Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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PF-03622905
CAS :<p>PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.</p>Formule :C24H35N7O3Couleur et forme :SolidMasse moléculaire :469.59Ep300/CREBBP-IN-8
CAS :<p>Ep300/CREBBP-IN-8, IC50: 0.014/0.018 μM, potent Ep300/CREBBP inhibitor, oral, for cancer research.</p>Formule :C25H27F2N5O3Couleur et forme :SolidMasse moléculaire :483.51BRCA1-IN-1
CAS :<p>BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM).</p>Formule :C27H33F2N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.54HDAC-IN-68 hydrochloride
<p>HDAC-IN-68 (hydrochloride) (Compound 29) is an HDACs inhibitor with an IC50 value of 0.04 μM and induces microtubule fragmentation by activating katanin, a microtubule-severing protein. It is applicable in cancer research.</p>Formule :C27H25ClN8O6Masse moléculaire :592.15856Biguanide
CAS :<p>Biguanide can reduce oxidative stress in rats with hyperglycemia.</p>Formule :C2H7N5Couleur et forme :SolidMasse moléculaire :101.11BRD3067
CAS :<p>BRD3067, a Tubacin derivative, inhibits HDAC6 (IC50 15 nM) and acts as a negative control for Tubacin A, showing anticancer and anti-inflammatory effects.</p>Formule :C21H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.43Bryostatin 3
CAS :<p>Bryostatin 3 is a protein kinase C activator.</p>Formule :C46H64O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :888.99MSC2504877
CAS :<p>MSC2504877 inhibits tankyrase, boosts CDK4/6 inhibitors, blocks Cyclin D2/E2 upregulation, and strengthens phospho-Rb suppression.</p>Formule :C17H18N2O2Degré de pureté :99.72%Couleur et forme :SoildMasse moléculaire :282.34pan-BET/BD2-IN-1
<p>Pan-BET/BD2-IN-1 (compound 6b) is a selective BET protein inhibitor with BRDT-1Ki of 1.05 μM and BRD4-1Ki of 0.68 μM. It effectively inhibits the growth of MM.1S cancer cells with an IC50 value of 2.6 μM.</p>Couleur et forme :Odour SolidPOI ligand 1
<p>POI ligand 1 serves as a template for the non-selective HDAC inhibitor Vorinostat. It functions as a target protein ligand (PROTAC target protein ligand) in the creation of PROTAC HDAC degraders with anti-tumor properties. Additionally, POI ligand 1 is utilized in the synthesis of FF2049.</p>Formule :C14H21N3O3Couleur et forme :SolidMasse moléculaire :279.335SJ1008030
CAS :<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formule :C42H43N13O7SCouleur et forme :SolidMasse moléculaire :873.94BRD4 degrader AT1
CAS :<p>BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.</p>Formule :C48H58ClN9O5S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :972.68Malantide
CAS :<p>Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.</p>Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89dBET23
CAS :<p>dBET23 is a BRD4 degrader.</p>Formule :C43H45ClN8O9SCouleur et forme :SolidMasse moléculaire :885.38CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Couleur et forme :SolidmTOR/HDAC-IN-1
CAS :<p>mTOR/HDAC-IN-1, a dual inhibitor for mTOR & HDAC1 with IC50s 0.49 & 0.91 nM, potential anti-cancer agent.</p>Formule :C23H23N11O3Couleur et forme :SolidMasse moléculaire :501.5MT1
CAS :<p>MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).</p>Formule :C54H66Cl2N10O9S2Couleur et forme :SolidMasse moléculaire :1134.2XF056-132
CAS :<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11HDAC-IN-26
CAS :<p>HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.</p>Formule :C24H28FN5O3Couleur et forme :SolidMasse moléculaire :453.518CBP/p300-IN-14
CAS :<p>CBP/p300-IN-14, patent WO2021213521A1's compound 27, inhibits CBP/EP300 with 3.3 nM IC50.</p>Formule :C30H31F2N7O2Couleur et forme :SolidMasse moléculaire :559.622MR44397
<p>MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.</p>Formule :C23H26N4O2SCouleur et forme :SolidMasse moléculaire :422.54DBL-6-13
<p>DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.</p>Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.59Ep300/CREBBP-IN-2
CAS :<p>Ep300/CREBBP-IN-2: Potent, oral Ep300 & CREBBP inhibitor; IC50s: 0.052μM & 0.148μM; cancer research.</p>Formule :C26H27F3N4O4Couleur et forme :SolidMasse moléculaire :516.51mUNO
