Chromatine/Épigénétique
Les inhibiteurs de la chromatine/épigénétique sont des composés qui modulent la structure et la fonction de la chromatine ou interfèrent avec les modifications épigénétiques, telles que la méthylation de l'ADN et la modification des histones. Ces inhibiteurs sont des outils essentiels pour étudier la régulation de l'expression génique et le rôle de l'épigénétique dans des maladies telles que le cancer, les troubles neurologiques et les anomalies du développement. En ciblant les processus épigénétiques, ces inhibiteurs peuvent modifier les schémas d'expression génique et offrir de nouvelles perspectives thérapeutiques. Chez CymitQuimica, nous offrons une large sélection d'inhibiteurs de la chromatine/épigénétique de haute qualité pour soutenir vos recherches en biologie moléculaire, génétique et épigénétique.
Sous-catégories appartenant à la catégorie "Chromatine/Épigénétique"
2613 produits trouvés pour "Chromatine/Épigénétique"
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AB3067
AB3067 is a PROTAC degrader targeting BET protein, efficiently recruiting two distinct E3 ligases, Cereblon and VHL, with strong affinity (demonstrated by IC50 values of 559 nM for VHL and 190 nM for CRBN in vivo HEK293). It degrades BRD2, BRD3, BRD4, and CRBN with DC50 values of 2.1~2.3, 1.6, 15, and 75 nM, respectively. Additionally, AB3067 inhibits the proliferation of RKO cells, with an EC50 of 111 nM. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL and CRBN)Formule :C74H91ClFN11O17S2Couleur et forme :SolidMasse moléculaire :1525.16PROTAC BET Degrader-1
CAS :PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Formule :C44H45N11O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :871.9PROTAC BRD4 Degrader-9
CAS :PROTAC BRD4 Degrader-9 degrades BRD4 in PC3 cells; binds VHL and BRD4; DC50: STEAP1-0.86 nM, CLL1-7.6 nM.Formule :C59H71F2N9O15S4Couleur et forme :SolidMasse moléculaire :1312.5ZXH-3-26
CAS :ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Formule :C38H37ClN8O7SDegré de pureté :98.90% - 98.90%Couleur et forme :SolidMasse moléculaire :785.27PRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively.Formule :C27H30F3N7O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :669.7BRD4-IN-4
CAS :BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFormule :C17H18N2O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :330.4HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56PRMT5-IN-4
CAS :PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formule :C11H13N3O4SCouleur et forme :SolidMasse moléculaire :283.3TAT-cyclo-CLLFVY
CAS :Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).Formule :C111H188N42O24S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2559.1Sirtuin modulator 5
CAS :Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Formule :C24H23N3O4Couleur et forme :SolidMasse moléculaire :417.46ZMF-23
ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis andFormule :C22H23Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.36[Ala107]MBP(104-118)
CAS :Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Formule :C67H104N20O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1493.68PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13PRO-HD1
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50Degré de pureté :98%Couleur et forme :Odour SolidCD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Couleur et forme :SolidNamoline
CAS :Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Formule :C10H3ClF3NO4Couleur et forme :SolidMasse moléculaire :293.58Myelin Basic Protein TFA
MHP4-14 TFA, synthetic peptide 4-14 of myelin, selective PKC substrate (Km=7μM), not phosphorylated by other kinases.Formule :C62H104F3N21O19Couleur et forme :SolidMasse moléculaire :1504.61HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Degré de pureté :98%Couleur et forme :Odour SolidPROTAC BRD4-binding moiety 1
CAS :BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.Formule :C23H21N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43GSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62PROTAC BRD4 Degrader-13
CAS :PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Formule :C68H85F2N11O17P2S2Couleur et forme :SolidMasse moléculaire :1492.55TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Couleur et forme :Odour SolidMZP-54
CAS :MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Formule :C55H66ClN7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1036.67PF-03622905
CAS :PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Formule :C24H35N7O3Couleur et forme :SolidMasse moléculaire :469.59SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37A-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54BRD4 degrader AT1
CAS :BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.Formule :C48H58ClN9O5S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :972.68MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28PKC β pseudosubstrate
CAS :Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Formule :C177H294N62O38S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3994.84SJ1008030
CAS :SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Formule :C42H43N13O7SCouleur et forme :SolidMasse moléculaire :873.94Okicenone
CAS :Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
Formule :C15H14O4Couleur et forme :SolidMasse moléculaire :258.27BAY-184
CAS :BAY-184,KAT6A/B inhibitor (IC50=71/83 nM). Suppresses ERα activity. Impedes breast cancer proliferation.Formule :C23H20N2O4SDegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :420.48CAY10591
CAS :SIRT1 activated by CAY10591, mimics caloric restriction, extends lifespan, inhibits apoptosis, suppresses TNF-α, and promotes fat mobilization.
Formule :C20H25N5O2Couleur et forme :SolidMasse moléculaire :367.44BETd-246
CAS :BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Formule :C48H55N11O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :946.02α-Hydroxyglutaric Acid
CAS :α-Hydroxyglutaric Acid is a natural product for research related to life sciences. The catalog number is T36624 and the CAS number is 2889-31-8.Formule :C5H8O5Couleur et forme :SolidMasse moléculaire :148.114PROTAC BRD9-binding moiety 5
CAS :PROTAC BRD9 binder moiety 5 selectively binds BRD9 with IC50 4.20μM, used in PROTAC synthesis, shows cancer cell antiproliferative activity.Formule :C19H18N6OCouleur et forme :SolidMasse moléculaire :346.39QA-68
QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.Formule :C61H72N10O10S2Couleur et forme :SolidMasse moléculaire :1169.42ZIP
CAS :Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formule :C90H154N30O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1928.4PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.Formule :C53H64N12O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1045.22PF-04577806
CAS :PF-04577806: potent & selective PKC inhibitor, ATP competitive, blocks PKCα/βI/βII/γ/θ (IC50: 2.4-45.9 nM), may reverse diabetic retinal leakage.Formule :C26H37N7O3Couleur et forme :SolidMasse moléculaire :495.628Lyngbyatoxin A
CAS :Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.
Formule :C27H39N3O2Couleur et forme :SolidMasse moléculaire :437.62DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Couleur et forme :Odour SolidPumecitinib
CAS :Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Formule :C17H20N8O2SDegré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :400.46Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCouleur et forme :Odour SolidRef: TM-L2200
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderWDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Couleur et forme :Odour SolidPROTAC CBP/P300 Degrader-1
CAS :PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Formule :C46H53F2N11O6Couleur et forme :SolidMasse moléculaire :893.998PROTAC BRD4 Degrader-32
PROTACBRD4 Degrader-32 (Compound 22) is a potent BRD4 PROTAC degrader with a DC50 of 0.20 nM. It employs a unique carbon-carbon linker to connect the BRD4 binding domain with the CRBN binding domain, forming a ternary complex that induces BRD4 ubiquitination and facilitates proteasomal degradation. PROTACBRD4 Degrader-32 holds promise for research into BRD4-related cancers, such as hematological malignancies.Formule :C42H42ClN5O5Couleur et forme :SolidMasse moléculaire :731.28745Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Couleur et forme :SolidMalantide
CAS :Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Formule :C72H124N22O21Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1633.89
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