Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2616 produits trouvés pour "Chromatine/Épigénétique"
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Tankyrase-IN-2
CAS :Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectivelyFormule :C17H14F2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.3PKC-IN-4
CAS :PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM.Formule :C21H25N5SCouleur et forme :SolidMasse moléculaire :379.52UL04
CAS :UL04 is an inhibitor of CREBBP bromodomain.Formule :C18H17NO5Couleur et forme :SolidMasse moléculaire :327.331,2,3,4,5,6-Hexabromocyclohexane
CAS :Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.Formule :C6H6Br6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.54p32 Inhibitor M36
CAS :p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1.Formule :C23H28N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.52Helenalin Acetate
CAS :Helenalin Acetate: anti-inflammatory, anti-cancer, hinders C/EBPß and p300 cooperation.Formule :C17H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.34DM-01
CAS :DM-01 is a potent and selective inhibitor of EZH2.Formule :C23H24F3N3O2Couleur et forme :SolidMasse moléculaire :431.45UMB-136
CAS :UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.Formule :C24H27N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.5Setin-1
CAS :Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.Formule :C29H21F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.48MT477
CAS :MT477 inhibits PKC-α, impairs Ras/ERK1/2 phosphorylation, induces apoptosis, and reduces proliferation in various cancer cells.Formule :C31H30N2O12S3Couleur et forme :SolidMasse moléculaire :718.77GSK 525768A
CAS :GSK 525768A, the inactive enantiomer of GSK525762A, exhibits no activity towards BET.Formule :C22H22ClN5O2Couleur et forme :SolidMasse moléculaire :423.9ITF3756
CAS :ITF3756 is a selective HDAC6 inhibitor.Formule :C13H11N5O2SDegré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :301.32TAK-418
CAS :TAK-418 is an orally active LSD1/KDM1A inhibitor with a 2.9 nM IC50, potential for autism therapy.Formule :C17H25ClN2O2SDegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :356.91Ref: TM-T39252
1mg131,00€5mg313,00€1mL*10mM (DMSO)366,00€10mg494,00€25mg1.009,00€50mg1.359,00€100mg1.818,00€200mg2.457,00€MI-2-2
CAS :MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.Formule :C17H20F3N5S2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :415.5OXFBD03
CAS :OXFBD03 is the bromodomain and extra terminal domain bromodomain family member BRD4(1) inhibitor.Formule :C20H19NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :337.37LY 170198
CAS :LY 170198 is a protein kinase C inhibitor.Formule :C22H25N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :439.46MDK8228
CAS :MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.Formule :C31H41N5O3Couleur et forme :SolidMasse moléculaire :531.69HDAC3-IN-T247
CAS :HDAC3-IN-T247 (HDAC3 inhibitor T247) is a histone deacetylase 3 (HDAC3) inhibitor with antiviral activity that inhibits the proliferation of cancer cells.Formule :C21H19N5OSDegré de pureté :98.11% - 98.94%Couleur et forme :SolidMasse moléculaire :389.47Ref: TM-T24131
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg610,00€50mg867,00€100mg1.153,00€Bromodomain inhibitor-8
CAS :Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases.Formule :C26H25ClN2O3Couleur et forme :SolidMasse moléculaire :448.94(1S,2R)-Tranylcypromine hydrochloride
CAS :(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.Formule :C9H12ClNCouleur et forme :SolidMasse moléculaire :169.651Gue1654
CAS :Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formule :C23H17N3OS3Degré de pureté :98.02% - 98.04%Couleur et forme :SolidMasse moléculaire :447.6CID-4785700
CAS :CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75Formule :C22H23ClFN3O3Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :431.89Ref: TM-T71740
