Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
422 produits trouvés pour "Méthyltransférase de l’ADN"
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FTX-6058
CAS :<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.417PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Couleur et forme :Odour SolidA-893
CAS :<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Formule :C29H38Cl2N4O4Couleur et forme :SolidMasse moléculaire :577.54UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Formule :C47H70N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :847.09PROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13SW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Formule :C44H64N6O9Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :821.01ND-L11B free base
<p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>Formule :C37H51F3N10O2Couleur et forme :SolidMasse moléculaire :724.862PARP/EZH2-IN-1
CAS :<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Formule :C43H41FN8O5Couleur et forme :SolidMasse moléculaire :768.85PRMT5-IN-12
CAS :<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696EEDi-5285
CAS :<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Formule :C24H22FN5O3SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :479.53Chaetocin
CAS :<p>Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.</p>Formule :C30H28N6O6S4Degré de pureté :98.36% - 98.82%Couleur et forme :SolidMasse moléculaire :696.84EPZ-719
CAS :<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Formule :C22H31FN4O3SCouleur et forme :SolidMasse moléculaire :450.57PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Formule :C23H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.52G9a-IN-3
<p>G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.</p>Formule :C26H29N5O3Couleur et forme :SolidMasse moléculaire :459.22704EPZ020411 2HCl (1700663-41-7(free base))
<p>EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).</p>Formule :C25H40Cl2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.51UNC2399
CAS :<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Couleur et forme :Odour SolidHDACs/EZH2-IN-1
<p>HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis).</p>Formule :C29H36BrN7O4Couleur et forme :SolidMasse moléculaire :626.54CPI-1328
CAS :<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Formule :C41H47ClN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.37MS33
CAS :<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5XF067-68
CAS :<p>XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14WDR5-47
CAS :<p>WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.</p>Formule :C19H20ClFN4O3Degré de pureté :98.15%Couleur et forme :SoildMasse moléculaire :406.84XF056-132
CAS :<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Formule :C51H57F4N9O7SCouleur et forme :SolidMasse moléculaire :1016.11PRMT5-MTA-IN-2
<p>PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.</p>Formule :C30H25F2N7O2Couleur et forme :SolidMasse moléculaire :553.56PRMT5-IN-15
CAS :<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Formule :C24H23F3N6O2Couleur et forme :SolidMasse moléculaire :484.483EEDi-5273
CAS :<p>EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.</p>Formule :C26H22F4N6O2Couleur et forme :SolidMasse moléculaire :526.496CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571MS1943
CAS :<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Formule :C42H54N8O3Degré de pureté :95.41% - 95.82%Couleur et forme :SolidMasse moléculaire :718.93OTS186935 FA
<p>OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.</p>Formule :C26H28ClN5O4Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :509.98PRMT1-IN-1
CAS :<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702NSC 370284
CAS :<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43UNC10013
<p>UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.</p>Couleur et forme :Odour SolidEZH2-IN-15
CAS :<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Formule :C32H44N4O4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :548.72EPZ-025654
CAS :<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08SAH-EZH2
CAS :<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05Gintemetostat
CAS :<p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>Formule :C25H26F4N8O2Couleur et forme :SolidMasse moléculaire :546.52AMI-1 free acid
CAS :<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Formule :C21H16N2O9S2Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :504.49PROTAC EZH2 Degrader-1
CAS :<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Formule :C54H67N7O8Couleur et forme :SolidMasse moléculaire :942.15(R)-HH2853
CAS :<p>(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.</p>Formule :C31H36F3N7O3Degré de pureté :97.53% - 98.85%Couleur et forme :SolidMasse moléculaire :611.66EZM0414 TFA
CAS :<p>EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.</p>Formule :C24H30F4N4O4Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :514.51MS8511 hydrochloride
CAS :<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Formule :C28H42ClN5O3Couleur et forme :SolidMasse moléculaire :532.122'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS :<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Formule :C9H13ClFN3O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :281.67O6BTG-octylglucoside
CAS :O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formule :C24H34BrN5O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :616.53DA-3003-1
CAS :<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Formule :C15H16ClN3O3Degré de pureté :99.27% - 99.79%Couleur et forme :SolidMasse moléculaire :321.76EHMT2-IN-1
CAS :<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Formule :C18H23N7OCouleur et forme :SolidMasse moléculaire :353.425'-Azido-5'-deoxyadenosine
CAS :<p>5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.</p>Formule :C10H12N8O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :292.25EPZ020411
CAS :<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.6AZ505 ditrifluoroacetate
CAS :<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Formule :C33H40Cl2F6N4O8Couleur et forme :SolidMasse moléculaire :805.59
