Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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JAK3-IN-9
CAS :<p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>Formule :C17H23N5O4SCouleur et forme :SolidMasse moléculaire :393.46PARP-2/1-IN-2
CAS :<p>PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.</p>Formule :C13H16N4OCouleur et forme :SolidMasse moléculaire :244.29ZLD10A
CAS :<p>ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.</p>Formule :C37H48N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.8WAY-260022
CAS :<p>WAY-260022 is the norepinephrine transporter inhibitor.</p>Formule :C21H31F3N2O2Degré de pureté :97.61% - 99.41%Couleur et forme :SolidMasse moléculaire :400.48LB-205
CAS :<p>LB-205 is a Zn 2+ dependent pan-inhibitor of class I and class II HDACs. It also has a long half-life in vivo.</p>Formule :C18H21N3O2SCouleur et forme :SolidMasse moléculaire :343.44CBP/p300-IN-10
CAS :<p>CBP/p300-IN-10, potent EP300/CREBBP inhibitor; IC50: 26 nM/39 nM. Potential for cancer research.</p>Formule :C25H24F5N5O3Couleur et forme :SolidMasse moléculaire :537.48INCB16562
CAS :<p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>Formule :C19H11Cl2N5Couleur et forme :SolidMasse moléculaire :380.23Guadecitabine
CAS :<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Formule :C18H24N9O10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.41Aurora A/PKC-IN-1
CAS :<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Formule :C16H14N6OSe2Couleur et forme :SolidMasse moléculaire :464.24PRMT5-IN-10
CAS :<p>PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.</p>Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Formule :C29H39Cl3FN9O3Couleur et forme :SolidMasse moléculaire :687.04Depudecin
CAS :<p>Depudecin, a polyketide from Alternaria brassicicola, has an 11-carbon chain with two epoxides and six stereocenters, inhibits HDAC, and is anti-angiogenic.</p>Formule :C11H16O4Couleur et forme :SolidMasse moléculaire :212.24UNC0379 TFA
CAS :<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Formule :C25H36F3N5O4Couleur et forme :SolidMasse moléculaire :527.589Bromodomain inhibitor-8
CAS :<p>Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases.</p>Formule :C26H25ClN2O3Couleur et forme :SolidMasse moléculaire :448.94F-amidine
CAS :<p>F-amidine is a bioavailable irreversible PAD4 inactivator.</p>Formule :C14H19FN4O2Couleur et forme :SolidMasse moléculaire :294.32JNJ-9350
CAS :<p>JNJ-9350: SMOX inhibitor (IC50 0.01 μM), PAO inhibitor (IC50 0.79 μM), for cancer research.</p>Formule :C25H22N6OCouleur et forme :SolidMasse moléculaire :422.48CPI-455 HCl
CAS :<p>CPI-455: specific KDM5A inhibitor, IC50=10±1nM, increases H3K4me3, reduces DTPs in cancer cells.</p>Formule :C16H15ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :314.77ZL0454
CAS :<p>ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).</p>Formule :C18H22N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.46S2101
CAS :<p>S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.</p>Formule :C16H16ClF2NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.75LEM-14-1189
CAS :<p>LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.</p>Formule :C35H34N6O5S2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :682.81BRD4-BD1-IN-2
CAS :<p>BRD4-BD1-IN-2: Potent, selective BRD4-BD1 inhibitor, IC50=2.51µM; 20x less active on BD2; for cardiovascular/cancer research.</p>Formule :C20H15Br3N4O2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :583.07PI3K/HDAC-IN-1
CAS :<p>PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).</p>Formule :C22H25FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.46MAT2A-IN-4
CAS :<p>MAT2A-IN-4 can be used for the cancer research that is an inhibitor of methionine adenosyltransferase 2A (MAT2A)[1].</p>Formule :C18H16ClN3OCouleur et forme :SolidMasse moléculaire :325.79SIRT5 inhibitor 2
CAS :<p>SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.</p>Formule :C18H12Cl2N2O3SDegré de pureté :99.38% - 99.87%Couleur et forme :SolidMasse moléculaire :407.27MC4343
<p>MC4343, a potent dual inhibitor targeting both EZH2 and histone deacetylase, presents promising potential for cancer research applications.</p>Formule :C36H41N5O4Couleur et forme :SolidMasse moléculaire :607.74Furamidine dihydrochloride
CAS :<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Formule :C18H18Cl2N4ODegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :377.27KD 5170
CAS :<p>KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].</p>Formule :C20H25N3O5S2Couleur et forme :SolidMasse moléculaire :451.561,2,3,4,5,6-Hexabromocyclohexane
