Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
957 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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TAK1 inhibitor
CAS :<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formule :C22H19ClN6O2SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :466.94Elomotecan hydrochloride
CAS :<p>Elomotecan hydrochloride (BN 80927), a potent hCPT analog, inhibits topoisomerases I/II, outperforming other anticancer drugs.</p>Formule :C29H33Cl2N3O4Couleur et forme :SolidMasse moléculaire :558.51-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS :<p>Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.</p>Formule :C48H84NO8PCouleur et forme :SolidMasse moléculaire :834.16Topoisomerase I/II inhibitor 5
<p>TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.</p>Couleur et forme :Odour SolidCP 84364
CAS :<p>CP 84364 is a metabolite of CP-80794.</p>Formule :C14H18N2O4Couleur et forme :SolidMasse moléculaire :278.30Elinafide
CAS :<p>Elinafide, a dinaphthylimide cytotoxic agent, is a DNA-targeted anticancer agent that has shown antitumor activity in in vitro and in vivo assays.</p>Formule :C31H28N4O4Degré de pureté :97.29%Couleur et forme :SolidMasse moléculaire :520.58Murrayanol
<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>Formule :C24H29NO2Couleur et forme :SolidMasse moléculaire :363.501Hippeastrine
CAS :<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Formule :C17H17NO5Couleur et forme :SolidMasse moléculaire :315.32Diflomotecan
CAS :<p>Diflomotecan (BN 80915) is a strong oral topoisomerase I inhibitor with high plasma stability and significant preclinical anti-cancer efficacy.</p>Formule :C21H16F2N2O4Couleur et forme :SolidMasse moléculaire :398.36DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidCUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Couleur et forme :Odour Solid1-Methyladenosine-d3
<p>1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.</p>Couleur et forme :Odour SolidPyronaridine tetraphosphate
CAS :<p>Pyronaridine tetraphosphate is a DNA topoisomerase 2 inhibitor with antimalarial and antitumor activity for the treatment of P. falciparum infection.</p>Formule :C29H44ClN5O18P4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :910.03HDAC3/8 ligand-1
<p>HDAC3/8 ligand-1 (compound 40) serves as a ligand for the target protein of PROTAC, utilized in the synthesis of YX968.</p>Formule :C14H22N4OCouleur et forme :SolidMasse moléculaire :262.35DST Crosslinker
CAS :<p>DST is a cleavable, bifunctional crosslinker; it doesn't disrupt protein disulfides, breaks with oxidizers.</p>Formule :C12H12N2O10Couleur et forme :SolidMasse moléculaire :344.232Banoxantrone-d12 dihydrochloride
CAS :<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formule :C22H30Cl2N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.48Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour SolidSpCas9 D10A Nickase
<p>SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.</p>Anticancer agent 177
<p>Anticanceragent 177 (Compound 11b) is an NAMPT inhibitor and DNA alkylating agent with antitumor activity both in vitro and in vivo.</p>Formule :C28H36Cl2N4O2Masse moléculaire :530.22153GJ071 oxalate
CAS :<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formule :C20H29N3O7SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :455.53Corydamine
<p>Corydamine is a useful organic compound for research related to life sciences and the catalog number is T124768.</p>Formule :C20H18N2O4Couleur et forme :SolidMasse moléculaire :350.374(±)4-HDHA
CAS :<p>(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.</p>Formule :C22H32O3Degré de pureté :97.97%Couleur et forme :SolidMasse moléculaire :344.49Dichlorogelignate
CAS :<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formule :C32H34O18Couleur et forme :SolidMasse moléculaire :706.6PDPH Crosslinker
CAS :<p>PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.</p>Formule :C8H11N3OS2Couleur et forme :SolidMasse moléculaire :229.32HDAC-IN-52
CAS :<p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>Formule :C24H20N4O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :396.4415-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Couleur et forme :Odour Solid20-carboxy Arachidonic Acid
CAS :<p>20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.</p>Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.456Amorfrutin B
CAS :<p>Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.</p>Formule :C26H32O4Couleur et forme :SolidMasse moléculaire :408.538ABP/PPAR modulator 1
<p>ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.</p>Formule :C33H39NO7Couleur et forme :SolidMasse moléculaire :561.67Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>AsCas12a Nuclease
<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>25-Hydroxytachysterol3
