Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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TC-A 2317 hydrochloride
CAS :<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93TC-AC28
CAS :<p>TC-AC28 is a novel potent and selective Brd2(2) ligand.</p>Formule :C23H21N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.44Nesuparib
CAS :<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Formule :C23H24N6ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :400.48GSK4028
CAS :<p>GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.</p>Formule :C17H21BrN4OCouleur et forme :SolidMasse moléculaire :377.28HL23
CAS :<p>HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC).</p>Formule :C44H44N2O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :712.83BRD4 Inhibitor-23
CAS :<p>BRD4 Inhibitor-23: potent, oral, IC50: BRD4 BD-1 6.21 nM, BD-2 1.44 nM. See WO2022033542A1 Example 1.</p>Formule :C22H19F2N3O4SCouleur et forme :SolidMasse moléculaire :459.47HIF-2α-IN-6
CAS :<p>HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].</p>Formule :C15H13F4NO3SCouleur et forme :SolidMasse moléculaire :363.33TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51AMPK-IN-1
CAS :<p>AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.</p>Formule :C24H18ClN3O3Couleur et forme :SolidMasse moléculaire :431.87EPZ011989 HCl(1598383-40-4 Free base)
CAS :<p>EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.</p>Formule :C35H51N5O4·HClCouleur et forme :SolidMasse moléculaire :642.27TCJL37
CAS :<p>TCJL37: potent, selective TYK2 inhibitor (K i 1.6 nM), oral, for IBD research.</p>Formule :C17H11ClF2N4O2Couleur et forme :SolidMasse moléculaire :376.74CBP/p300-IN-19
CAS :<p>CBP/p300-IN-19 inhibits p300/CBP HAT (IC50: 1.4μM), less effective on PCAF/Myst3, shows anti-tumor properties.</p>Formule :C30H27N3O3Couleur et forme :SolidMasse moléculaire :477.55GSK2646264
CAS :<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48Gö 7874
CAS :<p>Gö 7874 is a potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC50 = 4 nM for rat brain PKC).</p>Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52HSP70/SIRT2-IN-2
CAS :<p>HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].</p>Formule :C17H13N3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.5LY3295668
CAS :<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95GNE-375
CAS :<p>GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.</p>Formule :C25H29N3O5Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :451.51HIF-2α agonist 2
CAS :HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formule :C13H8Br2N2O2SDegré de pureté :98.87%Couleur et forme :SoildMasse moléculaire :416.09EPZ031686
CAS :<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Formule :C26H34ClF3N4O4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :591.09E7016
CAS :<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Formule :C20H19N3O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :349.38CPI-0610 carboxylic acid
CAS :<p>CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.</p>Formule :C20H15ClN2O3Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :366.8JAK-IN-3
CAS :<p>JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.</p>Formule :C18H20N4O3Degré de pureté :98.04% - 98.19%Couleur et forme :SolidMasse moléculaire :340.38NPAS3-IN-1
CAS :<p>NPAS3-IN-1 is an NPAS3-ARNT heterodimerization inhibitor that regulates NPAS3 transcription by modulating the heterodimerization of NPAS3 with ARNT.</p>Formule :C10H5N3O2S3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :295.36hRIO2 kinase ligand-1
CAS :<p>hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM).</p>Formule :C17H14N2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :262.31CCT129202
CAS :<p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02KDM4-IN-4
CAS :<p>KDM4-IN-4 is a KDM4 inhibitor with anticancer activity that inhibits the KDM4A-Tudor structural domain for cancer research.</p>Formule :C16H23NODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :245.36AU-15330
CAS :<p>AU-15330 is a proteolytic targeting chimera (PROTAC) that simultaneously targets SMARCA4, SMARCA2, and PBRM1 for degradation and exhibits cytotoxicity in H3.3K27M cells but not in H3 wild-type cells. Cost-effective and quality-assured.</p>Formule :C39H49N9O5SDegré de pureté :98.21% - 99.62%Couleur et forme :SolidMasse moléculaire :755.93PARP-1-IN-4
CAS :<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Formule :C22H15Cl2N3O2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :424.28FHT-1015
