Sirtuine
Les sirtuines sont une famille de désacétylases dépendantes du NAD+ qui jouent un rôle crucial dans la régulation de processus cellulaires tels que la réparation de l'ADN, le vieillissement, le métabolisme et la résistance au stress. Les sirtuines influencent la réparation de l'ADN en désacétylant les protéines impliquées dans les voies de réparation, modulant ainsi leur activité. Les inhibiteurs et activateurs de sirtuines sont des outils précieux dans la recherche sur le vieillissement, le cancer et les maladies métaboliques, où la régulation de la réparation de l'ADN et de la longévité cellulaire est d'intérêt. Chez CymitQuimica, nous offrons une gamme de modulateurs de sirtuines de haute qualité pour soutenir vos recherches sur la réparation de l'ADN, le vieillissement cellulaire et la régulation métabolique.
91 produits trouvés pour "Sirtuine".
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SRT 2104
CAS :SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Formule :C26H24N6O2S2Degré de pureté :98.34% - 99.82%Couleur et forme :Yellow SolidMasse moléculaire :516.64Ref: TM-T6679
1mg43,00€5mg93,00€10mg124,00€25mg219,00€50mg358,00€100mg533,00€200mg763,00€500mg1.161,00€1g1.558,00€OSS_128167
CAS :OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formule :C19H14N2O6Degré de pureté :97.47% - 98.6%Couleur et forme :SolidMasse moléculaire :366.32AGK7
CAS :AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formule :C23H13Cl2N3O2Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :434.27SRT 2183
CAS :SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formule :C27H24N4O2SDegré de pureté :97.86%Couleur et forme :SolidMasse moléculaire :468.57Ref: TM-T16932
1mg52,00€2mg69,00€5mg102,00€1mL*10mM (DMSO)105,00€10mg157,00€25mg268,00€50mg408,00€100mg590,00€AK-7
CAS :AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Formule :C19H21BrN2O3SDegré de pureté :98.43% - 99.34%Couleur et forme :White SolidMasse moléculaire :437.35Ref: TM-T5490
1mg34,00€2mg47,00€5mg71,00€1mL*10mM (DMSO)89,00€10mg100,00€25mg177,00€50mg313,00€100mg512,00€Fisetin
CAS :Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formule :C15H10O6Degré de pureté :94.14% - 99.05%Couleur et forme :Yellow To Brown Crystalline PowderMasse moléculaire :286.244'-bromo-Resveratrol
CAS :4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Formule :C14H11BrO2Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :291.14CAY10602
CAS :CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formule :C22H15FN4O2SDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :418.44SIRT7 inhibitor 97491
CAS :SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formule :C15H12ClN3ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :285.73Ref: TM-T39233
1mg90,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€Tenovin-6 Hydrochloride
CAS :Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formule :C25H35ClN4O2SDegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :491.09Ref: TM-T8480
1mg37,00€2mg49,00€5mg66,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg133,00€50mg215,00€100mg356,00€SRT 1460
CAS :SRT 1460 is a SIRT1 activator.Formule :C26H29N5O4SDegré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :507.6Cambinol
CAS :Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formule :C21H16N2O2SDegré de pureté :98.02% - 99.83%Couleur et forme :SolidMasse moléculaire :360.43Ref: TM-T4019
1mg38,00€2mg50,00€1mL*10mM (DMSO)63,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Sirtinol
CAS :Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formule :C26H22N2O2Degré de pureté :97.12% - 99.96%Couleur et forme :Yellow SolidMasse moléculaire :394.47Ref: TM-T6671
2mg40,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg170,00€50mg324,00€100mg482,00€500mg1.063,00€B2
CAS :B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormule :C20H17ClN4O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :396.83MDL-800
CAS :MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formule :C21H16BrCl2FN2O6S2Degré de pureté :99.95% - 99.96%Couleur et forme :SolidMasse moléculaire :626.3SIRT6 activator 12q
CAS :SIRT6 activator 12q is a SIRT6 activator; EC50=5.3 μM; allosteric modulator; metabolism and aging research.Formule :C31H22N2O2Degré de pureté :98.53%Couleur et forme :White SolidMasse moléculaire :454.52SIRT5 inhibitor 5
CAS :SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Formule :C21H14ClN3O3SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :423.87SIRT2-IN-9
