Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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HIF-PHD-IN-4
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.Couleur et forme :Odour SolidTAS-119
CAS :TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36Ref: TM-T34787
1mg97,00€5mg235,00€1mL*10mM (DMSO)261,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€Protein Kinase C (19-36)
CAS :Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formule :C93H159N35O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2151.48HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formule :C60H69N17O11SCouleur et forme :SolidMasse moléculaire :1236.36SMARCA2 degrader-17
CAS :SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.Formule :C47H58N10O6SCouleur et forme :SolidMasse moléculaire :891.09MACTIDE-V
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.Formule :C109H156N22O27S2Couleur et forme :SolidMasse moléculaire :2269.09517Nicotinamide riboside malate
CAS :Orally active NAD+ booster, NR malate enhances metabolism, supports cognitive function, and is a vitamin B3 source.Formule :C15H20N2O10Couleur et forme :SolidMasse moléculaire :388.33PIM-IN-1
CAS :PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).Formule :C15H18ClFN4OCouleur et forme :SolidMasse moléculaire :324.78HSP90-IN-30
HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.Formule :C20H39B12N4O2Masse moléculaire :499.41897JAK1/TYK2-IN-1
CAS :JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Formule :C18H20F3N7OCouleur et forme :SolidMasse moléculaire :407.401PROTAC BRD4 Degrader-1
CAS :PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).Formule :C40H37N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.78FTX-6058 hydrochloride
CAS :FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87(rel)-Tranylcypromine D5 hydrochloride
CAS :(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride.Formule :C9H12ClNDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :174.682PROTAC_ERRα
CAS :PROTAC_ERRα is a potent, selective degrader of ERRα, efficiently facilitating its proteasomal degradation.Formule :C46H47F3N6O9S2Couleur et forme :SolidMasse moléculaire :949.03GXH-II-052
GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.Formule :C62H76Cl2F2N14O11S2Couleur et forme :SolidMasse moléculaire :1366.39C 21
CAS :PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94PROTAC BRD4 Degrader-27
CAS :PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.Formule :C37H30F2N6O7Couleur et forme :SolidMasse moléculaire :708.67Kiss2 peptide
CAS :Kiss2 peptide functions as a positive regulator of reproductive behavior. In COS-7 cells, it binds to its homologous G-protein coupled receptor Kiss2R (GPR54), activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This enhances the activity of cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).Formule :C63H84N16O12Masse moléculaire :1257.44Cath-L-dBET1
Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 μM in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.Couleur et forme :Odour Solid7-oxo Staurosporine
CAS :Antibiotic 7-oxo Staurosporine from S. platensis blocks various kinases, induces G2/M arrest in K562 cells, is cytotoxic, and impedes mycelial growth.Formule :C28H24N4O4Couleur et forme :SolidMasse moléculaire :480.51PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81UNC6864 (Kei)
UNC6864, an ethylisopropyllysine-containing ligand, exhibits binding affinity to wild-type CBX5, demonstrating a dissociation constant (K D) of 3.3 μM.Formule :C42H59N7O11Couleur et forme :SolidMasse moléculaire :837.96DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Couleur et forme :Odour SolidPRMT5-IN-11
CAS :PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31Foenumoside B
CAS :Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotesFormule :C60H96O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1217.39BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979Mersalyl
CAS :Mersalyl is an organic mercurial diuretic.Formule :C13H16HgNNaO6Couleur et forme :SolidMasse moléculaire :505.854JMJD6 inhibitor WL12
CAS :WL12 (ZINC6733033): First-in-class JMJD6 inhibitor; halts JMJD6-dependent cervical/liver cancer cell growth.
Formule :C16H11N3O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :277.28I-BET432
I-BET432, a BET inhibitor, blocks BRD4 BD1/BD2 (pIC50: 7.5/7.2), is oral, and targets cancer/inflammation.Formule :C18H21N3O3Couleur et forme :SolidMasse moléculaire :327.38E67-2
CAS :E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formule :C21H36N6O2Couleur et forme :SolidMasse moléculaire :404.559NPC-15437 dihydrochloride
CAS :NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Formule :C25H52Cl2N4O2Couleur et forme :SolidMasse moléculaire :511.62TO-1187
TO-1187 is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It enhances the ubiquitination and subsequent degradation of HDAC6, making it useful for research in hematological malignancies and solid tumors.Couleur et forme :Odour SolidPROTAC BRD2/BRD4 degrader-1
Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.Formule :C39H38N6O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :766.82Y16524
Y16524 is a potent inhibitor of the CBP/p300 bromodomain (CBP/p300bromodomain) with an IC50 value of 0.01 μM. It shows potential for research in acute myeloid leukemia (AML).Formule :C30H34ClN5O4Couleur et forme :SolidMasse moléculaire :564.075PROTAC BRD9-binding moiety 1
CAS :PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.Formule :C23H25N3O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :519.59BET-IN-25
BET-IN-25 (compound 7) is an orally bioactive inhibitor targeting the bromodomains BD1 and BD2, with IC50 values of 0.18 μM and 9.2 μM, respectively.Formule :C19H25N5O4SMasse moléculaire :419.16273HDAC8-IN-6
HDAC8-IN-6 (compound 3) is a potent inhibitor of HDAC8 with an IC50 of 5.1 μM and exhibits cytotoxicity.
Formule :C19H18IN3O2Masse moléculaire :447.04437XF056-132
CAS :XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11PROTAC BET Degrader-10
CAS :PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Formule :C39H39ClN8O6SCouleur et forme :SolidMasse moléculaire :783.3Ref: TM-T39374
200mgÀ demander500mgÀ demander5mg225,00€1mL*10mM (DMSO)309,00€10mg359,00€25mg672,00€50mg999,00€100mg1.485,00€CW-3308
CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.Formule :C45H48N6O8Couleur et forme :SolidMasse moléculaire :800.9PROTAC BRD4-DCAF1 degrader-1
CAS :PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.Formule :C60H64Cl2F2N8O9SCouleur et forme :SolidMasse moléculaire :1182.17JAK-IN-15
CAS :JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51OARV-771
CAS :OARV-771: VHL-based PROTAC targeting BET; DC50: Brd4-6nM, Brd2-1nM, Brd3-4nM; enhanced cell permeability.Formule :C49H59ClN8O8S2Couleur et forme :SolidMasse moléculaire :987.62Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formule :C44H64N6O9Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :821.01Pep2m, myristoylated
CAS :Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formule :C63H118N18O14SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1383.8Biotinylated-JQ1
CAS :Biotin-JQ1 is a bromodomain BRD4 binder; inhibits MM1.S cell growth with EC50 of 0.4μM.Formule :C39H53ClN8O6S2Couleur et forme :SolidMasse moléculaire :829.47FHD-609
CAS :FHD-609 is an effective BRD9 inhibitor and PROTAC degrader, depleting the SS18-SSX fusion protein, and can be used for the study of synovial sarcoma (SS).Formule :C47H56N8O6Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :829Ref: TM-T75135
1mg69,00€5mg147,00€1mL*10mM (DMSO)207,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€EEDi-5273
CAS :EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Formule :C26H22F4N6O2Couleur et forme :SolidMasse moléculaire :526.496Echinomycin
CAS :Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Formule :C51H64N12O12S2Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :1101.26