CAS :<p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>Formule :C6H6Br6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.54Bromodomain inhibitor-9
CAS :<p>Bromodomain inhibitor-9 selectively targets BRD4-1 (Kd 12 nM), used in metabolic, inflammatory, fibrotic, and autoimmune disease studies.</p>Formule :C24H28N4O5SCouleur et forme :SolidMasse moléculaire :484.57SYK/JAK-IN-1
CAS :<p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>Formule :C24H26N8O3Couleur et forme :SolidMasse moléculaire :474.52Tankyrase-IN-2
CAS :<p>Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively</p>Formule :C17H14F2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.3NSC-311068
CAS :<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Formule :C10H6N4O4SCouleur et forme :SolidMasse moléculaire :278.24GNE-272
CAS :<p>GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.</p>Formule :C22H25FN6O2Couleur et forme :SolidMasse moléculaire :424.47SD-1029
CAS :<p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>Formule :C25H32Br2Cl2N2O3Couleur et forme :SolidMasse moléculaire :639.256(5H)-Phenanthridinone
CAS :<p>6(5H)-Phenanthridinone suppresses PARP1/2, reduces RDM4 cell growth, downregulates pro-inflammatory genes, and alleviates EAE symptoms in rats.</p>Formule :C13H9NOCouleur et forme :SolidMasse moléculaire :195.22NCC-149
CAS :<p>NCC-149 is a HDAC8 inhibitor.</p>Formule :C16H14N4O2SCouleur et forme :SolidMasse moléculaire :326.37MS-1020
CAS :<p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>Formule :C21H18N2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :346.38AC-93253 iodide
CAS :<p>AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.</p>Formule :C23H25IN2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.43Jaspamycin
CAS :<p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>Formule :C12H12N4O5Couleur et forme :SolidMasse moléculaire :292.25Ac-Lys-AMC
CAS :<p>Ac-Lys-AMC (Hexanamide) is a fluorescent substrate for histone deacetylase HDACs.</p>Formule :C18H23N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :345.39(R)-UT-155
CAS :<p>(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.</p>Formule :C20H15F4N3O2Couleur et forme :SolidMasse moléculaire :405.35ZYJ-34v
CAS :<p>ZYJ-34v is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.</p>Formule :C27H35N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :497.58TUL01101
CAS :<p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>Formule :C22H25F2N5O2Couleur et forme :SolidMasse moléculaire :429.46ARTD10/PARP10-IN-1
CAS :<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Formule :C12H12N2O4Degré de pureté :99.14%Couleur et forme :SolidMasse moléculaire :248.23BPTF-IN-1
CAS :<p>BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.</p>Formule :C23H23FN6O3Couleur et forme :SolidMasse moléculaire :450.47CPI-4203
CAS :<p>CPI-4203 is a selective inhibitor of KDM5 demethylases.</p>Formule :C16H14N4OCouleur et forme :SolidMasse moléculaire :278.31LSD1-IN-13
CAS :<p>LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.</p>Formule :C23H29N3O2SCouleur et forme :SolidMasse moléculaire :411.56BI-9321
CAS :<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Formule :C22H21FN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.43SHP2/HDAC-IN-1
CAS :<p>SHP2/HDAC-IN-1: dual SHP2/HDAC inhibitor, IC50: 20.4 nM/25.3 nM, boosts antitumor immunity, aids cancer immunotherapy research.</p>Formule :C34H35Cl2N7O3Couleur et forme :SolidMasse moléculaire :660.59Acefylline piperazine
CAS :<p>Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.</p>Formule :C9H10N4O4·xC4H10N2Couleur et forme :SolidMasse moléculaire :562.54PKN1/2-IN-1
CAS :<p>PKN1/2-IN-1 is a potent and selective PKN2 inhibitor, membrane permeability and anticancer.Protein kinase N proteins (PKN) are effectors of Rho GTPases.</p>Formule :C14H15N3ODegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :241.29BiBET
CAS :<p>BiBET is a potent, selective, bivalent inhibitor of BET bromodomains.</p>Formule :C26H30N10O3Couleur et forme :SolidMasse moléculaire :530.58KDM2B-IN-3
CAS :<p>KDM2B-IN-3, from patent WO2016112284A1 as compound 183c, potently inhibits histone demethylase KDM2B, with cancer research potential.</p>Formule :C25H30N2O2Couleur et forme :SolidMasse moléculaire :390.52GS-626510
CAS :<p>GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).</p>Formule :C25H22N4OCouleur et forme :SolidMasse moléculaire :394.47AMPK activator
CAS :<p>AMPK activator</p>Formule :C22H21FO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.41,2-Didecanoylglycerol
