Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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dBET23
CAS :<p>dBET23 is a BRD4 degrader.</p>Formule :C43H45ClN8O9SCouleur et forme :SolidMasse moléculaire :885.38LH168
<p>LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.</p>Formule :C29H31F3N6O2SCouleur et forme :SolidMasse moléculaire :584.66KAT6-IN-2
<p>KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.</p>Couleur et forme :Odour SolidPRMT1-IN-1
CAS :<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702Nicotinamide riboside tartrate
CAS :<p>NRT is an oral NAD+ precursor, boosts NAD+, activates SIRT1/3, provides vitamin B3, enhances metabolism, and may mitigate Alzheimer's.</p>Formule :C15H20N2O11Couleur et forme :SolidMasse moléculaire :404.33CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Couleur et forme :SolidACBI2
CAS :<p>ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.</p>Formule :C56H68BrFN8O5SCouleur et forme :SolidMasse moléculaire :1064.16PROTAC SMARCA2/4-degrader-30
CAS :<p>Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.</p>Formule :C44H51N11O4Couleur et forme :SolidMasse moléculaire :797.95EP300/CBP ligand 2
<p>EP300/CBP ligand 2 (compound S19) serves as a specific ligand for the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). It plays a critical role in PROTAC technology by acting as a target protein ligand. By linking to an E3 ubiquitin ligase ligand via the PROTAC Linker, it facilitates the synthesis of PROTAC molecules capable of targeted protein degradation. For instance, when EP300/CBP ligand 2 is connected to the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc, it results in the formation of the PROTAC molecule dCE-2.</p>Formule :C20H18N6OCouleur et forme :SolidMasse moléculaire :358.4HD-TAC7
<p>HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.</p>Formule :C33H32FN7O7Couleur et forme :SolidMasse moléculaire :657.65HIF-1 inhibitor-5
<p>HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1</p>Formule :C28H35NO5Couleur et forme :SolidMasse moléculaire :465.58HAT-SIL-TG-1&AT
<p>HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.</p>Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36Go6976
CAS :<p>Go6976 is a PKC inhibitor, widely used in research to probe PKC functions in health and disease.</p>Formule :C24H18N4ODegré de pureté :95.89%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :378.43GSK 591 dihydrochloride
CAS :<p>Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.</p>Formule :C22H30Cl2N4O2Couleur et forme :SolidMasse moléculaire :453.41HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Couleur et forme :Odour SolidINCB059872
CAS :<p>INCB059872: potent, oral, selective LSD1 inhibitor for myeloid leukemia research.</p>Formule :C23H34N2O3Couleur et forme :SolidMasse moléculaire :386.536Protein Kinase C (19-36)
CAS :<p>Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.</p>Formule :C93H159N35O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2151.48PIM-IN-1
CAS :<p>PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).</p>Formule :C15H18ClFN4OCouleur et forme :SolidMasse moléculaire :324.78KDM5-C49 hydrochloride
<p>KDM5-C49 hydrochloride selectively inhibits KDM5A/B/C demethylases (IC50: 40/160/100 nM) for cancer research.</p>Formule :C15H25ClN4O3Couleur et forme :SolidMasse moléculaire :344.84JAK1/TYK2-IN-1
CAS :<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Formule :C18H20F3N7OCouleur et forme :SolidMasse moléculaire :407.401PROTAC BRD4 Degrader-1
CAS :<p>PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).</p>Formule :C40H37N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.78FTX-6058 hydrochloride
CAS :<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87HDAC6-IN-42
<p>HDAC6-IN-42 (compound 2b) is an HDAC6 inhibitor with an IC50 of 0.009 μM, demonstrating significant anti-leukemia activity and synergistic effects with Decitabine, indicating its potential use in the research of Acute Myeloid Leukemia (AML).</p>Formule :C24H28FN3O4Masse moléculaire :441.20638PROTAC_ERRα
CAS :<p>PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation.</p>Formule :C46H47F3N6O9S2Couleur et forme :SolidMasse moléculaire :949.03SMARCA2 degrader-17
CAS :<p>SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.</p>Formule :C47H58N10O6SCouleur et forme :SolidMasse moléculaire :891.09C 21
