Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
207 produits trouvés pour "Récepteur des androgènes"
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MI-136
CAS :<p>MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.</p>Formule :C23H21F3N6SDegré de pureté :98.63% - 99.12%Couleur et forme :SolidMasse moléculaire :470.51Apalutamide
CAS :<p>Apalutamide (ARN-509) is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.</p>Formule :C21H15F4N5O2SDegré de pureté :99.03% - 99.91%Couleur et forme :SolidMasse moléculaire :477.43S-23
CAS :<p>S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (</p>Formule :C18H13ClF4N2O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :416.75Iprodione
CAS :<p>Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.</p>Formule :C13H13Cl2N3O3Degré de pureté :98.82%Couleur et forme :Colorless Crystals Cream To Colorless Odorless PowderMasse moléculaire :330.17Testosterone undecanoate
CAS :<p>Testosterone undecanoate is a metabolite of Testosterone, which is a promising androgen for male hormonal contraception.</p>Formule :C30H48O3Degré de pureté :99.45% - 99.788%Couleur et forme :White Crystalline PowderMasse moléculaire :456.7CLP-3094
CAS :<p>CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor.</p>Formule :C15H13ClN2OSDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :304.79AC-262536
CAS :<p>AC-262536 is a selective androgen receptor (SAR) modulator and exhibits potent agonist activity at the androgen receptor.</p>Formule :C18H18N2ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :278.35Triptophenolide
CAS :<p>Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.</p>Formule :C20H24O3Degré de pureté :98.07% - ≥95%Couleur et forme :White PowderMasse moléculaire :312.4Boldenone Undecylenate
CAS :<p>Boldenone Undecylenate (Parenabol) is a synthetic steroid.</p>Formule :C30H44O3Degré de pureté :99.39%Couleur et forme :Light Yellow Oily MatterMasse moléculaire :452.67JNJ-63576253 free base
CAS :<p>JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR). JNJ-63576253 can be used for the research of CRPC.</p>Formule :C23H21F3N6O2SDegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :502.51Dimethylcurcumin
CAS :<p>Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer.</p>Formule :C23H24O6Degré de pureté :97.36% - 98.96%Couleur et forme :SolidMasse moléculaire :396.43Nandrolone phenylpropionate
CAS :<p>Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis</p>Formule :C27H34O3Degré de pureté :99.2% - 99.46%Couleur et forme :White Or Milky Crystalline PowderMasse moléculaire :406.56JNJ-63576253
CAS :<p>JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).</p>Formule :C23H22ClF3N6O2SDegré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :538.97Ailanthone
CAS :<p>Ailanthone (Δ13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR</p>Formule :C20H24O7Degré de pureté :99.71% - 99.96%Couleur et forme :SolidMasse moléculaire :376.43-(7,7-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-1H-indole-7-carbonitrile
CAS :<p>3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.</p>Formule :C18H14N4ODegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :302.33ARD-2128
CAS :<p>ARD-2128: potent oral PROTAC that degrades AR, curbing prostate cancer growth with no toxicity.</p>Formule :C45H50ClN7O6Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :820.372-hydroxy Flutamide
CAS :<p>2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer</p>Formule :C11H11F3N2O4Degré de pureté :99.45% - 99.82%Couleur et forme :SolidMasse moléculaire :292.21AH-3960
CAS :<p>AH-3960 是一种甲状腺激素受体 1 (PTHR1) 激动剂。</p>Formule :C13H22N4O3Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :282.34DSRM-3716
CAS :<p>Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of</p>Formule :C9H6INDegré de pureté :97.28% - 99.785%Couleur et forme :SolidMasse moléculaire :255.06Bavdegalutamide
