Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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MZ 1
CAS :MZ 1 is a BRD4 protein degrader based on PROTAC technology.Formule :C49H60ClN9O8S2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :1002.64Tazemetostat hydrobromide
CAS :Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Formule :C34H45BrN4O4Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :653.65Ref: TM-T17002
2mg40,00€5mg57,00€10mg77,00€50mg90,00€100mg150,00€200mg219,00€500mg358,00€1mL*10mM (DMSO)79,00€Curculigoside
CAS :1.Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44Hinokitiol
CAS :Hinokitiol prevents UVB-caused cell death, boosts antioxidant activity, and hinders breast cancer growth.Formule :C10H12O2Degré de pureté :99.49% - 99.98%Couleur et forme :SolidMasse moléculaire :164.2Pacritinib hydrochloride
CAS :Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formule :C28H32N4O3·xClHCouleur et forme :SolidKW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.69%Couleur et forme :SolidMasse moléculaire :332.4WIKI4
CAS :WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).Formule :C29H23N5O3SDegré de pureté :99.6% - 99.71%Couleur et forme :SolidMasse moléculaire :521.59FG-2216
CAS :FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formule :C12H9ClN2O4Degré de pureté :97.1% - >99.99%Couleur et forme :SolidMasse moléculaire :280.66Baricitinib
CAS :Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formule :C16H17N7O2SDegré de pureté :99% - >99.99%Couleur et forme :SolidMasse moléculaire :371.42Ref: TM-T2485
5mg48,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€1mL*10mM (DMSO)65,00€(E/Z)-Zotiraciclib
CAS :(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formule :C23H24N4ODegré de pureté :97.75% - 99.92%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T21503
1mg43,00€2mg56,00€5mg93,00€10mg113,00€25mg200,00€50mg330,00€100mg480,00€1mL*10mM (DMSO)90,00€CCT 137690
CAS :CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Formule :C26H31BrN8ODegré de pureté :98.51% - 99.89%Couleur et forme :SolidMasse moléculaire :551.48UNC0642
CAS :UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formule :C29H44F2N6O2Degré de pureté :98.75% - 99.5%Couleur et forme :SolidMasse moléculaire :546.7Ref: TM-T4166
1mg38,00€2mg50,00€5mg82,00€10mg124,00€25mg219,00€50mg358,00€100mg537,00€200mg782,00€1mL*10mM (DMSO)89,00€AZD1208
CAS :AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formule :C21H21N3O2SDegré de pureté :97.24% - 99.83%Couleur et forme :SolidMasse moléculaire :379.48BMS-911543
CAS :BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Formule :C23H28N8ODegré de pureté :97.69% - 99.98%Couleur et forme :SolidMasse moléculaire :432.52Buformin hydrochloride
CAS :Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Formule :C6H16ClN5Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :193.68Niraparib hydrochloride
CAS :Niraparib hydrochloride (MK-4827) is a PARP inhibitor with potential cancer treatment effects, causing DNA damage and apoptosis.Formule :C19H21ClN4ODegré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :356.85G5-7
CAS :G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formule :C22H19F2NO3Degré de pureté :97.3%Couleur et forme :SolidMasse moléculaire :383.39Ref: TM-T8742
1mg35,00€5mg71,00€10mg96,00€25mg172,00€50mg248,00€100mg348,00€200mg470,00€1mL*10mM (DMSO)78,00€PARP1-IN-5 dihydrochloride
CAS :PARP1-IN-5 dihydrochloride: oral, potent PARP-1 inhibitor (IC50=14.7 nM), for cancer research.Formule :C25H26Cl2N2O5SDegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :537.46Rucaparib tartrate
CAS :Rucaparib tartrate: oral PARP-1/2/3 inhibitor, Ki=1.4 nM; also inhibits H6PD; for studying CRPC.Formule :C23H24FN3O7Couleur et forme :SolidMasse moléculaire :473.457PFI-3
CAS :PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.Formule :C19H19N3O2Degré de pureté :99.58% - 99.94%Couleur et forme :SolidMasse moléculaire :321.37TP0463518
CAS :TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).Formule :C20H18ClN3O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :431.83FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :97% - 97.90%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg43,00€5mg63,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€1mL*10mM (DMSO)69,00€Palmatine chloride
CAS :Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formule :C21H22ClNO4Degré de pureté :97.9% - 99.47%Couleur et forme :SolidMasse moléculaire :387.86B2
CAS :B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormule :C20H17ClN4O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :396.83Windorphen
CAS :Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.Formule :C17H15ClO3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :302.75Fedratinib hydrochloride hydrate
CAS :Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formule :C27H40Cl2N6O4SDegré de pureté :98.96% - 99.87%Couleur et forme :SolidMasse moléculaire :615.61ME0328
