Altération de l'ADN/réparation de l'ADN
Les inhibiteurs de la réparation des dommages à l'ADN sont des composés qui interfèrent avec les processus impliqués dans la détection et la réparation des dommages à l'ADN. Ces inhibiteurs sont essentiels pour étudier les mécanismes de la stabilité génomique, de la mutagenèse et de la réponse aux dommages à l'ADN. Ils sont également importants dans la recherche sur le cancer, car de nombreuses tumeurs dépendent de voies spécifiques de réparation de l'ADN pour survivre. En inhibant ces voies, les inhibiteurs de la réparation des dommages à l'ADN peuvent améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité de la réparation des dommages à l'ADN pour soutenir vos recherches en biologie moléculaire, oncologie et pharmacologie.
Sous-catégories appartenant à la catégorie "Altération de l'ADN/réparation de l'ADN"
- ATM/ATR(71 produits)
- Alkylation de l'ADN(11 produits)
- Méthyltransférase de l’ADN(421 produits)
- Gyrase de l’ADN(11 produits)
- ADN-PK(51 produits)
- MTH1(1 produits)
- Antimétabolite nucléosidique/analogue(1.388 produits)
- Transcriptase inverse(43 produits)
- Sirtuine(88 produits)
- Télomérase(33 produits)
- Topoisomérase(136 produits)
Affichez 3 plus de sous-catégories
957 produits trouvés pour "Altération de l'ADN/réparation de l'ADN"
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Antitumor agent-28
CAS :<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formule :C25H32N6O4SCouleur et forme :SolidMasse moléculaire :512.63Becatecarin
CAS :<p>Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.</p>Formule :C33H34Cl2N4O7Couleur et forme :SolidMasse moléculaire :669.56CUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Couleur et forme :Odour SolidWistin
CAS :<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Formule :C23H24O10Couleur et forme :SolidMasse moléculaire :460.43WAY-323061
CAS :<p>WAY-323061 is a SIRT2 inhibitor.</p>Formule :C25H21N5O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :455.53Hippeastrine Hydrobromide
CAS :<p>Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.</p>Formule :C17H18BrNO5Couleur et forme :SolidMasse moléculaire :396.237Sulotroban
CAS :<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Formule :C16H17NO5SDegré de pureté :98.86% - 99.88%Couleur et forme :SolidMasse moléculaire :335.37TAS-103
CAS :<p>TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.</p>Formule :C20H19N3O2Couleur et forme :SolidMasse moléculaire :333.38Leriglitazone hydrochloride
CAS :<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Formule :C19H21ClN2O4SCouleur et forme :SolidMasse moléculaire :408.90DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Couleur et forme :Odour SolidGW 1929 hydrochloride
CAS :<p>Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.</p>Formule :C30H30ClN3O4Couleur et forme :SolidMasse moléculaire :532.04Gemfibrozil 1-O-β-glucuronide
CAS :<p>Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.</p>Formule :C21H30O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.46PR-104 sodium
CAS :<p>PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.</p>Formule :C14H19BrN4NaO12PSCouleur et forme :SolidMasse moléculaire :601.25Banoxantrone (D12)
CAS :<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formule :C22H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.55Monascin
CAS :<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formule :C21H26O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.43ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Couleur et forme :SolidMethylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Couleur et forme :Odour Solid15-deoxy-Δ-12,14-Prostaglandin J2
CAS :<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Formule :C20H28O3Degré de pureté :98%Couleur et forme :Neat OilMasse moléculaire :316.43CL2-MMT-SN38
CAS :<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Formule :C102H122N12O24Couleur et forme :SolidMasse moléculaire :1900.158CH-0793076
CAS :<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formule :C26H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51DB1255 2TFA
<p>DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.</p>Formule :C26H20F6N4O4S2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :630.5825-Hydroxytachysterol3
CAS :<p>25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.</p>Formule :C27H44O2Couleur et forme :SolidMasse moléculaire :400.64(±)9-HEPE
CAS :<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.4571-O-Hexadecyl-Rac-Glycerol
CAS :<p>1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.</p>Formule :C19H40O3Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :316.52HDAC6-IN-50
<p>HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).</p>Couleur et forme :Odour SolidTRF1-TIN2 interaction-IN-1
<p>TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.</p>Formule :C19H18O6SCouleur et forme :SolidMasse moléculaire :374.41Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Couleur et forme :Odour SolidHippeastrine
CAS :<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Formule :C17H17NO5Couleur et forme :SolidMasse moléculaire :315.32Et-29
CAS :<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formule :C34H46N6O6SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :666.83(±)4(5)-DiHDPA lactone
CAS :<p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.495CP 84364
CAS :<p>CP 84364 is a metabolite of CP-80794.</p>Formule :C14H18N2O4Couleur et forme :SolidMasse moléculaire :278.30AsCas12a Nuclease
<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>HDAC-IN-52
CAS :<p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>Formule :C24H20N4O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :396.4417-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS :<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formule :C22H32O3Couleur et forme :SolidMasse moléculaire :344.49517-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS :<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formule :C22H30O3Couleur et forme :SolidMasse moléculaire :342.479Saroglitazar Magnesium
CAS :<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formule :C50H56MgN2O8S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :901.43Stearolic acid
CAS :<p>Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.</p>Formule :C18H32O2Couleur et forme :SolidMasse moléculaire :280.452Amorfrutin B
CAS :<p>Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.</p>Formule :C26H32O4Couleur et forme :SolidMasse moléculaire :408.538STAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Formule :C28H32N2O7Couleur et forme :SolidMasse moléculaire :508.56Larsucosterol Ammonium salt
CAS :<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SoildMasse moléculaire :499.75PDPH Crosslinker
CAS :<p>PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.</p>Formule :C8H11N3OS2Couleur et forme :SolidMasse moléculaire :229.32GJ071 oxalate
CAS :<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formule :C20H29N3O7SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :455.53SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formule :C22H24N2O9SCouleur et forme :SolidMasse moléculaire :492.5HDAC-IN-76
<p>HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.</p>Formule :C27H26N4O4Couleur et forme :SolidMasse moléculaire :470.52(iso)-BRD20322
CAS :<p>(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.</p>Formule :C27H31N3O2Degré de pureté :99.60% - 99.60%Couleur et forme :SoildMasse moléculaire :429.55CHDI 00484077
CAS :<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Formule :C18H21F3N4O2Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :382.38HDAC1/6-IN-2
<p>HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.</p>Formule :C22H17FN4O3Couleur et forme :SolidMasse moléculaire :404.391-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS :<p>Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.</p>Formule :C48H84NO8PCouleur et forme :SolidMasse moléculaire :834.16(R)-VX-984
CAS :<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formule :C23H21D2N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.49
