NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
444 produits trouvés pour "NF-κB"
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IMD-vanillin
CAS :<p>IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.</p>Formule :C37H45N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :651.8Bay 65-1942 (R form)
CAS :<p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>Formule :C22H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :395.45IMD-biphenylC
CAS :<p>IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.</p>Formule :C35H33N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.67IRAK4-IN-28
CAS :<p>IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.</p>Formule :C27H31N9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :529.59ACHP Hydrochloride
CAS :<p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>Formule :C21H25ClN4O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :400.9IR-Crizotinib
CAS :<p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>Formule :C53H57Cl2FIN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1024.88Ginsenoside Rk1
CAS :<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formule :C42H70O12Degré de pureté :98.46% - 99.13%Couleur et forme :SolidMasse moléculaire :767Glabrescone C
CAS :<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Formule :C19H22O7Couleur et forme :SolidMasse moléculaire :362.37Dimethoxycurcumin
CAS :Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Formule :C23H24O6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :396.43RIP1 kinase inhibitor 4
CAS :<p>RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].</p>Formule :C23H23N5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.46IKK-IN-4
CAS :<p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>Formule :C18H19N5SCouleur et forme :SolidMasse moléculaire :337.44IKK-IN-1
CAS :IKK-IN-1 is an inhibitor of IKK.Formule :C22H26ClN3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.91PK68
CAS :<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Formule :C22H24N4O3SDegré de pureté :98.09% - 99.64%Couleur et forme :SolidMasse moléculaire :424.52LTβR-IN-1
CAS :<p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>Formule :C18H16N4O2Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :320.35RIPK1-IN-4
CAS :<p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>Formule :C23H23N5O2Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :401.46Oditrasertib
CAS :<p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>Formule :C14H15F2N3O2Degré de pureté :98.65% - 99.65%Couleur et forme :SolidMasse moléculaire :295.28Supercinnamaldehyde
CAS :<p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>Formule :C12H11NO2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :201.22Ocadusertib
CAS :<p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>Formule :C25H25N5O4Couleur et forme :SolidMasse moléculaire :459.50DBMB
CAS :<p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>Formule :C24H22N4OCouleur et forme :SolidMasse moléculaire :382.458NLRP3-IN-78
CAS :<p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>Formule :C12H5Cl2N3O4S2Couleur et forme :SolidMasse moléculaire :390.222
