable of reducing blood glucose levels and exhibits favorable pharmacokinetic properties. Antidiabetic agent 7 is suitable for research related to antihyperglycemic treatments.Formule :C27H21Cl2N5O3Couleur et forme :SolidMasse moléculaire :534.39SJ988497
CAS :SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formule :C36H36N10O5Couleur et forme :SolidMasse moléculaire :688.747-Hydroxyneolamellarin A
CAS :7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.Formule :C24H19NO5Couleur et forme :SolidMasse moléculaire :401.41DC-S239
CAS :Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formule :C15H15N3O5SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :349.36Ref: TM-T60002
2mg43,00€5mg66,00€10mg96,00€25mg187,00€50mg304,00€100mg482,00€200mg658,00€1mL*10mM (DMSO)73,00€DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formule :C28H33N5O3Couleur et forme :SolidMasse moléculaire :487.59HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.399RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Couleur et forme :Odour SolidNF-κB/HIF-1α-IN-1
NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.Formule :C24H27N7O4Couleur et forme :SolidMasse moléculaire :477.21245PROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Formule :C46H56F2N10O9SCouleur et forme :SolidMasse moléculaire :963.06Thalidomide-NH-CBP/p300 ligand 2
CAS :Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).Formule :C48H57F2N11O6Couleur et forme :SolidMasse moléculaire :922.052NCT-TFP
CAS :NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].Formule :C41H34F4N2O5Couleur et forme :SolidMasse moléculaire :710.71Go6976
CAS :Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.Formule :C24H18N4ODegré de pureté :95.89%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :378.43MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formule :C109H156N22O27S2Couleur et forme :SolidMasse moléculaire :2269.09517PROTAC BET Degrader-10
CAS :PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formule :C39H39ClN8O6SCouleur et forme :SolidMasse moléculaire :783.3Ref: TM-T39374
5mg225,00€10mg359,00€25mg672,00€50mg999,00€100mg1.485,00€200mgÀ demander500mgÀ demander1mL*10mM (DMSO)309,00€MS479
MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM). It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.Couleur et forme :Odour SolidVinSpinIn
CAS :VinSpinIn is a probe for the Spin family proteins.Formule :C42H58N8O4Couleur et forme :SolidMasse moléculaire :738.98JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formule :C30H33FN4O3SCouleur et forme :SolidMasse moléculaire :548.67M-1211
CAS :M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.Formule :C42H57FN6O6SCouleur et forme :SolidMasse moléculaire :793.01Menin-MLL inhibitor 21
CAS :Menin-mll inhibitor 21 is a selective, oral and irreversible Menin inhibitor. Menin-MLL inhibitor 21 promotes selective proliferation of β cells and improvement of β cell function in human islet cultures in vitro. Menin-MLL inhibitor 21 enhances glycemic control in animal models of diabetes. Menin-MLL inhibitor 21 induced a dose-dependent increase in insulin secretion that was augmented by a GLP-1 receptor agonist (RA).Formule :C31H34N8O3Degré de pureté :99.95%Couleur et forme :SoildMasse moléculaire :566.65Ref: TM-T64381
1mg93,00€5mg200,00€10mg313,00€25mg637,00€50mg1.071,00€100mg1.431,00€1mL*10mM (DMSO)250,00€JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Couleur et forme :Odour SolidiHAC
iHAC is an inhibitor-HSP90 anchoring chimera that covalently binds to the BRD4 ligand (+)-JQ-1, targeting HSP90 and thereby inhibiting cancer cell proliferation. This compound also triggers an anti-tumor immune response and is effective in suppressing the recurrence and metastasis of 4T1 breast cancer in mouse models.Formule :C50H46ClIN16O7S3Couleur et forme :SolidMasse moléculaire :1241.56BTR2004
BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.Couleur et forme :Odour SolidTNKS-2-IN-2
CAS :TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Formule :C26H23N3O6Degré de pureté :99.45%Couleur et forme :SoildMasse moléculaire :473.48CPI-268456
CAS :CPI-268456 is a compound which has bioactive.Formule :C20H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :400.26Dihydrochlamydocin analog-1
CAS :Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Formule :C28H40N4O6Couleur et forme :SolidMasse moléculaire :528.64ZINC000014708529
ZINC000014708529 is a potent SIRT7 inhibitor exhibiting high affinity for SIRT7 and is utilized in cancer research [1].Couleur et forme :Odour SolidSirt2-IN-7
Sirt2-IN-7, a selective SIRT2 inhibitor, has IC50 and Ki values of 178.2 nM and 154.3 nM, useful in cancer research.Formule :C22H38Cl2K3N3OSCouleur et forme :SolidMasse moléculaire :831.98ND-L11B free base
ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.Formule :C37H51F3N10O2Couleur et forme :SolidMasse moléculaire :724.862Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Couleur et forme :Odour SolidPRMT5 ligand 1
CAS :PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formule :C20H26N6O2Couleur et forme :SolidMasse moléculaire :382.459PROTAC BRD4-binding moiety 1
CAS :BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formule :C23H21N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43R 8605
CAS :R 8605 is a third-generation retinoid.Formule :C22H27NO4Couleur et forme :SolidMasse moléculaire :369.45Malantide
CAS :Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Couleur et forme :Odour SolidOKI-006
CAS :OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.Formule :C21H30N4O5S2Couleur et forme :SolidMasse moléculaire :482.62A-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54dBAZ2
dBAZ2 is a pioneering PROTAC degrader targeting BAZ2A and BAZ2B, with DC50 values of 180 nM for BAZ2A and 250 nM for BAZ2B.Formule :C54H64FN11O5S2Couleur et forme :SolidMasse moléculaire :1030.29PF-03622905
CAS :PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Formule :C24H35N7O3Couleur et forme :SolidMasse moléculaire :469.59(+)-JQ-1-aldehyde
(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].Couleur et forme :SolidZSNI-21
ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.Formule :C26H25N3O5Couleur et forme :SolidMasse moléculaire :459.49α-Hydroxyglutaric Acid
CAS :α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formule :C5H8O5Couleur et forme :SolidMasse moléculaire :148.114PRO-HD1
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50Degré de pureté :98%Couleur et forme :Odour SolidBRD4-IN-4
CAS :BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormule :C17H18N2O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :330.4PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13PRMT1-IN-1
CAS :PRMT1-IN-1 is a PRMT1 inhibitor.
Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formule :C122H203N45O36S2Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :2940.33Ref: TM-T11740L
1mg166,00€2mg213,00€5mg313,00€10mg442,00€25mg642,00€50mg880,00€100mg1.179,00€200mg1.594,00€iRucaparib-AP6
CAS :iRucaparib-AP6: a specific, non-trapping PARP1 degrader; inhibits the enzyme's activity and scaffolding.Formule :C46H55FN6O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :886.96HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.Formule :C43H63F3N6O6S2Couleur et forme :SolidMasse moléculaire :881.12Bryostatin 3
CAS :Bryostatin 3 is a protein kinase C activator.Formule :C46H64O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :888.99MSC2504877
CAS :MSC2504877 inhibits tankyrase, boosts CDK4/6 inhibitors, blocks Cyclin D2/E2 upregulation, and strengthens phospho-Rb suppression.
Formule :C17H18N2O2Degré de pureté :99.72%Couleur et forme :SoildMasse moléculaire :282.34CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06
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