Sirtuine
Les sirtuines sont une famille de désacétylases dépendantes du NAD+ qui jouent un rôle crucial dans la régulation de processus cellulaires tels que la réparation de l'ADN, le vieillissement, le métabolisme et la résistance au stress. Les sirtuines influencent la réparation de l'ADN en désacétylant les protéines impliquées dans les voies de réparation, modulant ainsi leur activité. Les inhibiteurs et activateurs de sirtuines sont des outils précieux dans la recherche sur le vieillissement, le cancer et les maladies métaboliques, où la régulation de la réparation de l'ADN et de la longévité cellulaire est d'intérêt. Chez CymitQuimica, nous offrons une gamme de modulateurs de sirtuines de haute qualité pour soutenir vos recherches sur la réparation de l'ADN, le vieillissement cellulaire et la régulation métabolique.
88 produits trouvés pour "Sirtuine"
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Nicotinamide riboside
CAS :<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formule :C11H15N2O5Degré de pureté :98.82% - 99.58%Couleur et forme :SolidMasse moléculaire :255.25Resveratrol
CAS :<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Formule :C14H12O3Degré de pureté :99.82% - 99.96%Couleur et forme :Off-White To Tan PowderMasse moléculaire :228.24MC3482
CAS :<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Formule :C33H38N4O8Degré de pureté :98% - 99.90%Couleur et forme :SoildMasse moléculaire :618.68SIRT-IN-2
CAS :<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Formule :C15H21N5O3S2Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :383.49SIRT5 inhibitor 9
CAS :<p>SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.</p>Formule :C24H29ClN8O4SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :561.06Z26395438
CAS :<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formule :C17H15FN2ODegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :282.31Et-29
CAS :<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formule :C34H46N6O6SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :666.83SIRT-IN-5
<p>SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.</p>Couleur et forme :Odour SolidSIRT1-IN-1
CAS :<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29SIRT5 inhibitor 8
CAS :<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Formule :C22H25ClN8O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :501SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Degré de pureté :98%Couleur et forme :Odour SolidSIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Formule :C55H91N9O15SCouleur et forme :SolidMasse moléculaire :1150.43BML-278
CAS :<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formule :C24H25NO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :391.46SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formule :C22H24N2O9SCouleur et forme :SolidMasse moléculaire :492.5SJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Couleur et forme :Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS :<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Formule :C20H15N3O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :361.42SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Formule :C24H15N3O2SCouleur et forme :SolidMasse moléculaire :409.46MIND4-19
CAS :<p>MIND4-19 is an inhibitor of SIRT2 with antitumor activity.</p>Formule :C22H19N3OSDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :373.47Sirtuin modulator 2
CAS :<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formule :C19H15N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.41Sirt1/2-IN-4
<p>Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (</p>Formule :C21H20N4O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.54WAY-323061
CAS :<p>WAY-323061 is a SIRT2 inhibitor.</p>Formule :C25H21N5O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :455.53SIRT5 inhibitor 3
CAS :<p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>Formule :C22H12FN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.35ADTL-SA1215
CAS :<p>ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.</p>Formule :C26H29I2NO3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :657.32Thiomyristoyl
CAS :<p>Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.</p>Formule :C34H51N3O3SDegré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :581.85Selisistat S-enantiomer
CAS :<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Formule :C13H13ClN2ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :248.71Suramin Sodium Salt
CAS :<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Formule :C51H34N6Na6O23S6Degré de pureté :97.47% - 99.97%Couleur et forme :WhiteMasse moléculaire :1429.15CAY10602
CAS :<p>CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.</p>Formule :C22H15FN4O2SDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :418.44Nicotinamide riboside chloride