CAS :<p>Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR).</p>Formule :C41H43ClFN9O6Degré de pureté :97.17% - 99.04%Couleur et forme :SolidMasse moléculaire :812.29N-desmethyl Enzalutamide
CAS :<p>N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide.</p>Formule :C20H14F4N4O2SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :450.41Enzalutamide carboxylic acid
CAS :<p>Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .</p>Formule :C20H13F4N3O3SDegré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :451.39Clascoterone
CAS :<p>Clascoterone (CB-03-01) is a new topical and peripherally selective androgen antagonist.</p>Formule :C24H34O5Degré de pureté :99.2% - 99.64%Couleur et forme :SolidMasse moléculaire :402.52LY2452473
CAS :<p>LY2452473 (OPK 88004) is an orally available and selective androgen receptor modulator with potential anticancer activity for the study of prostate cancer.</p>Formule :C22H22N4O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :374.44Masofaniten
CAS :<p>Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancer.</p>Formule :C24H24Cl2N4O4SDegré de pureté :98.42% - 98.66%Couleur et forme :SolidMasse moléculaire :535.44AR antagonist 6
CAS :<p>AR antagonist 6 (compound 6i), a diphenyl ether androgen receptor (AR) antagonist, binds to the AR with an affinity of 120 nM. It demonstrates low toxicity and effective in vitro activity in the golden Syrian hamster ear model. [19] [1]</p>Formule :C16H12F3NO2Couleur et forme :SolidMasse moléculaire :307.27GDC-2992
CAS :<p>GDC-2992 is a selective androgen receptor (AR) degradator that degrades AR and inhibits proliferation in VCaP cells,CRPC.</p>Formule :C45H51ClN8O5Degré de pureté :99.82%Couleur et forme :SoildMasse moléculaire :819.39Estromustine
CAS :<p>Estromustine, an active metabolite of estramustine phosphate, is used to treat prostate cancer.</p>Formule :C23H29Cl2NO3Couleur et forme :SolidMasse moléculaire :438.39Procymidone
CAS :<p>Procymidone is a broad-spectrum fungicide that inhibits fungal glycerol triester synthesis, thereby disrupting hyphal growth. androgen receptor (AR) antagonist</p>Formule :C13H11Cl2NO2Degré de pureté :99.86%Couleur et forme :Colorless SolidMasse moléculaire :284.14JNJ-37654032
CAS :<p>JNJ-37654032: orally active, nonsteroidal SARM. Mixed AR agonist/antagonist. Selective for muscle, grows levator ani, max at 3mg/kg, ED(50) 0.8mg/kg.</p>Formule :C11H7Cl2F3N2OCouleur et forme :SolidMasse moléculaire :311.09BMS-564929
CAS :<p>BMS-564929 is an AR agonist that upregulates the expression and activity of fat-producing enzymes, reducing VAT content and lipid levels.</p>Formule :C14H12ClN3O3Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :305.72(R)-Bicalutamide
CAS :<p>(R)-Bicalutamide, an AR antagonist with antitumor properties, is crucial in prostate cancer research.</p>Formule :C18H14F4N2O4SCouleur et forme :SolidMasse moléculaire :430.37LG-121071
CAS :<p>LG-121071: oral SARM, high-affinity AR full agonist, Ki=17 nM.</p>Formule :C15H15F3N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.29Honokiol DCA
CAS :<p>Honokiol DCA inhibits DRP1, enhances respiration via mitochondrial repair, and is active against Vemurafenib-resistant melanoma.</p>Formule :C22H18Cl4O4Couleur et forme :SolidMasse moléculaire :488.19Lubabegron fumarate
CAS :<p>Lubabegron (LY591281, LY488756 fumarate) is a beta-agonist approved in 2018 to lower ammonia in cattle waste, aiding environment and health.</p>Formule :C29H29N3O3SC4H4O4Couleur et forme :SolidMasse moléculaire :557.66Gumelutamide
CAS :<p>Gumelutamide, a tetrahydropyridopyrimidine compound, functions as both an antiandrogen and an antineoplastic agent by acting as an androgen antagonist.</p>Formule :C22H21ClN6OCouleur et forme :SolidMasse moléculaire :420.89TFM-4AS-1
CAS :<p>androgen receptor modulator</p>Formule :C27H33F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.56HG122