CAS :<p>FHT-1205 is a potent inhibitor (IC50 ≤ 10 nM) of SMARCA4/SMARCA2 ATPase (BRG1 and BRM).</p>Formule :C25H25N5O4S3Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :555.69HS94
CAS :<p>HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.</p>Formule :C15H15N5O2SDegré de pureté :95.04%Couleur et forme :SolidMasse moléculaire :329.38Y06137
CAS :<p>Y06137, selective BET inhibitor, Kd 81 nM for BRD4(1), researched for castration-resistant prostate cancer treatment.</p>Formule :C27H32N4O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :444.57CeMMEC1
CAS :<p>CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).</p>Formule :C19H16N2O4Degré de pureté :98.9% - 99.92%Couleur et forme :SolidMasse moléculaire :336.34Aurora B inhibitor 1
CAS :<p>Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.</p>Formule :C25H26ClF2N7O2Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :529.97L-Moses dihydrochloride
<p>L-Moses (L-45) dihydrochloride is the first, potent, selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor (Kd: 126 nM).</p>Formule :C21H26Cl2N6Couleur et forme :SolidMasse moléculaire :433.38MC2652
<p>MC2652, a potent LSD1 inhibitor, suppresses leukemia (MV4-11, NB4) and impedes prostate cancer (LNCaP) cell growth.</p>Formule :C22H20N2OCouleur et forme :SolidMasse moléculaire :328.41KDOAM-25 citrate
CAS :<p>KDOAM-25 citrate inhibits KDM5A/B/C/D (IC50: 71, 19, 69, 69 nM); boosts H3K4 methylation, hinders MM1S cell growth. [1]</p>Formule :C21H33N5O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :499.51BSI-401
CAS :<p>BSI-401 is an oral inhibitor of PARP-1. It can inhibit pancreatic cancer either when used alone or in synergy with Oxaliplatin.</p>Formule :C9H4INO4Couleur et forme :SolidMasse moléculaire :317.037HDAC6-IN-13
<p>HDAC6-IN-13: potent, selective HDAC6 inhibitor; oral; IC50=0.019μM; targets HDAC1/2/3; crosses blood-brain barrier; anti-inflammatory.</p>Formule :C23H22N4OCouleur et forme :SolidMasse moléculaire :370.45DS-9300
CAS :<p>DS-9300, an orally administered potent and selective inhibitor of EP300/CBP HAT, exhibits a significant inhibitory activity with an IC50 value of 28 nM.</p>Formule :C25H26F3N5O3Couleur et forme :SolidMasse moléculaire :501.506K465
CAS :<p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>Formule :C26H33ClFN9ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :542.05Balomenib
CAS :<p>Balomenib is an inhibitor of the menin-MLL interaction, effectively blocking the men1-MLL4-43 interaction with an IC50 of less than 0.075 μM. It inhibits cell growth in MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM), and HEK293 (CC50 < 2 μM) cells. Balomenib also exhibits antitumor activity.</p>Formule :C33H34F3N7O2Couleur et forme :SolidMasse moléculaire :617.664O6BTG-C8-αGlu
CAS :<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525KH-259
<p>KH-259: potent, selective CNS-penetrant HDAC6 inhibitor with 0.26 μM IC50; shows antidepressant effects in mice.</p>Formule :C20H25N3O2Couleur et forme :SolidMasse moléculaire :339.43BRD4-IN-7
CAS :<p>BRD4-IN-7, also known as compound 120, acts as a BRD4 inhibitor.</p>Formule :C29H24F2N4O3Couleur et forme :SolidMasse moléculaire :514.52PAD2-IN-1 hydrochloride
<p>PAD2-IN-1 hydrochloride: potent, selective PAD2 inhibitor; 95x less on PAD4, 79x less on PAD3; benzimidazole derivative.</p>Formule :C25H30ClFN6O3Couleur et forme :SolidMasse moléculaire :517PRMT5-IN-50
CAS :<p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496WIZ degrader 8
CAS :<p>WIZ degrader 8 (compound 10) is a potent and selective molecular glue degrader of the transcription factor WIZ, effectively inducing HbF expression. It promotes WIZ degradation and HbF induction, suggesting its potential use as an inhibitor for sickle cell disease.</p>Formule :C21H27N3O4Couleur et forme :SolidMasse moléculaire :385.457BRD4 Inhibitor-33
CAS :<p>BRD4 Inhibitor-33 (example 13), a potent inhibitor of BRD4, is applicable in research related to both acute and chronic kidney diseases [1].</p>Formule :C24H20N4O2Couleur et forme :SolidMasse moléculaire :396.44MAT2A-IN-19
CAS :<p>MAT2A-IN-19 (Compound I-3) is an inhibitor of methionine adenosyltransferase 2A (MAT2A), with an IC50 of 32.93 nM.</p>Formule :C23H15F5N6O3Couleur et forme :SolidMasse moléculaire :518.396JPHM-2-167
CAS :<p>PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.</p>Formule :C30H28N6O2Couleur et forme :SolidMasse moléculaire :504.582
