Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formule :C41H47ClN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.37MMH1
MMH1, a novel molecular glue degrader of BRD4, operates by enlisting the CUL4 and DCAF16 ligases to target the second bromodomain (BRD4 BD2) [1].Couleur et forme :Odour SolidDot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formule :C34H37ClF3N9O4SCouleur et forme :SolidMasse moléculaire :760.23PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81JPS016
CAS :JPS016: benzamide VHL E3-ligase PROTAC, degrades HDAC1/2, triggers apoptosis in HCT116 cells.Formule :C48H63N7O8SCouleur et forme :SolidMasse moléculaire :898.12HDAC6 degrader-3
CAS :HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Formule :C41H41F4N7O11Couleur et forme :SolidMasse moléculaire :883.8PROTAC BRD4 Degrader-12
CAS :PROTAC BRD4 Degrader-12 targets BRD4 in PC3 cells; conjugates with STEAP1, CLL1; DC50: 0.39/0.24 nM.Formule :C62H77F2N9O12S4Couleur et forme :SolidMasse moléculaire :1306.58HD-TAC7
CAS :HD-TAC7 is a PROTAC degrader targeting HDAC, with IC50 values of 3.6/4.2/1.1 μM for HDAC1/HDAC2/HDAC3. It can reduce the expression of NF-κB p65.Formule :C33H32FN7O7Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :657.65HDAC6-IN-61
HDAC6-IN-61 (Compound 4e) is an HDAC6 inhibitor with an IC50 of 73 nM, demonstrating greater selectivity compared to other HDAC isomers. It also acts as an activator of GPR40. HDAC6-IN-61 can increase the acetylation of tubulin and phosphorylation levels of ERK. This compound is relevant for studying neuroinflammation, including Alzheimer's disease.Couleur et forme :Odour SolidHSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Degré de pureté :98%Couleur et forme :Odour SolidDNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Couleur et forme :Odour SolidPROTAC BRD4-binding moiety 1
CAS :BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formule :C23H21N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43PROTAC SMARCA2 degrader-23
CAS :PROTAC SMARCA2 degrader-23 (Example 1) is an effective and selective degrader of PROTAC SMARCA2, with a DC50 value of less than 100 nM. It has potential for use in cancer research.Formule :C47H57N9O6SCouleur et forme :SolidMasse moléculaire :876.08BT-O2C
CAS :BT-O2C is a highly selective p300 PROTAC degrader that effectively reduces p300 levels in HAP1 cells. It exhibits significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines, with an IC50 of 152-221 nM, and notably decreases the expression of CDS target genes (ETV1, ETV4, ETV5). BT-O2C is applicable in cancer research.Formule :C48H48F5N9O8Couleur et forme :SolidMasse moléculaire :973.94PRMT5-IN-9
CAS :PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formule :C25H23F3N6OCouleur et forme :SolidMasse moléculaire :480.495MOCPAC
CAS :MOCPAC is an HDAC1 specific substrate [1] .Formule :C27H31N3O6Couleur et forme :SolidMasse moléculaire :493.55DC-S239
CAS :Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formule :C15H15N3O5SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :349.36Ref: TM-T60002
2mg43,00€5mg66,00€10mg96,00€25mg187,00€50mg304,00€100mg482,00€200mg658,00€1mL*10mM (DMSO)73,00€METTL16-IN-1
METTL16-IN-1 is a potent inhibitor of METTL16, with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. It effectively suppresses the binding of U6 snRNA deletion to the METTL16 MTD, with an IC50 value of 2.5 μM. METTL16-IN-1 also exhibits antitumor activity.Formule :C19H12BrN3O6S2Masse moléculaire :520.93509PROTAC BRD4-DCAF1 degrader-1
CAS :PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.Formule :C60H64Cl2F2N8O9SCouleur et forme :SolidMasse moléculaire :1182.17Ep300/CREBBP-IN-3
CAS :Ep300/CREBBP-IN-3 inhibits Ep300 & CREBBP (IC50: 0.056 & 0.095 μM respectively); potential for cancer research.Formule :C26H25F4N5O3Couleur et forme :SolidMasse moléculaire :531.50Anemonin (6CI)
CAS :Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.Formule :C10H8O4Couleur et forme :SolidMasse moléculaire :192.17IQZ23
CAS :IQZ23 inhibits fat cell formation, activates AMPK, cuts triglycerides (EC50=0.033 μM), may aid obesity/metabolic study.Formule :C26H29N5O2Couleur et forme :SolidMasse moléculaire :443.551SJ10542
CAS :SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formule :C41H46N12O5SCouleur et forme :SolidMasse moléculaire :818.95SYY-B085-1
