Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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BRD7-IN-1 free base
CAS :BRD7-IN-1, a BI7273 derivative, transforms into PROTAC VZ185 (targets BRD7/9 with 4.5/1.8 nM DC50s) via a VHL linker.Formule :C22H26N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.473β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS :3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.
Formule :C30H52O4Couleur et forme :SolidMasse moléculaire :476.742SMD-3040 TFA
SMD-3040 TFA is a selective SMARCA2 degrader comprising SMARCA2/4 ligands, a linker, and VHL ligands, utilized in PROTAC drug synthesis.Degré de pureté :98%Couleur et forme :Odour SolidFTX-6058
CAS :FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417CARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06PROTAC HDAC6 degrader 4
PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]Formule :C39H42FN9O7Couleur et forme :SolidMasse moléculaire :767.81PROTAC BRD4 Degrader-19
CAS :PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utilityFormule :C44H38N8O5S2Couleur et forme :SolidMasse moléculaire :822.95GSK8573
CAS :GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).Formule :C20H21NO3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :323.39HDAC6 ligand-3
HDAC6ligand-3 serves as a ligand for HDAC6 and can be utilized as a target protein ligand in the synthesis of [PROTAC] HDAC6 degrader4.Formule :C20H21N3O3Couleur et forme :SolidMasse moléculaire :351.399DS-103
DS-103 is an HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC50 values of 0.029, 0.123, 0.022, 0.367, and 9.26 μM, respectively. It also inhibits the malignant malaria parasite [Plasmodium falciparum 3D7] with an IC50 of 5.08 μM. In A2780 and Cal27 cells, DS-103 exhibits cytotoxicity with IC50 values of 1.48 μM and 1.47 μM, respectively, and reverses cisplatin resistance in these cells with IC50 values of 4.62 μM and 2.23 μM. DS-103 acts synergistically with cisplatin, enhancing apoptosis induced by cisplatin.Formule :C28H33N5O3Couleur et forme :SolidMasse moléculaire :487.59SR-0813
CAS :SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.Formule :C25H32N6O3SDegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.62Ref: TM-T40229
1mg39,00€5mg86,00€10mg124,00€25mg253,00€50mg384,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)94,00€MAK-683 hydrochloride
CAS :MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :SolidMasse moléculaire :412.85SIRT1-IN-1
CAS :SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29Ref: TM-T9648
1mg92,00€5mg192,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€1mL*10mM (DMSO)195,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Couleur et forme :LiquidHSP90/LSD1-IN-1
HSP90/LSD1-IN-1 (compound 6) is a dual inhibitor of HSP90 and LSD1. This compound effectively inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI50 values of 0.24 μM and 0.30 μM, respectively.Couleur et forme :Odour SolidHyp-dBET1
Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.Couleur et forme :Odour SolidJAK-IN-15
CAS :JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formule :C22H23FN4O3SCouleur et forme :SolidMasse moléculaire :442.51DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Couleur et forme :Odour SolidPROTAC BRD4 Degrader-10
CAS :Compound 8b, a dual-ligand PROTAC, targets VHL & BRD4, degrades BRD4 in PC3 cells; conjugates with STEAP1/CLL1, DC50: 1.3/18 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderDNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Couleur et forme :Odour SolidTyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCouleur et forme :Odour SolidRef: TM-L2200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderVanicoside A
CAS :Vanicoside A is a protein kinase C( PKC ) inhibitor from Polygonum pensylvanicum [1] .Formule :C51H50O21Couleur et forme :SolidMasse moléculaire :998.93GSK9311 hydrochloride
CAS :GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Formule :C24H32ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474CBB1007 trihydrochloride (1379573-92-8 free base)
CAS :CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Formule :C27H37Cl3N8O4Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :644.0Ref: TM-T10699L2
2mg131,00€5mg187,00€10mg283,00€50mg665,00€100mg1.034,00€200mgÀ demander500mgÀ demander1mL*10mM (DMSO)264,00€Bryostatin 3
CAS :Bryostatin 3 is a protein kinase C activator.Formule :C46H64O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :888.99(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).Formule :C56H67F2N9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1096.31KDM1A-IN-29
CAS :KDM1A-IN-29 is a histone demethylase inhibitor.Formule :C16H16ClN3O4SCouleur et forme :SoildMasse moléculaire :381.83NSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43ZL0590
CAS :ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.Formule :C23H27F3N4O4SDegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :512.55Ref: TM-T60072
1mg71,00€5mg152,00€10mg222,00€25mg401,00€50mg602,00€100mg887,00€1mL*10mM (DMSO)167,00€PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Couleur et forme :Odour SolidMalantide
CAS :Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89NP213
CAS :NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).Formule :C42H84N28O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1093.3GSK J5
CAS :GSK J5: schistosome, helminth inhibitor; trematode insecticide; boosts schistosome death dose/time-wise.Formule :C24H27N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :417.5Ref: TM-T22821
1mg47,00€5mg126,00€10mg202,00€25mg449,00€50mg655,00€100mg934,00€500mg1.872,00€1mL*10mM (DMSO)117,00€Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS :Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formule :C56H110N22O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1315.61Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Couleur et forme :Odour SolidRef: TM-L3510
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderSW2_110A
CAS :SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.Formule :C42H60N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :760.96HIF-1 α (556-574)
CAS :HIF-1 alpha (556-574) is a 19-mer fragment vital for gene expression in low oxygen; it binds VHL with critical proline 564 for stability.Formule :C101H150D2N20O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2254.6PROTAC SMARCA2/4-degrader-28
CAS :PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formule :C54H68ClN9O11S2Couleur et forme :SolidMasse moléculaire :1118.75Anemonin (6CI)
CAS :Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.Formule :C10H8O4Couleur et forme :SolidMasse moléculaire :192.17GSK040
CAS :GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Formule :C29H34N4O4Couleur et forme :SolidMasse moléculaire :502.6ACBI2
CAS :ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.Formule :C56H68BrFN8O5SCouleur et forme :SolidMasse moléculaire :1064.16A-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54JAK-STAT Compound Library
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;Couleur et forme :Odour SolidRef: TM-L3700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPROTAC BRD4 Degrader-5
CAS :PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Formule :C50H62ClN9O8S2Couleur et forme :SolidMasse moléculaire :1016.67ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Couleur et forme :Odour SolidProtein Kinase C (19-36)
CAS :Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Formule :C93H159N35O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2151.48LSD1/HDAC6-IN-1
LSD1/HDAC6-IN-1 is an oral dual inhibitor of LSD1/HDAC6 with anti-tumor effects, useful for multiple myeloma research.Couleur et forme :SolidSNIPER(BRD)-1
CAS :SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Formule :C53H66ClN9O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1056.73BRD4 degrader-6
CAS :BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Formule :C61H71BClN9O7S2Couleur et forme :SolidMasse moléculaire :1152.67