1mg315,00€5mg873,00€10mg1.080,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg4.419,00€DHPCC-9
CAS :DHPCC-9 is an inhibitor of Pim kinase.Formule :C15H10N2OCouleur et forme :SolidMasse moléculaire :234.25DC_501
CAS :DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.Formule :C25H23Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.38Guadecitabine
CAS :Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.Formule :C18H24N9O10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.41AMPK activator 4
CAS :Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Formule :C24H21ClN2O3Degré de pureté :99.97% - 99.99%Couleur et forme :SolidMasse moléculaire :420.89Ref: TM-T62238
1mg86,00€5mg173,00€1mL*10mM (DMSO)203,00€10mg334,00€25mg563,00€50mg802,00€100mg1.099,00€500mg2.187,00€INCB16562
CAS :INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.Formule :C19H11Cl2N5Couleur et forme :SolidMasse moléculaire :380.23LB-205
CAS :LB-205 is a Zn 2+ dependent pan-inhibitor of class I and class II HDACs. It also has a long half-life in vivo.Formule :C18H21N3O2SCouleur et forme :SolidMasse moléculaire :343.44PARP-1/2-IN-1
CAS :PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM).Formule :C24H27FN4O3Couleur et forme :SolidMasse moléculaire :438.49NSC-311068
CAS :NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Formule :C10H6N4O4SCouleur et forme :SolidMasse moléculaire :278.24JAK3-IN-9
CAS :JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.Formule :C17H23N5O4SCouleur et forme :SolidMasse moléculaire :393.466-Methyl-5-azacytidine
CAS :6-Methyl-5-azacytidine is a potent DNMT inhibitor.Formule :C9H14N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23SB-429201
CAS :SB-429201 is an effective, selective inhibitor of HDAC1.Formule :C28H24N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.5JAK-IN-30
CAS :JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formule :C19H26N8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :398.53GSK360A
CAS :GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.Formule :C17H17FN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.33MicroRNA-21-IN-2
CAS :MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.Formule :C17H15N3O3SDegré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :341.38Tripartin
CAS :Tripartin specifically inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells.Formule :C10H8Cl2O4Couleur et forme :SolidMasse moléculaire :263.07MAT2A inhibitor 1
CAS :MAT2A inhibitor 1 is an inhibitor of methionine adenosyltransferase 2A (MATA2) (IC50 < l00 nM).Formule :C31H22N6OSCouleur et forme :SolidMasse moléculaire :526.61ZYJ-34c
CAS :ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).Formule :C31H42N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.69BPTF-IN-1
CAS :BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.Formule :C23H23FN6O3Couleur et forme :SolidMasse moléculaire :450.47EZM 2302
CAS :EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Formule :C29H37ClN6O5Degré de pureté :97.47% - ≥98%Couleur et forme :SolidMasse moléculaire :585.09CD161
CAS :CD161: powerful, selective oral BET inhibitor; IC50: 28.2 nM (BRD4 BD1), 7.2 nM (BRD4 BD2); strong anticancer properties.Formule :C26H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.48DCE_254
CAS :DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Formule :C21H17N9OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.48Dot1L-IN-7
CAS :Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.Formule :C23H27N9O2Couleur et forme :SolidMasse moléculaire :461.52Givinostat hydrochloride monohydrate
CAS :Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.Formule :C24H27N3O4·HCl·H2ODegré de pureté :97.97% - 99.51%Couleur et forme :SolidMasse moléculaire :475.97Langkamide
CAS :Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.Formule :C16H17NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :303.31TyK2-IN-2
