Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
229 produits trouvés pour "Récepteur des androgènes"
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Anticancer agent 135
Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7Formule :C23H21F3N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.5RLA-5331
RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.Formule :C40H43F3N6O7SCouleur et forme :SolidMasse moléculaire :808.87PROTAC AR Degrader-8
CAS :PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]Formule :C40H41N5O7Couleur et forme :SolidMasse moléculaire :703.783ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formule :C62H74ClFN8O7SCouleur et forme :SolidMasse moléculaire :1129.83LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Couleur et forme :Odour SolidGalloylalbiflorin
CAS :Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Formule :C30H32O15Couleur et forme :SolidMasse moléculaire :632.57ARD-266
CAS :ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.Formule :C52H59ClN6O7Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :915.51PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formule :C43H49ClN6O5Couleur et forme :SolidMasse moléculaire :765.339ARD-61
CAS :ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Formule :C61H71ClN8O7SCouleur et forme :SolidMasse moléculaire :1095.8AR ligand-33
AR ligand-33 is a ligand for the androgen receptor (AR), and it can be used as a target protein ligand for the synthesis of PROTAC AR Degrader-8.Formule :C25H28N2O3Couleur et forme :SolidMasse moléculaire :404.501BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Formule :C42H46ClN5O7Couleur et forme :SolidMasse moléculaire :767.308582-sec-Butylphenol
CAS :2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.Formule :C10H14OCouleur et forme :SolidMasse moléculaire :150.22Ludaterone
CAS :Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.Formule :C20H25ClO5Couleur et forme :SolidMasse moléculaire :380.86RD162
CAS :RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).Formule :C22H16F4N4O2SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :476.45Ref: TM-T21740
1mg44,00€5mg113,00€10mg177,00€25mg371,00€50mg553,00€100mg788,00€1mL*10mM (DMSO)137,00€Dehydroisoandrosterone 3-acetate
CAS :Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.Formule :C21H30O3Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :330.46PROTAC AR-NTD degrader 1
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminalFormule :C41H47ClN6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.3Dipropyl phthalate
CAS :Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formule :C14H18O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :250.29PROTAC AR-V7 degrader-1
CAS :Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Formule :C41H52N6O6S2Couleur et forme :SolidMasse moléculaire :789.023-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Couleur et forme :Odour SolidODM-204
CAS :ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Formule :C20H21F3N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :374.40RLA-4842
RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.Formule :C42H46F3N5O8SCouleur et forme :SolidMasse moléculaire :837.9Lambertianic acid
CAS :Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formule :C20H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.441ARCC-4
CAS :ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Formule :C53H56F3N7O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.18Adrenocorticotropic hormone
CAS :ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Couleur et forme :SolidARD-2051
CAS :ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading ARFormule :C43H45ClN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :789.322-Ethylhexyl trans-4-methoxycinnamate
CAS :2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.Formule :C18H26O3Degré de pureté :98.92%Couleur et forme :Pale Yellow LiquidMasse moléculaire :290.4Gridegalutamide
CAS :Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formule :C41H45F3N8O5SCouleur et forme :SolidMasse moléculaire :818.91Cl-4AS-1
CAS :steroidal androgen receptor agonistFormule :C26H33ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :441.01K2-B4-5e
K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.Formule :C52H49ClN8O6SMasse moléculaire :948.31843Androgen receptor antagonist 9
