Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
229 produits trouvés pour "Récepteur des androgènes"
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Galloylalbiflorin
CAS :Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Formule :C30H32O15Couleur et forme :SolidMasse moléculaire :632.57MTX-23
CAS :MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducingFormule :C43H53F2N7O7S2Couleur et forme :SolidMasse moléculaire :882.05K2-B4-5e
K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.Formule :C52H49ClN8O6SMasse moléculaire :948.3184317β-hydroxy Exemestane
CAS :17β-hydroxy Exemestane is the primary active metabolite of exemestane .Formule :C20H26O2Couleur et forme :SolidMasse moléculaire :298.42Gridegalutamide
CAS :Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formule :C41H45F3N8O5SCouleur et forme :SolidMasse moléculaire :818.91PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Formule :C45H68F3N3O11Couleur et forme :SolidMasse moléculaire :884.03ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formule :C62H74ClFN8O7SCouleur et forme :SolidMasse moléculaire :1129.83Dipropyl phthalate
CAS :Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formule :C14H18O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :250.29PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formule :C43H49ClN6O5Couleur et forme :SolidMasse moléculaire :765.339Faznolutamide
CAS :Faznolutamide is an antiandrogen agent [1] [2] .Formule :C19H17FN4O2SCouleur et forme :SolidMasse moléculaire :384.43PROTAC AR Degrader-8
CAS :PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]Formule :C40H41N5O7Couleur et forme :SolidMasse moléculaire :703.7833-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Couleur et forme :Odour SolidARD-2051
CAS :ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading ARFormule :C43H45ClN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :789.32Lambertianic acid
CAS :Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formule :C20H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.4419,10-Dihydrophenanthrene
CAS :9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Formule :C14H12Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :180.25Linuron
CAS :Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Formule :C9H10Cl2N2O2Degré de pureté :99.08%Couleur et forme :White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicideMasse moléculaire :249.09LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Couleur et forme :Odour SolidCl-4AS-1
CAS :steroidal androgen receptor agonistFormule :C26H33ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.01PROTAC AR Degrader-10
PROTACAR Degrader-10 is a protein degrader targeting androgen receptors (AR) with a DC50 value of ≤100 nM, and can be used in prostate cancer research.6-Amino-5-bromoquinoxaline
CAS :Compound PDK0245, with CAS No. 50358-63-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0245 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C8H6BrN3Couleur et forme :Yellow SolidMasse moléculaire :224.05