CAS :TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).Formule :C16H18N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.35DDP-38003 dihydrochloride
CAS :DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).Formule :C21H28Cl2N4ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :423.38aPKC-I
CAS :aPKC-I specifically inhibits PKCζ/i, blocks VEGF effects, and prevents IR-induced permeability in cells and live models.Formule :C15H17NO4SCouleur et forme :SolidMasse moléculaire :307.36NAT2-IN-1
CAS :NAT2-IN-1 (APA) is a selective inhibitor of the drug metabolism enzyme N-acetyltransferase 2 (NAT2), capable of targeting and eliminating cells with slow NAT2Formule :C19H20N4O3Couleur et forme :SolidMasse moléculaire :352.39SC-10
CAS :SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formule :C17H22ClNO2SDegré de pureté :99.24% - 99.58%Couleur et forme :SolidMasse moléculaire :339.88Piribedil dihydrochloride
CAS :dopamine agonistFormule :C16H20Cl2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.26Tinostamustine HCl
CAS :Tinostamustine (EDO-S101) is an alkylating HDACi fusion molecule, enhancing potency and overcoming drug resistance.Formule :C19H29Cl3N4O2Couleur et forme :SolidMasse moléculaire :451.82CTK7A
CAS :CTK7A is a water-soluble inhibitor of p300. CTK7A inhibits tumor growth in xenografted mice.Formule :C28H24N2NaO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.498BF1
CAS :BF1 is an inhibitor of HAT (histone acetyltransferase) active both in vitro and in vivo.Formule :C12H12ClN3SCouleur et forme :SolidMasse moléculaire :265.76Farnesylthiotriazole
CAS :Farnesylthiotriazole is a persistent PKC activator agent.Formule :C17H27N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.48SIRT1-IN-3
CAS :SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].Formule :C13H15BrN2OCouleur et forme :SolidMasse moléculaire :295.17DC_C66
CAS :DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.Formule :C28H22NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.48CPI-4203
CAS :CPI-4203 is a selective inhibitor of KDM5 demethylases.Formule :C16H14N4OCouleur et forme :SolidMasse moléculaire :278.31CAY10721
CAS :CAY10721 inhibits SIRT3 (39% at 200 μM), linked to OSCC and breast cancer; lowers OSCC growth, enhances radio/chemo sensitivity.Formule :C18H13N3O3SCouleur et forme :SolidMasse moléculaire :351.38M122
CAS :M122 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.Formule :C24H25N5OS2Couleur et forme :SolidMasse moléculaire :463.62CSV0C018875 Hydrochloride
CAS :CSV0C018875 Hydrochloride: Novel G9a inhibitor with low toxicity, effective in enzyme/cell assays, outperforms BIX-0129.Formule :C18H18Cl2N2OCouleur et forme :SolidMasse moléculaire :349.255NV03
CAS :NV03 is a selective antagonist of the UHRF1-H3K9me3 interaction (Kd=2.4 μM) for cancer research. a ligand for E3 ligases in PROTAC synthesis.Formule :C19H27N5O2SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :389.52Tenovin-D3
CAS :Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.Formule :C22H27Cl3N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :533.9ML399
CAS :ML399 inhibits menin–MLL interaction, selectively blocking oncogenic MLL signaling in leukemia cells, supporting functional genomics and therapeutic research.Formule :C27H28FN3O2Degré de pureté :97.84% - 98.20%Couleur et forme :SolidMasse moléculaire :445.53JAK3-IN-1
CAS :JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formule :C26H30ClN7O2Couleur et forme :SolidMasse moléculaire :508.02MI-1
CAS :MI-1 inhibits Menin-MLL interaction with an IC 50 of 1.9 μM [1].Formule :C19H25N5S2Couleur et forme :SolidMasse moléculaire :387.57HIF-IN-33
CAS :HIF-IN-33 is an inhibitor of HIF pathway.Formule :C21H17F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :414.38HIF-PHD-IN-2
CAS :HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].Formule :C17H15N5O3SCouleur et forme :SolidMasse moléculaire :369.4HDAC-IN-30
CAS :HDAC-IN-30 is a potent HDAC inhibitor targeting HDAC1, 2, 3, 6, and 8 with strong antitumor efficacy.