CAS :Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1].Formule :C19H14F3N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.39Inocoterone acetate
CAS :Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Formule :C18H26O3Couleur et forme :SolidMasse moléculaire :290.40Linuron
CAS :Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Formule :C9H10Cl2N2O2Degré de pureté :99.08%Couleur et forme :White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicideMasse moléculaire :249.09Enzalutamide-d3
CAS :Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.Formule :C21H16F4N4O2SCouleur et forme :SolidMasse moléculaire :467.45Anti-Androgen receptor Antibody (8R912)
Anti-Androgen receptor Antibody (8R912) is a Mouse antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8R912) can be used in ICC/IF.Couleur et forme :Odour LiquidAnti-Androgen receptor Antibody (7Q574)
Anti-Androgen receptor Antibody (7Q574) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (7Q574) can be used in ELISA, WB, IHC.Couleur et forme :Odour LiquidMK-0773
CAS :MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.Formule :C27H34FN5O2Degré de pureté :98.38% - 99.14%Couleur et forme :SolidMasse moléculaire :479.59Ref: TM-T16090
1mg82,00€2mg105,00€5mg170,00€10mg260,00€25mg439,00€50mgÀ demander1mL*10mM (DMSO)177,00€Anti-Androgen receptor Antibody (8H883)
Anti-Androgen receptor Antibody (8H883) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8H883) can be used in ELISA, IHC.Couleur et forme :Odour LiquidARD-1676
CAS :ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand.Formule :C44H46ClN7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :788.33Alternariol (Standard)
CAS :Alternariol (Standard) is the standard substance of Alternariol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.Formule :C14H10O5Couleur et forme :SolidMasse moléculaire :258.23Estradiol valerate
CAS :β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.Formule :C23H32O3Degré de pureté :99.11% - 99.9%Couleur et forme :NaMasse moléculaire :356.51Tricaprin (Standard)
CAS :Tricaprin (Standard) is the standard substance of Tricaprin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Glycerol Tridecanoate is an orally active precursor (DA precursor) of caprylic acid that can be hydrolyzed to caprylic acid. It is a major component of medium chain triglycerides (MCT) and has antiandrogenic and antihyperglycemic properties. It can be used as an additive in food, pharmaceuticals and cosmetics.Formule :C33H62O6Couleur et forme :SolidMasse moléculaire :554.84Dehydroepiandrosterone-d2
CAS :Dehydroepiandrosterone-d2 is a deuterated compound of Dehydroepiandrosterone.Formule :C19H26D2O2Couleur et forme :SolidMasse moléculaire :290.44Rezvilutamide
CAS :Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.Formule :C22H20F3N3O4SDegré de pureté :99.96% - 99.97%Couleur et forme :SolidMasse moléculaire :479.47D4-abiraterone
CAS :D4-abiraterone is the active metabolite of abiraterone.Δ4-Abiraterone is a inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.Formule :C24H29NODegré de pureté :99.75% - 99.8%Couleur et forme :SolidMasse moléculaire :347.49Leelamine hydrochloride
CAS :Leelamine hydrochloride, a pine bark extract, inhibits androgen receptor and CB1, reducing lipid synthesis in prostate cancer.Formule :C20H32ClNDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.93(Rac)-PF-998425
CAS :(Rac)-PF-998425: nonsteroidal AR antagonist, potent & selective, IC50: 26 nM (binding), 90 nM (cellular), potential for androgenetic alopecia study.Formule :C14H14F3NOCouleur et forme :SolidMasse moléculaire :269.267Apalutamide-13C-d3
Apalutamide-13C-d3 is a 13C and 2H labeled Apalutamide. Apalutamide is an androgen receptor (AR) antagonist, used in research on prostate diseases.Formule :CC20H12F4N5O2SD3Couleur et forme :SolidMasse moléculaire :481.45Fenarimol
CAS :Fenarimol, a pyrimidine-type fungicide, exhibits potent inhibitory activity against BR biosynthesis.Formule :C17H12Cl2N2OCouleur et forme :SolidMasse moléculaire :331.2Darolutamide
CAS :Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).Formule :C19H19ClN6O2Degré de pureté :97.36% - >99.99%Couleur et forme :SolidMasse moléculaire :398.85Ref: TM-T6915
1mg50,00€2mg66,00€5mg100,00€10mg158,00€25mg250,00€50mg358,00€100mg512,00€200mg732,00€1mL*10mM (DMSO)101,00€Androgen receptor-IN-4
CAS :3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.Formule :C18H14N4ODegré de pureté :98.41%Couleur et forme :SolidMasse moléculaire :302.33
