Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
229 produits trouvés pour "Récepteur des androgènes"
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BMS-986365
CAS :BMS-986365 (CC-94676) is an orally available, selective and highly potent AR degrader with potential anticancer activity that inhibits AR signaling and suppresses tumor growth for the study of prostate cancer.Formule :C41H45F3N8O5SDegré de pureté :98.69% - 99.96%Couleur et forme :SoildMasse moléculaire :818.91ORM-15341
CAS :ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)Formule :C19H17ClN6O2Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :396.83Vosilasarm
CAS :RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Formule :C20H16ClN5O2Degré de pureté :99.01% - 99.6%Couleur et forme :A Crystalline SolidMasse moléculaire :393.82Topilutamide
CAS :Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.Formule :C13H11F6N3O5Degré de pureté :98.77% - 99.24%Couleur et forme :SolidMasse moléculaire :403.23Ref: TM-T13184
1mg52,00€5mg113,00€10mg178,00€25mg371,00€50mg583,00€100mg830,00€200mg1.134,00€1mL*10mM (DMSO)124,00€Nilutamide
CAS :Nilutamide, a nonsteroidal anti-androgen, treats prostate cancer by blocking androgen receptors, not affecting other hormone receptors.Formule :C12H10F3N3O4Degré de pureté :98.67% - 99.78%Couleur et forme :Crystalline SolidMasse moléculaire :317.22Chlormadinone acetate
CAS :Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.Formule :C23H29ClO4Degré de pureté :98.11% - 98.97%Couleur et forme :Crystals From Menthanol Or Ether Crystalline SolidMasse moléculaire :404.93Bicalutamide
CAS :Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting theFormule :C18H14F4N2O4SDegré de pureté :98% - 99.87%Couleur et forme :Off-White Crystalline SolidMasse moléculaire :430.37Ligandrol
CAS :Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.Formule :C14H12F6N2ODegré de pureté :99.94% - >99.99%Couleur et forme :SolidMasse moléculaire :338.253,3'-Diindolylmethane
CAS :3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.Formule :C17H14N2Degré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :246.31Zanoterone
CAS :Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders and
Formule :C23H32N2O3SDegré de pureté :99.03% - 99.92%Couleur et forme :SoildMasse moléculaire :416.58Allylestrenol
CAS :Allylestrenol (Gestanin) is a synthetic steroid with progestational activity.Formule :C21H32ODegré de pureté :>99.99%Couleur et forme :White Crystalline PowderMasse moléculaire :300.48Luxdegalutamide
CAS :Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades theFormule :C45H54FN7O6Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :807.95UT-155
CAS :UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).Formule :C20H15F4N3O2Degré de pureté :98.94%Couleur et forme :SolidMasse moléculaire :405.35Ref: TM-T13272
1mg50,00€5mg105,00€10mg167,00€25mg260,00€50mg356,00€100mg505,00€200mg825,00€1mL*10mM (DMSO)117,00€Flutamide
CAS :Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.Formule :C11H11F3N2O3Degré de pureté :99.6% - 99.96%Couleur et forme :SolidMasse moléculaire :276.21UT-34
CAS :UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormule :C15H12F4N4O2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :356.27Ref: TM-T13273
1mg50,00€5mg113,00€10mg177,00€25mg334,00€50mg505,00€100mg782,00€1mL*10mM (DMSO)124,00€Adrenocorticotropic hormone TFA
Adrenocorticotropic hormone TFA is an adrenocorticotropic hormone involved in neurohormonal regulation of the body.Degré de pureté :99.71%Couleur et forme :Odour SolidN-Desmethyl-Apalutamide
CAS :N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.Formule :C20H13F4N5O2SDegré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :463.41Ref: TM-T12146
1mg111,00€5mg245,00€10mg354,00€25mg532,00€50mg735,00€100mg982,00€200mg1.333,00€1mL*10mM (DMSO)264,00€Ostarine
CAS :Ostarine (MK-2866) is a non-steroidal SARM mimicking testosterone to boost muscle growth, libido, fertility, and may help prevent muscle wasting in cancer.Formule :C19H14F3N3O3Degré de pureté :99.69% - 99.90%Couleur et forme :SolidMasse moléculaire :389.33AS-601811
CAS :AS-601811 is a bio-active chemical.Formule :C15H17NODegré de pureté :98.05% - 99.58%Couleur et forme :SolidMasse moléculaire :227.3Adrenosterone
CAS :Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.Formule :C19H24O3Degré de pureté :98.13% - 98.29%Couleur et forme :SolidMasse moléculaire :300.39Spironolactone
CAS :Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.Formule :C24H32O4SDegré de pureté :99.87%Couleur et forme :White PowderMasse moléculaire :416.57SK33
CAS :SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.Formule :C20H13F9N2O3Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :500.31Ref: TM-T12928
