Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
232 produits trouvés pour "Récepteur des androgènes".
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SJ1008066
CAS :SJ1008066 is a MAGE-A11 inhibitor with an IC50 of 0.13 μM. It binds to the MAGE homology domain (MHD) and disrupts the MAGE-A11:PCF11 interaction.Formule :C21H22N4Couleur et forme :SolidMasse moléculaire :330.43Androgen receptor ligand 1
CAS :Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.Formule :C19H16F4N2OCouleur et forme :SolidMasse moléculaire :364.34LX1
CAS :LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35PROTAC Androgen receptor degrader-1
CAS :PROTAC Androgen receptor degrader-1 is a PROTAC degrader targeting the androgen receptor (DC50 = 6 nM), prostate cancer.Formule :C43H48ClN9O2Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :758.35KF-19418
CAS :KF-19418 is a follicle stimulant that directly activates follicles in vitro and promotes hair growth in vivo.Formule :C21H14N4OCouleur et forme :SolidMasse moléculaire :338.36GLPG0492 (R enantiomer)
CAS :GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator.Formule :C19H14F3N3O3Couleur et forme :SolidMasse moléculaire :389.33Pentomone
CAS :Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46Androstatrione
CAS :Androstatrione is an androgenic compound.Formule :C19H26O3Couleur et forme :SolidMasse moléculaire :302.41SC428
CAS :SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.Formule :C15H10F3N3OSCouleur et forme :SolidMasse moléculaire :337.32AR antagonist 4
AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).Formule :C29H36N4OCouleur et forme :SolidMasse moléculaire :456.62ERβ agonist-1
CAS :ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.Formule :C25H36O2Couleur et forme :SolidMasse moléculaire :368.55FL442
CAS :FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).Formule :C15H13F3N2OCouleur et forme :SolidMasse moléculaire :294.27
