NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
445 produits trouvés pour "NF-κB"
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Edasalonexent
CAS :<p>Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.</p>Formule :C31H42N2O3Degré de pureté :99.13% - >99.99%Couleur et forme :SolidMasse moléculaire :490.68IMD-ferulic
<p>IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.</p>Formule :C36H41N7O4Couleur et forme :SolidMasse moléculaire :635.76Ro 106-9920
CAS :<p>Inhibitor of NF-κB activation</p>Formule :C10H7N5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :245.26Bay 65-1942 hydrochloride
CAS :<p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>Formule :C22H26ClN3O4Couleur et forme :SolidMasse moléculaire :431.91HPN-01
CAS :<p>HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.</p>Formule :C19H16ClN3O3SDegré de pureté :98.07% - 98.17%Couleur et forme :SolidMasse moléculaire :401.87RIP2 Kinase Inhibitor 3
CAS :<p>RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.</p>Formule :C19H24N4O3SDegré de pureté :99.32% - 99.52%Couleur et forme :SolidMasse moléculaire :388.48NF-κB-IN-2
CAS :<p>NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.</p>Formule :C15H18O3Couleur et forme :SolidMasse moléculaire :246.3Gue1654
CAS :<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Formule :C23H17N3OS3Degré de pureté :98.02% - 98.04%Couleur et forme :SolidMasse moléculaire :447.6GSK319347A
CAS :<p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>Formule :C22H19N3O5S2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :469.53IKKβ-IN-1
CAS :<p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>Formule :C31H30N4O4SCouleur et forme :SolidMasse moléculaire :554.66DMX-129
CAS :<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Formule :C19H17FN8Couleur et forme :SolidMasse moléculaire :376.39TNF-α-IN-18
CAS :<p>TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.</p>Formule :C16H7ClF2O4Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :336.67Anti-inflammatory agent 21
CAS :<p>Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.</p>Formule :C24H21FO6Couleur et forme :SolidMasse moléculaire :424.42HSR1304
CAS :<p>HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.</p>Formule :C24H21ClN2O3Couleur et forme :SolidMasse moléculaire :420.89Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Formule :C29H34N2O15Couleur et forme :SolidMasse moléculaire :650.58NF-κB/PON1-IN-1
CAS :<p>NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.</p>Formule :C20H16N6O4S2Couleur et forme :SolidMasse moléculaire :468.51RI-962
CAS :<p>RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.</p>Formule :C28H28N6O2Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :480.56TRAF-STOP inhibitor 6877002
CAS :<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Formule :C17H17NODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :251.32Bay 65-1942 free base
CAS :<p>Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.</p>Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45Asperbisabolane L
<p>Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.</p>Formule :C12H14O3Couleur et forme :SolidMasse moléculaire :206.24TBK1/IKKε-IN-4
CAS :<p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>Formule :C28H35N7O4Couleur et forme :SolidMasse moléculaire :533.62PHA-408
CAS :<p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>Formule :C29H27ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.02IMD-catechol
CAS :<p>IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.</p>Formule :C31H34N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64NF-κB-IN-8
CAS :<p>NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.</p>Formule :C24H21N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :399.44CAY10575
CAS :<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Formule :C22H21N3O6S2Couleur et forme :SolidMasse moléculaire :487.55IMD-biphenylA
CAS :<p>IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune</p>Formule :C35H33N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.67NF-κB-IN-11
CAS :<p>NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.</p>Formule :C19H18O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.34HE 3286
CAS :<p>Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.</p>Formule :C21H30O3Couleur et forme :SolidMasse moléculaire :330.46SP-100030
CAS :<p>SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.</p>Formule :C14H5ClF9N3ODegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :437.65Zabedosertib
CAS :<p>Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.</p>Formule :C20H21F3N4O4SDegré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :470.47GSK2983559 free acid
CAS :<p>GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.</p>Formule :C21H23N4O7PS2Degré de pureté :97.8700% - 98.61%Couleur et forme :SolidMasse moléculaire :538.53B022
CAS :<p>B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.</p>Formule :C19H16ClN5OSDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :397.88NFATc1-IN-1
CAS :<p>NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.</p>Formule :C13H8F2INO2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :375.11Zharp2-1
CAS :<p>Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).</p>Formule :C19H18N3O2PSDegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :383.4RIPK1-IN-9
CAS :<p>RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).</p>Formule :C26H25FN6O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :472.51HS271
CAS :<p>HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).</p>Formule :C21H24F3N5O2Degré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :435.44IRAK4-IN-20
CAS :<p>IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).</p>Formule :C22H25F3N4O3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :450.45GSK840
CAS :<p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>Formule :C21H23N3O3Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :365.43PF-184
<p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.</p>Formule :C32H32ClFN6O4Couleur et forme :SolidMasse moléculaire :619.09WEHI-345
CAS :<p>WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.</p>Formule :C22H23N7ODegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :401.46RIPK1-IN-16
CAS :<p>RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.</p>Formule :C20H19N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.46Ginsenoside Rk1
CAS :<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767PF 184
CAS :<p>IKKβ inhibitor</p>Formule :C32H32ClFN6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.09RIP1 kinase inhibitor 4
CAS :<p>RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].</p>Formule :C23H23N5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.46IMD-biphenylC
CAS :<p>IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.</p>Formule :C35H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.67CGA-JK3
CAS :<p>CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.</p>Formule :C15H19NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :261.32PK68
CAS :<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Formule :C22H24N4O3SDegré de pureté :98.09% - 99.64%Couleur et forme :SolidMasse moléculaire :424.52IRAK inhibitor 3
CAS :<p>IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.</p>Formule :C21H21N5O4SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :439.49IMD-vanillin
CAS :<p>IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.</p>Formule :C37H45N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :651.8TBK1-IN-1
CAS :<p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>Formule :C27H37N7O2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :491.63
