Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
422 produits trouvés pour "Méthyltransférase de l’ADN"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
UNC0224
CAS :<p>UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.</p>Formule :C26H43N7O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :485.67MY-1B
CAS :<p>MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.</p>Formule :C22H18BrN3O2Degré de pureté :99.81% - >99.99%Couleur et forme :SoildMasse moléculaire :436.3GSK-1268997
CAS :<p>GSK-1268997 is a bio-active chemical.</p>Formule :C21H23N7O3SDegré de pureté :99.33% - 99.81%Couleur et forme :SolidMasse moléculaire :453.52G9a-IN-2
CAS :<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Formule :C30H42N4O4Couleur et forme :SolidMasse moléculaire :522.68F5446
CAS :<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Formule :C26H17ClN2O8SDegré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :552.94SW155246
CAS :<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Formule :C16H11ClN2O5SDegré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :378.79Furamidine dihydrochloride
CAS :<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Formule :C18H18Cl2N4ODegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :377.27TFMB-(S)-2-HG
CAS :<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Formule :C13H11F3O4Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :288.22OTS186935
CAS :OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formule :C25H26ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.96WDR5-IN-4
CAS :<p>WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.</p>Formule :C25H22Cl2FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.385WKS
CAS :<p>5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.</p>Formule :C24H36ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.03PRMT5-IN-C17
CAS :<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Formule :C18H17N3O4SCouleur et forme :SolidMasse moléculaire :371.41BIX-01338 hydrate
CAS :<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Formule :C32H26F3N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.56CMP-5 hydrochloride
CAS :<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Formule :C21H22ClN3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.87Furamidine
CAS :<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Formule :C18H16N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :304.356-Methyl-5-azacytidine
CAS :<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Formule :C9H14N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23Dot1L-IN-7
CAS :<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Formule :C23H27N9O2Couleur et forme :SolidMasse moléculaire :461.52DS-437
CAS :<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Formule :C15H23N7O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :397.45SGC6870
CAS :<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Formule :C23H21BrN2O2SCouleur et forme :SolidMasse moléculaire :469.39UNC2327
CAS :<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Formule :C14H17N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.38RSC-133
CAS :promotes the reprogramming of human somatic cells to pluripotent stem cellsFormule :C18H15N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.33DCE_42
CAS :<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Formule :C22H19N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.51EZH2-IN-3
CAS :<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Formule :C27H28ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490DC_C66
CAS :<p>DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.</p>Formule :C28H22NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.48Dot1L-IN-5
CAS :<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Formule :C23H19ClF2N8O5SCouleur et forme :SolidMasse moléculaire :592.96OTS186935 trihydrochloride
CAS :<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Formule :C25H29Cl4N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :573.34DM-01
CAS :<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Formule :C23H24F3N3O2Couleur et forme :SolidMasse moléculaire :431.452′-Deoxy-5-nitrocytidine
CAS :<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Formule :C9H12N4O6Couleur et forme :SolidMasse moléculaire :272.21RM65
CAS :<p>RM65 is an arginine methyltransferase inhibitor.</p>Formule :C34H32N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.76SKF 91488 dihydrochloride
CAS :<p>histamine N-methyltransferase inhibitor</p>Formule :C7H19Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.22Guadecitabine
CAS :<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Formule :C18H24N9O10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :557.41PDAT
CAS :<p>PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.</p>Formule :C15H23N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :245.36JS1310
CAS :<p>JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.</p>Formule :C23H22FN5O3Couleur et forme :SolidMasse moléculaire :435.45NSD3-IN-3
CAS :<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Formule :C15H17N5O2SCouleur et forme :SolidMasse moléculaire :331.39NSD3-IN-2
CAS :<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.4CSV0C018875
CAS :<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Formule :C18H17ClN2OCouleur et forme :SolidMasse moléculaire :312.79Dihydro-5-azacytidine acetate
CAS :<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Formule :C10H18N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.27PRMT5-IN-17
CAS :<p>PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.</p>Formule :C26H33N7O2Couleur et forme :SolidMasse moléculaire :475.59BAY-598 R-isomer
CAS :<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Formule :C22H20Cl2F2N6O3Couleur et forme :SolidMasse moléculaire :525.34CPI-905
CAS :<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Formule :C18H20N2O5Couleur et forme :SolidMasse moléculaire :344.36DNMT3A-IN-1
CAS :<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Formule :C30H38N6O4Couleur et forme :SolidMasse moléculaire :546.66CM-579
CAS :<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Formule :C29H40N4O3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :492.65NSC-311068
CAS :<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Formule :C10H6N4O4SCouleur et forme :SolidMasse moléculaire :278.24EZH2-IN-11
CAS :<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Formule :C28H36ClN3O5SCouleur et forme :SolidMasse moléculaire :562.12EZH2-IN-9
CAS :<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Formule :C28H32ClF2N3O5SCouleur et forme :SolidMasse moléculaire :596.09AA-CW236
CAS :<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Formule :C17H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :400.78NSD3-IN-1
CAS :<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Formule :C13H13N5OSCouleur et forme :SolidMasse moléculaire :287.34BI-9321
CAS :<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Formule :C22H21FN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.43UNC0379 TFA
CAS :<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Formule :C25H36F3N5O4Couleur et forme :SolidMasse moléculaire :527.589DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Formule :C29H39Cl3FN9O3Couleur et forme :SolidMasse moléculaire :687.04
