Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2235 produits trouvés pour "Chromatine/Épigénétique"
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CARM1-IN-3 dihydrochloride
<p>CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).</p>Formule :C24H34Cl2N4O2Couleur et forme :SolidMasse moléculaire :481.46KDOAM-25 trihydrochloride
<p>KDOAM-25 trihydrochloride selectively inhibits KDM5 enzymes, boosts H3K4 methylation, and suppresses MM1S cell growth.</p>Formule :C15H28Cl3N5O2Couleur et forme :SolidMasse moléculaire :416.77LSD1-IN-19
<p>LSD1-IN-19 is a potent, selective LSD1 inhibitor with Ki of 0.108 μM and 72h IC50 values of 0.17-0.40 μM.</p>Formule :C33H42N6O2Couleur et forme :SolidMasse moléculaire :554.73CFT8634
CAS :<p>CFT8634 degrades BRD9, for synovial sarcoma and SMARCB1 tumor research, from patent WO2021178920A1.</p>Formule :C37H45F3N6O5Couleur et forme :SolidMasse moléculaire :710.79P300 bromodomain-IN-1
<p>P300 bromodomain-IN-1 blocks c-Myc, induces G1/G0 arrest, apoptosis. Potent EP300 inhibitor (IC50: 49 nM).</p>Formule :C29H31ClN4O4Couleur et forme :SolidMasse moléculaire :535.03SCH-1473759
CAS :<p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.54QCA570
CAS :<p>QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).</p>Formule :C39H33N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :695.79Londamocitinib
CAS :<p>Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.</p>Formule :C28H31F2N7O4SDegré de pureté :98.64% - 99.56%Couleur et forme :SolidMasse moléculaire :599.65MAO A/HDAC-IN-1
<p>MAO A/HDAC-IN-1 is an effective monoamine oxidase A (MAO A) and HDAC dual inhibitor, which can be used for glioma research.</p>Formule :C21H24ClN3O3Couleur et forme :SolidMasse moléculaire :401.89BRD4 D1-IN-2
<p>BRD4 D1-IN-2 (compound 26), a BRD4 D1 inhibitor, IC50 <0.092 μM, 15 nM affinity, >500x selectivity over BRD2 D1/BRD4 D2.</p>Formule :C33H39F3N6OCouleur et forme :SolidMasse moléculaire :592.7HDAC6-IN-12
<p>HDAC6-IN-12 is a potent inhibitor of HDAC6 that binds in the DNA chain, causing DNA damage and exhibiting anticancer effects that can be used in cancer research</p>Formule :C24H39F2N3O5Couleur et forme :SolidMasse moléculaire :487.58Balanol
CAS :<p>Balanol is an ATP-competitive Protein Kinase C and Protein Kinase A inhibitor.</p>Formule :C28H26N2O10Couleur et forme :SolidMasse moléculaire :550.51Tyk2-IN-17
CAS :<p>Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].</p>Formule :C20H20F2N8OCouleur et forme :SolidMasse moléculaire :426.42Tyk2-IN-14
CAS :<p>Tyk2-IN-14, a small molecule inhibitor of TYK2, is significant in treating inflammatory diseases and conditions linked to hypersecretion of IFNa and interferons [1].</p>Formule :C22H21N9O2Couleur et forme :SolidMasse moléculaire :443.46PARP-1-IN-1
<p>PARP-1-IN-1: Selective, oral PARP-1 inhibitor with 0.96 nM IC50; well-tolerated and effective in single-dose MDA-MB-436 model.</p>Formule :C23H25FN4OCouleur et forme :SolidMasse moléculaire :392.47B026
CAS :<p>B026: Oral p300/CBP HAT inhibitor, IC50: p300 1.8 nM, CBP 9.5 nM; targets AR+ prostate cancer cells.</p>Formule :C27H23F4N5O4Couleur et forme :SolidMasse moléculaire :557.5Pim-1 kinase inhibitor 6
CAS :<p>Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].</p>Formule :C21H10BrCl2N3Couleur et forme :SolidMasse moléculaire :455.13DS44470011
CAS :<p>DS44470011 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) with oral bioavailability. It enhances the release of erythropoietin (EPO) from cells and is utilized in research related to renal anemia.</p>Formule :C21H19N3O4Couleur et forme :SolidMasse moléculaire :377.39IBL-302
CAS :<p>IBL-302 (AMU302), an orally available dual-signaling inhibitor targeting PIM and PI3K/AKT/mTOR, is effective against breast cancer and neuroblastoma. It has shown in vivo efficacy in a nude mouse xenograft model by combating trastuzumab resistance. Additionally, IBL-302 augments the effectiveness of widely used cytotoxic chemotherapy drugs such as cisplatin, doxorubicin, and etoposide [1] [2] [3].</p>Formule :C25H18FN5O4S3Couleur et forme :SolidMasse moléculaire :567.64SE-7552
CAS :<p>SE-7552, a derivative of 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO), serves as an orally active, highly selective non-hydroxamate HDAC6 inhibitor, boasting an IC50 of 33 nM. It exhibits over 850-fold selectivity against all other known HDAC isozymes. Demonstrating efficacy in vivo, SE-7552 effectively inhibits the growth of multiple myeloma. Additionally, it functions as an anti-obesity agent in diet-induced obese mice [1] [2].</p>Formule :C15H12F3N5OCouleur et forme :SolidMasse moléculaire :335.28Menin-MLL inhibitor 26
CAS :<p>Menin-MLL inhibitor 26: Active reference, inhibits cell growth, used in leukemia research.</p>Formule :C27H29F3N6O3SCouleur et forme :SolidMasse moléculaire :574.62EED ligand 1
<p>EED ligand 1: potent PRC2 inhibitor targeting EED subunit.</p>Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41MDH1/2-IN-1
CAS :<p>MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.</p>Formule :C25H33NO4Couleur et forme :SolidMasse moléculaire :411.534JAK1/TYK2-IN-4
