Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2612 produits trouvés pour "Chromatine/Épigénétique"
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MS31 trihydrochloride
MS31 trihydrochloride: a selective SPIN1 inhibitor, binds H3K4me3 (IC50: 77-243 nM), non-toxic to healthy cells.Formule :C20H30Cl3N3O2Couleur et forme :SolidMasse moléculaire :450.83SC-43
CAS :SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formule :C21H13ClF3N3O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :431.8Ethyl 3,4-dihydroxybenzoate
CAS :Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formule :C9H10O4Degré de pureté :99.88%Couleur et forme :White Crystal Or PowderMasse moléculaire :182.17AMG-47a
CAS :AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formule :C29H28F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :535.56(E/Z)-Zotiraciclib
CAS :(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formule :C23H24N4ODegré de pureté :97.75% - 99.92%Couleur et forme :SolidMasse moléculaire :372.46Ref: TM-T21503
1mg43,00€2mg56,00€5mg93,00€10mg113,00€25mg200,00€50mg330,00€100mg480,00€1mL*10mM (DMSO)90,00€Menin-MLL inhibitor 20
CAS :Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.Formule :C33H40N8O4Degré de pureté :97.77%Couleur et forme :SolidMasse moléculaire :612.72Ref: TM-T9399
1mg38,00€5mg86,00€10mg128,00€25mg250,00€50mg369,00€100mg527,00€200mg712,00€1mL*10mM (DMSO)95,00€WM-8014
CAS :WM-8014 (MOZ-IN-3) is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.Formule :C20H17FN2O3SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :384.42Ref: TM-T4362
1mg54,00€2mg78,00€5mg109,00€10mg166,00€25mg316,00€50mg470,00€100mg682,00€1mL*10mM (DMSO)129,00€Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41RGB-286638 free base
CAS :RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63Daphnetin
CAS :Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Formule :C9H6O4Degré de pureté :97.47% - 99.8%Couleur et forme :SolidMasse moléculaire :178.14PHD-1-IN-1
CAS :PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formule :C13H8N4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :220.23Ref: TM-T9627
1mg42,00€5mg92,00€10mg132,00€25mg231,00€50mg349,00€100mg522,00€200mg710,00€1mL*10mM (DMSO)90,00€FLLL32
CAS :FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formule :C28H32O6Degré de pureté :97% - 97.90%Couleur et forme :SolidMasse moléculaire :464.55Ref: TM-T6838
2mg43,00€5mg63,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€500mg797,00€1mL*10mM (DMSO)69,00€3-methyl-1,2,3,4-tetrahydroquinazolin-2-one
CAS :3-methyl-1,2,3,4-tetrahydroquinazolin-2-one is a inhibitor of BRD4 .Formule :C9H10N2ODegré de pureté :99.3% - 99.64%Couleur et forme :SolidMasse moléculaire :162.19Ref: TM-T50006
2mg37,00€5mg52,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€500mg642,00€1mL*10mM (DMSO)56,00€Alobresib
CAS :Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.Formule :C26H23N5O2Degré de pureté :97.63%Couleur et forme :SolidMasse moléculaire :437.49Ref: TM-T8495
1mg70,00€2mg87,00€5mg137,00€10mg260,00€25mg507,00€50mg713,00€100mg982,00€1mL*10mM (DMSO)150,00€C-82
CAS :C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.Formule :C33H34N6O4Degré de pureté :98.86% - 99.66%Couleur et forme :SolidMasse moléculaire :578.66Tubacin
CAS :Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.Formule :C41H43N3O7SDegré de pureté :97.62% - 98.75%Couleur et forme :SolidMasse moléculaire :721.86Reversine
CAS :Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formule :C21H27N7ODegré de pureté :98% - 99.45%Couleur et forme :SolidMasse moléculaire :393.49Ref: TM-T1825
