Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2616 produits trouvés pour "Chromatine/Épigénétique"
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PFI-1
CAS :PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.Formule :C16H17N3O4SDegré de pureté :98.74% - 99.19%Couleur et forme :SolidMasse moléculaire :347.39BI 2536
CAS :BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.Formule :C28H39N7O3Degré de pureté :98% - 99.88%Couleur et forme :SolidMasse moléculaire :521.65Ref: TM-T6173
1mg43,00€2mg56,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg98,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€Fedratinib
CAS :Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formule :C27H36N6O3SDegré de pureté :97.31% - 99.96%Couleur et forme :SolidMasse moléculaire :524.68Ref: TM-T1995
5mg50,00€1mL*10mM (DMSO)54,00€10mg65,00€50mg107,00€100mg127,00€200mg205,00€500mg447,00€1g592,00€PKC ζ pseudosubstrate acetate
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide.Formule :C78H132N30O18Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :1778.10DDP-38003 trihydrochloride
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.Formule :C21H29Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.84Picolinamide
CAS :Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.Formule :C6H6N2ODegré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :122.12Tofacitinib Citrate
CAS :Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formule :C22H28N6O8Degré de pureté :99.19% - 99.75%Couleur et forme :SolidMasse moléculaire :504.49Rucaparib
CAS :Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.Formule :C19H18FN3ODegré de pureté :98.24% - 99.80%Couleur et forme :SolidMasse moléculaire :323.36Ref: TM-T4463
2mg46,00€5mg70,00€1mL*10mM (DMSO)77,00€10mg109,00€25mg170,00€50mg222,00€100mg344,00€200mg512,00€500mg823,00€Iso-H7 dihydrochloride
CAS :Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formule :C14H19Cl2N3O2SDegré de pureté :99.53%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29MS049
CAS :MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.Formule :C15H24N2ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :248.36Ref: TM-T4378
2mg34,00€5mg49,00€1mL*10mM (DMSO)52,00€10mg80,00€25mg149,00€50mg222,00€100mg334,00€200mg494,00€Momelotinib HCl
CAS :Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formule :C23H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :487.38Ruxolitinib (S enantiomer)
CAS :Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formule :C17H18N6Degré de pureté :99.37% - 99.79%Couleur et forme :SolidMasse moléculaire :306.36AG14361
CAS :AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).Formule :C19H20N4ODegré de pureté :98.7% - 99.93%Couleur et forme :SolidMasse moléculaire :320.39J-147
CAS :J-147, a curcumin derivative, is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.Formule :C18H17F3N2O2Degré de pureté :99.61% - >99.99%Couleur et forme :SolidMasse moléculaire :350.33Tubacin
CAS :Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.Formule :C41H43N3O7SDegré de pureté :97.62% - 98.75%Couleur et forme :SolidMasse moléculaire :721.86UNC926 hydrochloride
CAS :UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.Formule :C16H22BrClN2ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :373.72Ref: TM-T9221
1mg84,00€5mg168,00€1mL*10mM (DMSO)168,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€3-methyl-1,2,3,4-tetrahydroquinazolin-2-one
CAS :3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .Formule :C9H10N2ODegré de pureté :99.3% - 99.64%Couleur et forme :SolidMasse moléculaire :162.19Ref: TM-T50006
2mg37,00€5mg52,00€1mL*10mM (DMSO)56,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€500mg642,00€TP0463518
CAS :TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).Formule :C20H18ClN3O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :431.83TCS-PIM-1-4a
CAS :SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formule :C11H6F3NO2SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :273.23PTACH
CAS :PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).Formule :C20H26N2O2S2Degré de pureté :87.44% - 99.74%Couleur et forme :SolidMasse moléculaire :390.56JAK-IN-5 hydrochloride
CAS :JAK-IN-5 hydrochloride is a JAK inhibitor [1].Formule :C27H32ClFN6OCouleur et forme :SolidMasse moléculaire :511.03MS31 trihydrochloride
