Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
460 produits trouvés pour "Méthyltransférase de l’ADN"
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MS453
CAS :MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.Formule :C20H27N5O3Couleur et forme :SolidMasse moléculaire :385.46S-Aristeromycinylhomocysteine
CAS :S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.Formule :C15H22N6O4SCouleur et forme :SolidMasse moléculaire :382.44CARM1-IN-1
CAS :CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Formule :C26H21Br2NO3Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :555.26Ref: TM-T10682L
1mg34,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg120,00€25mg236,00€50mg385,00€100mg600,00€200mg837,00€MS0124
CAS :MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
Formule :C20H29N5O3Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :387.48Bobcat339 hydrochloride
CAS :Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Formule :C16H13Cl2N3ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :334.2Ref: TM-T61012
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg80,00€25mg152,00€50mg236,00€100mg353,00€200mg517,00€CPUY074020
CAS :CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Formule :C25H28N4O2Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :416.52Ref: TM-T10882
1mg71,00€5mg147,00€1mL*10mM (DMSO)159,00€10mg205,00€25mg319,00€50mg450,00€100mg587,00€200mg803,00€TNG908
CAS :TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Formule :C21H23N5O2SDegré de pureté :98.08% - 98.24%Couleur et forme :SolidMasse moléculaire :409.51Ref: TM-T73494
1mg66,00€5mg145,00€1mL*10mM (DMSO)158,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€WDR5-0102
CAS :WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.
Formule :C18H19ClN4O3Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :374.82Procainamide
CAS :Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Formule :C13H21N3ODegré de pureté :99.79% - 99.92%Couleur et forme :SolidMasse moléculaire :235.33TM2-115
CAS :TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].Formule :C28H38N6O2Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :490.64LEM-14
CAS :LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.
Formule :C25H26N4O4SDegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :478.56DW14800
CAS :DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formule :C31H36N4O3Degré de pureté :99.55% - 99.68%Couleur et forme :SolidMasse moléculaire :512.64Ref: TM-T11131
1mg93,00€2mg123,00€5mg205,00€1mL*10mM (DMSO)233,00€10mg358,00€25mg680,00€50mg898,00€100mg1.341,00€Cedazuridine
CAS :Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.Formule :C9H14F2N2O5Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :268.21EZH2-IN-13
CAS :EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Formule :C34H45N5O3Degré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :571.75UNC0321
CAS :UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Formule :C27H45N7O3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :515.69MS67
CAS :MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14PRMT5-IN-29
CAS :PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Formule :C18H20Cl3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.74EPZ011989 HCl(1598383-40-4 Free base)
CAS :EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.Formule :C35H51N5O4·HClCouleur et forme :SolidMasse moléculaire :642.27(Iso)-MS4322
CAS :(Iso)-MS4322 ((Iso)-YS43-22) is a protein arginine methyltransferase 5 (PRMT5 ) degrader with potential anticancer activity.Formule :C55H76N10O12SDegré de pureté :99.05% - 99.79%Couleur et forme :SolidMasse moléculaire :1101.32CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFormule :C29H43Cl3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.04PRT543
CAS :PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Formule :C17H17ClN4O4Couleur et forme :SolidMasse moléculaire :376.79SMYD3-IN-1
CAS :SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Formule :C28H31ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.02UNC7145
CAS :UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Formule :C24H23N5O4Couleur et forme :SolidMasse moléculaire :445.4705MTDH-SND1 blocker 1
CAS :MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Formule :C14H13ClN4O3SCouleur et forme :SolidMasse moléculaire :352.8GSK3368715 hydrochloride
CAS :GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Formule :C20H38N4O2·HClCouleur et forme :SolidMasse moléculaire :403DY-46-2
CAS :DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48WM-586
CAS :WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Formule :C20H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.47EPZ-030456
CAS :EPZ-030456 is an effective and selective inhibitor of the SMYD3.Formule :C28H34ClN5O4SCouleur et forme :SolidMasse moléculaire :572.12RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54GSK-A
CAS :GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.Formule :C21H25N5O2Couleur et forme :SolidMasse moléculaire :379.46PRMT5-IN-25
CAS :PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Formule :C24H21F3N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :466.46Compound SA91-0178
CAS :SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Formule :C28H27N3O4Masse moléculaire :469.54DNMT-IN-3
CAS :DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].Formule :C37H39N7OCouleur et forme :SolidMasse moléculaire :597.75GSK-3484862
CAS :Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.45Ref: TM-T11469
1mg48,00€5mg113,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg318,00€50mg485,00€100mg692,00€500mg1.395,00€Bisegliptin
CAS :Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42UNC8153 TFA
CAS :UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFormule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7RK-701
CAS :RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54GSK-2807 free base
CAS :GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Formule :C19H32N8O5Couleur et forme :SolidMasse moléculaire :452.51EZH2-IN-14
CAS :EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69MS023 trihydrochloride
CAS :MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78CARM1-IN-3
CAS :CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormule :C24H32N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.54PRMT5-IN-16
CAS :PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.Formule :C25H34N8O2Couleur et forme :SolidMasse moléculaire :478.59PRMT5-IN-28
CAS :PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFormule :C18H19ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.82MAK683-CH2CH2COOH
CAS :MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Formule :C23H21FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :448.45EPZ031686
CAS :EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
Formule :C26H34ClF3N4O4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :591.09Dot1L-IN-1
CAS :The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.Formule :C32H36ClN9O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.21PRMT5-IN-37
CAS :PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37MM-589
CAS :MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formule :C28H44N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.70RK-0080552
CAS :RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Formule :C12H6N6O2Couleur et forme :SolidMasse moléculaire :266.215WDR5-IN-5
CAS :WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.Formule :C29H29F3N6OCouleur et forme :SolidMasse moléculaire :534.58