CAS :<p>JAK1/TYK2-IN-4 serves as a dual inhibitor targeting both JAK and TYK2, displaying IC50 values of 39 nM and 21 nM, respectively. It is also orally bioavailable [1].</p>Formule :C17H23N7OCouleur et forme :SolidMasse moléculaire :341.41WDR5-IN-5
CAS :<p>WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.</p>Formule :C29H29F3N6OCouleur et forme :SolidMasse moléculaire :534.58Aurora inhibitor 1
CAS :<p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>Formule :C23H25N9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.57BET-IN-8
<p>BET-IN-8 (Compound 27) is a potent inhibitor of BET (Ki: 0.83 μM, Kd: 0.571 μM), which ameliorates LPS-induced sepsis in vivo.BET-IN-8 has shown potential in</p>Formule :C22H21N3O4SCouleur et forme :SolidMasse moléculaire :423.48GSK8814
CAS :<p>GSK8814 is a selective and ATAD2/2B bromodomain chemical probe and inhibitor (binding constant pKd=8.1 and a pKi=8.9 in BROMOscan).</p>Formule :C28H35F2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.61Basroparib
CAS :<p>Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.</p>Formule :C18H21F2N7O3Couleur et forme :SolidMasse moléculaire :421.4BRD-7880
CAS :<p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67PRMT5-IN-1 hydrochloride
<p>PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.</p>Formule :C19H20Cl2N4O5Couleur et forme :SolidMasse moléculaire :455.29DS17701585
<p>DS17701585: Oral EP300/CBP inhibitor; potent on CBP, EP300, H3K27, & SOX2; useful for cancer research.</p>Formule :C24H26N4O5SCouleur et forme :SolidMasse moléculaire :482.55Tyk2-IN-15
CAS :<p>Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].</p>Formule :C21H25F2N7OCouleur et forme :SolidMasse moléculaire :429.47BRD4-BD1/2-IN-2
CAS :<p>BRD4-BD1/2-IN-2 inhibits BRD4 BD1/BD2 with IC50 <300 nM/<0.5 nM (WO2021233371A1).</p>Formule :C30H33N5O4Couleur et forme :SolidMasse moléculaire :527.61HDAC2-IN-1
<p>HDAC2-IN-1 is an oral HDAC2 inhibitor (IC50: 0.5 μM), crosses the blood-brain barrier, and inhibits HDAC1 and HDAC8.</p>Formule :C22H23ClN4OSCouleur et forme :SolidMasse moléculaire :426.96PRMT5-IN-18
CAS :<p>PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.</p>Formule :C32H42N4O4Couleur et forme :SolidMasse moléculaire :546.70HDAC-IN-33
<p>HDAC-IN-33 inhibits HDAC1/2/6 (IC50: 24/46/47 nM), exhibits potent antitumor activity in vitro and in vivo, and activates antitumor immunity.</p>Formule :C21H25N3O3Couleur et forme :SolidMasse moléculaire :367.44MTL-CEBPA
<p>MTL-CEPBA is a small activating RNA that targets C/EBPα upregulation and exhibits anti-inflammatory and anti-cancer effects.</p>Couleur et forme :SolidAurora A inhibitor 1
CAS :<p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>Formule :C25H28ClF2N5O2Couleur et forme :SolidMasse moléculaire :503.97ORIC-944
CAS :<p>ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.</p>Formule :C26H25FN6ODegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :456.52Pocenbrodib
CAS :<p>Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.</p>Formule :C28H32FN3O6Degré de pureté :98.48% - 99.54%Couleur et forme :SolidMasse moléculaire :525.57GSK3368715 dihydrochloride
CAS :<p>GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.</p>Formule :C20H40Cl2N4O2Degré de pureté :99.66% - 99.66%Couleur et forme :SolidMasse moléculaire :439.46LLY-283
CAS :<p>LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.</p>Formule :C17H18N4O4Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :342.35DN02
<p>DN02: a potent, selective BRD8(1) bromodomain probe; Ki=32 nM; 30x more affine than BRD8(2).</p>Formule :C22H24FN3O3Degré de pureté :98.22% - 99.74%Couleur et forme :SolidMasse moléculaire :397.44EZM0414
CAS :<p>EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.</p>Formule :C22H29FN4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :400.49INCB054329
CAS :<p>INCB054329 is a BET inhibitor targeting BRD2/3/4 and BRDT with IC50s ranging from 1-119 nM.</p>Formule :C19H16N4O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :348.36AMG-193
CAS :<p>AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.</p>Formule :C22H19F3N4O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :444.41BRD0639
CAS :<p>BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.</p>Formule :C21H22ClN5O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :475.95Sinefungin
CAS :<p>Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral</p>Formule :C15H23N7O5Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :381.39JDTic
CAS :<p>JDTic, a 4-phenylpiperidine derivative distantly related to analgesics like meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan, exhibits a notably long duration of action, maintaining effects in animals for weeks following a single dose. This duration is not due to irreversible binding to the kappa opioid receptor but rather to altered activity of c-Jun N-terminal kinases. As a highly selective antagonist for the κ-opioid receptor, without influencing the μ- or δ-opioid receptors, JDTic has shown potential in animal studies for producing antidepressant and anxiolytic effects. It also demonstrates promise in treating addiction to substances such as cocaine and morphine, distinguishing itself structurally from other kappa antagonists like norbinaltorphimine.</p>Formule :C28H39N3O3Couleur et forme :SolidMasse moléculaire :465.63
