Topoisomérase
Les topoisomérases sont des enzymes qui régulent la topologie de l'ADN lors de processus tels que la réplication, la transcription et la ségrégation des chromosomes en introduisant des cassures transitoires dans les brins d'ADN pour soulager le stress torsionnel. Les inhibiteurs de topoisomérase interfèrent avec ce processus, entraînant l'accumulation de cassures dans l'ADN et l'induction de la mort cellulaire, en particulier dans les cellules à division rapide. Ces inhibiteurs sont largement utilisés comme agents chimiothérapeutiques dans le traitement du cancer. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de topoisomérase de haute qualité pour soutenir vos recherches sur la réplication de l'ADN, la thérapie contre le cancer et la régulation du cycle cellulaire.
126 produits trouvés pour "Topoisomérase".
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Gatifloxacin
CAS :Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.Formule :C19H22FN3O4Degré de pureté :99.50% - 99.85%Couleur et forme :SolidMasse moléculaire :375.39Etoposide
CAS :Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).Formule :C29H32O13Degré de pureté :99.19% - 99.94%Couleur et forme :Crystals From Methanol SolidMasse moléculaire :588.56Doxorubicin hydrochloride
CAS :Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Formule :C27H29NO11·HClDegré de pureté :98% - 99.99%Couleur et forme :Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Masse moléculaire :579.99Mitoxantrone dihydrochloride
CAS :Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.Formule :C22H30Cl2N4O6Degré de pureté :97.05% - >99.99%Couleur et forme :SolidMasse moléculaire :517.4Nalidixic acid
CAS :Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.Formule :C12H12N2O3Degré de pureté :99.9% - 99.95%Couleur et forme :Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Masse moléculaire :232.24DRF-1042 HCl
DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.Formule :C22H21ClN2O6Degré de pureté :97.93%Couleur et forme :Yellow SolidMasse moléculaire :444.87Topotecan hydrochloride
CAS :Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.Formule :C23H24ClN3O5Degré de pureté :97.88% - 99.41%Couleur et forme :White Crystalline SolidMasse moléculaire :457.92Enoxacin hydrate
CAS :Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.Formule :C15H17FN4O3H2ODegré de pureté :99.50%Couleur et forme :White SolidMasse moléculaire :347.34Irinotecan hydrochloride trihydrate
CAS :Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formule :C33H45ClN4O9Degré de pureté :98.22% - 99.96%Couleur et forme :Yellow SolidMasse moléculaire :677.18Irinotecan Hydrochloride
CAS :Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Formule :C33H39ClN4O6Degré de pureté :98% - 99.94%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :623.14Ref: TM-T0486L
10mg34,00€25mg49,00€50mg65,00€1mL*10mM (DMSO)71,00€100mg89,00€200mg129,00€500mg254,00€Ciprofloxacin monohydrochloride
CAS :Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.Formule :C17H18FN3O3·HClDegré de pureté :99.5% - 99.73%Couleur et forme :SolidMasse moléculaire :367.80Enoxacin
CAS :Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.Formule :C15H17FN4O3Degré de pureté :99.60% - 99.89%Couleur et forme :White SolidMasse moléculaire :320.32Berberine chloride
CAS :Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Formule :C20H18ClNO4Degré de pureté :99.47% - 99.93%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :371.80XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.Formule :C23H25ClN4O2Degré de pureté :98.52%Couleur et forme :SolidMasse moléculaire :424.92Daunorubicin hydrochloride
CAS :Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFormule :C27H29NO10·HClDegré de pureté :96.21% - 99.53%Couleur et forme :Cancer DrugMasse moléculaire :563.99Ref: TM-T1511
5mg34,00€10mg52,00€1mL*10mM (DMSO)59,00€25mg87,00€50mg113,00€100mg177,00€200mg281,00€500mg442,00€Nalidixic acid sodium salt
CAS :Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.Formule :C12H11N2NaO3Degré de pureté :99.72% - 99.95%Couleur et forme :White To Off-White PowderMasse moléculaire :254.22Ciprofloxacin
CAS :Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!Formule :C17H18FN3O3Degré de pureté :98.77% - 99.91%Couleur et forme :White PowderMasse moléculaire :331.34Teniposide
CAS :Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFormule :C32H32O13SDegré de pureté :97.7% - 99.45%Couleur et forme :SolidMasse moléculaire :656.65Levofloxacin hydrate
CAS :Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Formule :C18H20FN3O4H2ODegré de pureté :98.26%Couleur et forme :White SolidMasse moléculaire :370.38Hycanthone
CAS :Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Formule :C20H24N2O2SDegré de pureté :98.78%Couleur et forme :Yellow-Orange Powder (Ntp 1992)Masse moléculaire :356.48Lurtotecan
