Méthyltransférase de l’ADN
Les méthyltransférases de l'ADN (DNMT) sont des enzymes qui catalysent l'ajout de groupes méthyles aux résidus de cytosine dans l'ADN, conduisant à la silenciation des gènes. Une méthylation aberrante de l'ADN est associée à diverses maladies, y compris le cancer. Les inhibiteurs de DNMT bloquent l'activité de ces enzymes, réactivant ainsi les gènes silencieux et induisant l'apoptose dans les cellules cancéreuses. Les inhibiteurs de DNMT sont largement utilisés dans la recherche épigénétique et la thérapie contre le cancer. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de DNMT de haute qualité pour soutenir vos recherches en épigénétique, méthylation de l'ADN et biologie du cancer.
422 produits trouvés pour "Méthyltransférase de l’ADN"
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PRMT5-IN-29
CAS :<p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>Formule :C18H20Cl3N5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :492.74CARM1-IN-3
CAS :<p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>Formule :C24H32N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.54MS67
CAS :<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Formule :C52H59F4N9O7SCouleur et forme :SolidMasse moléculaire :1030.14WM-586
CAS :<p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>Formule :C20H20F3N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.47Bisegliptin
CAS :<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Formule :C18H26FN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :351.42PRMT5-IN-28
CAS :<p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>Formule :C18H19ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.82SMYD3-IN-1
CAS :<p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>Formule :C28H31ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :507.02RK-701
CAS :<p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54DY-46-2
CAS :<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Formule :C19H22N6O5SDegré de pureté :99.12% - 99.12%Couleur et forme :SolidMasse moléculaire :446.48RK-0133114
<p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>Formule :C26H30N4O3Couleur et forme :SolidMasse moléculaire :446.54MS023 trihydrochloride
CAS :<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Formule :C17H28Cl3N3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :396.78EZH2-IN-14
CAS :<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Formule :C31H39N7O2Couleur et forme :SolidMasse moléculaire :541.69PRT543
CAS :<p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>Formule :C17H17ClN4O4Couleur et forme :SolidMasse moléculaire :376.79PRMT5-IN-16
CAS :<p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>Formule :C25H34N8O2Couleur et forme :SolidMasse moléculaire :478.59EPZ-030456
CAS :<p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>Formule :C28H34ClN5O4SCouleur et forme :SolidMasse moléculaire :572.12GSK-3484862
CAS :<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Formule :C19H19N5OSDegré de pureté :99.87% - 99.963%Couleur et forme :SolidMasse moléculaire :365.45UNC8153 TFA
CAS :<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Formule :C35H38F3N5O7Degré de pureté :96.44%Couleur et forme :SolidMasse moléculaire :697.7EPZ031686
CAS :<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Formule :C26H34ClF3N4O4SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :591.09PF-06726304 acetate
CAS :<p>PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.</p>Formule :C24H25Cl2N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.38GSK3368715 3HCl
CAS :<p>GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81</p>Formule :C20H41Cl3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.92HLCL-61
CAS :<p>HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).</p>Formule :C23H24N2OCouleur et forme :SolidMasse moléculaire :344.45(1-Nitroethene-1,2-diyl)dibenzene
CAS :<p>(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.</p>Formule :C14H11NO2Couleur et forme :SolidMasse moléculaire :225.24RL5a
CAS :<p>RL5a (compound C23) is a novel inhibitor of SETD8.</p>Formule :C17H19N3OCouleur et forme :SolidMasse moléculaire :281.35MMSET-IN-1
CAS :<p>MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .</p>Formule :C18H29N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.47Octyl-α-hydroxyglutarate
CAS :<p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>Formule :C13H24O5Masse moléculaire :260.33SGC6870N
CAS :<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Formule :C23H21BrN2O2SMasse moléculaire :469.39PRMT5-IN-50
CAS :<p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>Formule :C26H23F3N6OCouleur et forme :SolidMasse moléculaire :492.496RK-0080552
CAS :<p>RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.</p>Formule :C12H6N6O2Couleur et forme :SolidMasse moléculaire :266.215TDI-015051
CAS :<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formule :C22H22FN5O4SCouleur et forme :SolidMasse moléculaire :471.505PRMT5-IN-37
CAS :<p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>Formule :C21H15F4N5O2Couleur et forme :SolidMasse moléculaire :445.37PRMT5-IN-49
CAS :<p>PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.</p>Formule :C19H22N2O2Couleur et forme :SolidMasse moléculaire :310.39NSD2-PWWP1-IN-2
CAS :<p>NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.</p>Formule :C29H30N4Couleur et forme :SolidMasse moléculaire :434.575PRMT5-IN-3
CAS :<p>PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.</p>Formule :C22H23F3N4O3Couleur et forme :SolidMasse moléculaire :448.44MS117
<p>MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].</p>Formule :C17H22N4OCouleur et forme :SolidMasse moléculaire :298.38SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formule :C20H20N6O5SCouleur et forme :SolidMasse moléculaire :456.48EZH2-IN-12
<p>EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.</p>Formule :C23H23Cl2N3O3Couleur et forme :SolidMasse moléculaire :460.35PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formule :C25H24N4OCouleur et forme :SolidMasse moléculaire :396.48WDR5-IN-5
CAS :<p>WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.</p>Formule :C29H29F3N6OCouleur et forme :SolidMasse moléculaire :534.58PRMT5-IN-1 hydrochloride
<p>PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.</p>Formule :C19H20Cl2N4O5Couleur et forme :SolidMasse moléculaire :455.29NSD2-PWWP1-IN-3
CAS :<p>NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.</p>Formule :C34H39N5O2Couleur et forme :SolidMasse moléculaire :549.706Pociredir
CAS :<p>Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.</p>Formule :C22H18FN5O2Couleur et forme :SolidMasse moléculaire :403.41PRMT5-MTA-IN-3
CAS :<p>PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.</p>Formule :C19H17F3N6O3Couleur et forme :SolidMasse moléculaire :434.372MM-589
CAS :<p>MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>Formule :C28H44N8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :572.70MS8511
CAS :<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formule :C28H41N5O3Couleur et forme :SolidMasse moléculaire :495.66PRMT5-IN-21
<p>PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.</p>Formule :C18H18F2N6O3Couleur et forme :SolidMasse moléculaire :404.37O6BTG-C8-αGlu
CAS :<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Formule :C24H34BrN5O7SCouleur et forme :SolidMasse moléculaire :616.525NSD2-PWWP1-IN-1
CAS :<p>NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.</p>Formule :C28H30N4Couleur et forme :SolidMasse moléculaire :422.565EED ligand 1
<p>EED ligand 1: potent PRC2 inhibitor targeting EED subunit.</p>Formule :C19H19FN8OCouleur et forme :SolidMasse moléculaire :394.41MS8815
CAS :<p>MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.</p>Formule :C65H87N9O8SCouleur et forme :SolidMasse moléculaire :1154.51RU-0415529
CAS :<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Formule :C21H29N3O4SCouleur et forme :SolidMasse moléculaire :419.538