CAS :<p>1,2-Didecanoylglycerol has functions as bioregulator of protein kinase C in human platelets.</p>Formule :C23H44O5Couleur et forme :SolidMasse moléculaire :400.59LW479
CAS :<p>LW479 is a novel inhibitor of HDAC and is a promising candidate for the prevention of breast cancer.</p>Formule :C21H23BrN2O4SCouleur et forme :SolidMasse moléculaire :479.39NSD3-IN-1
CAS :<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Formule :C13H13N5OSCouleur et forme :SolidMasse moléculaire :287.34HPB
CAS :<p>HPB is a selective HDAC6 deacetylase inhibitor</p>Formule :C18H20N2O4Couleur et forme :SolidMasse moléculaire :328.36KDM5A-IN-1
CAS :<p>KDM5A-IN-1 is a pan-histidine lysine demethylase 5 KDM5 inhibitor that inhibits KDM5A, KDM5B, and KDM5C.Can be used in the study of cancer.</p>Formule :C15H22N4O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :290.36Galegine hydrochloride
CAS :<p>Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.</p>Formule :C6H14ClN3Couleur et forme :SolidMasse moléculaire :163.65DC_517
CAS :<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Formule :C33H35N3O2Couleur et forme :SolidMasse moléculaire :505.65HDAC-IN-43
CAS :<p>HDAC-IN-43: potent HDAC 1/3/6 inhibitor (IC50: 82 nM HDAC1, 45 nM HDAC3, 24 nM HDAC6); weak PI3K/mTOR (IC50: 3.6μM, 3.7μM); anti-proliferative.</p>Formule :C22H28N6O4Couleur et forme :SolidMasse moléculaire :440.5L 888607 Racemate
CAS :<p>L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.</p>Formule :C19H15ClFNO2SCouleur et forme :SolidMasse moléculaire :375.84Tyk2-IN-7
CAS :<p>Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).</p>Formule :C18H15D3N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.46TK4b
CAS :<p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).</p>Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.41Pulrodemstat Methylbenzenesulfonate
CAS :<p>LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.</p>Formule :C31H31F2N5O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :623.67ZIKV-IN-3
CAS :<p>ZIKV-IN-3, an andrographolide derivative, inhibits ZIKV NS5 MTase (IC50: 18.34 μM) and replication. Used for Zika virus research.</p>Formule :C39H41NO4Couleur et forme :SolidMasse moléculaire :587.75YM-53601 free base
CAS :<p>YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.</p>Formule :C21H21FN2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.4EP009
CAS :<p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>Formule :C14H24O2Couleur et forme :SolidMasse moléculaire :224.34MDK8228
CAS :<p>MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.</p>Formule :C31H41N5O3Couleur et forme :SolidMasse moléculaire :531.69NVS-BET-1
CAS :<p>NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.</p>Formule :C22H21ClN4O2Couleur et forme :SolidMasse moléculaire :408.88SIRT2-IN-11
CAS :<p>SIRT2-IN-11 (AEM1), a SIRT2 inhibitor (IC50 18.5μM), induces apoptosis and affects p53, used in cancer research.</p>Formule :C21H22N2OCouleur et forme :SolidMasse moléculaire :318.41RM65
CAS :<p>RM65 is an arginine methyltransferase inhibitor.</p>Formule :C34H32N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.76HIF-1α-IN-3
CAS :<p>HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].</p>Formule :C19H17N5O2Couleur et forme :SolidMasse moléculaire :347.37CBB1003
CAS :<p>CBB1003 is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).</p>Formule :C25H31N9O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.57PF-739
CAS :<p>PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.</p>Formule :C23H23ClN2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.89HDAC-IN-29
CAS :<p>HDAC-IN-29 (compound 13b) is a potent pan- HDAC inhibitor with antitumor activity.</p>Formule :C20H23N3O4SCouleur et forme :SolidMasse moléculaire :401.48DC-BPi-03
CAS :<p>DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .</p>Formule :C14H14N4O2SDegré de pureté :98.96%Couleur et forme :SolidMasse moléculaire :302.35Butyrolactone 3
CAS :<p>Butyrolactone 3 (MB-3) is a Gcn5 inhibitor with weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and can be used in cancer.</p>Formule :C9H12O4Degré de pureté :98.99% - 99.5%Couleur et forme :SolidMasse moléculaire :184.19EZH2-IN-13
CAS :<p>EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.</p>Formule :C34H45N5O3Degré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :571.75Butyzamide
CAS :<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Formule :C29H32Cl2N2O5SDegré de pureté :99.51% - 99.83%Couleur et forme :SoildMasse moléculaire :591.55TNG908
CAS :<p>TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.</p>Formule :C21H23N5O2SDegré de pureté :98.08% - 98.24%Couleur et forme :SolidMasse moléculaire :409.51PU139