CAS :<p>mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.</p>Formule :C22H39N7O8SCouleur et forme :SolidMasse moléculaire :561.652EZH2-IN-15
CAS :<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Formule :C32H44N4O4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :548.72ATF3 inducer 1
CAS :<p>ATF3 inducer 1 is an ATF3 inducer with lipid-lowering activity, alleviating glucose intolerance and insulin resistance induced by high-fat diet (HFD).</p>Formule :C12H10N2O3Degré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :230.22HD-TAC7
<p>HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.</p>Formule :C33H32FN7O7Couleur et forme :SolidMasse moléculaire :657.65OARV-771
CAS :<p>OARV-771: VHL-based PROTAC targeting BET; DC50: Brd4-6nM, Brd2-1nM, Brd3-4nM; enhanced cell permeability.</p>Formule :C49H59ClN8O8S2Couleur et forme :SolidMasse moléculaire :987.62(S,R,S)-AHPC-C5-COOH
CAS :<p>E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.</p>Formule :C29H42N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.73PROTAC SMARCA2/4-degrader-27
CAS :<p>PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.</p>Formule :C49H58FN9O6SCouleur et forme :SolidMasse moléculaire :920.11Cath-L-dBET1
<p>Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.</p>Couleur et forme :Odour SolidJHDM-IN-1
CAS :<p>JHDM-IN-1 inhibits JHDMs; IC50: 3.4 μM JMJD2C, 4.3 μM JMJD2A, 5.9 μM JMJD2E, 10 μM PHF8, 43 μM JMJD3.</p>Formule :C27H29N3O6Couleur et forme :SolidMasse moléculaire :491.54ZINC000014708529
<p>ZINC000014708529 is a potent SIRT7 inhibitor exhibiting high affinity for SIRT7 and is utilized in cancer research [1].</p>Couleur et forme :Odour SolidSIRT1/2/3-IN-1
CAS :<p>Potent SIRT1/2/3-IN-1 inhibits SIRT1/2/3 with IC50: 0.54, 0.25, 0.72 μM; used in cancer research.</p>Formule :C46H63N9O8S2Couleur et forme :SolidMasse moléculaire :934.18NF-κB/HIF-1α-IN-1
<p>NF-κB/HIF-1α-IN-1 (compound 9c) effectively inhibits the NF-κB activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-κB/HIF-1α-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-κB and HIF-1α, and induces Nrf2.</p>Formule :C24H27N7O4Couleur et forme :SolidMasse moléculaire :477.21245MZP-55
CAS :<p>MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)</p>Formule :C57H70ClN7O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1080.73TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485N-Desmethyltamoxifen
CAS :<p>N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.</p>Formule :C25H27NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.49AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175OKI-006
CAS :<p>OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.</p>Formule :C21H30N4O5S2Couleur et forme :SolidMasse moléculaire :482.62PROTAC SMARCA2/4-degrader-31
CAS :<p>PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.</p>Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95PROTAC BRD4-binding moiety 1
CAS :<p>BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.</p>Formule :C23H21N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine
CAS :<p>(S,R,S)-AHPC-C2-amide targets Smad3 degradation and boosts HIF-α; it has anti-fibrotic and renal protective roles.</p>Formule :C41H46N6O6SCouleur et forme :SolidMasse moléculaire :750.91SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Formule :C41H47ClN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.37(rel)-Tranylcypromine D5 hydrochloride
CAS :<p>(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.</p>Formule :C9H12ClNDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :174.682TAS-119
CAS :<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36KDM4 ligand-1
<p>KDM4ligand-1 is a ligand targeting the protein (histone lysine demethylase KDM4) in PROTACs. It can be utilized for the synthesis of PROTACs.</p>Couleur et forme :Odour SolidEchinomycin
CAS :<p>Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.</p>Formule :C51H64N12O12S2Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :1101.26