1mg34,00€5mg71,00€10mg110,00€25mg212,00€50mg340,00€100mg550,00€200mg780,00€1mL*10mM (DMSO)90,00€AR antagonist 1
CAS :AR antagonist 1 is a potent antagonist of the androgen receptor.Formule :C15H19ClN2ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :278.78Ref: TM-T10359
1mg57,00€5mg118,00€10mg170,00€25mg279,00€50mg371,00€100mg522,00€200mg710,00€1mL*10mM (DMSO)112,00€Andarine
CAS :Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).Formule :C19H18F3N3O6Degré de pureté :99.88%Couleur et forme :Pale Yellow SolidMasse moléculaire :441.36Cyproterone acetate
CAS :Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues andFormule :C24H29ClO4Degré de pureté :98.43% - 99.83%Couleur et forme :Crystals From Diisopropyl Ether OdourMasse moléculaire :416.94ACP-105
CAS :ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgenFormule :C16H19ClN2ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :290.79Ref: TM-T14116
2mg38,00€5mg58,00€10mg90,00€25mg164,00€50mg226,00€100mg325,00€200mg455,00€1mL*10mM (DMSO)65,00€Medroxyprogesterone Acetate
CAS :Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. Farlutin is a long-acting contraceptive.Formule :C24H34O4Degré de pureté :99.05% - 99.44%Couleur et forme :White PowderMasse moléculaire :386.522,2,5,7,8-Pentamethyl-6-Chromanol
CAS :2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation andFormule :C14H20O2Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :220.31Proxalutamide
CAS :Proxalutamide is a potent antagonist of the androgen receptor (AR).Formule :C24H19F4N5O2SDegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :517.5Ref: TM-T15445
1mg79,00€5mg168,00€10mg258,00€25mg508,00€50mg777,00€100mg1.132,00€200mg1.516,00€1mL*10mM (DMSO)192,00€Octinoxate
CAS :Octinoxate (Octyl 4-methoxycinnamate) is an organic compound that is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun.Formule :C18H26O3Degré de pureté :99.93%Couleur et forme :Less To Pale Yellow Viscous Liquid (Ntp 1992) Physical Description Colorless To Pale Yellow Viscous Liquid (Ntp 1992)Masse moléculaire :290.40BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Formule :C42H46ClN5O7Couleur et forme :SolidMasse moléculaire :767.30858Nuclear Receptor Compound Library
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
Couleur et forme :Odour SolidARD-2585
CAS :ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Formule :C41H43ClN8O5Couleur et forme :SolidMasse moléculaire :763.28Tibolone
CAS :Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for theFormule :C21H28O2Degré de pureté :99.70% - 99.71%Couleur et forme :White To Off-White Crystalline PowderMasse moléculaire :312.45TD-802
CAS :TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.Formule :C52H61ClN10O6Couleur et forme :SolidMasse moléculaire :957.56K2-B4-5e
K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.Formule :C52H49ClN8O6SMasse moléculaire :948.31843Cl-4AS-1
CAS :steroidal androgen receptor agonistFormule :C26H33ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.01Dipropyl phthalate
CAS :Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formule :C14H18O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :250.29PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formule :C43H49ClN6O5Couleur et forme :SolidMasse moléculaire :765.3399,10-Dihydrophenanthrene
CAS :9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Formule :C14H12Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :180.25ODM-204
CAS :ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Formule :C20H21F3N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.40Adrenocorticotropic hormone
CAS :ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Couleur et forme :SolidLambertianic acid
CAS :Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formule :C20H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.441ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formule :C62H74ClFN8O7SCouleur et forme :SolidMasse moléculaire :1129.83Faznolutamide
CAS :Faznolutamide is an antiandrogen agent [1] [2] .Formule :C19H17FN4O2SCouleur et forme :SolidMasse moléculaire :384.43PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Formule :C45H68F3N3O11Couleur et forme :SolidMasse moléculaire :884.03Inocoterone acetate
CAS :Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Formule :C18H26O3Couleur et forme :SolidMasse moléculaire :290.40Linuron
CAS :Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Formule :C9H10Cl2N2O2Degré de pureté :99.08%Couleur et forme :White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicideMasse moléculaire :249.09LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Couleur et forme :Odour Solid3-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Couleur et forme :Odour Solid