CAS :<p>PU139 is a novel inhibitor of histone acetyltransferase (HAT).</p>Formule :C12H7FN2OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :246.26Crebinostat
CAS :<p>Crebinostat: potent HDAC inhibitor, boosts synapsin-1 in neurons, enhances memory and gene Egr1 expression in mice.</p>Formule :C20H23N3O3Degré de pureté :94.96%Couleur et forme :SolidMasse moléculaire :353.41DCPLA-ME
CAS :<p>DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerative</p>Formule :C21H38O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :322.53STS-E412
CAS :<p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>Formule :C15H15ClN4O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :318.76Raxofelast
CAS :<p>Raxofelast (IRFI-016), a vitamin-like, hydrophilic antioxidant, mitigates ischemia-reperfusion in testis and may treat diabetic issues and atherosclerosis.</p>Formule :C15H18O5Degré de pureté :99.74% - 99.97%Couleur et forme :SolidMasse moléculaire :278.3BAY-299
CAS :<p>BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.</p>Formule :C25H23N3O4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :429.47LEM-14
CAS :<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Formule :C25H26N4O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :478.56CMP-5
CAS :<p>CMP-5 is a PRMT5 inhibitor with antiviral activity, inhibits PRMT5 methyltransferase activity, and can be used in the study of SARS virus infection.</p>Formule :C21H21N3Degré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :315.41TM2-115
CAS :<p>TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].</p>Formule :C28H38N6O2Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :490.64ZEN-3219
CAS :<p>ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).</p>Formule :C19H18N2O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :322.36TGP-377/421
CAS :<p>TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 dual inhibitor that inhibits miR-377 and miR-421 by binding to their functional sites.</p>Formule :C20H16N6Degré de pureté :98.48%Couleur et forme :SolidMasse moléculaire :340.38DW14800
CAS :<p>DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.</p>Formule :C31H36N4O3Degré de pureté :99.55% - 99.68%Couleur et forme :SolidMasse moléculaire :512.64Cedazuridine
CAS :<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Formule :C9H14F2N2O5Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :268.21CEP-9722
CAS :<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Formule :C24H26N4O3Degré de pureté :98.38% - 98.56%Couleur et forme :SolidMasse moléculaire :418.49GRK6-IN-1
CAS :<p>GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.</p>Formule :C22H23ClN6O2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :438.91Procainamide
CAS :<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Formule :C13H21N3ODegré de pureté :99.92% - 99.92%Couleur et forme :SolidMasse moléculaire :235.33CPUY074020
CAS :<p>CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.</p>Formule :C25H28N4O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :416.52NSC 694623
CAS :<p>NSC 694623: Potent HAT inhibitor, IC50=15.9 μM against PCAF, anti-cancer properties.</p>Formule :C16H16N2OSDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :284.38Flosequinan
CAS :<p>Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.</p>Formule :C11H10FNO2SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :239.27Chiauranib
CAS :<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formule :C27H21N3O3Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :435.47SK-575
CAS :<p>SK-575 is a potent PARP1-degrading agent effective against BRCA1/2 mutant cancers, even at low doses, and enhances tumor inhibition in mice.</p>Formule :C47H53FN8O8Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :876.97β-NF-JQ1
CAS :<p>β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins.</p>Formule :C45H42ClN5O6SDegré de pureté :97.58% - 99.15%Couleur et forme :SolidMasse moléculaire :816.36BRD4 Inhibitor-20
CAS :<p>BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity.</p>Formule :C18H18N2O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :358.41GSK-690
CAS :<p>GSK-690 is a potent, reversible and selective inhibitors of Lysine Specific Demethylase 1.</p>Formule :C24H23N3ODegré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :369.46CD532
CAS :<p>CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.</p>Formule :C26H25F3N8ODegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :522.52JAK-STAT-IN-1
CAS :<p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>Formule :C21H21N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :375.42ML192