CAS :<p>HG122 promotes AR degradation via proteasome, inhibiting castration-resistant prostate cancer.</p>Formule :C15H13N5O5Couleur et forme :SolidMasse moléculaire :343.29Androgen receptor antagonist 4
CAS :<p>Compound AT2 is an AR inhibitor with anticancer effects, blocking DHT action and AR nuclear translocation (IC50=0.15μM).</p>Formule :C22H18ClNCouleur et forme :SolidMasse moléculaire :331.84AZD3514
CAS :<p>AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.</p>Formule :C25H32F3N7O2Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :519.56AR antagonist 2
CAS :<p>AR antagonist 2 (compound 58) is a potent inhibitor of the androgen receptor (AR) (IC50: 0.95 μM).</p>Formule :C22H17ClFN5O2SCouleur et forme :SolidMasse moléculaire :469.92AR antagonist 5
CAS :<p>Compound 30a, known as AR Antagonist 5, is a selective androgen receptor (AR) antagonist that demonstrates an IC 50 value of 134.8 nM. It exhibits favorable pharmacokinetic properties, characterized by high skin exposure and low plasma exposure [1].</p>Formule :C23H21F3N6O2Couleur et forme :SolidMasse moléculaire :470.45CSRM617
CAS :<p>CSRM617: selective ONECUT2 inhibitor, Kd 7.43 uM, binds OC2-HOX, induces apoptosis, tolerable in mouse prostate cancer model.</p>Formule :C10H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :255.23MK-4541
CAS :<p>MK-4541: oral, selective AR modulator, blocks 5α-reductase, curbs AR+ prostate cancer growth, effective in mouse model.</p>Formule :C22H31F3N2O3Couleur et forme :SolidMasse moléculaire :428.49(R)-UT-155
CAS :<p>(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.</p>Formule :C20H15F4N3O2Couleur et forme :SolidMasse moléculaire :405.35Carbazole derivative 1
CAS :<p>Carbazole derivative 1 is used to reduce androgen or oestrogen levels in mammals.</p>Formule :C18H13FN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :276.31VPC-3033
CAS :<p>VPC-3033 is an antagonist of the androgen receptor. It acts by inhibiting the LNCaP cell line as well as cell lines with the wild-type androgen receptor.</p>Formule :C21H14O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :298.33Androgen receptor antagonist 3
CAS :<p>Androgen receptor antagonist 3 (Compound C18) has anticancer activities that is an antagonist of androgen receptor (AR) (IC 50 = 2.4 μM) [1].</p>Formule :C22H18ClNCouleur et forme :SolidMasse moléculaire :331.84RU 58642
CAS :<p>RU 58642 is an effective systemic antiandrogen for androgen-dependent disorders.</p>Formule :C15H11F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.27VPC-13789
CAS :<p>VPC-13789: potent, selective oral antiandrogen for CRPC with 0.19 μM IC50 in LNCaP cells.</p>Formule :C21H16F3N3OCouleur et forme :SolidMasse moléculaire :383.37Topterone
CAS :<p>Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in</p>Formule :C22H34O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :330.5Ar-V7-IN-1
CAS :<p>Ar-V7-IN-1 (compound 47) is a potent inhibitor of Ar-V7,associated with resistance to AR-targeted therapy with desmoplasia-resistant prostate cancer (mCRPC).</p>Formule :C10H10Br2N4OSCouleur et forme :SolidMasse moléculaire :394.09Prochloraz
CAS :<p>Prochloraz: broad-spectrum imidazole fungicide; blocks placental aromatase (IC50=40nM), estrogen/androgen receptors; activates aryl hydrocarbon receptors.</p>Formule :C15H16Cl3N3O2Degré de pureté :99.75% - 99.79%Couleur et forme :Colorless SolidMasse moléculaire :376.67Androgen receptor antagonist 1
CAS :<p>Androgen receptor antagonist 1, an oral full AR antagonist (IC50 59 nM), for PROTAC synthesis, reducing AR protein by 24–47% in LNCaP cells at 1–10 μM.</p>Formule :C21H25ClN4O3Degré de pureté :99.054%Couleur et forme :SolidMasse moléculaire :416.9Bromopropylate
CAS :<p>Bromopropylate is an insecticide. Bromopropylate is the active substance in fumigant strips for mites.</p>Formule :C17H16Br2O3Degré de pureté :98%Couleur et forme :White Crystalline Solid Yellowish CrystalsMasse moléculaire :428.11Dimethomorph
