Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
460 produits trouvés pour "Méthyltransférase de l’ADN"
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Hinokitiol
CAS :Hinokitiol prevents UVB-caused cell death, boosts antioxidant activity, and hinders breast cancer growth.Formule :C10H12O2Degré de pureté :99.49% - 99.98%Couleur et forme :SolidMasse moléculaire :164.2GSK343
CAS :GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormule :C31H39N7O2Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :541.69GSK126
CAS :GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Formule :C31H38N6O2Degré de pureté :98% - 99.67%Couleur et forme :SolidMasse moléculaire :526.67Ref: TM-T2079
2mg42,00€5mg62,00€1mL*10mM (DMSO)71,00€10mg94,00€25mg143,00€50mg215,00€100mg331,00€200mg432,00€(S)-HH2853
CAS :(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Formule :C31H36F3N7O3Degré de pureté :97.18% - 99.74%Couleur et forme :SolidMasse moléculaire :611.66CBHcy
CAS :CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.Formule :C9H17NO4SDegré de pureté :>99.99% - >99.99%Couleur et forme :SolidMasse moléculaire :235.3MRK-740
CAS :MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.Formule :C25H32N6O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :464.56MS023 dihydrochloride
CAS :MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.Formule :C17H27Cl2N3ODegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :360.32TNG-462
CAS :TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Formule :C28H36N6O2SDegré de pureté :98.7%Couleur et forme :SolidMasse moléculaire :520.69Ref: TM-T79873
1mg147,00€5mg255,00€1mL*10mM (DMSO)294,00€10mg383,00€25mg575,00€50mg863,00€100mg1.305,00€200mg1.755,00€MIV-6R
CAS :MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.Formule :C27H35N3ODegré de pureté :99.81% - 99.88%Couleur et forme :SolidMasse moléculaire :417.59BI-9321 trihydrochloride
CAS :BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Formule :C22H24Cl3FN4Degré de pureté :99.12% - 99.34%Couleur et forme :SolidMasse moléculaire :469.81PFI-2
CAS :PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over otherFormule :C23H25F4N3O3SDegré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :499.52GSK2807 Trifluoroacetate
CAS :GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Formule :C21H33F3N8O7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :566.53TETi76
CAS :TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.Formule :C10H16O5Couleur et forme :SolidMasse moléculaire :216.23Acedapsone
CAS :Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.Formule :C16H16N2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.37Tazemetostat trihydrochloride
CAS :Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Formule :C34H47Cl3N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :682.12UNC0224
CAS :UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Formule :C26H43N7O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :485.67MY-1B
CAS :MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Formule :C22H18BrN3O2Degré de pureté :99.81% - >99.99%Couleur et forme :SoildMasse moléculaire :436.3GSK-1268997
CAS :GSK-1268997 is a bio-active chemical.Formule :C21H23N7O3SDegré de pureté :99.33% - 99.81%Couleur et forme :SolidMasse moléculaire :453.52EZH2-IN-11
CAS :EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Formule :C28H36ClN3O5SCouleur et forme :SolidMasse moléculaire :562.12DC_517
CAS :DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Formule :C33H35N3O2Couleur et forme :SolidMasse moléculaire :505.65LEM-14-1189
CAS :LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.Formule :C35H34N6O5S2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :682.81PRMT5:MEP50 PPI
PRMT5:MEP50 PPI inhibitor with anti-tumor and anti-proliferative effects on lung and prostate cancers.Formule :C24H22N4O4Couleur et forme :SolidMasse moléculaire :430.46PRMT5-IN-17
CAS :PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.Formule :C26H33N7O2Couleur et forme :SolidMasse moléculaire :475.59DNMT3A-IN-1
CAS :DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).Formule :C30H38N6O4Couleur et forme :SolidMasse moléculaire :546.66WDR5-IN-4
CAS :WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.Formule :C25H22Cl2FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.38CSV0C018875 Hydrochloride
CAS :CSV0C018875 Hydrochloride: Novel G9a inhibitor with low toxicity, effective in enzyme/cell assays, outperforms BIX-0129.Formule :C18H18Cl2N2OCouleur et forme :SolidMasse moléculaire :349.255RSC-133
CAS :promotes the reprogramming of human somatic cells to pluripotent stem cellsFormule :C18H15N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :305.33D 595
CAS :D595 is a phenethylamine-type calcium channel blocker. The most potent phenylethylamine with respect to negative inotropy was D595 (EC50: 794 nmol/l).Formule :C25H32Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.44EPZ033294
CAS :EPZ033294 has potential anticancer and antiproliferative activity.Formule :C20H22ClN7ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :411.89ML399
CAS :ML399 inhibits menin–MLL interaction, selectively blocking oncogenic MLL signaling in leukemia cells, supporting functional genomics and therapeutic research.Formule :C27H28FN3O2Degré de pureté :97.84% - 98.20%Couleur et forme :SolidMasse moléculaire :445.53BAY-6035-R-isomer
CAS :BAY-6035 is an inhibitor of the methylation of MEKK2 peptide.Formule :C22H28N4O3Couleur et forme :SolidMasse moléculaire :396.48DCE_42
CAS :DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Formule :C22H19N9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.51PDAT
CAS :PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.Formule :C15H23N3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :245.36Furamidine dihydrochloride
CAS :Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Formule :C18H18Cl2N4ODegré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :377.27EZH2-IN-3
CAS :EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.Formule :C27H28ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4903-Deazaneplanocin A
CAS :3-Deazaneplanocin A (DZNep) is an EZH2 and AHCY inhibitor with antipoxigenic activity that inhibits fibrosis in the liver, kidneys, peritoneum, and airways.Formule :C12H14N4O3Degré de pureté :99.03% - 99.68%Couleur et forme :SolidMasse moléculaire :262.27Dihydro-5-azacytidine acetate
CAS :Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Formule :C10H18N4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.27Valemetostat tosylate
CAS :Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Formule :C33H42ClN3O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :660.22NSD3-IN-2
CAS :NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.Formule :C17H15N5OSCouleur et forme :SolidMasse moléculaire :337.4MM-102
CAS :MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.Formule :C35H49F2N7O4Degré de pureté :98.77% - 99.99%Couleur et forme :SolidMasse moléculaire :669.8Ref: TM-T6333
1mg37,00€2mg49,00€5mg100,00€1mL*10mM (DMSO)147,00€10mg165,00€25mg334,00€50mg515,00€100mg737,00€EPZ032597
CAS :EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormule :C20H23N7ODegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :377.44PRMT4-IN-1
CAS :PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].Formule :C23H28FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.49Guadecitabine sodium
CAS :Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Formule :C18H24N9NaO10PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.407SMYD2-IN-1
CAS :SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Formule :C25H25Cl2F2N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.41JS1310
CAS :JS1310 is a selective PRMT7 inhibitor (IC50: 5 μM against human PRMT7). JS1310 has shown anti-cancer effects on different cancer cells.Formule :C23H22FN5O3Couleur et forme :SolidMasse moléculaire :435.45DC_C66
CAS :DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.Formule :C28H22NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.48EML741
CAS :EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.Formule :C31H49N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.75OTS186935
CAS :OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Formule :C25H26ClN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :463.96CPI-905
CAS :CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Formule :C18H20N2O5Couleur et forme :SolidMasse moléculaire :344.36Dot1L-IN-5
CAS :Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].Formule :C23H19ClF2N8O5SCouleur et forme :SolidMasse moléculaire :592.96