CAS :<p>ML192 (CID1434953) is a selective GPR55 ligand antagonist.</p>Formule :C20H22N4O2SDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :382.48SRX3177
CAS :<p>SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.</p>Formule :C31H32N6O4SDegré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :584.69KRH102140
CAS :<p>KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.</p>Formule :C25H24FNODegré de pureté :98.31% - 99.61%Couleur et forme :SolidMasse moléculaire :373.46Bisaramil hydrochloride
CAS :<p>Bisaramil hydrochloride (Bisaramil) is an antiarrhythmic compound that inhibits free radical production.</p>Formule :C17H24Cl2N2O2Degré de pureté :98.64% - 99.48%Couleur et forme :SolidMasse moléculaire :359.29AGI-24512
CAS :<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Formule :C24H24N4O2Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :400.47MAT2A-IN-9
CAS :<p>MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.</p>Formule :C14H8ClF3N4ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :340.69R 59-022 hydrochloride
CAS :<p>R 59-022 hydrochloride is a 5-HT antagonist, PKC activator, DGK inhibitor (IC50: 2.8 µM), and modulates lipid production in platelets and neutrophils.</p>Formule :C27H27ClFN3OSDegré de pureté :97.7%Couleur et forme :SolidMasse moléculaire :496.04OXF BD 02
CAS :<p>OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.</p>Formule :C18H17NO3Degré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :295.33MS0124
CAS :<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Formule :C20H29N5O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :387.48CARM1-IN-1
CAS :<p>CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.</p>Formule :C26H21Br2NO3Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :555.26LSD1-IN-20
CAS :<p>LSD1-IN-20: Dual LSD1/G9a inhibitor, Ki 0.44/0.68 μM; hampers THP-1, MDA-MB-231 cell growth with IC50 0.51/1.60 μM at 72h.</p>Formule :C27H38N6O2Degré de pureté :98.44% - 99.57%Couleur et forme :SolidMasse moléculaire :478.63EB-47
CAS :<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Formule :C24H27N9O6Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :537.53Corin
CAS :<p>Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).</p>Formule :C26H28N4O2Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :428.53JAK1-IN-8
CAS :<p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).</p>Formule :C22H23FN4O3SDegré de pureté :98.4%Couleur et forme :SolidMasse moléculaire :442.51OXFBD04
CAS :<p>OXFBD04: Potent BRD4 inhibitor, IC50=166nM, acts on BET bromodomains; moderate CREBBP affinity; anti-cancer properties.</p>Formule :C17H16N2O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :296.32ZEN-3862
CAS :<p>ZEN-3862, a BET inhibitor, blocks BRD4(BD1) at 0.16 μM & BRD4(BD2) at 0.13 μM; usable in PROTACs for BRD4 degradation.</p>Formule :C19H17FN2O3Degré de pureté :97.1%Couleur et forme :SolidMasse moléculaire :340.35OUL232
CAS :<p>OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.</p>Formule :C10H10N4O2SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :250.28Izencitinib
CAS :<p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>Formule :C22H26N8Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :402.50PARP10-IN-2
CAS :<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Formule :C14H10N2O2Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :238.24ZEN-3411
CAS :<p>ZEN-3411 is an BET inhibitor that inhibits BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2) and suppresses the growth of tumor cells overproducing BET proteins.</p>Formule :C21H20N4O2Degré de pureté :97.51% - 98.84%Couleur et forme :SolidMasse moléculaire :360.41AGI-43192
CAS :<p>AGI-43192: potent MAT2A inhibitor, crosses blood-brain barrier, may help study SAM in CNS and treat cancer.</p>Formule :C23H16ClF3N6ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :484.86HDAC6 degrader 9c
CAS :<p>HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.</p>Formule :C37H45N9O10Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :775.81ZEN-2759
CAS :<p>ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).</p>Formule :C17H16N2O2Degré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :280.32Bobcat339 hydrochloride
CAS :<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Formule :C16H13Cl2N3ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :334.2GSK761
<p>GSK761 inhibits SP140 (IC50: 77.79 nM), hinders monocyte-to-macrophage differentiation, and prompts CD206+ regulatory macrophages.</p>Formule :C40H46N4O4Couleur et forme :SolidMasse moléculaire :646.82CBB1007 hydrochloride
