RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
143 produits trouvés pour "RCC"
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CCR8 antagonist 1
CAS :CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Formule :C26H29N3O5SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :495.59Cafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour LiquidBertilimumab
CAS :Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].Couleur et forme :LiquidDenrakibart
Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.Couleur et forme :Odour LiquidBMS-753426
CAS :BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Formule :C25H33F3N6O2Couleur et forme :SolidMasse moléculaire :506.574CHS-114
CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidINCB 3284 dimesylate
CAS :INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.Formule :C28H39F3N4O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :712.76CCR4 antagonist 3 hydrochloride
CAS :Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Formule :C24H27Cl2N7O·xHClCouleur et forme :SolidTagmokitug
CAS :Tagmokitug is a humanized IgG1κ monoclonal antibody inhibitor targeting CCR8. It exhibits anti-tumor activity and is applicable in cancer immunotherapy research, including studies on breast cancer, colon cancer, and lung cancer.CH-0076989
CAS :CH-0076989 is a chemokine receptor CCR3 agonist.Formule :C24H22Br2N2O2Couleur et forme :SolidMasse moléculaire :530.25Plozalizumab
CAS :Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of
Degré de pureté :96.4%Couleur et forme :LiquidMasse moléculaire :146.02 kDaPF-232798
CAS :PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.Formule :C29H40FN5O2Couleur et forme :SolidMasse moléculaire :509.66CMKLR1 antagonist 1
CMKLR1 antagonist 1 (compound S-26d) is a potent, orally active antagonist of the chemokine-like receptor 1 (CMKLR1), exhibiting a pIC50 of 7.44 in hCMKLR1-Couleur et forme :Odour SolidMaceneolignan H
CAS :Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.Formule :C24H30O7Couleur et forme :SolidMasse moléculaire :430.49Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Couleur et forme :Odour SolidCCR6 antagonist 1
CAS :CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.
Formule :C17H12F3NO2Degré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :319.28SQA1
CAS :SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formule :C22H26N4O5Couleur et forme :SolidMasse moléculaire :426.47CCR4 antagonist 3
CAS :Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.Formule :C24H27Cl2N7OCouleur et forme :SolidMasse moléculaire :500.43HGS101
HGS101 is a fully humanized CCR5 monoclonal antibody that exhibits high affinity for CCR5. It binds to the second extracellular loop (ECL-2) and functions as a signaling antagonist. HGS101 restores the inhibitory effect of Maraviroc in Maraviroc-resistant HIV-1 infected PBMCs. In an uninfected simian immunodeficiency virus model of rhesus monkeys, HGS101 shows anti-HIV activity by inhibiting CCR5 signaling.Couleur et forme :Odour LiquidLanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Couleur et forme :Odour Liquid