Formule :C22H23N5O3Couleur et forme :SolidMasse moléculaire :405.45HMS607P03
CAS :HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway.Formule :C26H19ClN4O3S2Couleur et forme :SolidMasse moléculaire :535.04Trotabresib
CAS :Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.Formule :C21H21NO4SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :383.46Ref: TM-T36395
1mg92,00€5mg188,00€1mL*10mM (DMSO)215,00€10mg311,00€25mg528,00€50mg755,00€100mg1.017,00€S-Aristeromycinylhomocysteine
CAS :S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.Formule :C15H22N6O4SCouleur et forme :SolidMasse moléculaire :382.44A2B57
CAS :A2B57 is a selective SIRT2 inhibitor.Formule :C22H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.42MPT0G211
CAS :MPT0G211: oral HDAC6 inhibitor with IC50=0.291 nM, 1000x selectivity, neuroprotective, anti-metastatic, crosses blood-brain barrier for Alzheimer's.Formule :C17H15N3O2Degré de pureté :99.93% - 99.98%Couleur et forme :SolidMasse moléculaire :293.32Ref: TM-T60616
1mg92,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg560,00€50mg782,00€100mg1.063,00€200mg1.459,00€CSV0C018875
CAS :CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].Formule :C18H17ClN2OCouleur et forme :SolidMasse moléculaire :312.79LW479
CAS :LW479 is a novel inhibitor of HDAC and is a promising candidate for the prevention of breast cancer.Formule :C21H23BrN2O4SCouleur et forme :SolidMasse moléculaire :479.39CPI-455 HCl
CAS :CPI-455: specific KDM5A inhibitor, IC50=10±1nM, increases H3K4me3, reduces DTPs in cancer cells.Formule :C16H15ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :314.77(2R,5S)-Ritlecitinib
CAS :(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].Formule :C15H19N5OCouleur et forme :SolidMasse moléculaire :285.34(R)-OR-S1
CAS :(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.Formule :C26H34BrN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.47HIF-1/2α-IN-2
CAS :HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.Formule :C16H11FN4O2SCouleur et forme :SolidMasse moléculaire :342.35AMPK activator
CAS :AMPK activatorFormule :C22H21FO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.4Povorcitinib
CAS :Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Formule :C23H22F5N7OCouleur et forme :SolidMasse moléculaire :507.469HDAC-IN-5
CAS :HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.Formule :C26H24F3N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.56SRTCX1003
CAS :SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.Formule :C23H23N5O3SCouleur et forme :SolidMasse moléculaire :449.53JAK-2/3-IN-2
CAS :JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).Formule :C19H19ClN2OSCouleur et forme :SolidMasse moléculaire :358.89Aurora Kinases-IN-3
CAS :Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formule :C20H16F3N3O4Couleur et forme :SolidMasse moléculaire :419.35PBRM1-BD2-IN-6
CAS :PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.Formule :C16H15ClN2OCouleur et forme :SolidMasse moléculaire :286.76JFD00244
CAS :JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect.Formule :C30H26N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.54Bromodomain inhibitor-9
CAS :Bromodomain inhibitor-9 selectively targets BRD4-1 (Kd 12 nM), used in metabolic, inflammatory, fibrotic, and autoimmune disease studies.Formule :C24H28N4O5SCouleur et forme :SolidMasse moléculaire :484.57BET-BAY 002 (S enantiomer)
CAS :The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).Formule :C22H18ClN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.86Bromodomain IN-1
CAS :Bromodomain IN-1 is an inhibitor of Bromodomain.Formule :C22H23ClN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.96Bisindolylmaleimide II
CAS :protein kinase C (PKC) inhibitorFormule :C27H26N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.52JAK3-IN-12
CAS :JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.Formule :C19H19N5O4SCouleur et forme :SolidMasse moléculaire :413.45KCN1
CAS :KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.Formule :C26H27NO5SCouleur et forme :SolidMasse moléculaire :465.56SIRT2-IN-10
CAS :SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.Formule :C28H21N5OSCouleur et forme :SolidMasse moléculaire :475.56IHCH-3064
CAS :IHCH-3064: dual-action cancer immunotherapy, A2AR affinity (Ki 2.2 nM), selective HDAC1 inhibitor (IC50 80.2 nM).Formule :C25H21N9O2Couleur et forme :SolidMasse moléculaire :479.49MAT2A inhibitor 3