CAS :<p>CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.</p>Formule :C27H39Cl5N8O4Couleur et forme :SoildMasse moléculaire :716.91KH-3
CAS :<p>KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.</p>Formule :C21H22N2O4S2Couleur et forme :SolidMasse moléculaire :430.54PARP7-IN-16
CAS :<p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>Formule :C25H26FN4NaO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :488.49PHD-IN-1
CAS :<p>PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.</p>Formule :C24H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.49CBP/p300-IN-17
CAS :<p>CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM).</p>Formule :C25H28N4O3Couleur et forme :SolidMasse moléculaire :432.51JAK2-IN-4
CAS :<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56PARP-2-IN-1
CAS :<p>PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).</p>Formule :C21H19F4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.4FHT-1204
CAS :<p>FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).</p>Formule :C24H23N5O5S2Couleur et forme :SolidMasse moléculaire :525.6HDAC-IN-38
CAS :<p>HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.</p>Formule :C27H28ClN3O2Couleur et forme :SolidMasse moléculaire :461.98PI3K/HDAC-IN-2
CAS :<p>PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.</p>Formule :C23H23N7O4Couleur et forme :SolidMasse moléculaire :461.47FHT-2344
CAS :<p>FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].</p>Formule :C23H24N6O5S2Couleur et forme :SolidMasse moléculaire :528.6HDAC6-IN-34
CAS :<p>HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].</p>Formule :C18H18F3N3O3Couleur et forme :SolidMasse moléculaire :381.35DNMT-IN-3
CAS :<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75F-Amidine TFA
CAS :<p>F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.</p>Formule :C14H19FN4O2CF3COOHCouleur et forme :SolidMasse moléculaire :408.4Itacnosertib (hydrocholide)
CAS :<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formule :C26H29ClN8OCouleur et forme :SolidMasse moléculaire :505.01CW 008
CAS :<p>CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.</p>Formule :C21H14F2N6O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :420.37JBI-589
CAS :<p>JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.</p>Formule :C29H28FN5OCouleur et forme :SolidMasse moléculaire :481.56JAK-IN-26
CAS :<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Formule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46JAK-IN-1
CAS :<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Formule :C20H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.44CAY10398
CAS :<p>CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).</p>Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.367MS023 trihydrochloride
CAS :<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78dBRD4-BD1
CAS :<p>dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.</p>Formule :C50H53F3N8O9Couleur et forme :SolidMasse moléculaire :967Tubulin/JAK2-IN-1
CAS :<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Formule :C22H20N6O3Couleur et forme :SolidMasse moléculaire :416.43KDM5-IN-1
CAS :<p>KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.</p>Formule :C17H20N6ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :324.38HIF-2α-IN-13
CAS :<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Formule :C15H14ClF4NO2Couleur et forme :SolidMasse moléculaire :351.72KF21213
CAS :<p>KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.</p>Formule :C19H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.4Lepzacitinib
CAS :<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Formule :C18H21N5O3Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :355.39KAT modulator-1
CAS :<p>KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].</p>Formule :C20H36O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.5BY27
CAS :<p>BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.</p>Formule :C22H21ClN6Degré de pureté :99.4% - 99.68%Couleur et forme :SolidMasse moléculaire :404.89Lin281632
CAS :<p>Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.</p>Formule :C15H15N5ODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :281.31BRCA1-IN-2
CAS :<p>BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.</p>Formule :C26H33N4O7PDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :544.54ZL0420
CAS :<p>ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.</p>Formule :C16H16N4O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :296.32ZINC08792355
