Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
422 produits trouvés pour "Méthyltransférase de l’ADN"
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UNC6934
CAS :<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Formule :C24H21N5O4Degré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :443.45Amodiaquine hydrochloride
CAS :<p>Amodiaquine dihydrochloride: 4-aminoquinoline antimalarial, histamine N-methyltransferase inhibitor (Ki 18.6 nM), Nurr1 agonist, anti-inflammatory.</p>Formule :C20H24Cl3N3OCouleur et forme :SolidMasse moléculaire :428.78UNC3866
CAS :<p>UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Formule :C43H66N6O8Degré de pureté :88.06% - 99.62%Couleur et forme :SolidMasse moléculaire :795.02UNC0642
CAS :<p>UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).</p>Formule :C29H44F2N6O2Degré de pureté :98.75% - 99.5%Couleur et forme :SolidMasse moléculaire :546.7MR837
CAS :<p>MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.</p>Formule :C16H14N2OSDegré de pureté :99.77% - 99.85%Couleur et forme :SolidMasse moléculaire :282.36Hinokitiol
CAS :<p>Hinokitiol prevents UVB-caused cell death, boosts antioxidant activity, and hinders breast cancer growth.</p>Formule :C10H12O2Degré de pureté :99.49% - 99.67%Couleur et forme :SolidMasse moléculaire :164.2UNC0379
CAS :<p>UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.</p>Formule :C23H35N5O2Degré de pureté :94.41% - 99.97%Couleur et forme :SolidMasse moléculaire :413.56MS023
CAS :<p>MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,</p>Formule :C17H25N3ODegré de pureté :98.31% - 99.87%Couleur et forme :SolidMasse moléculaire :287.45-Fluoro-2'-deoxycytidine
CAS :<p>5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .</p>Formule :C9H12FN3O4Degré de pureté :97.91%Couleur et forme :Fine White PowderMasse moléculaire :245.21SGC2085
CAS :<p>SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).</p>Formule :C19H24N2O2Degré de pureté :99.61% - 99.71%Couleur et forme :SolidMasse moléculaire :312.41Bobcat339
CAS :<p>Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.</p>Formule :C16H12ClN3ODegré de pureté :97.79% - 99.24%Couleur et forme :SolidMasse moléculaire :297.74EPZ004777 hydrochloride
CAS :<p>EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.</p>Formule :C28H42ClN7O4Couleur et forme :SolidMasse moléculaire :576.13MRTX-1719
CAS :<p>MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.</p>Formule :C23H18ClFN6O2Degré de pureté :98.27% - 99.18%Couleur et forme :SolidMasse moléculaire :464.88MS37452
CAS :<p>MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).</p>Formule :C22H26N2O5Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :398.45DCLX069
CAS :<p>DCLX069: PRMT1 inhibitor, IC50=17.9µM, targets SAM pocket, inhibits breast/liver cancer, and AML cell growth.</p>Formule :C20H25N3O2Degré de pureté :97.76%Couleur et forme :SolidMasse moléculaire :339.43GSK503
CAS :<p>GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.</p>Formule :C31H38N6O2Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :526.67EPZ011989
CAS :<p>EPZ011989: potent, selective oral EZH2 inhibitor, Ki < 3 nM, 15x more selective than EZH1, >3000x over other HMTases.</p>Formule :C35H51N5O4Degré de pureté :98% - 99.45%Couleur et forme :SolidMasse moléculaire :605.81GSK343
CAS :<p>GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against</p>Formule :C31H39N7O2Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :541.696-Thioguanine
CAS :<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Formule :C5H5N5SDegré de pureté :98.34% - >99.99%Couleur et forme :Odorless Or Almost Odorless Pale Yellow Crystalline PowderMasse moléculaire :167.19γ-Oryzanol
CAS :<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Formule :C40H58O4Degré de pureté :mixture - mixtureCouleur et forme :White Or White Crystalline Powder OdourlessMasse moléculaire :602.9GSK591
CAS :<p>GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).</p>Formule :C22H28N4O2Degré de pureté :99.35% - 99.45%Couleur et forme :SolidMasse moléculaire :380.48Succinic acid sodium
CAS :<p>Succinic acid sodium is an orally active anxiolytic.</p>Formule :C4H6O4·xNaCouleur et forme :SolidPiribedil
CAS :Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Formule :C16H18N4O2Degré de pureté :99.79% - 99.82%Couleur et forme :SolidMasse moléculaire :298.34CM-272
CAS :<p>CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.</p>Formule :C28H38N4O3Degré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :478.633-deazaneplanocin A HCl
CAS :<p>3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.</p>Formule :C12H15ClN4O3Degré de pureté :93.24% - 98.9%Couleur et forme :SolidMasse moléculaire :298.73UNC3866 TFA(1872382-47-2 free base)
CAS :<p>UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Formule :C45H67F3N6O10Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :909.04EPZ005687