CAS :<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94mUNO
CAS :<p>mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to murine CD206, targeting tumor-associated macrophages that express CD206/MRC1. Additionally, mUNO can interact with human recombinant CD206.</p>Formule :C22H39N7O8SCouleur et forme :SolidMasse moléculaire :561.652Y16526
<p>Y16526 is a potent inhibitor of the CBP/p300 bromodomain (CBP/p300bromodomain) with an IC50 of 0.03 μM. Y16524 shows potential for research in acute myeloid leukemia (AML).</p>Formule :C30H34FN5O4Couleur et forme :SolidMasse moléculaire :547.62GXH-II-052
<p>GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.</p>Formule :C62H76Cl2F2N14O11S2Couleur et forme :SolidMasse moléculaire :1366.39TYK2 activator-1
<p>TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.</p>Formule :C23H21FN4O2Couleur et forme :SolidMasse moléculaire :404.16485Sirt2-IN-7
<p>Sirt2-IN-7, a selective SIRT2 inhibitor, has IC50 and Ki values of 178.2 nM and 154.3 nM, useful in cancer research.</p>Formule :C22H38Cl2K3N3OSCouleur et forme :SolidMasse moléculaire :831.98PROTAC PARP1 degrader-4
<p>PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.</p>Formule :C51H62FN7O6SCouleur et forme :SolidMasse moléculaire :920.145WWL0245
CAS :<p>WWL0245 is a potent and selective BRD4-targeting PROTAC that exhibits sub-nanomolar degradation efficiency (DC50 < 1 nM) for BRD4 over BRD2/3 and PLK1 (DC50 > 1</p>Formule :C45H51N11O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :873.96PRMT5-IN-11
CAS :<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31Foenumoside B
CAS :<p>Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes</p>Formule :C60H96O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1217.39BBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979MAT2A-IN-11
<p>MAT2A Allosteric Inhibitor 1, also known as Compound 5, is a selective inhibitor of methionine adenosyltransferase (MAT) demonstrating potent activity with an</p>Formule :C21H22N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.44JMJD6 inhibitor WL12
CAS :<p>WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.</p>Formule :C16H11N3O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :277.28BRD9 Degrader-1
<p>BRD9 Degrader-1 functions as a BRD9 degrader, demonstrating micromolar binding affinity towards BRD9 and nanomolar affinity for the ternary complex involving</p>Degré de pureté :98%Couleur et forme :Odour SolidIzilendustat
CAS :<p>Tert-butyl compound inhibits human EGLN-1; confirmed by spectrometry after 20 mins.</p>Formule :C22H28ClN3O4Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :433.93NPC-15437 dihydrochloride
CAS :<p>NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.</p>Formule :C25H52Cl2N4O2Couleur et forme :SolidMasse moléculaire :511.62TO-1187
<p>TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.</p>Couleur et forme :Odour SolidBET-IN-17
<p>BET-IN-17, also known as compound 16, serves as a pan-inhibitor for BET, exhibiting inhibitory potencies (pIC50) of 7.8 for BET BD1 and 7.6 for BET BD2 [1].</p>Formule :C30H36N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.63CARM1 degrader-2
<p>PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated</p>Formule :C72H100N12O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1277.71MC4171
<p>MC4171 is a selective KAT8 inhibitor with antiproliferative activity and can be used to study cancer.</p>Formule :C21H15N3O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :357.36TH1834
CAS :<p>TH1834 is a specific inhibitor of Tip60/KAT5 histone acetyltransferase. TH1834 induces apoptosis and DNA damage in MCF.</p>Formule :C33H40N6O3Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :568.71DTP3
CAS :<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6GSK2879552
CAS :<p>GSK2879552: oral, irreversible LSD1 inhibitor with potential cancer-fighting properties.</p>Formule :C23H28N2O2Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :364.48GSK-J2
CAS :<p>GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.</p>Formule :C22H23N5O2Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :389.45AZ505 ditrifluoroacetate
CAS :<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Formule :C33H40Cl2F6N4O8Couleur et forme :SolidMasse moléculaire :805.59
