Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
207 produits trouvés pour "Récepteur des androgènes"
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Topterone
CAS :<p>Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in</p>Formule :C22H34O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :330.5Ar-V7-IN-1
CAS :<p>Ar-V7-IN-1 (compound 47) is a potent inhibitor of Ar-V7,associated with resistance to AR-targeted therapy with desmoplasia-resistant prostate cancer (mCRPC).</p>Formule :C10H10Br2N4OSCouleur et forme :SolidMasse moléculaire :394.09Prochloraz
CAS :<p>Prochloraz: broad-spectrum imidazole fungicide; blocks placental aromatase (IC50=40nM), estrogen/androgen receptors; activates aryl hydrocarbon receptors.</p>Formule :C15H16Cl3N3O2Degré de pureté :99.75% - 99.79%Couleur et forme :Colorless SolidMasse moléculaire :376.67Androgen receptor antagonist 1
CAS :<p>Androgen receptor antagonist 1, an oral full AR antagonist (IC50 59 nM), for PROTAC synthesis, reducing AR protein by 24–47% in LNCaP cells at 1–10 μM.</p>Formule :C21H25ClN4O3Degré de pureté :99.054%Couleur et forme :SolidMasse moléculaire :416.9Bromopropylate
CAS :<p>Bromopropylate is an insecticide. Bromopropylate is the active substance in fumigant strips for mites.</p>Formule :C17H16Br2O3Degré de pureté :98%Couleur et forme :White Crystalline Solid Yellowish CrystalsMasse moléculaire :428.11Dimethomorph
CAS :<p>Dimethomorph is a fungicide and sterol biosynthesis inhibitor that inhibits fungal cell wall formation,. inhibits androgen receptor (AR) .</p>Formule :C21H22ClNO4Degré de pureté :99.2%Couleur et forme :Solid CrystallineMasse moléculaire :387.86MK-3984
CAS :<p>MK-3984 is a selective androgen receptor modulator, used in the study of conditions caused by androgen deficiency.</p>Formule :C17H12F7NO2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :395.27Bifluranol
CAS :<p>Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic</p>Formule :C17H18F2O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :292.32VPC-14449
CAS :<p>VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.</p>Formule :C10H10Br2N4OSDegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :394.09Ralaniten
CAS :<p>Ralaniten (EPI-002), a potent AR-NTD antagonist, inhibits AR with IC50 of 7.4 μM, for CRPC study.</p>Formule :C21H27ClO5Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :394.89LGD-2226
CAS :<p>LGD-2226: selective oral androgen receptor modulator, EC50: 0.2nM, Ki: 1.5nM. Treats muscle loss, osteoporosis, sexual issues.</p>Formule :C14H9F9N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.22S-40503
CAS :<p>S-40503 is an investigational selective androgen receptor modulator (SARM).</p>Formule :C15H23N3O3Couleur et forme :SolidMasse moléculaire :293.36Cyprodinil
CAS :<p>Cyprodinil is a fungicide blocking methionine synthesis in fungi and hinders B. cinerea, P. herpotrichoides, H. oryzae growth; it's also an AR agonist.</p>Formule :C14H15N3Couleur et forme :SolidMasse moléculaire :225.29BMS-641988
CAS :<p>BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.</p>Formule :C20H20F3N3O5SDegré de pureté :99.57% - 99.92%Couleur et forme :SoildMasse moléculaire :471.45GLPG0492
CAS :<p>GLPG0492 is a novel selective androgen receptor modulator.</p>Formule :C19H14F3N3O3Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :389.33ONC1-13B
CAS :<p>ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.</p>Formule :C22H16F4N4O3SDegré de pureté :99.36% - 99.85%Couleur et forme :SolidMasse moléculaire :492.45Ralaniten triacetate
CAS :<p>Ralaniten triacetate (EPI-506) is a precursor of Ralaniten, an AR-NTD inhibitor, which can be used in the study of prostate and breast cancer.</p>Formule :C27H33ClO8Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :521.00Androgen receptor-IN-5
CAS :<p>Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties.</p>Formule :C22H10Cl2F4N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.31(rel)-BMS-641988
CAS :<p>(rel)-BMS-641988, a relative configuration of the potent nonsteroidal androgen receptor antagonist BMS-641988, holds potential for prostate cancer research.</p>Formule :C20H20F3N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.45LGD-2941
CAS :<p>LGD-2941 is an androgen receptor modulator. LGD-2941 is used for the treatment of hypogonadism, female sexual dysfunction and menopausal syndrome.</p>Formule :C17H16F6N2O2Couleur et forme :SolidMasse moléculaire :394.31Androgen receptor degrader-1
CAS :<p>Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].</p>Formule :C15H14ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :335.74Androgen receptor degrader-2
