Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
957 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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Namitecan
CAS :<p>Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.</p>Formule :C23H22N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.44ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Formule :C25H29FN6O3Couleur et forme :SolidMasse moléculaire :480.53Gimatecan
CAS :<p>Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formule :C25H25N3O5Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :447.48DNA-PK-IN-9
<p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>Formule :C21H21N5O2Couleur et forme :SolidMasse moléculaire :375.42Intoplicine
CAS :<p>Intoplicine is an inhibitor of DNA topoisomerase I and II.</p>Formule :C21H24N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.442-Ethylhexyl diphenyl phosphate
CAS :<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Formule :C20H27O4PCouleur et forme :SolidMasse moléculaire :362.40DLK-IN-1
CAS :<p>DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.</p>Formule :C20H24F3N5O2Couleur et forme :SolidMasse moléculaire :423.43L2H2-6OTD
CAS :<p>L2H2-6OTD is a telomerase inhibitor with G-quadruplex loops; IC50: 15 nM.</p>Formule :C30H30N10O8Couleur et forme :SolidMasse moléculaire :658.62SP-C01
CAS :<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Formule :C22H22F4N2O5Couleur et forme :SolidMasse moléculaire :470.41DNA crosslinker 4 dihydrochloride
CAS :<p>DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.</p>Formule :C16H24Cl2N8OCouleur et forme :SolidMasse moléculaire :415.3215-keto-Prostaglandin E2
CAS :<p>15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression.</p>Formule :C20H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :350.45TDI-015051
CAS :<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Formule :C17H11Cl2F3N2O3SCouleur et forme :SolidMasse moléculaire :451.25HDAC6-IN-51
CAS :<p>HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.</p>Formule :C24H24ClN5O3Couleur et forme :SolidMasse moléculaire :465.93DNA-PK-IN-15
CAS :<p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>Formule :C23H23N9OCouleur et forme :SolidMasse moléculaire :441.49DNA-PK-IN-2
CAS :<p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>Formule :C20H23N5O3Couleur et forme :SolidMasse moléculaire :381.43DNA crosslinker 3 dihydrochloride
CAS :<p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>Formule :C15H22Cl2N8OCouleur et forme :SolidMasse moléculaire :401.29TH1338
CAS :<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formule :C22H21N3O4Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :391.42SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48TERT activator-2
CAS :<p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>Formule :C21H22N2O2Couleur et forme :SolidMasse moléculaire :334.412PPARγ phosphorylation inhibitor 1
<p>PPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binding agent (IC50: 24 nM) with antidiabetic effects.</p>Formule :C22H14Cl2N2O4Couleur et forme :SolidMasse moléculaire :441.26E-3030 free acid
CAS :<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Formule :C22H23ClFNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.87PPARγ modulator-2
CAS :<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Formule :C26H21NO7S3SeCouleur et forme :SolidMasse moléculaire :634.6(1S,2R,7S)-Sitafloxacin
CAS :<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Formule :C19H18ClF2N3O3Couleur et forme :SolidMasse moléculaire :409.81(S)-WSD0628
CAS :<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Formule :C23H23F2N5O2Couleur et forme :SolidMasse moléculaire :439.458(1R,2S,7R)-Sitafloxacin
CAS :<p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>Formule :C19H18ClF2N3O3Couleur et forme :SolidMasse moléculaire :409.814Amezalpat
CAS :<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Formule :C34H41N3O4Couleur et forme :SolidMasse moléculaire :555.707ATR-IN-19
CAS :<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Formule :C18H19N7OSCouleur et forme :SolidMasse moléculaire :381.45Topotecan acetate
CAS :<p>Topotecan acetate is an inhibitor of topoisomerase.</p>Formule :C25H27N3O7Couleur et forme :SolidMasse moléculaire :481.498RU-0415529
CAS :<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Formule :C22H27N5O3SCouleur et forme :SolidMasse moléculaire :441.55O6BTG-C8-αGlu
CAS :<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525PPARγ-IN-5
CAS :<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Formule :C22H23ClO7Couleur et forme :SolidMasse moléculaire :434.867PPARα/δ agonist 3
CAS :<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Formule :C23H25F3N2O4Couleur et forme :SolidMasse moléculaire :450.451Topoisomerase I inhibitor 8
CAS :<p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>Formule :C24H21FN2O4Couleur et forme :SolidMasse moléculaire :420.43ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formule :C25H30N6O2Couleur et forme :SolidMasse moléculaire :446.54Topoisomerase I/II inhibitor 2
<p>Compound 1a inhibits Topoisomerase I/II, shrinks mouse liver tumors, IC50: 6.83/9.82 μM for LM9/Huh7 cells.</p>Formule :C19H16N2O4Couleur et forme :SolidMasse moléculaire :336.34SIRT6 activator 2
CAS :<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45TP3011
CAS :<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Formule :C26H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.51(Rac)-RG108
CAS :<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326Simmitecan hydrochloride
CAS :<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Formule :C34H39ClN4O6Degré de pureté :98.20% - 98.93%Couleur et forme :SolidMasse moléculaire :635.15KU-60019
CAS :<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formule :C30H33N3O5SDegré de pureté :98.05% - 98.50%Couleur et forme :SolidMasse moléculaire :547.67BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Formule :C21H17F2N5ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :393.39OBI-3424
CAS :<p>OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.</p>Formule :C21H25N4O6PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.427Zabofloxacin hydrochloride
CAS :<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Formule :C19H21ClFN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.86Merbarone
CAS :<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Formule :C11H9N3O3SCouleur et forme :SolidMasse moléculaire :263.27NSC61610
CAS :<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Formule :C34H24N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.59Phenanthriplatin
CAS :<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Formule :C13H11ClN4O3PtCouleur et forme :SolidMasse moléculaire :501.79YF438
CAS :<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Formule :C23H26N4O5Couleur et forme :SolidMasse moléculaire :438.48SR-4370
CAS :<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Formule :C17H18F2N2ODegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :304.33Mavodelpar free base
CAS :<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formule :C31H30FNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.57Fotemustine
CAS :<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Formule :C9H19ClN3O5PCouleur et forme :SolidMasse moléculaire :315.69MDL-811
CAS :<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formule :C25H25BrCl2FN3O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.42ATR-IN-24
CAS :<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formule :C23H26N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :418.49Antitumor agent-104
CAS :<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Formule :C31H33FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.63Lerzeparib
CAS :<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Formule :C21H20FN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.4PARP7-IN-16 free base
CAS :<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Formule :C25H27FN4O4Couleur et forme :SolidMasse moléculaire :466.50