CAS :MAT2A inhibitor 3 can be used in the cancer research.Formule :C16H14ClN3OCouleur et forme :SolidMasse moléculaire :299.75Sirt2-IN-1
CAS :Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formule :C28H27N7O2S2Degré de pureté :99.57% - 99.84%Couleur et forme :SolidMasse moléculaire :557.69Ref: TM-T12920
1mg100,00€5mg203,00€1mL*10mM (DMSO)253,00€10mg323,00€25mg513,00€50mg697,00€100mg888,00€500mg1.783,00€PB131
CAS :PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitableFormule :C16H16FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.32KDM2/7-IN-1
CAS :KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.Formule :C15H27NO4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :285.38BRM/BRG1 ATP Inhibitor-3
CAS :BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.Formule :C26H25N5O2S2Couleur et forme :SolidMasse moléculaire :503.64ZLD10A
CAS :ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.Formule :C37H48N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.8Tyk2-IN-5
CAS :Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Formule :C21H19FN8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.43HIF-1α-IN-3
CAS :HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].Formule :C19H17N5O2Couleur et forme :SolidMasse moléculaire :347.37TNKS-IN-41
CAS :TNKS-IN-41 highly potent and selective inhibitor of tankyrase.Formule :C24H22N10O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.5NSD3-IN-2
CAS :NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.4EZH2-IN-3
CAS :EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.Formule :C27H28ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490NSD3-IN-3
CAS :"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."Formule :C15H17N5O2SCouleur et forme :SolidMasse moléculaire :331.39NC-III-49-1
CAS :NC-III-49-1: potent BET inhibitor, binds BRD4/BRDT, inhibits cell growth, reduces c-Myc expression.Formule :C44H50N4O11S2Couleur et forme :SoildMasse moléculaire :875.02Cercosporamide
CAS :Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.Formule :C16H13NO7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.28HDAC-IN-44
CAS :HDAC-IN-44 is an HDAC inhibitor (IC50: 61.2 nM) with strong anti-cancer effects.Formule :C26H27BrN4O4Couleur et forme :SolidMasse moléculaire :539.42BET bromodomain inhibitor 2
CAS :BET bromodomain inhibitor 2 is a potent inhibitor of the BET-type bromodomain (IC50: 14.1 μM).Formule :C23H30N2O5SCouleur et forme :SolidMasse moléculaire :446.56Furamidine
CAS :Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.Formule :C18H16N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.35BNS
CAS :BNS is a potent, prolyl-hydroxylase 2 (PHD2)-selective inhibitor.Formule :C18H16N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46HDAC6-IN-11
CAS :HDAC6-IN-11 (Compound 9) is a cancer cell growth blocker, selectively inhibiting HDAC6 (>300-fold) with an IC50 of 20.7 nM.Formule :C19H16N2O4Couleur et forme :SolidMasse moléculaire :336.34GDC-4379
CAS :GDC-4379 is a JAK1 inhibitor that can be used to study asthma.Formule :C21H18ClF2N7O3Couleur et forme :SolidMasse moléculaire :489.86XMD-12
CAS :XMD-12 is a selective pan-Aurora Kinase inhibitor, with an IC50 of 5.6/18.4/24.6 nM for Aurora A/B/C, anti-tumor, promote the apoptosis of cancer cells.Formule :C24H26N6O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :430.5HDAC6-IN-10
CAS :HDAC6-IN-10 is a potent HDAC6 inhibitor with 0.73 nM IC50, highly selective, and hinders multiple myeloma cell growth.Formule :C21H20N4O4Couleur et forme :SolidMasse moléculaire :392.41WAY-260022
CAS :WAY-260022 is the norepinephrine transporter inhibitor.Formule :C21H31F3N2O2Degré de pureté :97.61% - 99.41%Couleur et forme :SolidMasse moléculaire :400.48Dimethyl-bisphenol A
CAS :DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.Formule :C17H20O2Couleur et forme :SolidMasse moléculaire :256.34HDAC1-IN-4
CAS :HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).Formule :C21H24BrClN6O2Couleur et forme :SolidMasse moléculaire :507.82ZL0454
CAS :ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).Formule :C18H22N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.46NVS-BET-1
CAS :NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.Formule :C22H21ClN4O2Couleur et forme :SolidMasse moléculaire :408.88DC_517
