NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
445 produits trouvés pour "NF-κB"
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IRAK4-IN-28
CAS :<p>IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.</p>Formule :C27H31N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.59NF-κB-IN-13
CAS :<p>NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1</p>Formule :C20H20O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :340.37(Rac)-BAY-985
CAS :<p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>Formule :C27H30F3N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.58ACHP Hydrochloride
CAS :<p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>Formule :C21H25ClN4O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :400.9RIPK2-IN-3
CAS :<p>RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.</p>Formule :C25H22N4O2Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :410.47IR-Crizotinib
CAS :<p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>Formule :C53H57Cl2FIN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.88Trovafloxacin mesylate
CAS :<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.46IKK-IN-4
CAS :<p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>Formule :C18H19N5SCouleur et forme :SolidMasse moléculaire :337.44Bay 65-1942 (R form)
CAS :<p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45GGTI 2147
CAS :<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Formule :C28H30N4O3Degré de pureté :98.69%Couleur et forme :SolidMasse moléculaire :470.56IKK-IN-1
CAS :<p>IKK-IN-1 is an inhibitor of IKK.</p>Formule :C22H26ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.91Glabrescone C
CAS :<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Formule :C19H22O7Couleur et forme :SolidMasse moléculaire :362.37Dimethoxycurcumin
CAS :<p>Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.</p>Formule :C23H24O6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :396.43Supercinnamaldehyde
CAS :<p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>Formule :C12H11NO2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :201.22Oditrasertib
CAS :<p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>Formule :C14H15F2N3O2Degré de pureté :98.65% - 99.65%Couleur et forme :SolidMasse moléculaire :295.28LTβR-IN-1
CAS :<p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>Formule :C18H16N4O2Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :320.35RIPK1-IN-4
CAS :<p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>Formule :C23H23N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :401.46MAY0132
CAS :<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Formule :C16H15ClF3NCouleur et forme :SolidMasse moléculaire :313.745AS2690168 (free base)
CAS :<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formule :C17H13F3N4OCouleur et forme :SolidMasse moléculaire :346.306SBI-0640726
CAS :<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Formule :C23H15ClN2O2Couleur et forme :SolidMasse moléculaire :386.83