1mg35,00€2mg50,00€5mg66,00€10mg84,00€25mg156,00€50mg212,00€100mg371,00€1mL*10mM (DMSO)66,00€J-147
CAS :J-147, a curcumin derivative, is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.Formule :C18H17F3N2O2Degré de pureté :99.61% - >99.99%Couleur et forme :SolidMasse moléculaire :350.33PLX51107
CAS :PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).Formule :C26H22N4O3Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :438.48Ref: TM-TQ0253
1mg52,00€2mg77,00€5mg113,00€10mg178,00€25mg313,00€50mg464,00€100mg672,00€1mL*10mM (DMSO)124,00€SHR0302
CAS :SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formule :C18H22N8O2SDegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :414.48Ref: TM-T9195
1mg80,00€5mg183,00€10mg298,00€25mg512,00€50mg817,00€100mg1.311,00€1mL*10mM (DMSO)167,00€OUL35
CAS :OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.Formule :C14H12N2O3Degré de pureté :99.2%Couleur et forme :SolidMasse moléculaire :256.26EPZ005687
CAS :EPZ005687 is a potent and selective inhibitor of EZH2.Formule :C32H37N5O3Degré de pureté :97.06% - 99.64%Couleur et forme :SolidMasse moléculaire :539.67Rucaparib Phosphate
CAS :Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formule :C19H18FN3O·H3PO4Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :421.36Ref: TM-T6127
1mg35,00€2mg50,00€5mg74,00€10mg109,00€25mg178,00€50mg235,00€100mg371,00€200mg553,00€1mL*10mM (DMSO)74,00€JAK3-IN-6
CAS :JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormule :C19H18N4O3Degré de pureté :99.94% - 99.94%Couleur et forme :SolidMasse moléculaire :350.37Ruxolitinib (S enantiomer)
CAS :Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formule :C17H18N6Degré de pureté :99.37% - 99.79%Couleur et forme :SolidMasse moléculaire :306.36Momelotinib HCl
CAS :Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formule :C23H24Cl2N6O2Couleur et forme :SolidMasse moléculaire :487.38BRD4770
CAS :BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.Formule :C25H23N3O3Degré de pureté :99.53% - 99.82%Couleur et forme :SolidMasse moléculaire :413.47XAV-939
CAS :XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).Formule :C14H11F3N2OSDegré de pureté :97.47% - 99.67%Couleur et forme :SolidMasse moléculaire :312.31GSK2879552 2HCl (1401966-69-5(free base))
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
Formule :C23H30Cl2N2O2Degré de pureté :99.87% - ≥95%Couleur et forme :SolidMasse moléculaire :437.41Ref: TM-T4418
1mg59,00€2mg86,00€5mg109,00€10mg175,00€25mg293,00€50mg411,00€100mg610,00€500mg1.301,00€WZ4003
CAS :WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.Formule :C25H29ClN6O3Degré de pureté :99.65% - >99.99%Couleur et forme :SolidMasse moléculaire :496.99Ref: TM-T6291
5mg48,00€10mg73,00€25mg111,00€50mg166,00€100mg241,00€200mg358,00€500mg590,00€1mL*10mM (DMSO)50,00€Iso-H7 dihydrochloride
CAS :Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Formule :C14H19Cl2N3O2SDegré de pureté :99.53%Couleur et forme :White Crystalline SolidMasse moléculaire :364.29ABBV-744
CAS :ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.Formule :C28H30FN3O4Degré de pureté :97.03% - >99.99%Couleur et forme :SolidMasse moléculaire :491.55Ref: TM-T4697
1mg44,00€2mg56,00€5mg90,00€10mg142,00€25mg284,00€50mg409,00€100mg500,00€200mg718,00€1mL*10mM (DMSO)90,00€Menin-MLL inhibitor MI-2
CAS :Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.Formule :C18H25N5S2Degré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :375.55Ref: TM-T2649
2mg39,00€5mg58,00€10mg84,00€25mg160,00€50mg230,00€100mg356,00€200mg522,00€1mL*10mM (DMSO)64,00€UMB298