CAS :DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Formule :C33H35N3O2Couleur et forme :SolidMasse moléculaire :505.65ZIKV-IN-3
CAS :ZIKV-IN-3, an andrographolide derivative, inhibits ZIKV NS5 MTase (IC50: 18.34 μM) and replication. Used for Zika virus research.Formule :C39H41NO4Couleur et forme :SolidMasse moléculaire :587.75MAT2A-IN-5
CAS :MAT2A-IN-5 inhibits MAT2A in tumors, curbing growth in gastric, colon, liver, and pancreatic cancers.Formule :C17H12ClF3N2OCouleur et forme :SolidMasse moléculaire :352.74HPB
CAS :HPB is a selective HDAC6 deacetylase inhibitorFormule :C18H20N2O4Couleur et forme :SolidMasse moléculaire :328.36SIRT6-IN-1
CAS :SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.Formule :C19H14N4O5SCouleur et forme :SolidMasse moléculaire :410.4ZIKV-IN-2
CAS :ZIKV-IN-2 blocks ZIKV replication, is a strong NS5 MTase inhibitor (IC50: 38.86 μM), and aids Zika virus research.Formule :C39H42O4Couleur et forme :SolidMasse moléculaire :574.75Antiproliferative agent-17
CAS :Antiproliferative Agent-17 exhibits both antimicrobial properties against Gram-positive bacteria and anticancer activity [1].Formule :C26H28N2OSCouleur et forme :SolidMasse moléculaire :416.584-iodo-SAHA
CAS :4-Iodo-SAHA (1k), an oral HDAC inhibitor for cancer research, has EC50s from 0.12 to 1.3 μM across various cell lines.Formule :C14H19IN2O3Couleur et forme :SolidMasse moléculaire :390.22AA-CW236
CAS :AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Formule :C17H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :400.78LP99
CAS :LP99 is an epigenetic probe.Formule :C26H30ClN3O4SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :516.05Ref: TM-T15784
100mgÀ demander1mg43,00€5mg96,00€1mL*10mM (DMSO)97,00€10mg145,00€25mg305,00€50mg442,00€NN-390
CAS :NN-390: selective HDAC6 inhibitor, IC50 9.8 μM, blood-brain barrier penetrant, potential for metastatic group 3 neural tube cancer research.Formule :C17H16F4N2O4SCouleur et forme :SolidMasse moléculaire :420.38EZH2-IN-9
CAS :EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Formule :C28H32ClF2N3O5SCouleur et forme :SolidMasse moléculaire :596.09DC-CPin7
CAS :DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].Formule :C19H22N2O5Couleur et forme :SolidMasse moléculaire :358.39OICR-0547
CAS :OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.Formule :C28H29F3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.55CypD inhibitor C-9
CAS :CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress.Formule :C22H22N4O4S2Couleur et forme :SolidMasse moléculaire :470.56Aurora Kinases-IN-2
CAS :Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Formule :C22H18ClN5O3Couleur et forme :SolidMasse moléculaire :435.86EZH2-IN-11
CAS :EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Formule :C28H36ClN3O5SCouleur et forme :SolidMasse moléculaire :562.12JAK-IN-14
CAS :JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Formule :C19H15FN4ODegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :334.35Ref: TM-T9764
1mg81,00€5mg170,00€1mL*10mM (DMSO)178,00€10mg268,00€25mg555,00€50mg888,00€100mg1.414,00€200mg1.882,00€DC-BPi-11
CAS :DC-BPi-11 inhibits BPTF at IC50 698 nM and significantly reduces leukemia cell growth.Formule :C20H23N5O2SCouleur et forme :SolidMasse moléculaire :397.493-Deazaneplanocin A
CAS :3-Deazaneplanocin A (DZNep) is an EZH2 and AHCY inhibitor with antipoxigenic activity that inhibits fibrosis in the liver, kidneys, peritoneum, and airways.Formule :C12H14N4O3Degré de pureté :99.03% - 99.68%Couleur et forme :SolidMasse moléculaire :262.27KDOAM-25
CAS :KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).Formule :C15H25N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :307.39Tripolin A
CAS :Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Formule :C15H11NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.25HDAC-IN-29
CAS :HDAC-IN-29 (compound 13b) is a potent pan- HDAC inhibitor with antitumor activity.Formule :C20H23N3O4SCouleur et forme :SolidMasse moléculaire :401.48MC-1353
CAS :MC-1353 is a potent, selective inhibitor of HDAC class I.Formule :C16H16N2O3Couleur et forme :SolidMasse moléculaire :284.31MZ-242
CAS :MZ-242 is an effective and selective inhibitor of Sirt2.Formule :C24H27N7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.65DPQ
CAS :DPQ inhibits PARP-1, aids in neuroprotection, restores ATP, and lessens neuronal injury from NMDA.