CAS :<p>Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].</p>Formule :C16H16ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :349.77N-Nitrosodicyclohexylamine
CAS :<p>N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition</p>Formule :C12H22N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :210.32Celiprolol hydrochloride
CAS :<p>Celiprolol hydrochloride (Selectrol) is a cardioselective beta-1 adrenergic antagonist that has intrinsic sympathomimetic activity.</p>Formule :C20H33N3O4·HClCouleur et forme :White Crystalline SolidMasse moléculaire :415.96Androgen receptor antagonist 5
CAS :<p>AR antagonist 5 blocks AR (IC50: 6.17 μM), hinders LNCaP cell growth, and has anti-tumor effects in mouse models.</p>Formule :C21H15F4N5O3SCouleur et forme :SolidMasse moléculaire :493.43Trimegestone
CAS :<p>Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.</p>Formule :C22H30O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :342.47JJH260
CAS :<p>JJH260, a N-hydroxy hydantoin carbamate, inhibits AIG1 and ADTRP with IC50 values of 0.57 μM and 8.5 μM, respectively, and targets ABHD6, LYPLA1/2.</p>Formule :C29H34ClN5O5Couleur et forme :SolidMasse moléculaire :568.06JNJ-26146900
CAS :<p>JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand with tissue-selective activity in rats. JNJ-26146900 binds to the rat AR with a K(i) of 400nM.</p>Formule :C15H15F3N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.35VPC-14228
CAS :<p>VPC-14228 is a specific AR-DBD inhibitor that acts by inhibiting both Y594A and Q592A mutants.</p>Formule :C13H14N2OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :246.33PLK1/BRD4-IN-1
CAS :<p>PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM).</p>Formule :C31H43N9O2Couleur et forme :SolidMasse moléculaire :573.73RU 59063
CAS :<p>RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands.</p>Formule :C17H18F3N3O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :385.4YXG-158
CAS :<p>YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1</p>Formule :C30H36FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.62Androgen receptor degrader-3
CAS :<p>Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential</p>Formule :C45H51ClN8O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :819.39EPI-7170
CAS :<p>EPI-7170: Ralaniten analogue, blocks androgen receptor, inhibits transcription in AR & variants, fights enzalutamide-resistant prostate cancer.</p>Formule :C22H28Cl3NO6SCouleur et forme :SolidMasse moléculaire :540.88ID11916
CAS :<p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>Formule :C29H27F3N8O3SCouleur et forme :SolidMasse moléculaire :624.637Androstatrione
CAS :<p>Androstatrione is an androgenic compound.</p>Formule :C19H26O3Couleur et forme :SolidMasse moléculaire :302.41Androgen receptor antagonist 12
CAS :<p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.21SJ1008066
CAS :<p>SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.</p>Formule :C21H22N4Couleur et forme :SolidMasse moléculaire :330.43Androgen receptor antagonist 11
CAS :<p>Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.</p>Formule :C20H19F3N4O3SCouleur et forme :SolidMasse moléculaire :452.45AR/BET protein degrader-1
CAS :<p>AR/BET protein degrader-1 (Compound 149) is a dual-targeting protein degrader of Androgen Receptor and BET (bromodomain and extra-terminal domain), suitable for cancer research.</p>Formule :C43H44N6O5Masse moléculaire :724.85GLPG0492 (R enantiomer)
CAS :<p>GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.</p>Formule :C19H14F3N3O3Couleur et forme :SolidMasse moléculaire :389.33VNPP433-3β
CAS :<p>VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.</p>Formule :C29H34N4Couleur et forme :SolidMasse moléculaire :438.61AR antagonist 4
<p>AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).</p>Formule :C29H36N4OCouleur et forme :SolidMasse moléculaire :456.62AR antagonist 10
CAS :<p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871FL442
CAS :<p>FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).</p>Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27(+)-JJ-74-138
CAS :<p>(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).</p>Formule :C22H22F8N2OSCouleur et forme :SolidMasse moléculaire :514.48LX1
CAS :<p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35Androgen receptor degrader-5
CAS :<p>Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.</p>Formule :C29H25F4N5O2Couleur et forme :SolidMasse moléculaire :551.53Androgen receptor ligand 1
CAS :<p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>Formule :C19H16F4N2OCouleur et forme :SolidMasse moléculaire :364.34A4B17
<p>A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.</p>Formule :C14H7F4NSCouleur et forme :SolidMasse moléculaire :297.27
