NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
445 produits trouvés pour "NF-κB"
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Vamorolone
CAS :<p>Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.</p>Formule :C22H28O4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :356.46Robinin
CAS :<p>Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.</p>Formule :C33H40O19Degré de pureté :98.78% - 99.13%Couleur et forme :SolidMasse moléculaire :740.66Engeletin
CAS :<p>1.</p>Formule :C21H22O10Degré de pureté :99.72% - 99.99%Couleur et forme :SolidMasse moléculaire :434.39Polygalasaponin F
CAS :<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>Formule :C53H86O23Degré de pureté :98% - 99.83%Couleur et forme :SolidMasse moléculaire :1091.24Embelin
CAS :<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Formule :C17H26O4Degré de pureté :97.07% - 99.88%Couleur et forme :SolidMasse moléculaire :294.39Triptolide
CAS :<p>Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.</p>Formule :C20H24O6Degré de pureté :97.19% - 99.97%Couleur et forme :White To Off-White SolidMasse moléculaire :360.4Barlerin
CAS :<p>Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and protective effect on oxygen-glucose deprivation-induced injury</p>Formule :C19H28O12Degré de pureté :99.83% - ≥95%Couleur et forme :SolidMasse moléculaire :448.42TBK1/IKKε-IN-5
CAS :<p>TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).</p>Formule :C28H31N7O3Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :513.59Mollugin
CAS :<p>Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.</p>Formule :C17H16O4Degré de pureté :99.87% - ≥95%Couleur et forme :SolidMasse moléculaire :284.31Tyrosol
CAS :<p>Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most</p>Formule :C8H10O2Degré de pureté :99.24% - 99.86%Couleur et forme :SolidMasse moléculaire :138.16PI-1840
CAS :<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formule :C22H26N4O3Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :394.47SM-7368
CAS :<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Formule :C10H5ClN4O5SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :328.69IRAK-1-4 Inhibitor I
CAS :<p>IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.</p>Formule :C20H21N5O4Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :395.41Tomatidine
CAS :<p>Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.</p>Formule :C27H45NO2Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :415.6511-Keto-β-boswellic acid
CAS :<p>11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.</p>Formule :C30H46O4Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :470.68RIPA-56
CAS :<p>RIPA-56 is an inhibitor of RIP1</p>Formule :C13H19NO2Degré de pureté :99.53% - 99.93%Couleur et forme :SolidMasse moléculaire :221.3Zimlovisertib
CAS :<p>Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).</p>Formule :C18H20FN3O4Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :361.37Malachite green oxalate
CAS :<p>Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.</p>Formule :C23H25N2·C2HO4C2H2O4Couleur et forme :Dark Green Crystals With A Metallic LusterMasse moléculaire :463.51Sarsasapogenin
CAS :<p>Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.</p>Formule :C27H44O3Degré de pureté :90% - 99.73%Couleur et forme :White Or Off-Withe PowderMasse moléculaire :416.64Obtusifolin
CAS :<p>Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.</p>Formule :C16H12O5Degré de pureté :99.78% - 99.99%Couleur et forme :SolidMasse moléculaire :284.26Neferine
CAS :<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Formule :C38H44N2O6Degré de pureté :98.81% - 99.65%Couleur et forme :SolidMasse moléculaire :624.77Gossypin
CAS :<p>Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.</p>Formule :C21H20O13Degré de pureté :97.57% - 98.97%Couleur et forme :SolidMasse moléculaire :480.38Aconine
CAS :<p>1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.</p>Formule :C25H41NO9Degré de pureté :99.61% - 99.93%Couleur et forme :SolidMasse moléculaire :499.59Madecassic acid
CAS :<p>Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.</p>Formule :C30H48O6Degré de pureté :98.80% - 99.69%Couleur et forme :SolidMasse moléculaire :504.7Delanzomib
CAS :<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Formule :C21H28BN3O5Degré de pureté :95.52% - 99.46%Couleur et forme :SolidMasse moléculaire :413.28Deoxyelephantopin
CAS :<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Formule :C19H20O6Degré de pureté :99.6% - 99.71%Couleur et forme :SolidMasse moléculaire :344.36JH-X-119-01
CAS :<p>JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.</p>Formule :C25H20N6O3Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :452.46Aristolochic acid A
CAS :<p>Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.</p>Formule :C17H11NO7Degré de pureté :99.85% - 99.97%Couleur et forme :Yellow PowderMasse moléculaire :341.27Indole-3-carbinol
CAS :<p>Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase</p>Formule :C9H9NODegré de pureté :98.59% - >99.99%Couleur et forme :SolidMasse moléculaire :147.17GSK-872
CAS :<p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>Formule :C19H17N3O2S2Degré de pureté :99.87% - 99.94%Couleur et forme :SolidMasse moléculaire :383.493'-Sialyllactose sodium
CAS :<p>3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.</p>Formule :C23H38NNaO19Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :655.53(S)-(+)-Ibuprofen
CAS :<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Formule :C13H18O2Degré de pureté :99.51% - 99.86%Couleur et forme :Colourless Crystalline SolidMasse moléculaire :206.281,3-Dibenzyl-5-fluorouracil
CAS :<p>1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.</p>Formule :C18H15FN2O2Couleur et forme :SolidMasse moléculaire :310.32Gatralimab
CAS :<p>Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion & repopulation in Phase 1, supporting its study for relapsing MS.</p>Degré de pureté :95%Couleur et forme :LiquidKamebakaurin
CAS :<p>Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.</p>Formule :C20H30O5Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :350.45E3330
CAS :<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formule :C21H30O6Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :378.46BAY32-5915
CAS :<p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>Formule :C10H7NO3Degré de pureté :96.48% - 97%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :189.17IMD-biphenylB
CAS :<p>IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.</p>Formule :C35H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.67SZM679
<p>SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.</p>Formule :C27H18F5N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.51NF-κB-IN-3
CAS :<p>NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.</p>Formule :C24H18ClF3N2O2Couleur et forme :SolidMasse moléculaire :458.861-Dehydro-[10]-gingerdione
CAS :<p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>Formule :C21H30O4Couleur et forme :SolidMasse moléculaire :346.46ABD-350
CAS :<p>ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.</p>Formule :C19H22F2O2Couleur et forme :SolidMasse moléculaire :320.37MHY884
CAS :<p>MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.</p>Formule :C15H14ClNO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :323.79IT-901
CAS :<p>IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.</p>Formule :C17H14N2O4SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :342.37IKK2-IN-4
CAS :<p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>Formule :C12H11N3O2SDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :261.3CID-2858522
CAS :<p>CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).</p>Formule :C28H39N3O3Degré de pureté :96.12%Couleur et forme :SolidMasse moléculaire :465.63DHMEQ racemate
CAS :<p>DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.</p>Formule :C13H11NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :261.23AP-1/NF-κB activation inhibitor 1
CAS :<p>AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal</p>Formule :C13H11F3N4O4Degré de pureté :99.52% - 99.91%Couleur et forme :SolidMasse moléculaire :344.25APC-0576
CAS :<p>APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.</p>Formule :C23H27N3O3Couleur et forme :SolidMasse moléculaire :393.48Avenanthramide-C methyl ester
CAS :<p>Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).</p>Formule :C17H15NO6Couleur et forme :SolidMasse moléculaire :329.3
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