MS31 trihydrochloride: a selective SPIN1 inhibitor, binds H3K4me3 (IC50: 77-243 nM), non-toxic to healthy cells.Formule :C20H30Cl3N3O2Couleur et forme :SolidMasse moléculaire :450.83MS023
CAS :MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formule :C17H25N3ODegré de pureté :98.31% - 99.87%Couleur et forme :SolidMasse moléculaire :287.4Ref: TM-T6900
1mg37,00€2mg49,00€1mL*10mM (DMSO)79,00€5mg84,00€10mg113,00€25mg230,00€50mg358,00€100mg532,00€500mg1.153,00€EB-47 dihydrochloride
CAS :EB 47 is an effective inhibitor of PARP-1 (IC50: 45 nM).Formule :C24H29Cl2N9O6Couleur et forme :SolidMasse moléculaire :610.45Rucaparib hydrochloride
CAS :Rucaparib hydrochloride (AG014699) is an oral PARP inhibitor with Ki 1.4 nM for PARP1 and hinders H6PD, studied in CRPC research.Formule :C19H19ClFN3OCouleur et forme :SolidMasse moléculaire :359.83Alisertib
CAS :Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formule :C27H20ClFN4O4Degré de pureté :98.31% - >99.99%Couleur et forme :SolidMasse moléculaire :518.92Ref: TM-T2241
5mg52,00€1mL*10mM (DMSO)59,00€10mg92,00€25mg146,00€50mg215,00€100mg334,00€200mg430,00€500mg705,00€(R)-(-)-JQ1 Enantiomer
CAS :(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
Formule :C23H25ClN4O2SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :456.998-CHLOROQUINAZOLIN-4(1H)-ONE
CAS :8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)Formule :C8H5ClN2ODegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :180.59AZ960
CAS :AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formule :C18H16F2N6Degré de pureté :96.02% - 99.88%Couleur et forme :SolidMasse moléculaire :354.36Ruboxistaurin mesylate
CAS :Ruboxistaurin: PKC beta inhibitor, eases oxidative stress, heart issues & nephropathy in diabetic rats, halts retinal neovascularization.Formule :C29H32N4O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.65Barasertib-HQPA
CAS :Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.
Formule :C26H30FN7O3Degré de pureté :98.43% - 99.29%Couleur et forme :SolidMasse moléculaire :507.56ARV-825
CAS :ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.Formule :C46H47ClN8O9SDegré de pureté :97.15% - 98%Couleur et forme :SolidMasse moléculaire :923.43E1231
CAS :E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Formule :C21H21N3O3Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :363.41Ref: TM-T9106
1mg34,00€5mg70,00€1mL*10mM (DMSO)94,00€10mg99,00€25mg195,00€50mg311,00€100mg449,00€500mg888,00€OAC1
CAS :OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.Formule :C14H11N3ODegré de pureté :99.49% - 99.65%Couleur et forme :SolidMasse moléculaire :237.26Ref: TM-T2040
1mg34,00€2mg47,00€5mg66,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg164,00€50mg299,00€100mg540,00€UNC0379
CAS :UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.Formule :C23H35N5O2Degré de pureté :94.41% - 99.97%Couleur et forme :SolidMasse moléculaire :413.56R59949
CAS :R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.Formule :C28H25F2N3OSDegré de pureté :97.04%Couleur et forme :SolidMasse moléculaire :489.58Ref: TM-T26019
1mg39,00€2mg52,00€5mg87,00€1mL*10mM (DMSO)95,00€10mg138,00€25mg281,00€50mg425,00€100mg625,00€200mg883,00€MPT0G211 mesylate
CAS :MPT0G211 mesylate: potent, selective HDAC6 inhibitor (IC50=0.291nM), oral, BBB-penetrating, anti-tau and metastasis, potential anticancer.Formule :C18H19N3O5SCouleur et forme :SolidMasse moléculaire :389.43EDO-S101
CAS :EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.Formule :C19H28Cl2N4O2Degré de pureté :98.02% - 99.44%Couleur et forme :SolidMasse moléculaire :415.36Curculigoside
CAS :1.Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44ACY-738
CAS :ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.Formule :C14H14N4O2Degré de pureté :98.85% - 99.89%Couleur et forme :SolidMasse moléculaire :270.29Ref: TM-T3509
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg165,00€25mg268,00€50mg439,00€100mg582,00€UNC0642
CAS :UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formule :C29H44F2N6O2Degré de pureté :98.75% - 99.5%Couleur et forme :SolidMasse moléculaire :546.7Ref: TM-T4166
1mg38,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)89,00€10mg124,00€25mg219,00€50mg358,00€100mg537,00€200mg782,00€CAY10602
CAS :CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formule :C22H15FN4O2SDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :418.44DL-α-Hydroxyglutaric acid disodium salt