CAS :ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.Formule :C19H19N3O2Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :321.37DL-α-Hydroxyglutaric acid disodium salt
CAS :DL-α-Hydroxyglutaric acid disodium salt (disodium 2-hydroxypentanedioate) is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuranFormule :C5H6Na2O5Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :192.08AG490
CAS :AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formule :C17H14N2O3Degré de pureté :98.6% - 99.85%Couleur et forme :Yellow SolidMasse moléculaire :294.3WH-4-025
CAS :WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.Formule :C39H38F3N7O5Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :741.76Ref: TM-T9219
1mg38,00€2mg50,00€5mg84,00€10mg130,00€25mg250,00€50mg396,00€100mg585,00€1mL*10mM (DMSO)93,00€MI-503
CAS :MI-503 is an efficient and selective Menin-MLL inhibitor. MI-503 has a significant inhibitory effect on human MLL leukemia cell line. Cost-effective and quality-assured.Formule :C28H27F3N8SDegré de pureté :99.87% - 99.99%Couleur et forme :SolidMasse moléculaire :564.63Ref: TM-TQ0069
1mg50,00€5mg114,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€1mL*10mM (DMSO)141,00€MK-8617
CAS :MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Formule :C24H21N5O4Degré de pureté :99.38% - >99.99%Couleur et forme :SolidMasse moléculaire :443.45Filgotinib
CAS :Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formule :C21H23N5O3SDegré de pureté :98.03% - ≥95%Couleur et forme :SolidMasse moléculaire :425.5OG-L002
CAS :OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.Formule :C15H15NODegré de pureté :97.05% - 98.62%Couleur et forme :SolidMasse moléculaire :225.29BAZ1A-IN-1
CAS :BAZ1A-IN-1, a potent inhibitor, KD 0.52 μM against BAZ1A, is effective in high-BAZ1A cancer cells, not in low-BAZ1A ones.Formule :C16H12N4O3SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :340.36Ref: TM-T9552
1mg84,00€5mg177,00€10mg268,00€25mg537,00€50mg803,00€100mg1.099,00€200mg1.468,00€1mL*10mM (DMSO)195,00€AMG-47a
CAS :AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56Danusertib
CAS :Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formule :C26H30N6O3Degré de pureté :97.88% - 98.79%Couleur et forme :White PowderMasse moléculaire :474.55A-769662
CAS :A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Formule :C20H12N2O3SDegré de pureté :97.52% - 99.58%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T2468
2mg37,00€5mg54,00€10mg74,00€25mg135,00€50mg244,00€100mg440,00€500mg964,00€1mL*10mM (DMSO)56,00€Amifostine sodium
CAS :Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Formule :C5H15N2NaO3PSCouleur et forme :SolidMasse moléculaire :237.21MPT0G211 mesylate
CAS :MPT0G211 mesylate: potent, selective HDAC6 inhibitor (IC50=0.291nM), oral, BBB-penetrating, anti-tau and metastasis, potential anticancer.Formule :C18H19N3O5SCouleur et forme :SolidMasse moléculaire :389.43MM-102 TFA
CAS :MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 interaction, impeding H3K4 HMT activity.Formule :C37H50F5N7O6Degré de pureté :99.4% - 99.78%Couleur et forme :SolidMasse moléculaire :783.83Ref: TM-T8768
1mg37,00€2mg49,00€5mg100,00€10mg165,00€25mg269,00€50mg399,00€100mg587,00€1mL*10mM (DMSO)141,00€CPI-455
CAS :CPI-455 is a specific KDM5 inhibitor.Formule :C16H14N4ODegré de pureté :97.87% - 99.03%Couleur et forme :SolidMasse moléculaire :278.31Ref: TM-T3552
1mg34,00€2mg49,00€5mg70,00€10mg105,00€25mg178,00€50mg335,00€100mg505,00€1mL*10mM (DMSO)70,00€UNC 669
CAS :UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.Formule :C15H20BrN3ODegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :338.24G007-LK
CAS :G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.Formule :C25H16ClN7O3SDegré de pureté :97.63% - 98.17%Couleur et forme :SolidMasse moléculaire :529.96Ref: TM-T6842
1mg50,00€2mg66,00€5mg94,00€10mg158,00€25mg315,00€50mg502,00€100mg707,00€1mL*10mM (DMSO)116,00€I-CBP112
CAS :I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.Formule :C27H36N2O5Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :468.59Ref: TM-T3969
1mg33,00€2mg50,00€5mg92,00€10mg161,00€25mg296,00€50mg425,00€100mg583,00€200mg785,00€1mL*10mM (DMSO)92,00€C-7280948
CAS :C-7280948 is a PRMT1 inhibitor.Formule :C14H16N2O2SDegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :276.35Ref: TM-T2097
5mg46,00€10mg66,00€25mg109,00€50mg178,00€100mg268,00€200mg414,00€500mg667,00€1mL*10mM (DMSO)49,00€Nexturastat A
CAS :Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.Formule :C19H23N3O3Degré de pureté :99.40% - 99.57%Couleur et forme :SolidMasse moléculaire :341.4DR2313
CAS :DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.Formule :C8H10N2OSDegré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :182.24JQKD82
CAS :JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.Formule :C27H40N4O5Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :500.63Pacritinib
CAS :Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formule :C28H32N4O3Degré de pureté :99.25% - 99.49%Couleur et forme :SolidMasse moléculaire :472.58