CAS :UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.Formule :C27H31ClN4O2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :479.01Ref: TM-T9194
1mg46,00€5mg94,00€10mg149,00€25mg250,00€50mg351,00€100mg480,00€200mg622,00€1mL*10mM (DMSO)99,00€(S)-CPI203
CAS :CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formule :C19H18ClN5OSDegré de pureté :99.01% - 99.92%Couleur et forme :SolidMasse moléculaire :399.9Ref: TM-T6026
2mg34,00€5mg55,00€10mg89,00€25mg170,00€50mg269,00€100mg424,00€200mg593,00€1mL*10mM (DMSO)58,00€C646
CAS :C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).Formule :C24H19N3O6Degré de pureté :98% - 99.21%Couleur et forme :SolidMasse moléculaire :445.42Ref: TM-T2452
2mg46,00€5mg65,00€10mg92,00€25mg185,00€50mg360,00€100mg532,00€500mg1.144,00€1mL*10mM (DMSO)65,00€PF-CBP1 hydrochloride
CAS :PF-CBP1 HCl selectively inhibits CREBBP bromodomain (IC50: 125 nM) and p300 (IC50: 363 nM).Formule :C29H37ClN4O3Degré de pureté :97.11% - 99.02%Couleur et forme :SolidMasse moléculaire :525.08BCI-121
CAS :BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.Formule :C14H18BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :340.22RO8191
CAS :RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formule :C14H5F6N5ODegré de pureté :98% - 98.85%Couleur et forme :SolidMasse moléculaire :373.21Ref: TM-T22142
1mg43,00€2mg55,00€5mg93,00€10mg137,00€25mg254,00€50mg380,00€100mg573,00€500mg1.189,00€GLPG0634 analog
CAS :GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Formule :C23H18N6O2Degré de pureté :99.52% - >99.99%Couleur et forme :SolidMasse moléculaire :410.43Ref: TM-T3076
1mg38,00€2mg50,00€5mg84,00€10mg137,00€25mg250,00€50mg442,00€100mg623,00€500mg1.305,00€1mL*10mM (DMSO)93,00€Tofacitinib Citrate
CAS :Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Formule :C22H28N6O8Degré de pureté :99.19% - 99.75%Couleur et forme :SolidMasse moléculaire :504.49MI-463
CAS :MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).Formule :C24H23F3N6SDegré de pureté :99.18% - >99.99%Couleur et forme :SolidMasse moléculaire :484.54SGC2085 HCl
CAS :SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formule :C19H24N2O2·HClDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :348.87Ref: TM-T4013
1mg93,00€2mg150,00€5mg190,00€10mg343,00€25mg567,00€50mg825,00€100mg1.130,00€1mL*10mM (DMSO)244,00€KC7F2
CAS :KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formule :C16H16Cl4N2O4S4Degré de pureté :98% - 99.11%Couleur et forme :SolidMasse moléculaire :570.38DDP-38003 trihydrochloride
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.Formule :C21H29Cl3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.84Deoxyshikonin
CAS :1.Formule :C16H16O4Degré de pureté :99.36% - ≥95%Couleur et forme :SolidMasse moléculaire :272.3BYK204165
CAS :BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)Formule :C15H12N2O2Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :252.27Ref: TM-T7896
1mg44,00€5mg66,00€10mg90,00€25mg167,00€50mg236,00€100mg349,00€200mg512,00€1mL*10mM (DMSO)73,00€Atractylenolide I
CAS :Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formule :C15H18O2Degré de pureté :97.55% - 99.92%Couleur et forme :SolidMasse moléculaire :230.30Bempedoic acid
CAS :Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C.Formule :C19H36O5Degré de pureté :99.85% - 99.94%Couleur et forme :SolidMasse moléculaire :344.49Ref: TM-T3625
2mg34,00€5mg50,00€10mg70,00€25mg118,00€50mg207,00€100mg333,00€500mg797,00€1mL*10mM (DMSO)52,00€GSK6853
CAS :GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.Formule :C22H27N5O3Degré de pureté :98.71% - 99.21%Couleur et forme :SolidMasse moléculaire :409.48