CAS :DL-α-Hydroxyglutaric acid disodium salt (disodium 2-hydroxypentanedioate) is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuranFormule :C5H6Na2O5Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :192.08Windorphen
CAS :Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.Formule :C17H15ClO3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :302.75PFI-3
CAS :PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.Formule :C19H19N3O2Degré de pureté :99.58% - 99.94%Couleur et forme :SolidMasse moléculaire :321.37Rucaparib tartrate
CAS :Rucaparib tartrate: oral PARP-1/2/3 inhibitor, Ki=1.4 nM; also inhibits H6PD; for studying CRPC.Formule :C23H24FN3O7Couleur et forme :SolidMasse moléculaire :473.457SKLB-23bb
CAS :SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.Formule :C21H24N4O4Degré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :396.44Ref: TM-T5830
1mg50,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg187,00€25mg304,00€50mg424,00€100mg587,00€200mg800,00€GSK121
CAS :GSK121 is an inhibitor of selective PAD4.
Formule :C25H26F3N5O3Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :501.51PJ34
CAS :PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
Formule :C17H17N3O2Degré de pureté :95.05% - 99.85%Couleur et forme :SolidMasse moléculaire :295.34WP1066
CAS :WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formule :C17H14BrN3ODegré de pureté :98.92% - 99.73%Couleur et forme :SolidMasse moléculaire :356.22Chromium(III) acetate
CAS :Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.Formule :C2H3O2CrDegré de pureté :99.9%Couleur et forme :Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InMasse moléculaire :76.37MIV-6R
CAS :MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.Formule :C27H35N3ODegré de pureté :99.81% - 99.88%Couleur et forme :SolidMasse moléculaire :417.59CBHcy
CAS :CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.Formule :C9H17NO4SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :235.3BI-9321 trihydrochloride
CAS :BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Formule :C22H24Cl3FN4Degré de pureté :99.12% - 99.34%Couleur et forme :SolidMasse moléculaire :469.81Talazoparib tosylate
CAS :PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.Formule :C26H22F2N6O4SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :552.55Ref: TM-T16979
2mg39,00€5mg58,00€1mL*10mM (DMSO)71,00€10mg84,00€25mg128,00€50mg178,00€100mg295,00€200mg409,00€CHDI-390576
CAS :CHDI-390576 is an HDAC inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, and HDAC 9, and can be used in cancer research.Formule :C19H13F4N3O2Degré de pureté :98.92% - 99.03%Couleur et forme :SolidMasse moléculaire :391.32TNG-462
CAS :TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Formule :C28H36N6O2SDegré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :520.69Ref: TM-T79873
1mg147,00€5mg255,00€1mL*10mM (DMSO)294,00€10mg383,00€25mg575,00€50mg863,00€100mg1.305,00€200mg1.755,00€Cerdulatinib hydrochloride
CAS :Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Formule :C20H28ClN7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :482MDL-800
CAS :MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formule :C21H16BrCl2FN2O6S2Degré de pureté :99.95% - 99.96%Couleur et forme :SolidMasse moléculaire :626.3Osunprotafib
CAS :Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.Cost-effective and quality-assured.Formule :C17H24FN3O4SDegré de pureté :97.11% - 99.91%Couleur et forme :SolidMasse moléculaire :385.45(S)-HH2853
CAS :(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Formule :C31H36F3N7O3Degré de pureté :97.18% - 99.74%Couleur et forme :SolidMasse moléculaire :611.66MRK-740
CAS :MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.Formule :C25H32N6O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :464.56Ruboxistaurin hydrochloride
CAS :Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formule :C28H28N4O3·HClDegré de pureté :99.14% - 99.28%Couleur et forme :SolidMasse moléculaire :505.01Ref: TM-T3689
1mg67,00€2mg87,00€5mg148,00€1mL*10mM (DMSO)190,00€10mg244,00€25mg487,00€50mg702,00€100mg982,00€500mg1.963,00€CX-6258 hydrochloride
CAS :CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Formule :C26H24ClN3O3·HClDegré de pureté :96.03% - 98.60%Couleur et forme :SolidMasse moléculaire :498.4Ref: TM-T6148
1mg40,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg222,00€50mg356,00€100mg537,00€200mg762,00€MS023 dihydrochloride
