Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one
CAS :1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one is an inhibitor Bromodomain-containing protein 4 (human).Formule :C17H19NODegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :253.34Ref: TM-T8601
1mg58,00€5mg116,00€10mg172,00€25mg281,00€50mg396,00€100mg537,00€200mg712,00€1mL*10mM (DMSO)109,00€GSK620
CAS :GSK620, a selective pan-BD2 inhibitor, has anti-inflammatory properties and favorable oral pharmacokinetics.Formule :C18H19N3O3Degré de pureté :99.42% - 99.88%Couleur et forme :SolidMasse moléculaire :325.36Ref: TM-T9020
2mg34,00€5mg49,00€10mg73,00€25mg136,00€50mg212,00€100mg314,00€200mg467,00€1mL*10mM (DMSO)87,00€Talazoparib
CAS :Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).Formule :C19H14F2N6ODegré de pureté :97.02% - 99.92%Couleur et forme :SolidMasse moléculaire :380.35Ref: TM-T6253
2mg42,00€5mg62,00€10mg88,00€25mg135,00€50mg187,00€100mg311,00€200mg429,00€500mg697,00€1mL*10mM (DMSO)67,00€Solcitinib
CAS :Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.
Formule :C22H23N5O2Degré de pureté :99.61% - 99.82%Couleur et forme :SolidMasse moléculaire :389.45Dbet57
CAS :dBET57: PROTAC-based BRD4BD1 degrader, DC50/5h at 500 nM, ineffective on BRD4BD2.Formule :C34H31ClN8O5SDegré de pureté :99.36% - 99.52%Couleur et forme :SolidMasse moléculaire :699.18Ref: TM-T5440
1mg47,00€5mg92,00€10mg147,00€25mg264,00€50mg409,00€100mg592,00€500mg1.224,00€1mL*10mM (DMSO)166,00€MAT2A inhibitor 4
CAS :MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancerFormule :C16H15ClFNDegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :275.75Ref: TM-T9262
1mg40,00€5mg90,00€10mg131,00€25mg220,00€50mg314,00€100mg426,00€200mg575,00€1mL*10mM (DMSO)89,00€Mivebresib
CAS :Mivebresib (ABBV-075) is a potent BET inhibitor with antitumor effects, disrupting gene expression and MYC, TMPRSS2-ETS proteins.Formule :C22H19F2N3O4SDegré de pureté :98.74% - 99.32%Couleur et forme :SolidMasse moléculaire :459.47Ref: TM-T3712
1mg55,00€2mg78,00€5mg92,00€10mg150,00€25mg244,00€50mg437,00€100mg625,00€1mL*10mM (DMSO)94,00€PHA-680632
CAS :PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formule :C28H35N7O2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :501.623-Aminobenzamide
CAS :3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction duringFormule :C7H8N2ODegré de pureté :98.4% - 99.5%Couleur et forme :White To Off-White PowderMasse moléculaire :136.15SF2523
CAS :SF2523 is a highly selective and potent inhibitor.Formule :C19H17NO5SDegré de pureté :99.1% - 99.51%Couleur et forme :SolidMasse moléculaire :371.41Ref: TM-T3986
1mg34,00€5mg74,00€10mg113,00€25mg260,00€50mg409,00€100mg605,00€500mg1.288,00€1mL*10mM (DMSO)82,00€JNJ-64619178
CAS :JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Formule :C22H23BrN6O2Degré de pureté :98.86% - 99.98%Couleur et forme :SolidMasse moléculaire :483.36Ref: TM-T15624
1mg84,00€5mg167,00€10mg260,00€25mg537,00€50mg893,00€100mg1.571,00€1mL*10mM (DMSO)172,00€GeA-69
CAS :GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).Formule :C20H16N2ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :300.35TTK21
CAS :TTK21 is an activator of CBP/p300 histone acetyltransferase activity.Formule :C17H15ClF3NO2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :357.75Ref: TM-T8778
1mg57,00€5mg105,00€10mg158,00€25mg308,00€50mg462,00€100mg692,00€500mg1.404,00€1mL*10mM (DMSO)114,00€PX-478
CAS :PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formule :C13H20Cl4N2O3Degré de pureté :97% - 99.79%Couleur et forme :SolidMasse moléculaire :394.12Ref: TM-T6961
1mg39,00€5mg84,00€10mg130,00€25mg193,00€50mg261,00€100mg411,00€200mg605,00€1mL*10mM (DMSO)84,00€LW6
CAS :LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Formule :C26H29NO5Degré de pureté :98.1% - 98.22%Couleur et forme :SolidMasse moléculaire :435.51Ref: TM-T3494
