Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
459 produits trouvés pour "Méthyltransférase de l’ADN"
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HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formule :C18H19N3O3Couleur et forme :SolidMasse moléculaire :325.36CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Formule :C24H34Cl2N4O2Couleur et forme :SolidMasse moléculaire :481.46(1-Nitroethene-1,2-diyl)dibenzene
CAS :(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formule :C14H11NO2Couleur et forme :SolidMasse moléculaire :225.24PRMT5-MTA-IN-3
CAS :PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.Formule :C19H17F3N6O3Couleur et forme :SolidMasse moléculaire :434.372(Rac)-RG108
CAS :(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.
Formule :C19H14N2O4Couleur et forme :SolidMasse moléculaire :334.326RL5a
CAS :RL5a (compound C23) is a novel inhibitor of SETD8.Formule :C17H19N3OCouleur et forme :SolidMasse moléculaire :281.35MMSET-IN-1
CAS :MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .Formule :C18H29N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.47Octyl-α-hydroxyglutarate
CAS :Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.
Formule :C13H24O5Masse moléculaire :260.33SGC6870N
CAS :SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.Formule :C23H21BrN2O2SMasse moléculaire :469.39RU-0415529
CAS :RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538MS8815
CAS :MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.Formule :C65H87N9O8SCouleur et forme :SolidMasse moléculaire :1154.51Pociredir
CAS :Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.41SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41NSD2-PWWP1-IN-3
CAS :NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.
Formule :C34H39N5O2Couleur et forme :SolidMasse moléculaire :549.706NSD2-PWWP1-IN-1
CAS :NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.Formule :C28H30N4Couleur et forme :SolidMasse moléculaire :422.565O6BTG-C8-αGlu
CAS :O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525AMI-408
CAS :AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.Formule :C20H13Cl2N6NaO5SCouleur et forme :SolidMasse moléculaire :543.32PRMT5-IN-48
CAS :PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formule :C30H37N5O3Couleur et forme :SolidMasse moléculaire :515.646EZH2-IN-12
EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.Formule :C23H23Cl2N3O3Couleur et forme :SolidMasse moléculaire :460.35PRMT5-IN-50
CAS :PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496PRMT5-IN-18
CAS :PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formule :C32H42N4O4Couleur et forme :SolidMasse moléculaire :546.70MM-589 TFA
CAS :MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formule :C30H45F3N8O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :686.72RK-0080552
CAS :RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Formule :C12H6N6O2Couleur et forme :SolidMasse moléculaire :266.215PRMT5-IN-37
CAS :PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37PRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.Formule :C19H20Cl2N4O5Couleur et forme :SolidMasse moléculaire :455.29PRMT5-IN-21
PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.Formule :C18H18F2N6O3Couleur et forme :SolidMasse moléculaire :404.37MS8511
CAS :MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.Formule :C28H41N5O3Couleur et forme :SolidMasse moléculaire :495.66PRMT5-IN-49
CAS :PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39NSD2-PWWP1-IN-2
CAS :NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575W4275
CAS :W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Formule :C25H36N6O3Couleur et forme :SolidMasse moléculaire :468.59PRMT5-IN-3
CAS :PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.Formule :C22H23F3N4O3Couleur et forme :SolidMasse moléculaire :448.44GSK3368715 3HCl
CAS :GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formule :C20H41Cl3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.92TDI-015051
CAS :TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formule :C25H24N4OCouleur et forme :SolidMasse moléculaire :396.48HLCL-61
CAS :HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45PF-06726304 acetate
CAS :PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Formule :C24H25Cl2N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.38MM-589
CAS :MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formule :C28H44N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.70WIZ degrader 1
CAS :WIZ degrader 1 (Compound 141) is a degrader of the wide-interval zinc-finger motif (WIZ) with an AC50 of 2 nM. It can induce the expression of fetal hemoglobin (HbF), exhibiting an EC50 value of 6 mM. WIZ degrader 1 is used in the research of genetic blood disorders.Formule :C25H33F2N5O2Masse moléculaire :473.56PRMT5-IN-44
CAS :PRMT5-IN-44 (compound 12) is an inhibitor of PRMT5, specifically utilized in cancer research.Formule :C23H19F4N5O2Couleur et forme :SolidMasse moléculaire :473.42ZL-28-6
CAS :ZL-28-6, a type I PRMT inhibitor (IC50: 18 nM), effectively targets CARM1 (a member of PRMT) within cells and is suitable for cancer research [1].Formule :C18H22Cl2N2OCouleur et forme :SolidMasse moléculaire :353.29MU1656
CAS :MU1656 is a selective inhibitor of histone methyltransferase DOT1L, which significantly inhibits cancer cell proliferation in hematological malignancies.Formule :C32H45N7O2Degré de pureté :96.92%Couleur et forme :SolidMasse moléculaire :559.75GSK3368715
CAS :GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFormule :C20H38N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.54WDR5-IN-5
CAS :WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.Formule :C29H29F3N6OCouleur et forme :SolidMasse moléculaire :534.58PRMT5-IN-32
CAS :PRMT5-IN-32, an inhibitor of PRMT5, inhibits HCT116 cell proliferation with an IC50 of 0.13 μM [1].Formule :C27H21F4N5O2Couleur et forme :SolidMasse moléculaire :523.48(2R)-Octyl-α-hydroxyglutarate sodium
CAS :(Sodium) (2R)-Octyl-α-hydroxyglutarate is the sodium salt variant of (2R)-Octyl-α-hydroxyglutarate, which has been shown to possess anti-inflammatory properties [1].Formule :C13H23NaO5Couleur et forme :SolidMasse moléculaire :282.31YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFormule :C23H34N4O3Couleur et forme :SolidMasse moléculaire :414.54LLY-283
CAS :LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.Formule :C17H18N4O4Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :342.35GSK3368715 dihydrochloride
CAS :GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.Formule :C20H40Cl2N4O2Degré de pureté :99.66% - 99.66%Couleur et forme :SolidMasse moléculaire :439.46EZM0414
CAS :EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Formule :C22H29FN4O2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :400.49ORIC-944
CAS :ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formule :C26H25FN6ODegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :456.52Ref: TM-T87073
1mg84,00€5mg165,00€10mg237,00€25mg402,00€50mg515,00€100mg774,00€1mL*10mM (DMSO)À demanderAMG-193
CAS :AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Formule :C22H19F3N4O3Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :444.41BRD0639
CAS :BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Formule :C21H22ClN5O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :475.95Sinefungin
CAS :Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFormule :C15H23N7O5Degré de pureté :98% - 98.12%Couleur et forme :SolidMasse moléculaire :381.39EHMT2-IN-2
CAS :EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.Formule :C21H22N6OCouleur et forme :SolidMasse moléculaire :374.44CARM1-IN-1 hydrochloride
CAS :CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.Formule :C26H22Br2ClNO3Couleur et forme :SolidMasse moléculaire :591.72BLL5 Maleate
CAS :BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.Formule :C21H21N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.41Igermetostat
CAS :Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].
Formule :C32H46N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :550.73BBDDL2059
CAS :BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.
Formule :C27H36N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :512.66