CAS :<p>ZINC08792355 is a novel inhibitor of SIRT1.</p>Formule :C31H24N4O3Couleur et forme :SolidMasse moléculaire :500.55RTS-V5
CAS :<p>RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).</p>Formule :C27H35N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.6CBP/p300-IN-5
CAS :<p>P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).</p>Formule :C29H27F5N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.55Luteolin 7-sulfate
CAS :<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>Formule :C15H10O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.3CLB-016
CAS :<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Formule :C17H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.38A1B11
CAS :<p>A1B11 is a selective SIRT2 inhibitor.</p>Formule :C22H25N5OCouleur et forme :SolidMasse moléculaire :375.47PARPYnD
CAS :<p>PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.</p>Formule :C34H31N9O3Couleur et forme :SolidMasse moléculaire :613.67I-BET762 carboxylic acid
CAS :<p>I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).</p>Formule :C20H17ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.83L-Moses
CAS :<p>L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).</p>Formule :C21H24N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46ZINC08792229
CAS :<p>ZINC08792229 is a novel inhibitor of SIRT1.</p>Formule :C30H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.52NSC756093
CAS :<p>NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.</p>Formule :C20H19NO4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :337.37HA-1004 dihydrochloride
CAS :<p>HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein</p>Formule :C12H16ClN5O2SDegré de pureté :98%Couleur et forme :White Crystalline SolidMasse moléculaire :329.81MS67
CAS :<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14KP-544
CAS :<p>KP-544 is an agent of neurotrophin potentiator.</p>Formule :C18H19ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.82CBP/p300-IN-19 hydrochloride
CAS :<p>CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.</p>Formule :C30H28ClN3O3Couleur et forme :SolidMasse moléculaire :514.02KT-531
CAS :<p>KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.</p>Formule :C17H14F4N2O4SCouleur et forme :SolidMasse moléculaire :418.36KDM2A/7A-IN-1
CAS :<p>KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.</p>Formule :C33H38N4ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :506.68Bisegliptin
CAS :<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42UNC8153 TFA
CAS :<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Formule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7GNE-955
CAS :<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Formule :C22H24N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.48Nezulcitinib
CAS :<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66SIRT5 inhibitor 7
CAS :<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Formule :C28H32ClN7O3SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :582.12GNE-207
CAS :<p>GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).</p>Formule :C29H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.59FT895
CAS :<p>FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.</p>Formule :C16H15F3N4O2Degré de pureté :98.95% - >99.99%Couleur et forme :SolidMasse moléculaire :352.31NHWD-870
CAS :<p>NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.</p>Formule :C29H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.59T-448 free base
CAS :<p>T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).</p>Formule :C17H20N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.43Ginsenoside Rk1
CAS :<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767(S)-Ro 32-0432
CAS :<p>(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].</p>Formule :C28H29ClN4O2Couleur et forme :SolidMasse moléculaire :489.01HDAC6/HSP90-IN-1
CAS :<p>HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.</p>Formule :C28H37N3O6Couleur et forme :SolidMasse moléculaire :511.61QC6352
CAS :<p>QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).</p>Formule :C24H25N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.47GNE-049
CAS :<p>GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.</p>Formule :C27H32F2N6O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :510.58JAK-IN-4
CAS :<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341PIM1-IN-1
CAS :<p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>Formule :C25H30N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.56CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Formule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04