CAS :<p>EPZ005687 is a potent and selective inhibitor of EZH2.</p>Formule :C32H37N5O3Degré de pureté :97.06% - 99.64%Couleur et forme :SolidMasse moléculaire :539.67Amodiaquine
CAS :<p>Amodiaquine is a synthetic aminoquinoline, used to treat malaria.</p>Formule :C20H22ClN3ODegré de pureté :99.78% - 99.99%Couleur et forme :Crystals From Absolute Ethanol SolidMasse moléculaire :355.86GSK3685032
CAS :<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>Formule :C22H24N6OSDegré de pureté :98.56% - 99.49%Couleur et forme :SolidMasse moléculaire :420.53SETDB1-TTD-IN-1 TFA
<p>SETDB1-TTD-IN-1 TFA: potent, selective SETDB1-TTD inhibitor (Kd: 88 nM), useful for related biological research.</p>Formule :C30H32F3N5O4Couleur et forme :SolidMasse moléculaire :583.6GSK126
CAS :<p>GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).</p>Formule :C31H38N6O2Degré de pureté :98% - 99.67%Couleur et forme :SolidMasse moléculaire :526.67EED226
CAS :<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Formule :C17H15N5O3SDegré de pureté :98.14% - 99.33%Couleur et forme :SolidMasse moléculaire :369.4GSK3326595
CAS :<p>GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).</p>Formule :C24H32N6O3Degré de pureté :97.7% - 99.63%Couleur et forme :SolidMasse moléculaire :452.55A-196
CAS :<p>A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over</p>Formule :C18H16Cl2N4Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :359.25JNJ-64619178
CAS :<p>JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.</p>Formule :C22H23BrN6O2Degré de pureté :98.44% - 99.63%Couleur et forme :SolidMasse moléculaire :483.36MM-102 TFA
CAS :<p>MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 interaction, impeding H3K4 HMT activity.</p>Formule :C37H50F5N7O6Degré de pureté :99.4% - 99.78%Couleur et forme :SolidMasse moléculaire :783.83JQEZ5
CAS :<p>JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).</p>Formule :C30H38N8O2Degré de pureté :98.14% - ≥98%Couleur et forme :SolidMasse moléculaire :542.68WDR5-0103
CAS :<p>WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).</p>Formule :C21H25N3O4Degré de pureté :98% - 99.61%Couleur et forme :SolidMasse moléculaire :383.44C-7280948
CAS :<p>C-7280948 is a PRMT1 inhibitor.</p>Formule :C14H16N2O2SDegré de pureté :99.55% - ≥95%Couleur et forme :SolidMasse moléculaire :276.35MIV-6R
CAS :<p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>Formule :C27H35N3ODegré de pureté :99.81% - 99.88%Couleur et forme :SolidMasse moléculaire :417.59TNG-462
CAS :<p>TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).</p>Formule :C28H36N6O2SDegré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :520.69BI-9321 trihydrochloride
CAS :BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Formule :C22H24Cl3FN4Degré de pureté :99.12% - 99.34%Couleur et forme :SolidMasse moléculaire :469.81(S)-HH2853
CAS :<p>(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.</p>Formule :C31H36F3N7O3Degré de pureté :97.18% - 99.74%Couleur et forme :SolidMasse moléculaire :611.66MRK-740
CAS :<p>MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.</p>Formule :C25H32N6O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :464.56MS023 dihydrochloride
CAS :<p>MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.</p>Formule :C17H27Cl2N3ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :360.32CBHcy
CAS :<p>CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.</p>Formule :C9H17NO4SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :235.3PFI-2
CAS :<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>Formule :C23H25F4N3O3SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :499.52GSK2807 Trifluoroacetate
CAS :<p>GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).</p>Formule :C21H33F3N8O7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :566.53Tazemetostat trihydrochloride
CAS :<p>Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.</p>Formule :C34H47Cl3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :682.12Acedapsone
CAS :<p>Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.</p>Formule :C16H16N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.37UNC0224
CAS :<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formule :C26H43N7O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :485.67MY-1B
CAS :<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Formule :C22H18BrN3O2Degré de pureté :99.81% - >99.99%Couleur et forme :SoildMasse moléculaire :436.3GSK-1268997
CAS :<p>GSK-1268997 is a bio-active chemical.</p>Formule :C21H23N7O3SDegré de pureté :99.33% - 99.81%Couleur et forme :SolidMasse moléculaire :453.52G9a-IN-2
CAS :<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Formule :C30H42N4O4Couleur et forme :SolidMasse moléculaire :522.68F5446
CAS :<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Formule :C26H17ClN2O8SDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :552.94SW155246
CAS :<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Formule :C16H11ClN2O5SDegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :378.79Furamidine dihydrochloride