CAS :Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.Formule :C28H30N4O6Degré de pureté :99.18%Couleur et forme :Yellow SolidMasse moléculaire :518.56Epirubicin hydrochloride
CAS :Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.Formule :C27H30ClNO11Degré de pureté :98.13% - 99.79%Couleur et forme :SolidMasse moléculaire :579.98Ref: TM-T0125
2mg37,00€5mg52,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg142,00€50mg226,00€100mg308,00€500mg745,00€Flumequine
CAS :Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.Formule :C14H12FNO3Degré de pureté :98.92% - 99.4%Couleur et forme :White Crystalline Powder SolidMasse moléculaire :261.25DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Couleur et forme :Odour SolidTopoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.Degré de pureté :98%Couleur et forme :Odour SolidAntitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targetsFormule :C70H82N8O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1355.51Garenoxacin
CAS :Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.41AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.Degré de pureté :98%Couleur et forme :Odour SolidVoreloxin
CAS :Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formule :C18H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.44DTS-108
CAS :DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.Formule :C145H233N43O33S2Couleur et forme :SolidMasse moléculaire :3170.8AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the lowDegré de pureté :98%Couleur et forme :Odour SolidCH-0793076
CAS :CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).Formule :C26H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.51Banoxantrone-D12
CAS :Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.Formule :C22H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.55CBX-12
CBX-12 is a peptide drug conjugate (PDC) that targets tumors in an antigen-independent manner and exhibits antitumor activity. Comprising a pH-sensitive peptide (pHLIP), an auto-cleavable linker, and the topoisomerase 1 (TOP1) inhibitor Exatecan, it effectively targets cancerous cells.Formule :C169H240FN35O49S2Couleur et forme :SolidMasse moléculaire :3629.05Topoisomerase II inhibitor 13
CAS :WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.Formule :C22H23N9Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :413.48Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).Formule :C53H83FN6O15Couleur et forme :SolidMasse moléculaire :1063.26Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formule :C25H26ClN3O5Degré de pureté :97.04%Couleur et forme :SoildMasse moléculaire :483.94Topo I/II-IN-1
Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.Formule :C15H13N3S2Couleur et forme :SolidMasse moléculaire :299.414TAK1 inhibitor
CAS :TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.Formule :C22H19ClN6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.94Chimmitecan
CAS :Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.Formule :C23H20N2O5Degré de pureté :98.35%Couleur et forme :Yellow SolidMasse moléculaire :404.42Banoxantrone-D12 dihydrochloride
CAS :Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Formule :C22H30Cl2N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.48Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formule :C21H21N3O2Couleur et forme :SolidMasse moléculaire :347.41Topoisomerase II inhibitor 19
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and a topoisomerase II inhibitor with an IC50 of 0.34 μM. It induces damage in ctDNA.Formule :C27H16ClN3OSMasse moléculaire :465.07026AuL1
AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.Formule :C29H50AuCl2N5Couleur et forme :SolidMasse moléculaire :736.61Topoisomerase IIα-IN-9
CAS :Topoisomerase IIα-IN-9 ,with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Topoisomerase IIα-IN-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C14H14O4SCouleur et forme :SolidMasse moléculaire :278.32Merbarone
CAS :Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.Formule :C11H9N3O3SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :263.27Genz-644282
CAS :Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formule :C22H21N3O5Degré de pureté :97.49%Couleur et forme :SolidMasse moléculaire :407.42EIDD-1931
CAS :EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.Formule :C9H13N3O6Degré de pureté :99.14% - 99.73%Couleur et forme :SolidMasse moléculaire :259.22Aurintricarboxylic acid
CAS :Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formule :C22H14O9Degré de pureté :85% - 97.1%Couleur et forme :Deep Red Coarse Crystalline PowderMasse moléculaire :422.34Betulinic acid
CAS :Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Formule :C30H48O3Degré de pureté :98.22% - 99.7%Couleur et forme :White Crystalline PowderMasse moléculaire :456.70