Formule :C18H26N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.41KP-302
CAS :KP-302 is a selective PAD inhibitor, reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.Formule :C20H23N5O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :365.43Ref: TM-T88080
1mg57,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg394,00€50mg640,00€100mg1.018,00€200mg1.378,00€PBRM1-BD2-IN-1
CAS :PBRM1-BD2-IN-1: Selective PBRM1 inhibitor with Kd 0.7μM, IC50 0.2μM, useful in cancer research.Formule :C17H19ClN2OCouleur et forme :SolidMasse moléculaire :302.8LSD1-IN-5
CAS :LSD1-IN-5, a reversible LSD1 inhibitor, boosts H3K4me2 without affecting LSD1 expression; IC50: 121 nM.Formule :C15H13BrN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.18OM-137
CAS :OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formule :C13H14N4O3SCouleur et forme :SolidMasse moléculaire :306.34PF-739
CAS :PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Formule :C23H23ClN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.89MAT2A-IN-6
CAS :MAT2A-IN-6 inhibits MAT2A, may slow MTAP-deficient cancer cell growth, has research value in cancer.Formule :C18H13ClF3N3O3Couleur et forme :SolidMasse moléculaire :411.76SIRT5 inhibitor 5
CAS :SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Formule :C21H14ClN3O3SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :423.87Valemetostat tosylate
CAS :Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Formule :C33H42ClN3O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :660.22SW155246
CAS :SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Formule :C16H11ClN2O5SDegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :378.79AMPK activator 8
CAS :AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Formule :C25H21ClN2O6Couleur et forme :SolidMasse moléculaire :480.9PIM1-IN-7
CAS :PIM1-IN-7 inhibits PIM-1 (IC50: 0.67μM), toxic to HCT-116/MCF-7 cells (IC50: 42.9/7.68μM).Formule :C23H23N5OCouleur et forme :SolidMasse moléculaire :385.46BRD4-BD1/2-IN-1
CAS :BRD4-BD1/2-IN-1 efficiently blocks BRD4 BD-1/2 under 100 nM IC50 (US20150148375A1, cmpd 5).Formule :C21H14F2N4O2Couleur et forme :SolidMasse moléculaire :392.36AMPK activator 9
CAS :AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Formule :C31H28F4N4O4Couleur et forme :SolidMasse moléculaire :596.57Tyk2-IN-7
CAS :Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).Formule :C18H15D3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.46VE-465
CAS :VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formule :C22H28N8OSCouleur et forme :SolidMasse moléculaire :452.58BRD4 Inhibitor-19
CAS :BRD4 inhibitors -19 are BET inhibitors that act on BRD4-BD1 (IC50: 55 nM) and can be used to study multiple myeloma.Formule :C29H25N5O3Couleur et forme :SolidMasse moléculaire :491.54NCDM-32B
CAS :NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.Formule :C15H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.41PNZ5
CAS :PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociationFormule :C20H18N2O2Degré de pureté :99.51% - 99.61%Couleur et forme :SolidMasse moléculaire :318.37Ref: TM-T12513
1mg109,00€1mL*10mM (DMSO)240,00€5mg243,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€200mg1.369,00€PRMT5-IN-17
CAS :PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.Formule :C26H33N7O2Couleur et forme :SolidMasse moléculaire :475.59IACS-9571 hydrochloride
CAS :IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).Formule :C32H43ClN4O8SCouleur et forme :SolidMasse moléculaire :679.22CX-6258
CAS :CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Formule :C26H24ClN3O3Degré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :461.94Ref: TM-T1834
1mg34,00€5mg75,00€1mL*10mM (DMSO)77,00€10mg101,00€25mg197,00€50mg295,00€100mg447,00€200mg623,00€BRM/BRG1 ATP Inhibitor-4
CAS :BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.Formule :C25H32N6O3SCouleur et forme :SolidMasse moléculaire :496.62KDM2B-IN-4
CAS :KDM2B-IN-4, from patent WO2016112284A1 as 182b, is a potent KDM2B inhibitor used in cancer research.Formule :C24H28N2O2Couleur et forme :SolidMasse moléculaire :376.49NSC-636819
CAS :NSC-636819 is a novel inhibitor of KDM4A/KDM4B.Formule :C22H12Cl4N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.15Akt Inhibitor X