2mg44,00€5mg65,00€10mg94,00€25mg173,00€50mg281,00€100mg424,00€500mg888,00€1mL*10mM (DMSO)65,00€Dehydrocorydaline
CAS :1.Formule :C22H24NO4Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :366.43Ref: TM-T5S2358
1mg49,00€2mg69,00€5mg105,00€10mg137,00€25mg197,00€50mg295,00€100mg447,00€1mL*10mM (DMSO)116,00€Belzutifan
CAS :"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Formule :C17H12F3NO4SDegré de pureté :99.34% - 99.88%Couleur et forme :SolidMasse moléculaire :383.34Ref: TM-T16679
1mg66,00€5mg144,00€10mg205,00€25mg389,00€50mg625,00€100mg888,00€200mg1.198,00€1mL*10mM (DMSO)158,00€I-BET151
CAS :I-BET151 (GSK1210151A) (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).Formule :C23H21N5O3Degré de pureté :97.34% - 99.63%Couleur et forme :SolidMasse moléculaire :415.44Ref: TM-T2120
1mg48,00€2mg65,00€5mg96,00€10mg115,00€25mg202,00€50mg339,00€100mg507,00€500mg1.130,00€1mL*10mM (DMSO)105,00€Veliparib
CAS :Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.Formule :C13H16N4ODegré de pureté :98.66% - 99%Couleur et forme :SolidMasse moléculaire :244.29Ref: TM-T2591
5mg54,00€10mg77,00€25mg120,00€50mg195,00€100mg314,00€200mg512,00€500mg807,00€1mL*10mM (DMSO)60,00€Tranylcypromine hemisulfate
CAS :Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset ofFormule :C9H11N1H2SO4Degré de pureté :98% - 99.96%Couleur et forme :SolidMasse moléculaire :182.23SGI-1027
CAS :SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).Formule :C27H23N7ODegré de pureté :99.45% - 99.78%Couleur et forme :SolidMasse moléculaire :461.52Ref: TM-T1904
5mg58,00€10mg94,00€25mg163,00€50mg296,00€100mg467,00€500mg1.035,00€1mL*10mM (DMSO)74,00€GSK467
CAS :GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).Formule :C17H13N5O2Degré de pureté :99.55% - 99.85%Couleur et forme :SolidMasse moléculaire :319.32MG 149
CAS :MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).Formule :C22H28O3Degré de pureté :98.69% - 99.86%Couleur et forme :SolidMasse moléculaire :340.46Ref: TM-T6584
1mg50,00€2mg71,00€5mg90,00€10mg167,00€25mg308,00€50mg492,00€100mg708,00€1mL*10mM (DMSO)108,00€UNC3866
CAS :UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Formule :C43H66N6O8Degré de pureté :88.06% - 99.62%Couleur et forme :SolidMasse moléculaire :795.02GW779439X
CAS :GW779439X is an inhibitor of CDK.Formule :C22H21F3N8Degré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :454.45Ref: TM-T8866
1mg58,00€2mg82,00€5mg113,00€10mg178,00€25mg404,00€50mg592,00€100mg845,00€1mL*10mM (DMSO)124,00€CCT241736
CAS :CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Formule :C22H23Cl2N7Degré de pureté :96.2% - 99.81%Couleur et forme :SolidMasse moléculaire :456.37G244-LM
CAS :G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.Formule :C18H22N4O3S2Degré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :406.52AMG 900
CAS :AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Formule :C28H21N7OSDegré de pureté :98.4% - 99.51%Couleur et forme :SolidMasse moléculaire :503.58Ref: TM-T6380
1mg49,00€5mg92,00€10mg158,00€25mg286,00€50mg442,00€100mg645,00€500mg1.341,00€1mL*10mM (DMSO)100,00€3-Methoxybenzamide
CAS :3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.Formule :C8H9NO2Degré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :151.16Amifostine trihydrate
CAS :Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Formule :C5H15N2O3PS·3H2ODegré de pureté :99.71% - 99.80%Couleur et forme :SolidMasse moléculaire :268.27Fosifidancitinib
CAS :Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.Formule :C21H21FN5O7PDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :505.39Ref: TM-T38624
1mg93,00€2mg117,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€ARV-771
CAS :ARV-771 is an effective BET degrader based on PROTAC technology.Cost-effective and quality-assured.Formule :C49H60ClN9O7S2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :986.64Ref: TM-T5435
1mg57,00€5mg113,00€10mg177,00€25mg354,00€50mg522,00€100mg732,00€200mg973,00€1mL*10mM (DMSO)192,00€Oclacitinib maleate