CAS :<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Formule :C18H18Cl2N4ODegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :377.27TFMB-(S)-2-HG
CAS :<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Formule :C13H11F3O4Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :288.22OTS186935
CAS :OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formule :C25H26ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.96WDR5-IN-4
CAS :<p>WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.</p>Formule :C25H22Cl2FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.385WKS
CAS :<p>5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.</p>Formule :C24H36ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.03PRMT5-IN-C17
CAS :<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Formule :C18H17N3O4SCouleur et forme :SolidMasse moléculaire :371.41BIX-01338 hydrate
CAS :<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Formule :C32H26F3N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.56CMP-5 hydrochloride
CAS :<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Formule :C21H22ClN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.87Furamidine
CAS :<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Formule :C18H16N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.356-Methyl-5-azacytidine
CAS :<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Formule :C9H14N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23Dot1L-IN-7
CAS :<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Formule :C23H27N9O2Couleur et forme :SolidMasse moléculaire :461.52DS-437
CAS :<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Formule :C15H23N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.45SGC6870
CAS :<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Formule :C23H21BrN2O2SCouleur et forme :SolidMasse moléculaire :469.39UNC2327
CAS :<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Formule :C14H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.38RSC-133
CAS :promotes the reprogramming of human somatic cells to pluripotent stem cellsFormule :C18H15N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.33DCE_42
CAS :<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Formule :C22H19N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.51EZH2-IN-3
CAS :<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Formule :C27H28ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490DC_C66
CAS :<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Formule :C28H22NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.48Dot1L-IN-5
CAS :<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Formule :C23H19ClF2N8O5SCouleur et forme :SolidMasse moléculaire :592.96OTS186935 trihydrochloride
CAS :<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Formule :C25H29Cl4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.34DM-01
CAS :<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Formule :C23H24F3N3O2Couleur et forme :SolidMasse moléculaire :431.452′-Deoxy-5-nitrocytidine
CAS :<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Formule :C9H12N4O6Couleur et forme :SolidMasse moléculaire :272.21RM65
CAS :<p>RM65 is an arginine methyltransferase inhibitor.</p>Formule :C34H32N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.76SKF 91488 dihydrochloride
CAS :<p>histamine N-methyltransferase inhibitor</p>Formule :C7H19Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.22Guadecitabine
CAS :<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Formule :C18H24N9O10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.41PDAT
CAS :<p>PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.</p>Formule :C15H23N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :245.36JS1310
CAS :<p>JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.</p>Formule :C23H22FN5O3Couleur et forme :SolidMasse moléculaire :435.45NSD3-IN-3
CAS :<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Formule :C15H17N5O2SCouleur et forme :SolidMasse moléculaire :331.39NSD3-IN-2
CAS :<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.4CSV0C018875
CAS :<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Formule :C18H17ClN2OCouleur et forme :SolidMasse moléculaire :312.79Dihydro-5-azacytidine acetate
CAS :<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Formule :C10H18N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.27PRMT5-IN-17
CAS :<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Formule :C26H33N7O2Couleur et forme :SolidMasse moléculaire :475.59BAY-598 R-isomer
CAS :<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Formule :C22H20Cl2F2N6O3Couleur et forme :SolidMasse moléculaire :525.34CPI-905
CAS :<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Formule :C18H20N2O5Couleur et forme :SolidMasse moléculaire :344.36DNMT3A-IN-1