CAS :MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.Formule :C17H27Cl2N3ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :360.32Zavondemstat
CAS :Zavondemstat (QC8222 free base) is a KDM4 inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.Formule :C26H29N3O3Degré de pureté :99.43% - 99.53%Couleur et forme :SolidMasse moléculaire :431.53RGFP966 (E-isomer)
CAS :RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.Formule :C21H19FN4ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :362.4R 59-022
CAS :R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.Formule :C27H26FN3OSDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :459.58Ref: TM-T16709
1mg35,00€5mg74,00€1mL*10mM (DMSO)75,00€10mg119,00€25mg269,00€50mg447,00€100mg733,00€200mg973,00€PFI-2
CAS :PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over otherFormule :C23H25F4N3O3SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :499.52NVP-BSK805
CAS :NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formule :C27H28F2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.55PF-03814735
CAS :PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48MK-5108
CAS :MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formule :C22H21ClFN3O3SDegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :461.94Dehydrocorydaline nitrate
CAS :DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.Formule :C22H24N2O7Degré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :428.44Ref: TM-T2S2362
1mg89,00€5mg205,00€1mL*10mM (DMSO)243,00€10mg334,00€25mg552,00€50mg782,00€100mg1.054,00€200mg1.414,00€SCH-1473759 hydrochloride
CAS :SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formule :C20H27ClN8OSDegré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :463GSK2807 Trifluoroacetate
CAS :GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Formule :C21H33F3N8O7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :566.53Diethyl bipy55'DC
CAS :"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."Formule :C16H16N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :300.31Tazemetostat trihydrochloride
CAS :Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Formule :C34H47Cl3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :682.12(R)-Dihydrolipoic acid
CAS :(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.Formule :C8H16O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :208.332-PADQZ
CAS :DPQ is an antiviral compound.Formule :C14H19N5O2Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :289.33Acedapsone
CAS :Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.Formule :C16H16N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.37TETi76
CAS :TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.Formule :C10H16O5Couleur et forme :SolidMasse moléculaire :216.23Nicotinamide-d4
CAS :Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.Formule :C6H2D4N2ODegré de pureté :99.746%Couleur et forme :SolidMasse moléculaire :126.15GSK 4027
CAS :GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.Formule :C17H21BrN4OCouleur et forme :SolidMasse moléculaire :377.28193 D7
CAS :193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.Formule :C16H15NO4SCouleur et forme :SolidMasse moléculaire :317.36(3S,4S)-Tofacitinib
CAS :(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Formule :C16H20N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.37GSK-J1 lithium salt
CAS :GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.Formule :C22H22LiN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.38BG48
CAS :BG48, a COMET probe, enables precise optical epigenetic control and photochromically blocks human histone deacetylases with visible light.Formule :C25H23N5OSCouleur et forme :SolidMasse moléculaire :441.55I-BET787
CAS :I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.Formule :C16H20ClN3O2Couleur et forme :SolidMasse moléculaire :321.80BChE/HDAC6-IN-2
CAS :BChE/HDAC6-IN-2 is an inhibitor of BChE and HDAC6 with neuroprotective and ROS scavenging activity and a metal ion co-agonist and inhibits tau phosphorylation.Formule :C27H30N4O4Degré de pureté :98.47%Couleur et forme :SoildMasse moléculaire :474.55Guanosine-5'-triphosphate disodium salt
CAS :5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.Formule :C10H14N5Na2O14P3Degré de pureté :95.69% - 99.96%Couleur et forme :Odorless White SolidMasse moléculaire :567.14BG14
CAS :BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.Formule :C21H21N5OCouleur et forme :SolidMasse moléculaire :359.433BG47