CAS :SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor.Formule :C27H23F4N5O4Couleur et forme :SolidMasse moléculaire :557.506Bryostatin 2
CAS :Protein kinase C (PKC) activatorFormule :C45H66O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :863PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8: BRD4 inhibitor with IC50s of 1.1/1.4 nM for BD1/BD2, degrades BRD4 in PC3 cells.Couleur et forme :LiquidPROTAC BRD4 Degrader-28
PROTAC BRD4 Degrader-28 (Compound 4) is a PROTAC degrader specifically targeting BRD4, and it holds potential for cancer research.Formule :C38H36ClN7O8SCouleur et forme :SolidMasse moléculaire :786.25Dihydrochlamydocin analog-1
CAS :Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Formule :C28H40N4O6Couleur et forme :SolidMasse moléculaire :528.64HDAC degrader-1
HDAC6degrader-6 (compound 10c) is a ByeTAC degrader specifically targeting HDAC6 and exhibits inhibitory effects on HDAC6, HDAC1, HDAC2, and HDAC3, with IC50 values noted. HDAC6degrader-6 induces apoptosis and is applicable for research in multiple myeloma.Couleur et forme :Odour SolidEldocasiran
CAS :Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].Formule :C423H529N161O305P42Couleur et forme :SolidMasse moléculaire :14049.5Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Couleur et forme :SolidMenin-MLL inhibitor 21
CAS :Menin-mll inhibitor 21 is a selective, oral and irreversible Menin inhibitor. Menin-MLL inhibitor 21 promotes selective proliferation of β cells and improvement of β cell function in human islet cultures in vitro. Menin-MLL inhibitor 21 enhances glycemic control in animal models of diabetes. Menin-MLL inhibitor 21 induced a dose-dependent increase in insulin secretion that was augmented by a GLP-1 receptor agonist (RA).Formule :C31H34N8O3Degré de pureté :99.95%Couleur et forme :SoildMasse moléculaire :566.65Ref: TM-T64381
1mg93,00€5mg200,00€10mg313,00€25mg637,00€50mg1.071,00€100mg1.431,00€1mL*10mM (DMSO)250,00€PROTAC SMARCA2/4-degrader-28
CAS :PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formule :C54H68ClN9O11S2Couleur et forme :SolidMasse moléculaire :1118.75ZINC000014708529
ZINC000014708529 is a potent SIRT7 inhibitor exhibiting high affinity for SIRT7 and is utilized in cancer research [1].Couleur et forme :Odour SolidDBL-6-13
DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.59CAM2602
CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.Couleur et forme :Odour SolidAUR1545
CAS :AUR1545 is a selective KAT2A/KAT2B degradator, inhibitory against AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.Formule :C41H50BrN9O5Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :828.8Myelin Basic Protein
CAS :Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formule :C60H103N21O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1390.59CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Formule :C25H22Cl2N6O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.45CPI-268456
CAS :CPI-268456 is a compound which has bioactive.Formule :C20H15Cl2N3O2Couleur et forme :SolidMasse moléculaire :400.26SR-0813
CAS :SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.Formule :C25H32N6O3SDegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.62Ref: TM-T40229
1mg39,00€5mg86,00€10mg124,00€25mg253,00€50mg384,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)94,00€MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Formule :C28H42ClN5O3Degré de pureté :98.9% - 98.96%Couleur et forme :SolidMasse moléculaire :532.12PROTAC PARP1 degrader-4
PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.Formule :C51H62FN7O6SCouleur et forme :SolidMasse moléculaire :920.145HDAC-IN-80
HDAC-IN-80 (compound 5) is a selective inhibitor of class I HDAC.Couleur et forme :Odour SolidZIP
CAS :Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formule :C90H154N30O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1928.4CBB1007 trihydrochloride (1379573-92-8 free base)
CAS :CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formule :C27H37Cl3N8O4Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :644.0Ref: TM-T10699L2
2mg131,00€5mg187,00€10mg283,00€50mg665,00€100mg1.034,00€200mgÀ demander500mgÀ demander1mL*10mM (DMSO)264,00€SAH-EZH2
CAS :EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2JHDM-IN-1
CAS :JHDM-IN-1 inhibits JHDMs; IC50: 3.4 μM JMJD2C, 4.3 μM JMJD2A, 5.9 μM JMJD2E, 10 μM PHF8, 43 μM JMJD3.Formule :C27H29N3O6Couleur et forme :SolidMasse moléculaire :491.54
