Sirtuine
Les sirtuines sont une famille de désacétylases dépendantes du NAD+ qui jouent un rôle crucial dans la régulation de processus cellulaires tels que la réparation de l'ADN, le vieillissement, le métabolisme et la résistance au stress. Les sirtuines influencent la réparation de l'ADN en désacétylant les protéines impliquées dans les voies de réparation, modulant ainsi leur activité. Les inhibiteurs et activateurs de sirtuines sont des outils précieux dans la recherche sur le vieillissement, le cancer et les maladies métaboliques, où la régulation de la réparation de l'ADN et de la longévité cellulaire est d'intérêt. Chez CymitQuimica, nous offrons une gamme de modulateurs de sirtuines de haute qualité pour soutenir vos recherches sur la réparation de l'ADN, le vieillissement cellulaire et la régulation métabolique.
88 produits trouvés pour "Sirtuine"
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Nicotinamide riboside
CAS :<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formule :C11H15N2O5Degré de pureté :98.82% - 99.58%Couleur et forme :SolidMasse moléculaire :255.25Resveratrol
CAS :<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Formule :C14H12O3Degré de pureté :99.82% - 99.96%Couleur et forme :Off-White To Tan PowderMasse moléculaire :228.24MC3482
CAS :<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Formule :C33H38N4O8Degré de pureté :98% - 99.90%Couleur et forme :SoildMasse moléculaire :618.68SIRT-IN-2
CAS :<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Formule :C15H21N5O3S2Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :383.49SIRT5 inhibitor 9
CAS :<p>SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.</p>Formule :C24H29ClN8O4SDegré de pureté :98.68%Couleur et forme :SolidMasse moléculaire :561.06Z26395438
CAS :<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formule :C17H15FN2ODegré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :282.31Et-29
CAS :<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formule :C34H46N6O6SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :666.83SIRT-IN-5
<p>SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.</p>Couleur et forme :Odour SolidSIRT1-IN-1
CAS :<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formule :C14H16N2ODegré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :228.29SIRT5 inhibitor 8
CAS :<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Formule :C22H25ClN8O2SDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :501SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Degré de pureté :98%Couleur et forme :Odour SolidSIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Formule :C55H91N9O15SCouleur et forme :SolidMasse moléculaire :1150.43BML-278
CAS :<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formule :C24H25NO4Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :391.46SIRT3 activator 2
<p>SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.</p>Formule :C22H24N2O9SCouleur et forme :SolidMasse moléculaire :492.5SJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Couleur et forme :Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS :<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Formule :C20H15N3O2SDegré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :361.42SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Formule :C24H15N3O2SCouleur et forme :SolidMasse moléculaire :409.46MIND4-19
CAS :<p>MIND4-19 is an inhibitor of SIRT2 with antitumor activity.</p>Formule :C22H19N3OSDegré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :373.47Sirtuin modulator 2
CAS :<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Formule :C19H15N3O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :349.41Sirt1/2-IN-4
<p>Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (</p>Formule :C21H20N4O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.54WAY-323061
CAS :<p>WAY-323061 is a SIRT2 inhibitor.</p>Formule :C25H21N5O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :455.53SIRT5 inhibitor 3
CAS :<p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>Formule :C22H12FN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.35ADTL-SA1215
CAS :<p>ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.</p>Formule :C26H29I2NO3Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :657.32Thiomyristoyl
CAS :<p>Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.</p>Formule :C34H51N3O3SDegré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :581.85Selisistat S-enantiomer
CAS :<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Formule :C13H13ClN2ODegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :248.71Suramin Sodium Salt
CAS :<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Formule :C51H34N6Na6O23S6Degré de pureté :97.47% - 99.97%Couleur et forme :WhiteMasse moléculaire :1429.15CAY10602
CAS :<p>CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.</p>Formule :C22H15FN4O2SDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :418.44Nicotinamide riboside chloride
CAS :<p>NR, also SRT647, is a B3 vitamin form; precursor to NAD+.</p>Formule :C11H15ClN2O5Degré de pureté :98.92% - 99.86%Couleur et forme :SolidMasse moléculaire :290.7AK-1
CAS :<p>AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.</p>Formule :C19H21N3O5SDegré de pureté :98.32% - 99.44%Couleur et forme :SolidMasse moléculaire :403.45E1231
CAS :<p>E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.</p>Formule :C21H21N3O3Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :363.41YK-3-237
CAS :<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Formule :C19H21BO7Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :372.18Scopolin
CAS :<p>Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.</p>Formule :C16H18O9Degré de pureté :98.97% - ≥95%Couleur et forme :SolidMasse moléculaire :354.31Agrimol B
CAS :<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formule :C37H46O12Degré de pureté :99.06% - ≥95%Couleur et forme :SolidMasse moléculaire :682.753-TYP
CAS :<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formule :C7H6N4Degré de pureté :99.16% - >99.99%Couleur et forme :SolidMasse moléculaire :146.15Tenovin-1
CAS :<p>Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.</p>Formule :C20H23N3O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :369.48Dihydrocoumarin
CAS :<p>Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).</p>Formule :C9H8O2Degré de pureté :98.46%Couleur et forme :Leaflets Room Temperature (Ntp 1992)Masse moléculaire :148.16Gardenia yellow
CAS :<p>Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.</p>Formule :C44H64O24Degré de pureté :98.24% - 98.82%Couleur et forme :Orange Yellow To Reddish Yellow PowderMasse moléculaire :976.96Tenovin-6
CAS :<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Formule :C25H34N4O2SDegré de pureté :97.71% - >99.99%Couleur et forme :SolidMasse moléculaire :454.63Selisistat
CAS :<p>Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).</p>Formule :C13H13ClN2ODegré de pureté :98.53% - 99.94%Couleur et forme :SolidMasse moléculaire :248.71SRT1720 hydrochloride
CAS :<p>SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).</p>Formule :C25H24ClN7OSDegré de pureté :98% - 99.93%Couleur et forme :SolidMasse moléculaire :506.22SRT 1720 dihydrochloride
CAS :<p>SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).</p>Formule :C25H25Cl2N7OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :542.48Ginkgolide C
CAS :<p>Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.</p>Formule :C20H24O11Degré de pureté :99.71% - 99.98%Couleur et forme :White PowderMasse moléculaire :440.4SirReal2
CAS :<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Formule :C22H20N4OS2Degré de pureté :98.96% - 99.75%Couleur et forme :SolidMasse moléculaire :420.55Ganoderic acid D
CAS :<p>Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.</p>Formule :C30H42O7Degré de pureté :98.06% - 99.98%Couleur et forme :SolidMasse moléculaire :514.65AGK2
CAS :<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Formule :C23H13Cl2N3O2Degré de pureté :98.68% - 99.17%Couleur et forme :SolidMasse moléculaire :434.27Salermide
CAS :<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Formule :C26H22N2O2Degré de pureté :97.09% - 99.55%Couleur et forme :SolidMasse moléculaire :394.47Inauhzin
CAS :<p>Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).</p>Formule :C25H19N5OS2Degré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :469.58UBCS039
CAS :<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Formule :C16H13N3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :247.29SRT 1720
CAS :<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Formule :C25H23N7OSDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :469.56Selisistat R-enantiomer
CAS :<p>Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).</p>Formule :C13H13ClN2ODegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :248.71
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