RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
143 produits trouvés pour "RCC"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
BMS-817399
CAS :BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Formule :C23H36ClN3O4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :454Ref: TM-T26861
1mg152,00€5mg319,00€1mL*10mM (DMSO)356,00€10mg485,00€25mg770,00€50mg1.035,00€100mg1.395,00€RP-23618
CAS :RP-23618 is a non-peptidic antagonist of RANTES.Formule :C30H35N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.76cis-J-113863
CAS :Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].Formule :C30H37Cl2IN2O2Couleur et forme :SolidMasse moléculaire :655.44IPG7236
CAS :IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancerFormule :C23H31N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.58SB-649701
CAS :SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Formule :C27H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54CCR2 antagonist 4
CAS :CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFormule :C21H21ClF3N3O2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :439.86Ref: TM-T13114
1mg52,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€PF-04634817
CAS :PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Formule :C25H36F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.58BMS-639623
CAS :BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.Formule :C25H32FN7O2Couleur et forme :SolidMasse moléculaire :481.57LMD-009
CAS :LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.Formule :C29H33N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.59PF-04634817 succinate
CAS :PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.Formule :C29H42F3N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :629.67CCR4 antagonist 4
CAS :CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].Formule :C24H27Cl2N7OCouleur et forme :SolidMasse moléculaire :500.42CMPD167
CAS :CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Formule :C35H47FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.77(Rac)-PF-4136309(1341224-83-6 Free base)
CAS :PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for humanFormule :C29H31F3N6O3Couleur et forme :SolidMasse moléculaire :568.59(1S)-CCR2 antagonist 1
CAS :(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47trans-J-113863
CAS :Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].Formule :C30H37Cl2IN2O2Couleur et forme :SolidMasse moléculaire :655.44VCH-286
CAS :VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.Formule :C34H50F2N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.78MLN-3897
CAS :MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Formule :C30H31ClN2O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :519.03AZD2423
CAS :AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFormule :C20H29ClFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.93K777
CAS :K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Formule :C32H38N4O4SDegré de pureté :98.43% - 99.14%Couleur et forme :SolidMasse moléculaire :574.73CCR3 antagonist 1
CAS :CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Formule :C19H21Cl2N3O4S2Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :490.42Ref: TM-T10156
1mg96,00€5mg178,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg462,00€50mg622,00€100mg837,00€