CAS :<p>NR, also SRT647, is a B3 vitamin form; precursor to NAD+.</p>Formule :C11H15ClN2O5Degré de pureté :98.92% - 99.86%Couleur et forme :SolidMasse moléculaire :290.7AK-1
CAS :<p>AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.</p>Formule :C19H21N3O5SDegré de pureté :98.32% - 99.44%Couleur et forme :SolidMasse moléculaire :403.45E1231
CAS :<p>E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.</p>Formule :C21H21N3O3Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :363.41YK-3-237
CAS :<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Formule :C19H21BO7Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :372.18Scopolin
CAS :<p>Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.</p>Formule :C16H18O9Degré de pureté :98.97% - ≥95%Couleur et forme :SolidMasse moléculaire :354.31Agrimol B
CAS :<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formule :C37H46O12Degré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :682.753-TYP
CAS :<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formule :C7H6N4Degré de pureté :99.16% - >99.99%Couleur et forme :SolidMasse moléculaire :146.15Tenovin-1
CAS :<p>Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.</p>Formule :C20H23N3O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :369.48Dihydrocoumarin
CAS :<p>Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).</p>Formule :C9H8O2Degré de pureté :98.46%Couleur et forme :Leaflets Room Temperature (Ntp 1992)Masse moléculaire :148.16Gardenia yellow
CAS :<p>Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.</p>Formule :C44H64O24Degré de pureté :98.24% - 98.82%Couleur et forme :Orange Yellow To Reddish Yellow PowderMasse moléculaire :976.96Tenovin-6
CAS :<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Formule :C25H34N4O2SDegré de pureté :97.71% - >99.99%Couleur et forme :SolidMasse moléculaire :454.63Selisistat
CAS :<p>Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).</p>Formule :C13H13ClN2ODegré de pureté :98.53% - 99.94%Couleur et forme :SolidMasse moléculaire :248.71SRT1720 hydrochloride
CAS :<p>SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).</p>Formule :C25H24ClN7OSDegré de pureté :98% - 99.93%Couleur et forme :SolidMasse moléculaire :506.22SRT 1720 dihydrochloride
CAS :<p>SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).</p>Formule :C25H25Cl2N7OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :542.48Ginkgolide C
CAS :<p>Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.</p>Formule :C20H24O11Degré de pureté :99.71% - 99.98%Couleur et forme :White PowderMasse moléculaire :440.4SirReal2
CAS :<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Formule :C22H20N4OS2Degré de pureté :98.96% - 99.75%Couleur et forme :SolidMasse moléculaire :420.55Ganoderic acid D
CAS :<p>Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.</p>Formule :C30H42O7Degré de pureté :98.06% - 99.98%Couleur et forme :SolidMasse moléculaire :514.65AGK2
CAS :<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Formule :C23H13Cl2N3O2Degré de pureté :98.68% - 99.17%Couleur et forme :SolidMasse moléculaire :434.27Salermide
CAS :<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Formule :C26H22N2O2Degré de pureté :97.09% - 99.55%Couleur et forme :SolidMasse moléculaire :394.47Inauhzin
CAS :<p>Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).</p>Formule :C25H19N5OS2Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :469.58UBCS039
CAS :<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Formule :C16H13N3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :247.29SRT 1720
CAS :<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Formule :C25H23N7OSDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :469.56Selisistat R-enantiomer
CAS :<p>Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).</p>Formule :C13H13ClN2ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :248.71Ophiopogonin D'
CAS :<p>Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.</p>Formule :C44H70O16Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :855.02SRT 2104
CAS :<p>SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.</p>Formule :C26H24N6O2S2Degré de pureté :98.34% - 99.82%Couleur et forme :SolidMasse moléculaire :516.64OSS_128167
CAS :<p>OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).</p>Formule :C19H14N2O6Degré de pureté :97.47% - 98.6%Couleur et forme :SolidMasse moléculaire :366.32AGK7
CAS :<p>AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.</p>Formule :C23H13Cl2N3O2Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :434.27SRT 2183
CAS :<p>SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).</p>Formule :C27H24N4O2SDegré de pureté :97.86%Couleur et forme :SolidMasse moléculaire :468.57AK-7
CAS :<p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>Formule :C19H21BrN2O3SDegré de pureté :98.43% - 99.34%Couleur et forme :SolidMasse moléculaire :437.35Fisetin
