Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
451 produits trouvés pour "Méthyltransférase de l’ADN".
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EPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :White SolidMasse moléculaire :450.57PRMT5-IN-43
CAS :PRMT5-IN-43 (compound 4A) is an inhibitor of PRMT5, primarily utilized in cancer research.Formule :C22H17ClF3N5O2Couleur et forme :SolidMasse moléculaire :475.85PRMT1-IN-1
CAS :PRMT1-IN-1 is a PRMT1 inhibitor.Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702MAK-683 hydrochloride
CAS :MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Formule :C20H18ClFN6ODegré de pureté :97.02% - >99.99%Couleur et forme :White SolidMasse moléculaire :412.85G9D-4
G9D-4 is an effective degrader of G9a with a DC50 value of 0.1 μM in PANC-1 cells, and it does not directly interfere with GLP proteins (DC50 greater than 10 μM). This compound plays a significant role in pancreatic cancer research.Couleur et forme :Odour SolidCARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formule :C27H35ClN6O3Couleur et forme :SolidMasse moléculaire :527.06DC-S239
CAS :Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formule :C15H15N3O5SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :349.36Ref: TM-T60002
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg187,00€50mg304,00€100mg482,00€200mg658,00€LLC0424
LLC0424 is a potent and selective degrader of the nuclear receptor-binding SET domain 2 (NSD2), with a DC50 of 20 nM. It reduces H3K36me2 levels and inhibits the growth of acute lymphoblastic leukemia (ALL) cell lines, making it useful for research in ALL.Couleur et forme :Odour SolidMS-8709
CAS :MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.Formule :C64H95F2N11O7SDegré de pureté :99.98%Masse moléculaire :1200.57MS2133
MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.Formule :C58H66ClF3N14O11S2Couleur et forme :SolidMasse moléculaire :1290.41175PROTAC PRMT3 degrader 1
PROTAC PRMT3 degrader 1 (compound 11) is a PROTAC molecule targeting PRMT3 for degradation. It effectively inhibits the growth of acute leukemia cells.Couleur et forme :Odour SolidNanaomycin A
CAS :Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).Formule :C16H14O6Degré de pureté :98%Couleur et forme :Yellow SolidMasse moléculaire :302.28EZH2-IN-19
CAS :EZH2-IN-19 (compound N40) is a potent inhibitor of the wild-type enhancer of zeste homolog 2 (EZH2), with an IC50 of 0.32 nM. It plays a significant role in cancer research.Formule :C40H55N7O3Couleur et forme :SolidMasse moléculaire :681.91SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Formule :C45H62Cl3N7O8Couleur et forme :SolidMasse moléculaire :935.37FTX-6058
CAS :FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Couleur et forme :Odour SolidA-893
CAS :A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Couleur et forme :Odour SolidPROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13N-acetyl-S-geranylgeranyl-L-Cysteine
CAS :N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic inhibitor for protein methyltransferase.Formule :C25H41NO3SCouleur et forme :SolidMasse moléculaire :435.67Larsucosterol Ammonium salt
CAS :Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Formule :C27H49NO5SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :499.75CM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571PRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696Tet1 peptide
CAS :Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Formule :C73H114N20O17Couleur et forme :SolidMasse moléculaire :1543.81OTS186935 FA
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.Formule :C26H28ClN5O4Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :509.98Ref: TM-T12344L1
1mg92,00€5mg222,00€1mL*10mM (DMSO)255,00€10mg371,00€25mg673,00€50mg1.044,00€100mg1.459,00€500mg2.907,00€XF067-68
CAS :XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14MS33
CAS :MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5Dot1L-IN-8
Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.Formule :C41H53N7O3SCouleur et forme :SolidMasse moléculaire :723.97EZH2-IN-4
CAS :EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.Formule :C29H41N3O3SCouleur et forme :SolidMasse moléculaire :511.73Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Couleur et forme :Odour SolidPRMT5-IN-15
CAS :PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.Formule :C24H23F3N6O2Couleur et forme :SolidMasse moléculaire :484.483ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Couleur et forme :Odour SolidMS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Couleur et forme :Odour SolidWDR5-47
CAS :WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.Formule :C19H20ClFN4O3Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :406.84Ref: TM-T67697
1mg85,00€5mg170,00€1mL*10mM (DMSO)185,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€EEDi-5273
CAS :EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Formule :C26H22F4N6O2Couleur et forme :SolidMasse moléculaire :526.496TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Couleur et forme :Odour SolidBBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formule :C37H47N5O5SCouleur et forme :SolidMasse moléculaire :673.32979G9a-IN-3
G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.Formule :C26H29N5O3Couleur et forme :SolidMasse moléculaire :459.22704UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Couleur et forme :Odour SolidUNC2399
CAS :UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its ICFormule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68DNMT2-IN-1
DNMT2-IN-1 (compound 80) is a novel DNMT2 (DNA methyltransferase 2) inhibitor with an IC50 of 1.2 μM, intended for research in neurological and metabolic disorders or cancer.Formule :C20H23BrN8O9SC2HF3O2Masse moléculaire :744.04207ALKBH1-IN-1
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor with IC50 values of 0.026 μM in fluorescence polarization assays and 1.39 μM in enzyme activity assays. It can regulate the levels of DNA 6mA modifications and is useful for studying the functions of ALKBH1 and DNA 6mA.Formule :C16H11F3N4O4Masse moléculaire :380.07324PRMT5-IN-9
CAS :PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formule :C25H23F3N6OCouleur et forme :SolidMasse moléculaire :480.495PRMT5-IN-4
CAS :PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formule :C11H13N3O4SCouleur et forme :SolidMasse moléculaire :283.3EPZ-025654
CAS :EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08(S)-Kaempferide
(S)-Kaempferide (ZINC167686681) is a DNA methyltransferase (DNMT) inhibitor used in tumor research.Formule :C16H12O6Couleur et forme :SolidMasse moléculaire :300.06339Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formule :C34H37ClF3N9O4SCouleur et forme :SolidMasse moléculaire :760.23C 21
CAS :PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formule :C90H161ClN36O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2166.94