CAS :<p>Dimethomorph is a fungicide and sterol biosynthesis inhibitor that inhibits fungal cell wall formation,. inhibits androgen receptor (AR) .</p>Formule :C21H22ClNO4Degré de pureté :99.2%Couleur et forme :Solid CrystallineMasse moléculaire :387.86MK-3984
CAS :<p>MK-3984 is a selective androgen receptor modulator, used in the study of conditions caused by androgen deficiency.</p>Formule :C17H12F7NO2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :395.27Bifluranol
CAS :<p>Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic</p>Formule :C17H18F2O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :292.32VPC-14449
CAS :<p>VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.</p>Formule :C10H10Br2N4OSDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :394.09Ralaniten
CAS :<p>Ralaniten (EPI-002), a potent AR-NTD antagonist, inhibits AR with IC50 of 7.4 μM, for CRPC study.</p>Formule :C21H27ClO5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :394.89LGD-2226
CAS :<p>LGD-2226: selective oral androgen receptor modulator, EC50: 0.2nM, Ki: 1.5nM. Treats muscle loss, osteoporosis, sexual issues.</p>Formule :C14H9F9N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.22S-40503
CAS :<p>S-40503 is an investigational selective androgen receptor modulator (SARM).</p>Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.36Cyprodinil
CAS :<p>Cyprodinil is a fungicide blocking methionine synthesis in fungi and hinders B. cinerea, P. herpotrichoides, H. oryzae growth; it's also an AR agonist.</p>Formule :C14H15N3Couleur et forme :SolidMasse moléculaire :225.29BMS-641988
CAS :<p>BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.</p>Formule :C20H20F3N3O5SDegré de pureté :99.57% - 99.92%Couleur et forme :SoildMasse moléculaire :471.45GLPG0492
CAS :<p>GLPG0492 is a novel selective androgen receptor modulator.</p>Formule :C19H14F3N3O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :389.33ONC1-13B
CAS :<p>ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.</p>Formule :C22H16F4N4O3SDegré de pureté :99.36% - 99.85%Couleur et forme :SolidMasse moléculaire :492.45Ralaniten triacetate
CAS :<p>Ralaniten triacetate (EPI-506) is a precursor of Ralaniten, an AR-NTD inhibitor, which can be used in the study of prostate and breast cancer.</p>Formule :C27H33ClO8Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :521.00Androgen receptor-IN-5
CAS :<p>Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties.</p>Formule :C22H10Cl2F4N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.31(rel)-BMS-641988
CAS :<p>(rel)-BMS-641988, a relative configuration of the potent nonsteroidal androgen receptor antagonist BMS-641988, holds potential for prostate cancer research.</p>Formule :C20H20F3N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.45LGD-2941
CAS :<p>LGD-2941 is an androgen receptor modulator. LGD-2941 is used for the treatment of hypogonadism, female sexual dysfunction and menopausal syndrome.</p>Formule :C17H16F6N2O2Couleur et forme :SolidMasse moléculaire :394.31Androgen receptor degrader-1
CAS :<p>Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].</p>Formule :C15H14ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.74Androgen receptor degrader-2
CAS :<p>Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].</p>Formule :C16H16ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.77N-Nitrosodicyclohexylamine
CAS :<p>N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition</p>Formule :C12H22N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :210.32Celiprolol hydrochloride
CAS :<p>Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity.</p>Formule :C20H33N3O4·HClCouleur et forme :White Crystalline SolidMasse moléculaire :415.96Androgen receptor antagonist 5
CAS :<p>AR antagonist 5 blocks AR (IC50: 6.17 μM), hinders LNCaP cell growth, and has anti-tumor effects in mouse models.</p>Formule :C21H15F4N5O3SCouleur et forme :SolidMasse moléculaire :493.43Trimegestone
