NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
446 produits trouvés pour "NF-κB"
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Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Formule :C18H19F3N2O2SeMasse moléculaire :432.05638IRAK4-IN-8
CAS :<p>IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.</p>Formule :C23H23F2N7O2SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :499.54IRAK4-IN-10
CAS :<p>IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.</p>Formule :C22H24N8Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :400.48IRAK inhibitor 2
CAS :<p>IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.</p>Formule :C17H14N4O2Degré de pureté :97.90% - 99.58%Couleur et forme :SolidMasse moléculaire :306.32DTP3
CAS :<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Formule :C26H35N7O5Couleur et forme :SolidMasse moléculaire :525.6Hesperidin methylchalcone
CAS :Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formule :C29H36O15Degré de pureté :99.53%Couleur et forme :Yellow PowderMasse moléculaire :624.59ML 120B dihydrochloride
CAS :MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Formule :C19H17Cl3N4O2Couleur et forme :SolidMasse moléculaire :439.72SEMBL
CAS :SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.Formule :C12H11NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :233.22Edecesertib
CAS :Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.Formule :C22H22FN7O2Degré de pureté :98.84% - 99.94%Couleur et forme :SolidMasse moléculaire :435.45RS 09
CAS :<p>TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.</p>Formule :C31H49N9O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :691.78BIZ 114
CAS :<p>BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.</p>Formule :C24H40O3Couleur et forme :SolidMasse moléculaire :376.571-Caffeoylquinic acid
CAS :1-Caffeoylquinic acid: a lignin precursor with anti-influenza, antioxidant properties, and moderates post-meal glucose release.Formule :C16H18O9Degré de pureté :99.15% - 99.16%Couleur et forme :SolidMasse moléculaire :354.31QNZ
CAS :<p>QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.</p>Formule :C22H20N4ODegré de pureté :99.17% - 99.18%Couleur et forme :White SolidMasse moléculaire :356.42TOMATIDINE HYDROCHLORIDE
CAS :<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Formule :C27H46ClNO2Degré de pureté :99.75% - ≥95%Couleur et forme :SolidMasse moléculaire :452.11Dauricine
CAS :<p>1.</p>Formule :C38H44N2O6Degré de pureté :99.24% - 99.75%Couleur et forme :White PowderMasse moléculaire :624.77BEC hydrochloride
CAS :<p>BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.</p>Formule :C5H12BNO4S·ClHDegré de pureté :98.65% - 99.28%Couleur et forme :SolidMasse moléculaire :229.49CAFESTOL
CAS :<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formule :C20H28O3Degré de pureté :97.06% - 99.08%Couleur et forme :SolidMasse moléculaire :316.43Morusin
CAS :Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formule :C25H24O6Degré de pureté :98.68% - 99.8%Couleur et forme :SolidMasse moléculaire :420.45Sulindac sodium
CAS :Sulindac (sodium) (MK-231) is an NSAID used for arthritis pain, swelling, gout, and as an immunomodulator in CRC therapy.Formule :C20H16FNaO3SCouleur et forme :SolidMasse moléculaire :378.39SC-514
CAS :<p>SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.</p>Formule :C9H8N2OS2Degré de pureté :99.88% - >99.99%Couleur et forme :SolidMasse moléculaire :224.3