CAS :BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.Formule :C25H22N4O2SCouleur et forme :SolidMasse moléculaire :442.54KR-39038
CAS :KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.Formule :C24H32ClFN6OCouleur et forme :SolidMasse moléculaire :475.00BRD 4354 ditrifluoroacetate
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).Formule :C25H25ClF6N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :610.93KAT6-IN-1
CAS :KAT6-IN-1 (compound E) is a selective, orally available inhibitor of histone acetyltransferases KAT6A and KAT6B, exhibiting antitumour activity for cancer.Formule :C19H18N4O5SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :414.43HDAC2-IN-2
CAS :HDAC2-IN-2 (compound 124) acts as an HDAC2 inhibitor, exhibiting a Kd value ranging from 0.1-1 μM.Formule :C18H15N3O3SCouleur et forme :SolidMasse moléculaire :353.40Asteltoxin
CAS :Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Formule :C23H30O7Couleur et forme :SolidMasse moléculaire :418.486CrBKA
CAS :CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .Formule :C28H31N3O6Couleur et forme :SolidMasse moléculaire :505.56AdipoR agonist 1
CAS :AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.Formule :C26H35N3O3Couleur et forme :SolidMasse moléculaire :437.57HDAC6-IN-27
CAS :HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].Formule :C15H15N3O4Couleur et forme :SolidMasse moléculaire :301.3PKCTheta-IN-2
CAS :PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).Formule :C24H23N5O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :413.47GSK-1268997
CAS :GSK-1268997 is a bio-active chemical.Formule :C21H23N7O3SDegré de pureté :99.33% - 99.81%Couleur et forme :SolidMasse moléculaire :453.52GW843682X
CAS :GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Formule :C22H18F3N3O4SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :477.46UNC0224
CAS :UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formule :C26H43N7O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :485.67E3330
CAS :E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formule :C21H30O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :378.46MY-1B
CAS :MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Formule :C22H18BrN3O2Degré de pureté :99.81% - >99.99%Couleur et forme :SoildMasse moléculaire :436.3Phorbol 12,13-dibutyrate
CAS :Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formule :C28H40O8Degré de pureté :99.32% - 99.37%Couleur et forme :SolidMasse moléculaire :504.61Ref: TM-T16526
1mg58,00€5mg160,00€1mL*10mM (DMSO)170,00€10mg268,00€25mg530,00€50mg827,00€100mg1.314,00€200mg1.773,00€TMPA
CAS :TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Formule :C21H32O6Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :380.48Ref: TM-T13173
1mg75,00€5mg164,00€1mL*10mM (DMSO)167,00€10mg260,00€25mg440,00€50mg620,00€100mg964,00€TAK-285
CAS :TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formule :C26H25ClF3N5O3Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :547.96Ref: TM-T6039
1mg38,00€5mg80,00€1mL*10mM (DMSO)96,00€10mg120,00€25mg216,00€50mg354,00€100mg512,00€200mg727,00€AMPK activator 6
CAS :AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49NSD3-IN-1
CAS :NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Formule :C13H13N5OSCouleur et forme :SolidMasse moléculaire :287.34LSD1-IN-12
CAS :LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-BFormule :C16H16N2OCouleur et forme :SolidMasse moléculaire :252.31Ilorasertib hydrochloride
CAS :Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formule :C25H22ClFN6O2SDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :525BiBET
CAS :BiBET is a potent, selective, bivalent inhibitor of BET bromodomains.Formule :C26H30N10O3Couleur et forme :SolidMasse moléculaire :530.58Resminostat
CAS :Resminostat (4SC-201) is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity.Formule :C16H19N3O4SDegré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :349.4IACS-9571
CAS :IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).Formule :C32H42N4O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :642.76SHP2/HDAC-IN-1
CAS :SHP2/HDAC-IN-1: dual SHP2/HDAC inhibitor, IC50: 20.4 nM/25.3 nM, boosts antitumor immunity, aids cancer immunotherapy research.Formule :C34H35Cl2N7O3Couleur et forme :SolidMasse moléculaire :660.59BI-9321