CAS :SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formule :C21H22N6OS2Degré de pureté :97.6%Couleur et forme :Yellow SolidMasse moléculaire :438.57SIRT5 inhibitor 6
CAS :SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Formule :C21H28N6O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :460.55SIRT5 inhibitor 4
CAS :SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Formule :C18H15N3O4SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :369.39SIRT5 inhibitor 2
CAS :SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Formule :C18H12Cl2N2O3SDegré de pureté :99.38% - 99.87%Couleur et forme :SolidMasse moléculaire :407.27Sirt2-IN-1
CAS :Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formule :C28H27N7O2S2Degré de pureté :99.57% - 99.84%Couleur et forme :SolidMasse moléculaire :557.69Ref: TM-T12920
1mg100,00€5mg203,00€1mL*10mM (DMSO)253,00€10mg323,00€25mg513,00€50mg697,00€100mg888,00€500mg1.783,00€SIRT2-IN-11
CAS :SIRT2-IN-11 is a selective SIRT2 inhibitor; IC50=12 nM; increases tubulin acetylation; cancer research tool.Formule :C21H22N2OCouleur et forme :SolidMasse moléculaire :318.412-APQC
CAS :2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.Formule :C23H24FN5ODegré de pureté :99.88%Couleur et forme :White SolidMasse moléculaire :405.47Ref: TM-T88667
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg212,00€25mg358,00€50mg512,00€100mg707,00€SIRT6-IN-5
CAS :SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formule :C19H14N2O6Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :366.32SIRT5 inhibitor 1
CAS :SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formule :C31H39FN6O6S2Degré de pureté :97.8%Couleur et forme :White SolidMasse moléculaire :674.81Ref: TM-T12921
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)442,00€10mg502,00€25mg884,00€50mg1.288,00€100mg1.728,00€Sirtuin modulator 1
CAS :Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formule :C31H32ClN5O2S2Degré de pureté :99.63%Couleur et forme :Yellow SolidMasse moléculaire :606.2Epigenetic factor-IN-1
CAS :Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Formule :C32H34FN5O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.77SIRT6-IN-3
CAS :SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormule :C21H30Br3ClN6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.73Sirtuin-1 inhibitor 1
CAS :Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formule :C20H17N3O2Degré de pureté :99.1% - 99.87%Couleur et forme :White SolidMasse moléculaire :331.37SIRT-IN-1
CAS :SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).Formule :C19H27N5O2SDegré de pureté :99.29%Couleur et forme :SolidMasse moléculaire :389.52Ref: TM-T12918
1mg57,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg409,00€50mg670,00€100mg954,00€SIRT5 inhibitor 7
CAS :SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Formule :C28H32ClN7O3SDegré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :582.12SRT3657
CAS :SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formule :C40H54N8O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :774.97SIRT6 activator 2
CAS :SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formule :C23H23N3O6Couleur et forme :SolidMasse moléculaire :437.45SIRT2-IN-14
CAS :**SIRT2-IN-14 (Compound 78)** is a selective SIRT2 inhibitor, demonstrating an IC50 value of 0.196 μM [1].Formule :C26H21N3O4Couleur et forme :SolidMasse moléculaire :439.46SIRT1-IN-5
CAS :SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Formule :C21H17N3O3SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :391.44CL5D
CAS :CL5D is an activator of the protein deacetylase SIRT6. It significantly enhances the deacetylase activity and catalytic efficiency of SIRT6. CL5D modulates SIRT6 activity by promoting its conformational changes, particularly relying on the Arg-65 residue. This compound can be used to study the activation mechanism of SIRT6 and its roles in metabolism, DNA repair, and aging.Formule :C29H11Cl7N2O6Masse moléculaire :731.58DCHC
CAS :DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.Formule :C15H8Cl2O3Couleur et forme :SolidMasse moléculaire :307.128Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formule :C28H46N8O6SCouleur et forme :SolidMasse moléculaire :622.78MC3138
CAS :MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formule :C25H25NO6Degré de pureté :99.57%Couleur et forme :Yellow SolidMasse moléculaire :435.47SIRT-IN-6
CAS :SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Formule :C7H4ClN3OSCouleur et forme :SolidMasse moléculaire :213.644
