Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2242 produits trouvés pour "Chromatine/Épigénétique"
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JAK2-IN-4
CAS :<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Formule :C23H27N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.56F-Amidine TFA
CAS :<p>F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.</p>Formule :C14H19FN4O2CF3COOHCouleur et forme :SolidMasse moléculaire :408.4ZINC08792355
CAS :<p>ZINC08792355 is a novel inhibitor of SIRT1.</p>Formule :C31H24N4O3Couleur et forme :SolidMasse moléculaire :500.55CBP/p300-IN-5
CAS :P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Formule :C29H27F5N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :618.55FHT-1204
CAS :<p>FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).</p>Formule :C24H23N5O5S2Couleur et forme :SolidMasse moléculaire :525.6RTS-V5
CAS :<p>RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).</p>Formule :C27H35N5O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.6CLB-016
CAS :<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Formule :C17H20N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.38A1B11
CAS :<p>A1B11 is a selective SIRT2 inhibitor.</p>Formule :C22H25N5OCouleur et forme :SolidMasse moléculaire :375.47PARP-2-IN-1
CAS :<p>PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).</p>Formule :C21H19F4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.4Luteolin 7-sulfate
CAS :<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>Formule :C15H10O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.3PARPYnD
CAS :<p>PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.</p>Formule :C34H31N9O3Couleur et forme :SolidMasse moléculaire :613.67NSC756093
CAS :<p>NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.</p>Formule :C20H19NO4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :337.37I-BET762 carboxylic acid
CAS :<p>I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).</p>Formule :C20H17ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.83KP-544
CAS :<p>KP-544 is an agent of neurotrophin potentiator.</p>Formule :C18H19ClN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.82L-Moses
CAS :L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Formule :C21H24N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.46HDAC-IN-38
CAS :<p>HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.</p>Formule :C27H28ClN3O2Couleur et forme :SolidMasse moléculaire :461.98ZINC08792229
CAS :<p>ZINC08792229 is a novel inhibitor of SIRT1.</p>Formule :C30H22N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.52HA-1004 dihydrochloride
CAS :<p>HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein</p>Formule :C12H16ClN5O2SDegré de pureté :98%Couleur et forme :White Crystalline SolidMasse moléculaire :329.81MS67
CAS :<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14CBP/p300-IN-19 hydrochloride
CAS :<p>CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.</p>Formule :C30H28ClN3O3Couleur et forme :SolidMasse moléculaire :514.02KT-531
CAS :<p>KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.</p>Formule :C17H14F4N2O4SCouleur et forme :SolidMasse moléculaire :418.36TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51Bisegliptin
CAS :<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42KDM2A/7A-IN-1
CAS :<p>KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.</p>Formule :C33H38N4ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :506.68GNE-955
CAS :<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Formule :C22H24N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.48UNC8153 TFA
CAS :<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Formule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7Nezulcitinib
CAS :<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Formule :C30H37N7O2Couleur et forme :SolidMasse moléculaire :527.66SIRT5 inhibitor 7
CAS :<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Formule :C28H32ClN7O3SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :582.12GNE-207
CAS :<p>GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).</p>Formule :C29H30N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :510.59FT895
CAS :<p>FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.</p>Formule :C16H15F3N4O2Degré de pureté :98.95% - >99.99%Couleur et forme :SolidMasse moléculaire :352.31Gö 7874
CAS :<p>Gö 7874 is a potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC).</p>Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52CW 008
CAS :<p>CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.</p>Formule :C21H14F2N6O2Degré de pureté :97.39%Couleur et forme :SolidMasse moléculaire :420.37JAK-IN-26
CAS :<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Formule :C22H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.46NHWD-870
CAS :<p>NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.</p>Formule :C29H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.59Itacnosertib (hydrocholide)
CAS :<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Formule :C26H29ClN8OCouleur et forme :SolidMasse moléculaire :505.01JBI-589
CAS :<p>JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.</p>Formule :C29H28FN5OCouleur et forme :SolidMasse moléculaire :481.56T-448 free base
CAS :<p>T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).</p>Formule :C17H20N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.43Ginsenoside Rk1
CAS :<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767(S)-Ro 32-0432
CAS :<p>(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].</p>Formule :C28H29ClN4O2Couleur et forme :SolidMasse moléculaire :489.01CBB1007 hydrochloride
CAS :<p>CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.</p>Formule :C27H39Cl5N8O4Couleur et forme :SoildMasse moléculaire :716.91HDAC6/HSP90-IN-1
CAS :<p>HDAC6/HSP90-IN-1 is a potent dual inhibitor of HDAC6 and HSP90 with IC50s 4.3 nM & 46.8 nM, respectively; curbs PD-L1 and tumor growth in H1975 mice.</p>Formule :C28H37N3O6Couleur et forme :SolidMasse moléculaire :511.61KH-3
CAS :<p>KH-3: HuR inhibitor, IC50 0.35 μM, halts cell growth, blocks HuR-FOXQ1 mRNA, curbs breast cancer invasion, slows lung colony growth.</p>Formule :C21H22N2O4S2Couleur et forme :SolidMasse moléculaire :430.54FHT-2344
CAS :<p>FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].</p>Formule :C23H24N6O5S2Couleur et forme :SolidMasse moléculaire :528.6MS023 trihydrochloride
CAS :<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78JAK-IN-1
CAS :<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Formule :C20H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.44QC6352
CAS :<p>QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).</p>Formule :C24H25N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.47GNE-049
CAS :<p>GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.</p>Formule :C27H32F2N6O2Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :510.58JAK-IN-4
CAS :<p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>Formule :C18H21N4Na2O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.341CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Formule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04PIM1-IN-1
CAS :<p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>Formule :C25H30N8O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.56