CAS :Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.Formule :C20H25ClN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :344.88PARP1-IN-9
CAS :PARP1-IN-9, potent PARP1 inhibitor with 30.51 nM IC50, outperforms Olaparib in anticancer efficacy.Formule :C18H21N3O5Couleur et forme :SolidMasse moléculaire :359.38Galegine hydrochloride
CAS :Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Formule :C6H14ClN3Couleur et forme :SolidMasse moléculaire :163.65JNJ-7925476 free base
CAS :JNJ-7925476 is an TRI antidepressant agent.Formule :C20H19NDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :273.37PS432
CAS :PS432 inhibits atypical PKCs, targets PIF-pocket, reduces tumors in mice sans side effects.Formule :C25H19ClN2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.95HDAC3-IN-T326
CAS :HDAC3-IN-T326: potent, selective HDAC3 inhibitor, boosts NF-κB acetylation, activates latent HIV gene expression.Formule :C21H18N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.47TC-E 5001
CAS :dual tankyrase (TNKS) inhibitorFormule :C20H19N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :409.46Dihydro-5-azacytidine acetate
CAS :Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Formule :C10H18N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.27Thi-DPPY
CAS :Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.Formule :C28H28ClN5O4SCouleur et forme :SolidMasse moléculaire :566.07JAK-IN-10
CAS :JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.Formule :C20H18FN5O3SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :427.45Ref: TM-T13571
1mg82,00€5mg167,00€1mL*10mM (DMSO)178,00€10mg246,00€25mg405,00€50mg572,00€100mg772,00€500mg1.539,00€MARK-IN-4
CAS :MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.Formule :C21H23N7OSCouleur et forme :SolidMasse moléculaire :421.52BETi-211
CAS :BETi-211 is a selective inhibitor BET bromodomain.Formule :C26H29N7O3Couleur et forme :SolidMasse moléculaire :487.55CTPB
CAS :CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments.Formule :C31H43ClF3NO2Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :554.13PB118
PB118 clears Aβ, boosts phagocytosis, enhances tubulin networks, reduces p-tau & inflammation in AD; HDAC6 IC50: 5.6 nM.Formule :C18H19FN2O2Couleur et forme :SoildMasse moléculaire :314.35dBRD9-A
CAS :Potent BRD9 degrader that binds selectively, fully degrades BRD9 at low doses, and hinders synovial sarcoma growth in vitro and in mice.Formule :C42H49N7O8Couleur et forme :SolidMasse moléculaire :779.88HDAC-IN-45
CAS :HDAC-IN-45, a small HDAC blocker, forms H-bonds with Y303 and shows anticancer properties; IC50 for HDAC1/2/3: 0.108/0.585/0.563 μM.Formule :C25H20ClFN8OCouleur et forme :SolidMasse moléculaire :502.93A2AAR/HDAC-IN-1
CAS :A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.Formule :C24H21N7O2Couleur et forme :SolidMasse moléculaire :439.47IND 1316
CAS :IND 1316 is an activator of AMP-activated protein kinase (AMPK).Formule :C22H17NO3Couleur et forme :SolidMasse moléculaire :343.38HIF-1α inhibitor-1
CAS :HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.Formule :C15H11N3O4Couleur et forme :SolidMasse moléculaire :297.27SMTIN-T140
CAS :SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Formule :C36H34BrClFN5OPDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :718.02CMP-5 hydrochloride
CAS :CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.Formule :C21H22ClN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.87FAK/aurora kinase-IN-1
CAS :FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Formule :C23H24ClN7O3Couleur et forme :SolidMasse moléculaire :481.93G9a-IN-2
CAS :G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).Formule :C30H42N4O4Couleur et forme :SolidMasse moléculaire :522.68BET-BAY 002
CAS :BET-BAY 002 is an effective BET bromodomain inhibitor demonstrating efficacy in vivo and in vitro against multiple myeloma and leukaemia models.Formule :C22H18ClN5OCouleur et forme :SolidMasse moléculaire :403.865-Aza-4'-thio-2'-deoxycytidine
CAS :5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].Formule :C8H12N4O3SCouleur et forme :SolidMasse moléculaire :244.27EZH2-IN-7
CAS :EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.Formule :C31H37D2N5O3SCouleur et forme :SolidMasse moléculaire :563.75
