Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
229 produits trouvés pour "Récepteur des androgènes"
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LG-121071
CAS :LG-121071: oral SARM, high-affinity AR full agonist, Ki=17 nM.Formule :C15H15F3N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.29AR antagonist 5
CAS :Compound 30a, known as AR Antagonist 5, is a selective androgen receptor (AR) antagonist that demonstrates an IC 50 value of 134.8 nM. It exhibits favorable pharmacokinetic properties, characterized by high skin exposure and low plasma exposure [1].Formule :C23H21F3N6O2Couleur et forme :SolidMasse moléculaire :470.45(R)-Bicalutamide
CAS :(R)-Bicalutamide, an AR antagonist with antitumor properties, is crucial in prostate cancer research.Formule :C18H14F4N2O4SCouleur et forme :SolidMasse moléculaire :430.37AR antagonist 2
CAS :AR antagonist 2 (compound 58) is a potent inhibitor of the androgen receptor (AR) (IC50: 0.95 μM).Formule :C22H17ClFN5O2SCouleur et forme :SolidMasse moléculaire :469.92Bromopropylate
CAS :Bromopropylate is an insecticide. Bromopropylate is the active substance in fumigant strips for mites.Formule :C17H16Br2O3Degré de pureté :98%Couleur et forme :White Crystalline Solid Yellowish CrystalsMasse moléculaire :428.11S-40503
CAS :S-40503 is an investigational selective androgen receptor modulator (SARM).Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.36Ralaniten
CAS :Ralaniten (EPI-002), a potent AR-NTD antagonist, inhibits AR with IC50 of 7.4 μM, for CRPC study.Formule :C21H27ClO5Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :394.89Ref: TM-T28502
1mg40,00€5mg88,00€10mg126,00€25mg250,00€50mg393,00€100mg628,00€200mg879,00€1mL*10mM (DMSO)87,00€Androgen receptor antagonist 1
CAS :Androgen receptor antagonist 1, an oral full AR antagonist (IC50 59 nM), for PROTAC synthesis, reducing AR protein by 24–47% in LNCaP cells at 1–10 μM.Formule :C21H25ClN4O3Degré de pureté :99.054%Couleur et forme :SolidMasse moléculaire :416.9RU 58642
CAS :RU 58642 is an effective systemic antiandrogen for androgen-dependent disorders.Formule :C15H11F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.27Cyprodinil
CAS :Cyprodinil is a fungicide blocking methionine synthesis in fungi and hinders B. cinerea, P. herpotrichoides, H. oryzae growth; it's also an AR agonist.Formule :C14H15N3Couleur et forme :SolidMasse moléculaire :225.29VPC-14449
CAS :VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.Formule :C10H10Br2N4OSDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :394.09BMS-564929
CAS :BMS-564929 is an AR agonist that upregulates the expression and activity of fat-producing enzymes, reducing VAT content and lipid levels.Formule :C14H12ClN3O3Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :305.72VPC-13789
CAS :VPC-13789: potent, selective oral antiandrogen for CRPC with 0.19 μM IC50 in LNCaP cells.Formule :C21H16F3N3OCouleur et forme :SolidMasse moléculaire :383.37Androgen receptor antagonist 3
CAS :Androgen receptor antagonist 3 (Compound C18) has anticancer activities that is an antagonist of androgen receptor (AR) (IC 50 = 2.4 μM) [1].Formule :C22H18ClNCouleur et forme :SolidMasse moléculaire :331.84(R)-UT-155
CAS :(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.Formule :C20H15F4N3O2Couleur et forme :SolidMasse moléculaire :405.35Lubabegron fumarate
CAS :Lubabegron (LY591281, LY488756 fumarate) is a beta-agonist approved in 2018 to lower ammonia in cattle waste, aiding environment and health.Formule :C29H29N3O3SC4H4O4Couleur et forme :SolidMasse moléculaire :557.66MK-4541
CAS :MK-4541: oral, selective AR modulator, blocks 5α-reductase, curbs AR+ prostate cancer growth, effective in mouse model.Formule :C22H31F3N2O3Couleur et forme :SolidMasse moléculaire :428.49HG122
CAS :HG122 promotes AR degradation via proteasome, inhibiting castration-resistant prostate cancer.Formule :C15H13N5O5Couleur et forme :SolidMasse moléculaire :343.29LGD-2226
CAS :LGD-2226: selective oral androgen receptor modulator, EC50: 0.2nM, Ki: 1.5nM. Treats muscle loss, osteoporosis, sexual issues.Formule :C14H9F9N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.22Dimethomorph
CAS :Dimethomorph is a fungicide and sterol biosynthesis inhibitor that inhibits fungal cell wall formation,. inhibits androgen receptor (AR) .Formule :C21H22ClNO4Degré de pureté :99.20%Couleur et forme :Solid CrystallineMasse moléculaire :387.86CSRM617
CAS :CSRM617: selective ONECUT2 inhibitor, Kd 7.43 uM, binds OC2-HOX, induces apoptosis, tolerable in mouse prostate cancer model.Formule :C10H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :255.23MK-3984
CAS :MK-3984 is a selective androgen receptor modulator, used in the study of conditions caused by androgen deficiency.Formule :C17H12F7NO2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :395.27TFM-4AS-1
CAS :androgen receptor modulatorFormule :C27H33F3N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.56VPC-3033
CAS :VPC-3033 is an antagonist of the androgen receptor. It acts by inhibiting the LNCaP cell line as well as cell lines with the wild-type androgen receptor.Formule :C21H14O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :298.33Topterone
