Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
460 produits trouvés pour "Méthyltransférase de l’ADN"
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PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formule :C55H60FN11O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.2TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Couleur et forme :Odour SolidGSK 591 dihydrochloride
CAS :Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Formule :C22H30Cl2N4O2Couleur et forme :SolidMasse moléculaire :453.41UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Formule :C47H70N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :847.09PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formule :C50H58FN11O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :960.13CS-VIP 8
CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.Formule :C43H52F4N12O7Couleur et forme :SolidMasse moléculaire :924.4018SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Formule :C44H64N6O9Degré de pureté :98%Couleur et forme :SoildMasse moléculaire :821.01MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Couleur et forme :SolidPRMT5-IN-12
CAS :PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formule :C32H40N4O4Couleur et forme :SolidMasse moléculaire :544.696EPZ-719
CAS :EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Formule :C22H31FN4O3SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :450.57MS1943
CAS :MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formule :C42H54N8O3Degré de pureté :95.41% - 95.82%Couleur et forme :SolidMasse moléculaire :718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formule :C34H37ClF3N9O4SCouleur et forme :SolidMasse moléculaire :760.23PARP/EZH2-IN-2
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.Formule :C33H31N7O3Masse moléculaire :573.24884PRMT5-IN-9
CAS :PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Formule :C25H23F3N6OCouleur et forme :SolidMasse moléculaire :480.495Chaetocin
CAS :Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.
Formule :C30H28N6O6S4Degré de pureté :98.36% - 98.82%Couleur et forme :SolidMasse moléculaire :696.84UNC2399
CAS :UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC
Formule :C67H104N10O17SCouleur et forme :SolidMasse moléculaire :1353.68MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Couleur et forme :Odour SolidFTX-6058 hydrochloride
CAS :FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formule :C22H19ClFN5O2Couleur et forme :SolidMasse moléculaire :439.87SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryDegré de pureté :98%Couleur et forme :Odour SolidPRMT5-IN-4
CAS :PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formule :C11H13N3O4SCouleur et forme :SolidMasse moléculaire :283.3MS33
CAS :MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formule :C64H84F3N11O7SCouleur et forme :SolidMasse moléculaire :1208.5XF067-68
CAS :XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14EZH2-IN-15
CAS :A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Formule :C32H44N4O4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :548.72Ref: TM-T67883
1mg130,00€5mg258,00€1mL*10mM (DMSO)311,00€10mg339,00€25mg578,00€50mg879,00€100mg1.314,00€MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formule :C15H26Cl2N2ODegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :321.28SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formule :C41H47ClN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.37UNC-4219 TFA
CAS :UNC4219 is a control for UNC3866, blocking Kme reader function in CBX & CDY chromodomains.Formule :C46H69F3N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :923.085Nanaomycin A
CAS :Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).Formule :C16H14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :302.28BML-278
CAS :BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormule :C24H25NO4Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :391.46SAH-EZH2
CAS :EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Formule :C155H256N48O40Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3432.05EPZ-025654
CAS :EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formule :C29H33ClN8O3Couleur et forme :SolidMasse moléculaire :577.08PROTAC PRMT3 degrader 1
PROTAC PRMT3 degrader 1 (compound 11) is a PROTAC molecule targeting PRMT3 for degradation. It effectively inhibits the growth of acute leukemia cells.Couleur et forme :Odour SolidG9a-IN-3
G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.Formule :C26H29N5O3Couleur et forme :SolidMasse moléculaire :459.22704EEDi-5285
CAS :EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Formule :C24H22FN5O3SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :479.53CM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Formule :C39H61N5O7Couleur et forme :SolidMasse moléculaire :711.4571NSC 370284
CAS :NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formule :C21H25NO6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :387.43PRMT1-IN-1
CAS :PRMT1-IN-1 is a PRMT1 inhibitor.
Formule :C20H7Br6NO5Couleur et forme :SolidMasse moléculaire :820.702WDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Couleur et forme :Odour SolidPRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.Formule :C30H25F2N7O2Couleur et forme :SolidMasse moléculaire :553.56GSK3735967
CAS :GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formule :C25H31N7OSCouleur et forme :SolidMasse moléculaire :477.62DC-S239
CAS :Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formule :C15H15N3O5SDegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :349.36Ref: TM-T60002
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg187,00€50mg304,00€100mg482,00€200mg658,00€CPI-1328
CAS :CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formule :C28H36ClN3O4SCouleur et forme :SolidMasse moléculaire :546.12UNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Couleur et forme :Odour SolidMRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Couleur et forme :Odour SolidEZH2-IN-4
CAS :EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.Formule :C29H41N3O3SCouleur et forme :SolidMasse moléculaire :511.73MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Formule :C28H42ClN5O3Degré de pureté :98.9% - 98.96%Couleur et forme :SolidMasse moléculaire :532.12PRMT5-IN-34
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).Formule :C23H19F2N5O2Masse moléculaire :435.15068EEDi-5273
CAS :EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Formule :C26H22F4N6O2Couleur et forme :SolidMasse moléculaire :526.496DDO-2093
CAS :DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Formule :C29H37ClFN9O3Couleur et forme :SolidMasse moléculaire :614.12AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Formule :C36H41ClN6O3S2Couleur et forme :SolidMasse moléculaire :705.332EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).Formule :C25H40Cl2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.51