CAS :<p>Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.</p>Formule :C15H10O6Degré de pureté :94.14% - 99.05%Couleur et forme :Yellow To Brown Crystalline PowderMasse moléculaire :286.244'-bromo-Resveratrol
CAS :<p>4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)</p>Formule :C14H11BrO2Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :291.14SIRT7 inhibitor 97491
CAS :<p>SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.</p>Formule :C15H12ClN3ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :285.73Tenovin-6 Hydrochloride
CAS :<p>Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.</p>Formule :C25H35ClN4O2SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :491.09SRT 1460
CAS :<p>SRT 1460 is a SIRT1 activator.</p>Formule :C26H29N5O4SDegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :507.6Cambinol
CAS :<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Formule :C21H16N2O2SDegré de pureté :98.02% - 99.83%Couleur et forme :SolidMasse moléculaire :360.43Sirtinol
CAS :<p>Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).</p>Formule :C26H22N2O2Degré de pureté :97.12% - 99.96%Couleur et forme :SolidMasse moléculaire :394.47B2
CAS :<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Formule :C20H17ClN4O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :396.83MDL-800
CAS :<p>MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.</p>Formule :C21H16BrCl2FN2O6S2Degré de pureté :99.95% - 99.96%Couleur et forme :SolidMasse moléculaire :626.3SIRT5 inhibitor 5
CAS :<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Formule :C21H14ClN3O3SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :423.87SIRT5 inhibitor 2
CAS :<p>SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.</p>Formule :C18H12Cl2N2O3SDegré de pureté :99.38% - 99.87%Couleur et forme :SolidMasse moléculaire :407.27SIRT2-IN-9
CAS :<p>SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.</p>Formule :C21H22N6OS2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :438.57SIRT5 inhibitor 6
CAS :<p>SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.</p>Formule :C21H28N6O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :460.55Sirt2-IN-1
CAS :<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Formule :C28H27N7O2S2Degré de pureté :99.57% - 99.84%Couleur et forme :SolidMasse moléculaire :557.69SIRT5 inhibitor 4
CAS :<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Formule :C18H15N3O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :369.39SIRT5 inhibitor 1
CAS :<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Formule :C31H39FN6O6S2Degré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :674.81SIRT6-IN-5
CAS :<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Formule :C19H14N2O6Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :366.32Sirtuin modulator 1
CAS :<p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.</p>Formule :C31H32ClN5O2S2Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :606.2WAY-354574
CAS :<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Formule :C20H23ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.93Sirtuin-1 inhibitor 1
CAS :<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Formule :C20H17N3O2Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :331.37Epigenetic factor-IN-1
CAS :<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Formule :C32H34FN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.77SRT3657
CAS :<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Formule :C40H54N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.97SIRT5 inhibitor 7
CAS :<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Formule :C28H32ClN7O3SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :582.12SIRT-IN-1
CAS :<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Formule :C19H27N5O2SDegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :389.52SIRT6-IN-3
CAS :<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Formule :C21H30Br3ClN6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.73SIRT-IN-6
CAS :<p>SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.</p>Formule :C7H4ClN3OSCouleur et forme :SolidMasse moléculaire :213.644SIRT1-IN-5
CAS :<p>SIRT1-IN-5 (215) is a modulator of the NAD-dependent protein deacetylase SIRT1.</p>Formule :C21H17N3O3SCouleur et forme :SolidMasse moléculaire :391.443MC3138
CAS :<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :435.47Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78SIRT6 activator 2
CAS :<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45DCHC
CAS :<p>DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.</p>Formule :C15H8Cl2O3Couleur et forme :SolidMasse moléculaire :307.128MDL-811
CAS :<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formule :C25H25BrCl2FN3O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :681.42
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