CAS :<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Formule :C30H38N6O4Couleur et forme :SolidMasse moléculaire :546.66CM-579
CAS :<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Formule :C29H40N4O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :492.65NSC-311068
CAS :<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Formule :C10H6N4O4SCouleur et forme :SolidMasse moléculaire :278.24EZH2-IN-11
CAS :<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Formule :C28H36ClN3O5SCouleur et forme :SolidMasse moléculaire :562.12EZH2-IN-9
CAS :<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Formule :C28H32ClF2N3O5SCouleur et forme :SolidMasse moléculaire :596.09AA-CW236
CAS :<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Formule :C17H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :400.78NSD3-IN-1
CAS :<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Formule :C13H13N5OSCouleur et forme :SolidMasse moléculaire :287.34BI-9321
CAS :<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Formule :C22H21FN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.43UNC0379 TFA
CAS :<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Formule :C25H36F3N5O4Couleur et forme :SolidMasse moléculaire :527.589DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Formule :C29H39Cl3FN9O3Couleur et forme :SolidMasse moléculaire :687.04PRMT5-IN-10
CAS :<p>PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.</p>Formule :C13H17N5O4Couleur et forme :SolidMasse moléculaire :307.31EZH2-IN-7
CAS :<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Formule :C31H37D2N5O3SCouleur et forme :SolidMasse moléculaire :563.755-Aza-4'-thio-2'-deoxycytidine
CAS :<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Formule :C8H12N4O3SCouleur et forme :SolidMasse moléculaire :244.27Lobelane Hydrochloride
CAS :<p>Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.</p>Formule :C22H30ClNCouleur et forme :SolidMasse moléculaire :343.93Fagaronine chloride
CAS :<p>Fagaronine chloride is a potent inhibitor of Topoisomerases I.</p>Formule :C21H20ClNO4Couleur et forme :SolidMasse moléculaire :385.84DC_501
CAS :<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Formule :C25H23Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.38Prospasmine
CAS :<p>Prospasmine is an anticholinergic.</p>Formule :C17H28ClNO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :313.87Setin-1
CAS :<p>Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.</p>Formule :C29H21F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.48DCE_254
CAS :<p>DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Formule :C21H17N9OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.48GSK926
CAS :<p>GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.</p>Formule :C29H35N7O2Couleur et forme :SolidMasse moléculaire :513.63Arazine
CAS :<p>Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.</p>Formule :C20H33NO3SDegré de pureté :90%Couleur et forme :SolidMasse moléculaire :367.55JNJ-7925476 free base
CAS :<p>JNJ-7925476 is an TRI antidepressant agent.</p>Formule :C20H19NDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :273.37(R)-OR-S1
CAS :<p>(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.</p>Formule :C26H34BrN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.47MS453
CAS :<p>MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.</p>Formule :C20H27N5O3Couleur et forme :SolidMasse moléculaire :385.46S-Aristeromycinylhomocysteine
CAS :<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>Formule :C15H22N6O4SCouleur et forme :SolidMasse moléculaire :382.44ZLD10A
CAS :<p>ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.</p>Formule :C37H48N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :612.8LEM-14-1189
CAS :<p>LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.</p>Formule :C35H34N6O5S2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :682.81Valemetostat tosylate
CAS :<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Formule :C33H42ClN3O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :660.22MM-102
CAS :<p>MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.</p>Formule :C35H49F2N7O4Degré de pureté :98.77% - 99.99%Couleur et forme :SolidMasse moléculaire :669.8EPZ032597
CAS :<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Formule :C20H23N7ODegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :377.44PRMT4-IN-1
CAS :<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Formule :C23H28FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.49SMYD2-IN-1
CAS :<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Formule :C25H25Cl2F2N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.41EML741
CAS :<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Formule :C31H49N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.75EZM 2302
CAS :<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Formule :C29H37ClN6O5Degré de pureté :97.47% - ≥98%Couleur et forme :SolidMasse moléculaire :585.09Dot1L-IN-2