CAS :Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Formule :C15H23N5O2S·C4H4O4Degré de pureté :99.17% - 99.92%Couleur et forme :SolidMasse moléculaire :453.51Ref: TM-T6914
1mg37,00€2mg52,00€5mg74,00€10mg94,00€25mg166,00€50mg258,00€100mg432,00€1mL*10mM (DMSO)81,00€CPI-169 racemate
CAS :CPI-169 racemate (CPI 169) is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
Formule :C27H36N4O5SDegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :528.66BET bromodomain inhibitor
CAS :BET bromodomain inhibitor is a potent BET inhibitor.Formule :C24H20ClN5O2Degré de pureté :98.22% - 99.85%Couleur et forme :SolidMasse moléculaire :445.9Ref: TM-T2072
1mg35,00€2mg50,00€5mg75,00€10mg114,00€25mg187,00€50mg264,00€100mg416,00€1mL*10mM (DMSO)84,00€ENMD-2076
CAS :ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formule :C21H25N7Degré de pureté :97.63% - ≥95%Couleur et forme :SolidMasse moléculaire :375.47(Z)-SMI-4a
CAS :(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Formule :C11H6F3NO2SDegré de pureté :97.66% - 99.93%Couleur et forme :SolidMasse moléculaire :273.23Oclacitinib
CAS :Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000Formule :C15H23N5O2SDegré de pureté :98% - 98.45%Couleur et forme :White To Off-White SolidMasse moléculaire :337.44lutidinic acid
CAS :lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
Formule :C7H5NO4Degré de pureté :98.06%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :167.12RG108
CAS :RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).Formule :C19H14N2O4Degré de pureté :98% - 99.43%Couleur et forme :SolidMasse moléculaire :334.33Ref: TM-T2038
5mg44,00€10mg65,00€25mg111,00€50mg195,00€100mg271,00€200mg380,00€500mg618,00€1mL*10mM (DMSO)52,00€SGC-CBP30
CAS :SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).Formule :C28H33ClN4O3Degré de pureté :99.05% - >99.99%Couleur et forme :SolidMasse moléculaire :509.04Ref: TM-T6668
1mg50,00€2mg67,00€5mg84,00€10mg113,00€25mg200,00€50mg334,00€100mg500,00€1mL*10mM (DMSO)94,00€AZD-1480
CAS :AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.Formule :C14H14ClFN8Degré de pureté :98.25% - 99.47%Couleur et forme :SolidMasse moléculaire :348.77JAK-IN-5 hydrochloride
CAS :JAK-IN-5 hydrochloride is a JAK inhibitor [1].Formule :C27H32ClFN6OCouleur et forme :SolidMasse moléculaire :511.03Barasertib-HQPA
CAS :Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.
Formule :C26H30FN7O3Degré de pureté :98.43% - 99.29%Couleur et forme :SolidMasse moléculaire :507.56ARV-825
CAS :ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.Formule :C46H47ClN8O9SDegré de pureté :97.15% - 98%Couleur et forme :SolidMasse moléculaire :923.43UNC6934
CAS :UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Formule :C24H21N5O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :443.45Ref: TM-T9584
1mg47,00€5mg92,00€10mg152,00€25mg326,00€50mg485,00€100mg670,00€200mg888,00€1mL*10mM (DMSO)101,00€Annaosanchun
CAS :Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Formule :C19H32O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :308.46Ruboxistaurin hydrochloride
CAS :Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formule :C28H28N4O3·HClDegré de pureté :99.14% - 99.28%Couleur et forme :SolidMasse moléculaire :505.01Ref: TM-T3689
1mg67,00€2mg87,00€5mg148,00€10mg244,00€25mg487,00€50mg702,00€100mg982,00€500mg1.963,00€1mL*10mM (DMSO)190,00€TNG-462
CAS :TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Formule :C28H36N6O2SDegré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :520.69Ref: TM-T79873
1mg147,00€5mg255,00€10mg383,00€25mg575,00€50mg863,00€100mg1.305,00€200mg1.755,00€1mL*10mM (DMSO)294,00€Osunprotafib
CAS :Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.Cost-effective and quality-assured.Formule :C17H24FN3O4SDegré de pureté :97.11% - 99.91%Couleur et forme :SolidMasse moléculaire :385.45
