Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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(Z)-SMI-4a
CAS :<p>(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.</p>Formule :C11H6F3NO2SDegré de pureté :97.66% - 99.93%Couleur et forme :SolidMasse moléculaire :273.23Oclacitinib
CAS :<p>Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000</p>Formule :C15H23N5O2SDegré de pureté :98% - 98.45%Couleur et forme :White To Off-White SolidMasse moléculaire :337.44lutidinic acid
CAS :<p>lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.</p>Formule :C7H5NO4Degré de pureté :98.06%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :167.12RG108
CAS :<p>RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).</p>Formule :C19H14N2O4Degré de pureté :98% - 99.43%Couleur et forme :SolidMasse moléculaire :334.33SGC-CBP30
CAS :<p>SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).</p>Formule :C28H33ClN4O3Degré de pureté :99.05% - >99.99%Couleur et forme :SolidMasse moléculaire :509.04AZD-1480
CAS :<p>AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.</p>Formule :C14H14ClFN8Degré de pureté :98.25% - 99.47%Couleur et forme :SolidMasse moléculaire :348.77JAK-IN-5 hydrochloride
CAS :<p>JAK-IN-5 hydrochloride is a JAK inhibitor [1].</p>Formule :C27H32ClFN6OCouleur et forme :SolidMasse moléculaire :511.03Barasertib-HQPA
CAS :<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formule :C26H30FN7O3Degré de pureté :98.43% - 99.29%Couleur et forme :SolidMasse moléculaire :507.56ARV-825
CAS :<p>ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.</p>Formule :C46H47ClN8O9SDegré de pureté :97.15% - 98%Couleur et forme :SolidMasse moléculaire :923.43UNC6934
CAS :<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Formule :C24H21N5O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :443.45Annaosanchun
CAS :<p>Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).</p>Formule :C19H32O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :308.46GS-829845
CAS :<p>GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life</p>Formule :C17H19N5O2SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :357.43CX-6258 hydrochloride
CAS :<p>CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).</p>Formule :C26H24ClN3O3·HClDegré de pureté :96.03% - 98.60%Couleur et forme :SolidMasse moléculaire :498.4CBHcy
CAS :<p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>Formule :C9H17NO4SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :235.3TNG-462
CAS :<p>TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).</p>Formule :C28H36N6O2SDegré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :520.69MIV-6R
CAS :<p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>Formule :C27H35N3ODegré de pureté :99.81% - 99.88%Couleur et forme :SolidMasse moléculaire :417.59Talazoparib tosylate
CAS :<p>PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.</p>Formule :C26H22F2N6O4SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :552.55Zavondemstat
CAS :<p>Zavondemstat (QC8222 free base) is a KDM4 inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.</p>Formule :C26H29N3O3Degré de pureté :99.43% - 99.53%Couleur et forme :SolidMasse moléculaire :431.53MS023 dihydrochloride
CAS :<p>MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.</p>Formule :C17H27Cl2N3ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :360.32Cerdulatinib hydrochloride
CAS :<p>Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.</p>Formule :C20H28ClN7O3SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :482Chromium(III) acetate
CAS :<p>Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.</p>Formule :C2H3O2CrDegré de pureté :99.9%Couleur et forme :Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InMasse moléculaire :76.37(S)-HH2853
CAS :<p>(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.</p>Formule :C31H36F3N7O3Degré de pureté :97.18% - 99.74%Couleur et forme :SolidMasse moléculaire :611.66MRK-740
CAS :<p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>Formule :C25H32N6O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :464.56BI-9321 trihydrochloride
CAS :<p>BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.</p>Formule :C22H24Cl3FN4Degré de pureté :99.12% - 99.34%Couleur et forme :SolidMasse moléculaire :469.81R 59-022
CAS :<p>R 59-022 (DKGI-I) is a DGK inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells.</p>Formule :C27H26FN3OSDegré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :459.58PFI-2
CAS :<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>Formule :C23H25F4N3O3SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :499.52NVP-BSK805
CAS :<p>NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.</p>Formule :C27H28F2N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.55MK-5108
CAS :<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>Formule :C22H21ClFN3O3SDegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :461.94Dehydrocorydaline nitrate
CAS :<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Formule :C22H24N2O7Degré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :428.44SCH-1473759 hydrochloride
CAS :<p>SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).</p>Formule :C20H27ClN8OSDegré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :463GSK2807 Trifluoroacetate
CAS :<p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>Formule :C21H33F3N8O7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :566.53(R)-Dihydrolipoic acid
CAS :<p>(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.</p>Formule :C8H16O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :208.33Solrikitug
CAS :<p>Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.</p>Degré de pureté :95%Couleur et forme :LiquidTazemetostat trihydrochloride
CAS :<p>Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.</p>Formule :C34H47Cl3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :682.12Acedapsone
CAS :<p>Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.</p>Formule :C16H16N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.37Diethyl bipy55'DC
CAS :<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Formule :C16H16N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :300.312-PADQZ
CAS :<p>DPQ is an antiviral compound.</p>Formule :C14H19N5O2Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :289.33Nicotinamide-d4
CAS :<p>Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.</p>Formule :C6H2D4N2ODegré de pureté :99.746%Couleur et forme :SolidMasse moléculaire :126.15193 D7
CAS :<p>193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.</p>Formule :C16H15NO4SCouleur et forme :SolidMasse moléculaire :317.36GSK 4027
CAS :<p>GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.</p>Formule :C17H21BrN4OCouleur et forme :SolidMasse moléculaire :377.28I-BET787
CAS :<p>I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.</p>Formule :C16H20ClN3O2Couleur et forme :SolidMasse moléculaire :321.80CrBKA
CAS :<p>CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity [1] .</p>Formule :C28H31N3O6Couleur et forme :SolidMasse moléculaire :505.56AdipoR agonist 1
CAS :<p>AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.</p>Formule :C26H35N3O3Couleur et forme :SolidMasse moléculaire :437.57HDAC6-IN-27
CAS :<p>HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].</p>Formule :C15H15N3O4Couleur et forme :SolidMasse moléculaire :301.3BG47
CAS :<p>BG47: a COMET probe for precise optical epigenetic control, inhibits histone deacetylases with light.</p>Formule :C25H22N4O2SCouleur et forme :SolidMasse moléculaire :442.54Guanosine-5'-triphosphate disodium salt
CAS :<p>5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.</p>Formule :C10H14N5Na2O14P3Degré de pureté :95.69% - 99.96%Couleur et forme :Odorless White SolidMasse moléculaire :567.14GSK-J1 lithium salt
CAS :<p>GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.</p>Formule :C22H22LiN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.38BG14
CAS :<p>BG14: High-res optical epigenetic control; photo-inhibits human histone deacetylases with visible light.</p>Formule :C21H21N5OCouleur et forme :SolidMasse moléculaire :359.433KAT6-IN-1
CAS :<p>KAT6-IN-1 is a potent KAT6 inhibitor. KAT6-IN-1 can be used in research of cancer [1] .</p>Formule :C19H18N4O5SCouleur et forme :SolidMasse moléculaire :414.43ZM39923
CAS :<p>ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).</p>Formule :C23H25NODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.45