CAS :<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Formule :C27H24N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.53Guadecitabine sodium
CAS :<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Formule :C18H24N9NaO10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.407GNA002
CAS :<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Formule :C42H55NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :701.89ZLD1039
CAS :<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Formule :C36H48N6O3Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :612.8PRMT5-IN-2
CAS :<p>PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.</p>Formule :C17H16ClFN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.78Tetrahydrouridine
CAS :<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Formule :C9H16N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23DC_517
CAS :<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Formule :C33H35N3O2Couleur et forme :SolidMasse moléculaire :505.65DW14800
CAS :<p>DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.</p>Formule :C31H36N4O3Degré de pureté :99.55% - 99.68%Couleur et forme :SolidMasse moléculaire :512.64Cedazuridine
CAS :<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Formule :C9H14F2N2O5Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :268.21Procainamide
CAS :<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Formule :C13H21N3ODegré de pureté :99.92% - 99.92%Couleur et forme :SolidMasse moléculaire :235.33TM2-115
CAS :<p>TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].</p>Formule :C28H38N6O2Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :490.64CARM1-IN-1
CAS :<p>CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.</p>Formule :C26H21Br2NO3Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :555.26WDR5-0102
CAS :<p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>Formule :C18H19ClN4O3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :374.82UNC0321
CAS :<p>UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.</p>Formule :C27H45N7O3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :515.69TNG908
CAS :<p>TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.</p>Formule :C21H23N5O2SDegré de pureté :98.08% - 98.24%Couleur et forme :SolidMasse moléculaire :409.51MS0124
CAS :<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Formule :C20H29N5O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :387.48Bobcat339 hydrochloride
CAS :<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Formule :C16H13Cl2N3ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :334.2CPUY074020
CAS :<p>CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.</p>Formule :C25H28N4O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :416.52LEM-14
CAS :<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Formule :C25H26N4O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :478.56EZH2-IN-13
CAS :<p>EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.</p>Formule :C34H45N5O3Degré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :571.75GSK-A
CAS :<p>GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.</p>Formule :C21H25N5O2Couleur et forme :SolidMasse moléculaire :379.46PRMT5-IN-25
CAS :<p>PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1</p>Formule :C24H21F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.46MAK683-CH2CH2COOH
CAS :<p>MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.</p>Formule :C23H21FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.45DNMT-IN-3
CAS :<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Formule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04EPZ011989 HCl(1598383-40-4 Free base)
CAS :<p>EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.</p>Formule :C35H51N5O4·HClCouleur et forme :SolidMasse moléculaire :642.27PRMT5-IN-29
CAS :<p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>Formule :C18H20Cl3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.74CARM1-IN-3
CAS :<p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>Formule :C24H32N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.54MS67
CAS :<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14WM-586
CAS :<p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>Formule :C20H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.47Bisegliptin
CAS :<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42PRMT5-IN-28
CAS :<p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>Formule :C18H19ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.82SMYD3-IN-1
CAS :<p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>Formule :C28H31ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.02RK-701
CAS :<p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54DY-46-2
CAS :<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48RK-0133114
<p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54MS023 trihydrochloride
CAS :<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78EZH2-IN-14