CAS :<p>Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.</p>Formule :C22H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.47JJH260
CAS :<p>JJH260, a N-hydroxy hydantoin carbamate, inhibits AIG1 and ADTRP with IC50 values of 0.57 μM and 8.5 μM, respectively, and targets ABHD6, LYPLA1/2.</p>Formule :C29H34ClN5O5Couleur et forme :SolidMasse moléculaire :568.06JNJ-26146900
CAS :<p>JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand with tissue-selective activity in rats. JNJ-26146900 binds to the rat AR with a K(i) of 400nM.</p>Formule :C15H15F3N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.35VPC-14228
CAS :<p>VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.</p>Formule :C13H14N2OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :246.33PLK1/BRD4-IN-1
CAS :<p>PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).</p>Formule :C31H43N9O2Couleur et forme :SolidMasse moléculaire :573.73RU 59063
CAS :<p>RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands.</p>Formule :C17H18F3N3O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :385.4YXG-158
CAS :<p>YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1</p>Formule :C30H36FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.62Androgen receptor degrader-3
CAS :<p>Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential</p>Formule :C45H51ClN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :819.39EPI-7170
CAS :<p>EPI-7170: Ralaniten analogue, blocks androgen receptor, inhibits transcription in AR & variants, fights enzalutamide-resistant prostate cancer.</p>Formule :C22H28Cl3NO6SCouleur et forme :SolidMasse moléculaire :540.88ID11916
CAS :<p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>Formule :C29H27F3N8O3SCouleur et forme :SolidMasse moléculaire :624.637Androstatrione
CAS :<p>Androstatrione is an androgenic compound.</p>Formule :C19H26O3Couleur et forme :SolidMasse moléculaire :302.41Androgen receptor antagonist 12
CAS :<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.21SJ1008066
CAS :<p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>Formule :C21H22N4Couleur et forme :SolidMasse moléculaire :330.43Androgen receptor antagonist 11
CAS :<p>Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.</p>Formule :C20H19F3N4O3SCouleur et forme :SolidMasse moléculaire :452.45AR/BET protein degrader-1
CAS :<p>AR/BET protein degrader-1 (Compound 149) is a dual-targeting protein degrader of Androgen Receptor and BET (bromodomain and extra-terminal domain), suitable for cancer research.</p>Formule :C43H44N6O5Masse moléculaire :724.85GLPG0492 (R enantiomer)
CAS :<p>GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.</p>Formule :C19H14F3N3O3Couleur et forme :SolidMasse moléculaire :389.33VNPP433-3β
CAS :<p>VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.</p>Formule :C29H34N4Couleur et forme :SolidMasse moléculaire :438.61AR antagonist 4
<p>AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).</p>Formule :C29H36N4OCouleur et forme :SolidMasse moléculaire :456.62AR antagonist 10
CAS :<p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871FL442
CAS :<p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27(+)-JJ-74-138
CAS :<p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>Formule :C22H22F8N2OSCouleur et forme :SolidMasse moléculaire :514.48LX1
CAS :<p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35Androgen receptor degrader-5
CAS :<p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53Androgen receptor ligand 1
CAS :<p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>Formule :C19H16F4N2OCouleur et forme :SolidMasse moléculaire :364.34A4B17
<p>A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.</p>Formule :C14H7F4NSCouleur et forme :SolidMasse moléculaire :297.27
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