CAS :<p>25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.</p>Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.64Chimmitecan
CAS :<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formule :C23H20N2O5Degré de pureté :98.35%Couleur et forme :SoildMasse moléculaire :404.42NHC-diphosphate
CAS :<p>NHC-diphosphate, a phosphorylated β-d-N4-Hydroxycytidine metabolite, is a potent antiviral against VEEV, CHIKV, and HCV.</p>Formule :C9H15N3O12P2Couleur et forme :SolidMasse moléculaire :419.18Larsucosterol Ammonium salt
CAS :<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :499.75nTZDpa
CAS :<p>nTZDpa is an antibiotic with antimicrobial activity.</p>Formule :C22H15Cl2NO2SCouleur et forme :SolidMasse moléculaire :428.33Abd110
CAS :<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formule :C41H42N8O7SCouleur et forme :SolidMasse moléculaire :790.89Pericosine A
CAS :<p>Pericosine A, a fungal metabolite from P. byssoides, shows anticancer effects (GI50s = 0.05-24.55 μM) and EGFR inhibition (40-70% at 100 μg/ml).</p>Formule :C8H11ClO5Couleur et forme :SolidMasse moléculaire :222.62N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS :<p>N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.</p>Formule :C27H45NO3Couleur et forme :SolidMasse moléculaire :431.661(iso)-BRD20322
CAS :<p>(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.</p>Formule :C27H31N3O2Degré de pureté :99.60% - 99.60%Couleur et forme :SoildMasse moléculaire :429.5517-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS :<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formule :C22H30O3Couleur et forme :SolidMasse moléculaire :342.479HDAC1/6-IN-2
<p>HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.</p>Formule :C22H17FN4O3Couleur et forme :SolidMasse moléculaire :404.39NHC-triphosphate tetrasodium
<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>Formule :C9H12N3Na4O15P3Couleur et forme :SolidMasse moléculaire :587.08Banoxantrone (D12)
CAS :<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formule :C22H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.55Mca-VDQVDGW-Lys(Dnp)-NH2
<p>Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.</p>Formule :C60H74N14O21Couleur et forme :SolidMasse moléculaire :1327.31Cytidine 5'-diphosphate trisodium salt
CAS :<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formule :C9H15N3Na3O11P2Degré de pureté :99.55%Couleur et forme :White Crystalline PowderMasse moléculaire :472.15Antitumor agent-63
CAS :<p>Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.</p>Formule :C38H46N4O18Couleur et forme :SolidMasse moléculaire :846.79Berzosertib
CAS :<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formule :C24H25N5O3SDegré de pureté :97.34% - >99.99%Couleur et forme :SolidMasse moléculaire :463.55Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formule :C21H22N2O6Couleur et forme :SolidMasse moléculaire :398.409Wistin
CAS :<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Formule :C23H24O10Couleur et forme :SolidMasse moléculaire :460.43Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formule :C53H83FN6O15Couleur et forme :SolidMasse moléculaire :1063.26Monascin
CAS :<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formule :C21H26O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.43Nanaomycin A
CAS :<p>Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).</p>Formule :C16H14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.28VH 032 amide-PEG1-acid
CAS :<p>VHL ligand for PROTAC R&D; E3 ligase with PEG1 linker and carboxylic acid for target conjugation.</p>Formule :C28H38N4O7SCouleur et forme :SolidMasse moléculaire :574.69Silatecan
CAS :<p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>Formule :C26H30N2O5SiCouleur et forme :SoildMasse moléculaire :478.61SMPB Crosslinker
CAS :<p>SMPB crosslinker reacts with sulfhydryl/amino groups, has a longer chain than MBS, and a non-cleavable spacer arm.</p>Formule :C18H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.33Amrubicin
CAS :<p>The compound is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II.</p>Formule :C25H25NO9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :483.47DMT-dG(ib) Phosphoramidite
CAS :<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>Formule :C44H54N7O8PDegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :839.92MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidCHDI 00484077
CAS :<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Formule :C18H21F3N4O2Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :382.38ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Couleur et forme :SolidSJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Couleur et forme :Odour SolidHDAC-IN-76
<p>HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.</p>Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formule :C22H24N2O9SCouleur et forme :SolidMasse moléculaire :492.5Leriglitazone