CAS :BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Formule :C22H21FN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.43LSD1-IN-13
CAS :LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.Formule :C23H29N3O2SCouleur et forme :SolidMasse moléculaire :411.56NSC 698600
CAS :NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].Formule :C14H12N2O2SCouleur et forme :SolidMasse moléculaire :272.32SPC-180002
CAS :SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Formule :C18H23NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :317.38TUL01101
CAS :TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.Formule :C22H25F2N5O2Couleur et forme :SolidMasse moléculaire :429.46SRTCX1002
CAS :SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor.Formule :C21H19N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.47BRD4884
CAS :BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.Formule :C18H19FN2O2Degré de pureté :99.19% - 99.21%Couleur et forme :SolidMasse moléculaire :314.35KD 5170
CAS :KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].Formule :C20H25N3O5S2Couleur et forme :SolidMasse moléculaire :451.56SIRT2-IN-11
CAS :SIRT2-IN-11 (AEM1), a SIRT2 inhibitor (IC50 18.5μM), induces apoptosis and affects p53, used in cancer research.Formule :C21H22N2OCouleur et forme :SolidMasse moléculaire :318.41HAT-IN-1
CAS :HAT-IN-1 is an inhibitor of HAT used in the research of cancer.Formule :C23H18BrF4N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.3F-amidine
CAS :F-amidine is a bioavailable irreversible PAD4 inactivator.Formule :C14H19FN4O2Couleur et forme :SolidMasse moléculaire :294.32UNC0379 TFA
CAS :UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Formule :C25H36F3N5O4Couleur et forme :SolidMasse moléculaire :527.589DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Formule :C29H39Cl3FN9O3Couleur et forme :SolidMasse moléculaire :687.04PARP-2/1-IN-2
CAS :PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.Formule :C13H16N4OCouleur et forme :SolidMasse moléculaire :244.29YM-53601
CAS :YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.Formule :C21H22ClFN2ODegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :372.86HPCG
CAS :HPCG is an inhibitor of HIF-1α prolyl hydroxylase.Formule :C8H8N2O4Couleur et forme :SolidMasse moléculaire :196.16BAY-598 R-isomer
CAS :BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Formule :C22H20Cl2F2N6O3Couleur et forme :SolidMasse moléculaire :525.34Sirtuin modulator 4
CAS :Sirtuin modulator 4 inhibits SIRT1 (EC50: 51-100 μM), may extend cell life and prevent diseases like diabetes and cancer.Formule :C18H10N2O2SCouleur et forme :SolidMasse moléculaire :318.35UNC6212 (Kme2)
UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .Formule :C39H53N7O11Couleur et forme :SolidMasse moléculaire :795.88iBRD4-BD1
CAS :iBRD4-BD1 inhibits BRD4 bromodomain selectively with 12 nM IC50, useful in inflammation and cancer research.Formule :C29H30F3N5OCouleur et forme :SolidMasse moléculaire :521.58CAY10669
CAS :CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.Formule :C20H22O4Couleur et forme :SolidMasse moléculaire :326.39WD2000-012547
CAS :WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).Formule :C17H14N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :262.31PU141
CAS :PU141 is a novel inhibitor of histone acetyltransferase (HAT).Formule :C14H9F3N2OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.29Kgp-IN-1
CAS :Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.Formule :C19H24F4N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.41CPI-905
CAS :CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Formule :C18H20N2O5Couleur et forme :SolidMasse moléculaire :344.36LT052
CAS :LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.Formule :C22H19N5O4SDegré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :449.48Binucleine 2
CAS :Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Formule :C13H11ClFN5Couleur et forme :SolidMasse moléculaire :291.71FNDR-20123 free base
CAS :FNDR-20123 is a safe, oral first-in-class anti-malarial HDAC inhibitor with low IC50s against Plasmodium and human HDACs.Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44Bromodomain inhibitor-10
CAS :Bromodomain inhibitor-10 (compound 128) suppresses BRD4-1/2 with Kd 15 nM/2.5 μM and curbs IL12p40 production.Formule :C20H20N4O3Couleur et forme :SolidMasse moléculaire :364.4UMB-32