CAS :Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone inFormule :C22H34O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :330.5Ar-V7-IN-1
CAS :Ar-V7-IN-1 (compound 47) is a potent inhibitor of Ar-V7,associated with resistance to AR-targeted therapy with desmoplasia-resistant prostate cancer (mCRPC).Formule :C10H10Br2N4OSCouleur et forme :SolidMasse moléculaire :394.09Carbazole derivative 1
CAS :Carbazole derivative 1 is used to reduce androgen or oestrogen levels in mammals.Formule :C18H13FN2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :276.31Seviteronel
CAS :Seviteronel (VT-464) is a novel CYP17 cleavage enzyme inhibitor and androgen receptor antagonist for the study of breast and prostate cancer.Formule :C18H17F4N3O3Degré de pureté :99.67% - 99.98%Couleur et forme :SolidMasse moléculaire :399.34BMS-641988
CAS :BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.Formule :C20H20F3N3O5SDegré de pureté :99.3% - 99.92%Couleur et forme :SoildMasse moléculaire :471.45Rosolutamide
CAS :Rosolutamide (ALZ-003) is a curcumin analog, an Nrf1 and Nrf2 activator.Formule :C28H32O6Degré de pureté :95.48% - 99.15%Couleur et forme :SolidMasse moléculaire :464.55Ralaniten triacetate
CAS :Ralaniten triacetate (EPI-506) is a precursor of Ralaniten, an AR-NTD inhibitor, which can be used in the study of prostate and breast cancer.Formule :C27H33ClO8Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :521.00Ref: TM-T36375
1mg154,00€5mg371,00€10mg620,00€25mg1.341,00€50mg1.783,00€100mg2.250,00€1mL*10mM (DMSO)425,00€ONC1-13B
CAS :ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Formule :C22H16F4N4O3SDegré de pureté :99.36% - 99.85%Couleur et forme :SolidMasse moléculaire :492.45GLPG0492
CAS :GLPG0492 is a novel selective androgen receptor modulator.Formule :C19H14F3N3O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :389.33Ref: TM-T11410L
1mg71,00€5mg156,00€10mg224,00€25mg358,00€50mg515,00€100mg692,00€200mg888,00€1mL*10mM (DMSO)166,00€Androgen receptor antagonist 5
CAS :AR antagonist 5 blocks AR (IC50: 6.17 μM), hinders LNCaP cell growth, and has anti-tumor effects in mouse models.Formule :C21H15F4N5O3SCouleur et forme :SolidMasse moléculaire :493.43Celiprolol hydrochloride
CAS :Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity.Formule :C20H33N3O4·HClCouleur et forme :White Crystalline SolidMasse moléculaire :415.96VPC-14228
CAS :VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.Formule :C13H14N2OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :246.33N-Nitrosodicyclohexylamine
CAS :N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in oppositionFormule :C12H22N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :210.32Androgen receptor degrader-2
CAS :Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].Formule :C16H16ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.77(rel)-BMS-641988
CAS :(rel)-BMS-641988, a relative configuration of the potent nonsteroidal androgen receptor antagonist BMS-641988, holds potential for prostate cancer research.Formule :C20H20F3N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.45JNJ-26146900
CAS :JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand with tissue-selective activity in rats. JNJ-26146900 binds to the rat AR with a K(i) of 400nM.Formule :C15H15F3N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.35Trimegestone
CAS :Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.Formule :C22H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.47YXG-158
CAS :YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1Formule :C30H36FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.62Androgen receptor degrader-3
CAS :Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potentialFormule :C45H51ClN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :819.39PLK1/BRD4-IN-1
CAS :PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).Formule :C31H43N9O2Couleur et forme :SolidMasse moléculaire :573.73Androgen receptor-IN-5
CAS :Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties.Formule :C22H10Cl2F4N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.31Androgen receptor degrader-1
CAS :Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].Formule :C15H14ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.74JJH260
CAS :JJH260, a N-hydroxy hydantoin carbamate, inhibits AIG1 and ADTRP with IC50 values of 0.57 μM and 8.5 μM, respectively, and targets ABHD6, LYPLA1/2.Formule :C29H34ClN5O5Couleur et forme :SolidMasse moléculaire :568.06EPI-7170
CAS :EPI-7170: Ralaniten analogue, blocks androgen receptor, inhibits transcription in AR & variants, fights enzalutamide-resistant prostate cancer.Formule :C22H28Cl3NO6SCouleur et forme :SolidMasse moléculaire :540.88LGD-2941
CAS :LGD-2941 is an androgen receptor modulator. LGD-2941 is used for the treatment of hypogonadism, female sexual dysfunction and menopausal syndrome.Formule :C17H16F6N2O2Couleur et forme :SolidMasse moléculaire :394.31RU 59063
CAS :RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands.Formule :C17H18F3N3O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :385.4Ref: TM-T20761
1mg93,00€5mg182,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)197,00€