CAS :<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69PRT543
CAS :<p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>Formule :C17H17ClN4O4Couleur et forme :SolidMasse moléculaire :376.79PRMT5-IN-16
CAS :<p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>Formule :C25H34N8O2Couleur et forme :SolidMasse moléculaire :478.59EPZ-030456
CAS :<p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>Formule :C28H34ClN5O4SCouleur et forme :SolidMasse moléculaire :572.12GSK-3484862
CAS :<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.45UNC8153 TFA
CAS :<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Formule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7EPZ031686
CAS :<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Formule :C26H34ClF3N4O4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :591.09PF-06726304 acetate
CAS :<p>PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.</p>Formule :C24H25Cl2N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.38GSK3368715 3HCl
CAS :<p>GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81</p>Formule :C20H41Cl3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.92HLCL-61
CAS :<p>HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).</p>Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45(1-Nitroethene-1,2-diyl)dibenzene
CAS :<p>(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.</p>Formule :C14H11NO2Couleur et forme :SolidMasse moléculaire :225.24RL5a
CAS :<p>RL5a (compound C23) is a novel inhibitor of SETD8.</p>Formule :C17H19N3OCouleur et forme :SolidMasse moléculaire :281.35MMSET-IN-1
CAS :<p>MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .</p>Formule :C18H29N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.47Octyl-α-hydroxyglutarate
CAS :<p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>Formule :C13H24O5Masse moléculaire :260.33SGC6870N
CAS :<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Formule :C23H21BrN2O2SMasse moléculaire :469.39PRMT5-IN-50
CAS :<p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496RK-0080552
CAS :<p>RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.</p>Formule :C12H6N6O2Couleur et forme :SolidMasse moléculaire :266.215TDI-015051
CAS :<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505PRMT5-IN-37
CAS :<p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37PRMT5-IN-49
CAS :<p>PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.</p>Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39NSD2-PWWP1-IN-2
CAS :<p>NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.</p>Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575PRMT5-IN-3
CAS :<p>PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.</p>Formule :C22H23F3N4O3Couleur et forme :SolidMasse moléculaire :448.44MS117
<p>MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].</p>Formule :C17H22N4OCouleur et forme :SolidMasse moléculaire :298.38SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48EZH2-IN-12
<p>EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.</p>Formule :C23H23Cl2N3O3Couleur et forme :SolidMasse moléculaire :460.35PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formule :C25H24N4OCouleur et forme :SolidMasse moléculaire :396.48WDR5-IN-5
CAS :<p>WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.</p>Formule :C29H29F3N6OCouleur et forme :SolidMasse moléculaire :534.58PRMT5-IN-1 hydrochloride
<p>PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.</p>Formule :C19H20Cl2N4O5Couleur et forme :SolidMasse moléculaire :455.29NSD2-PWWP1-IN-3
CAS :<p>NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.</p>Formule :C34H39N5O2Couleur et forme :SolidMasse moléculaire :549.706Pociredir
CAS :<p>Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.</p>Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.41PRMT5-MTA-IN-3
CAS :<p>PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.</p>Formule :C19H17F3N6O3Couleur et forme :SolidMasse moléculaire :434.372MM-589
CAS :<p>MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>Formule :C28H44N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.70MS8511
CAS :<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formule :C28H41N5O3Couleur et forme :SolidMasse moléculaire :495.66PRMT5-IN-21
<p>PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.</p>Formule :C18H18F2N6O3Couleur et forme :SolidMasse moléculaire :404.37O6BTG-C8-αGlu
CAS :<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525NSD2-PWWP1-IN-1
CAS :<p>NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.</p>Formule :C28H30N4Couleur et forme :SolidMasse moléculaire :422.565EED ligand 1
<p>EED ligand 1: potent PRC2 inhibitor targeting EED subunit.</p>Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41MS8815
CAS :<p>MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.</p>Formule :C65H87N9O8SCouleur et forme :SolidMasse moléculaire :1154.51RU-0415529
CAS :<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538