CAS :<p>Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.</p>Formule :C19H20N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.4423-epi-26-Deoxyactein
CAS :<p>23-epi-26-Deoxyactein is a naturally occurring compound exhibiting anti-obesity and anti-cancer properties when administered orally [1] [2] [3].</p>Formule :C37H56O10Couleur et forme :SolidMasse moléculaire :660.83CAY10599
CAS :<p>CAY10599 has a wide range of applications in life science related research.</p>Formule :C38H41NO5Couleur et forme :SolidMasse moléculaire :591.748STAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Formule :C28H32N2O7Couleur et forme :SolidMasse moléculaire :508.56CL2-MMT-SN38
CAS :<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Formule :C102H122N12O24Couleur et forme :SolidMasse moléculaire :1900.15817-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495CH-0793076
CAS :<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formule :C26H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.4115-deoxy-Δ-12,14-Prostaglandin J2
CAS :<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Formule :C20H28O3Degré de pureté :98%Couleur et forme :Neat OilMasse moléculaire :316.43Leriglitazone hydrochloride
CAS :<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Formule :C19H21ClN2O4SCouleur et forme :SolidMasse moléculaire :408.90SP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Formule :C22H17ClN2O2S2Degré de pureté :99.79%Couleur et forme :SoildMasse moléculaire :440.97NSC 370284
CAS :<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43Topoisomerase IIα-IN-9
CAS :<p>Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C14H14O4SCouleur et forme :SolidMasse moléculaire :278.32Saroglitazar Magnesium
CAS :<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formule :C50H56MgN2O8S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :901.43Elomotecan
CAS :<p>Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.</p>Formule :C29H32ClN3O4Couleur et forme :SolidMasse moléculaire :522.04Prednimustine
CAS :<p>Prednimustine (Leo 1031; NSC 134087), an ester of Prednisolone and Chlorambucil, is used in leukemia and lymphoma studies.</p>Formule :C35H45Cl2NO6Couleur et forme :SolidMasse moléculaire :646.64(R)-VX-984
CAS :<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formule :C23H21D2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.49Tibesaikosaponin V
CAS :<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Formule :C42H68O15Couleur et forme :SolidMasse moléculaire :812.98PPARγ/GR modulator 1
<p>PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibits</p>Formule :C14H10FNO4Couleur et forme :SolidMasse moléculaire :275.23Et-29
CAS :<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formule :C34H46N6O6SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :666.83PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Couleur et forme :Odour SolidSibiromycin
CAS :<p>Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.</p>Formule :C24H33N3O7Couleur et forme :SolidMasse moléculaire :475.542Hippeastrine Hydrobromide
CAS :<p>Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.</p>Formule :C17H18BrNO5Couleur et forme :SolidMasse moléculaire :396.237AZD-5099
CAS :<p>AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.</p>Formule :C21H27Cl2N5O6SCouleur et forme :SolidMasse moléculaire :548.44PARP/HDAC-IN-1
<p>PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.</p>Formule :C36H32F2N6O3Degré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :634.67GSK3735967
CAS :<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62Sulotroban
CAS :<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Formule :C16H17NO5SDegré de pureté :98.86% - 99.88%Couleur et forme :SolidMasse moléculaire :335.37Antitumor agent-28
CAS :<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formule :C25H32N6O4SCouleur et forme :SolidMasse moléculaire :512.63Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Couleur et forme :Odour Solid1-O-Hexadecyl-Rac-Glycerol
CAS :<p>1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.</p>Formule :C19H40O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :316.52Ciprofibrate impurity A
CAS :<p>Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate is a PPARα agonist[1].</p>Formule :C12H14O3Couleur et forme :SolidMasse moléculaire :206.241Z26395438
CAS :<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formule :C17H15FN2ODegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :282.31Becatecarin
CAS :<p>Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.</p>Formule :C33H34Cl2N4O7Couleur et forme :SolidMasse moléculaire :669.56Colibactin 742
CAS :<p>Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads</p>Formule :C37H42N8O5S2Couleur et forme :SolidMasse moléculaire :742.91Macrocalin B
CAS :<p>Macrocalin B is a diterpenoid against tumor cell proliferation and telomerase activity.</p>Formule :C20H26O6Couleur et forme :SolidMasse moléculaire :362.42