CAS :UMB-32: Potent, selective BRD4 inhibitor, Kd 550 nM, IC50 637 nM, also targets TAF1.Formule :C21H23N5OCouleur et forme :SolidMasse moléculaire :361.44CHIC35
CAS :CHIC-35 is a selective deacetylase SIRT1 inhibitor.Formule :C14H15ClN2OCouleur et forme :SolidMasse moléculaire :262.73OTS186935 trihydrochloride
CAS :OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).Formule :C25H29Cl4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.34RET-IN-19
CAS :RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Formule :C28H28N6O4SCouleur et forme :SolidMasse moléculaire :544.62GS-626510
CAS :GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).Formule :C25H22N4OCouleur et forme :SolidMasse moléculaire :394.47Tetrahydrouridine
CAS :Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formule :C9H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23HDAC/NAMPT-IN-1
CAS :HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.4PI3K/HDAC-IN-1
CAS :PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
Formule :C22H25FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.46KDM5-C49
CAS :KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.Formule :C15H24N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.38GNA002
CAS :GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Formule :C42H55NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :701.89EPZ032597
CAS :EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormule :C20H23N7ODegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :377.44Ro 31-8830
CAS :Ro 31-8830, a derivative of Ro 31-8425, has in vivo anti-inflammatory activity.Formule :C28H28N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.55ZYJ-34v
CAS :ZYJ-34v is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.Formule :C27H35N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.58Ac-Lys-AMC
CAS :Ac-Lys-AMC (Hexanamide) is a fluorescent substrate for histone deacetylase HDACs.Formule :C18H23N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.39S2101
CAS :S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.Formule :C16H16ClF2NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.75LEM-14-1189
CAS :LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.Formule :C35H34N6O5S2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :682.81BRD4-BD1-IN-2
CAS :BRD4-BD1-IN-2: Potent, selective BRD4-BD1 inhibitor, IC50=2.51µM; 20x less active on BD2; for cardiovascular/cancer research.
Formule :C20H15Br3N4O2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :583.07ZLD1039
CAS :ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Formule :C36H48N6O3Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :612.8HDAC/CK2-IN-1
CAS :HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.Formule :C15H18Br4N4O2Couleur et forme :SolidMasse moléculaire :605.95SIRT5 inhibitor 4
CAS :SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Formule :C18H15N3O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :369.39SIRT5 inhibitor 2
CAS :SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Formule :C18H12Cl2N2O3SDegré de pureté :99.38% - 99.87%Couleur et forme :SolidMasse moléculaire :407.272′-Deoxy-5-nitrocytidine
CAS :2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].Formule :C9H12N4O6Couleur et forme :SolidMasse moléculaire :272.21JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86MI-3
CAS :MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).Formule :C18H25N5S2Degré de pureté :98.66% - 99.61%Couleur et forme :SolidMasse moléculaire :375.55ET-JQ1-OH
CAS :ET-JQ1-OH is an allele-specific BET inhibitor.Formule :C21H21ClN4O2SCouleur et forme :SolidMasse moléculaire :428.93EML741
CAS :EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.Formule :C31H49N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.75AC-93253 iodide
CAS :AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.Formule :C23H25IN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.43RSC-133
CAS :promotes the reprogramming of human somatic cells to pluripotent stem cellsFormule :C18H15N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.33AMPK activator 12
CAS :AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Formule :C23H24BrNO2Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :426.35UNC2327
CAS :UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).Formule :C14H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.38IDO1 and HDAC1 Inhibitor
CAS :IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).Formule :C25H22BrFN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.4Aurora A/PKC-IN-1
CAS :Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formule :C16H14N6OSe2Couleur et forme :SolidMasse moléculaire :464.24MS-1020
CAS :MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.Formule :C21H18N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.38L 888607 Racemate
CAS :L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Formule :C19H15ClFNO2SCouleur et forme :SolidMasse moléculaire :375.84Sirt1/2-IN-1
CAS :Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.Formule :C22H13ClN2OS2Couleur et forme :SolidMasse moléculaire :420.93Y02224
CAS :Y02224 is a BET inhibitor. It shows the reasonable antiproliferative effect on leukemia cells.Formule :C20H17BrN2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.33K00135
CAS :K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Formule :C18H18N4ODegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :306.36SD-1029
CAS :SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formule :C25H32Br2Cl2N2O3Couleur et forme :SolidMasse moléculaire :639.25NCC-149
CAS :NCC-149 is a HDAC8 inhibitor.Formule :C16H14N4O2SCouleur et forme :SolidMasse moléculaire :326.37PS315
CAS :PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Formule :C23H19ClO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.85RM65
CAS :RM65 is an arginine methyltransferase inhibitor.Formule :C34H32N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.76INO-1001 methanesulfonate
CAS :INO-1001 methanesulfonate is a strong PARP inhibitor with chemosensitization and radiosensitization effects.Formule :C24H29N3O7S2Couleur et forme :SolidMasse moléculaire :535.63NR-160
CAS :NR-160 is a selective HDAC6 inhibitor (IC50=0.03μM), weaker on HDAC1-4,8, toxic to 7 cancer lines, boosts bortezomib and anthracycline effects.Formule :C25H21F3N6O3Couleur et forme :SolidMasse moléculaire :510.47NCGC00247743
CAS :NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.Formule :C24H29N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :391.51Dot1L-IN-5
CAS :Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].Formule :C23H19ClF2N8O5SCouleur et forme :SolidMasse moléculaire :592.96(R)-BAY1238097
CAS :(R)-BAY1238097 is a selective inhibitor against the binding of BET proteins to histones, used in acute myeloid leukemia (AML) and multiple myeloma (MM) studies.Formule :C25H33N5O3Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :451.56Ref: TM-T13442
1mg49,00€5mg101,00€1mL*10mM (DMSO)113,00€10mg172,00€25mg355,00€50mg620,00€100mg1.044,00€200mg1.404,00€D 595
CAS :D595 is a phenethylamine-type calcium channel blocker. The most potent phenylethylamine with respect to negative inotropy was D595 (EC50: 794 nmol/l).Formule :C25H32Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.44JAK3/BTK-IN-2
CAS :JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formule :C25H32N8O2Degré de pureté :99.64% - 99.87%Couleur et forme :SolidMasse moléculaire :476.57SB-284851-BT
CAS :SB-284851-BT: BRD4/p38α/BRDT inhibitor; IC50: BRD4-BD1 1.7µM, BRDT 18µM, BRD4 3.7µM; Kd p38α 0.47nM; reduces IL-8, affects c-Myc/NF-κB.Formule :C26H26FN5OCouleur et forme :SolidMasse moléculaire :443.52DFPM
CAS :DFPM activates plant resistance, inhibits root growth, reduces Col-0 root cell viability, and is light-sensitive in water.Formule :C16H15Cl2NOSCouleur et forme :SolidMasse moléculaire :340.276(5H)-Phenanthridinone
CAS :6(5H)-Phenanthridinone suppresses PARP1/2, reduces RDM4 cell growth, downregulates pro-inflammatory genes, and alleviates EAE symptoms in rats.Formule :C13H9NOCouleur et forme :SolidMasse moléculaire :195.22Metformin icosapent
CAS :Metformin icosapent activates AMPK, enhancing insulin sensitivity and reducing glucose absorption for better glycemic control.Formule :C24H41N5O2Couleur et forme :SolidMasse moléculaire :431.62YUKA1
CAS :YUKA1, a cell-permeable KDM5A inhibitor with a weak effect on KDM5C, increase H3K4me3 and inhibit the proliferation, prevent drug-resistant.Formule :C13H16N4O2SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :292.36Ref: TM-T17278
1mg105,00€5mg250,00€1mL*10mM (DMSO)268,00€10mg409,00€25mg802,00€50mg1.224,00€100mg1.783,00€200mg2.457,00€ST7710AA1
CAS :ST7710AA1 inhibits PARP-1, effectively targets in vitro, and overcomes Pgp-associated multidrug resistance.Formule :C20H22N4OCouleur et forme :SolidMasse moléculaire :334.41
