RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
136 produits trouvés pour "RCC"
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J-113863
CAS :<p>J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).</p>Formule :C30H37Cl2IN2O2Degré de pureté :95.11%Couleur et forme :SolidMasse moléculaire :655.44AZ084
CAS :<p>AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.</p>Formule :C26H34N4O2Degré de pureté :97.12%Couleur et forme :SolidMasse moléculaire :434.57RS102895 hydrochloride
CAS :<p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>Formule :C21H22ClF3N2O2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :426.86MK-0812 Succinate
CAS :<p>MK-0812 Succinate is an effective and selective CCR2 antagonist.</p>Formule :C28H40F3N3O7Degré de pureté :98.62% - 99.93%Couleur et forme :SolidMasse moléculaire :587.63CCR2-RA-[R]
CAS :<p>CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).</p>Formule :C18H19ClFNO3Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :351.8CCX140
CAS :<p>CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.</p>Formule :C20H13ClF3N5O3SDegré de pureté :99.66% - 99.95%Couleur et forme :SolidMasse moléculaire :495.86Leronlimab
CAS :<p>Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.</p>Degré de pureté :SDS-PAGE:95.0%;SEC-HPLC:99.6%Couleur et forme :LiquidMasse moléculaire :146.66 kDaMogamulizumab
CAS :<p>Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.</p>Degré de pureté :SDS-PAGE:97.3%;SEC-HPLC:99.4%Couleur et forme :LiquidMasse moléculaire :146.43 kDaINCB-9471
CAS :<p>INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.</p>Formule :C30H40F3N5O2Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :559.666ML604086
CAS :<p>ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.</p>Formule :C27H32N4O4SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :508.63INCB3344 R-isomer
<p>INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.</p>Formule :C29H34F3N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.59NI-0701
<p>NI-0701 is a humanized antibody targeting CCL5/RANTES.</p>Degré de pureté :95.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.5kDaCCR6 antagonist 1
CAS :<p>CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.</p>Formule :C17H12F3NO2Degré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :319.28WAY-639418
CAS :<p>WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.</p>Formule :C17H16ClN5Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :325.8CCR8 agonist 1
<p>CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.</p>Formule :C22H29NO3Couleur et forme :SolidMasse moléculaire :355.47Azirkitug
<p>Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidLanerkitug
<p>Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidCCR8 antagonist 1
CAS :<p>CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.</p>Formule :C26H29N3O5SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :495.59Bertilimumab
CAS :<p>Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].</p>Couleur et forme :LiquidCCR6 antagonist 2
<p>CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.</p>Formule :C19H24N4O4Couleur et forme :SolidMasse moléculaire :372.42Nebokitug
<p>Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidDenrakibart
<p>Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.</p>Couleur et forme :Odour LiquidPlozalizumab
CAS :<p>Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of</p>Degré de pureté :96.4%Couleur et forme :LiquidMasse moléculaire :146.02 kDaDenikitug
<p>Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidZn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formule :C115H145ClN18O31S2Zn2Couleur et forme :SolidMasse moléculaire :2505.83CCR2 antagonist 1
CAS :<p>CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).</p>Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47CH-0076989
CAS :<p>CH-0076989 is a chemokine receptor CCR3 agonist.</p>Formule :C24H22Br2N2O2Couleur et forme :SolidMasse moléculaire :530.25INCB 3284 dimesylate
CAS :<p>INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.</p>Formule :C28H39F3N4O10S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :712.76CCR6 inhibitor 1
CAS :<p>CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.</p>Formule :C24H23F3N4O3SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :504.52CHS-114
<p>CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour LiquidChemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidSQA1
CAS :<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formule :C22H26N4O5Couleur et forme :SolidMasse moléculaire :426.472-Methoxyhydroquinone
CAS :<p>2-Methoxyhydroquinone inhibits MAO-A and MAO-B and reduces TNF-α-induced CCL2 production, a precursor for synthesising the Hsp90 inhibitor Geldanamycin.</p>Formule :C7H8O3Degré de pureté :98.25%Couleur et forme :SolidMasse moléculaire :140.14CAP-100
<p>CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).</p>Couleur et forme :Odour LiquidMet-RANTES,human,acetate
<p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>Couleur et forme :Odour SolidMaceneolignan H
CAS :<p>Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.</p>Formule :C24H30O7Couleur et forme :SolidMasse moléculaire :430.49Cafelkibart
<p>Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Couleur et forme :Odour LiquidCCR4 antagonist 3 hydrochloride
CAS :<p>Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.</p>Formule :C24H27Cl2N7O·xHClCouleur et forme :SolidBMS-753426
CAS :<p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>Formule :C25H33F3N6O2Couleur et forme :SolidMasse moléculaire :506.574MLN-3897 TFA
<p>MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.</p>Formule :C32H32ClF3N2O6Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :633.05PF-232798
CAS :<p>PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.</p>Formule :C29H40FN5O2Couleur et forme :SolidMasse moléculaire :509.66CCR4 antagonist 3
CAS :<p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>Formule :C24H27Cl2N7OCouleur et forme :SolidMasse moléculaire :500.43CKLF1-C27 TFA
<p>CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.</p>Formule :C153H244F3N39O39Couleur et forme :SolidMasse moléculaire :3310.8GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Couleur et forme :Odour LiquidAZD2098
CAS :<p>AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.</p>Formule :C11H9Cl2N3O3SDegré de pureté :99.80% - >99.99%Couleur et forme :SolidMasse moléculaire :334.18Vercirnon
CAS :<p>Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.</p>Formule :C22H21ClN2O4SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :444.93BX471
CAS :<p>BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.</p>Formule :C21H24ClFN4O3Degré de pureté :98% - 99.94%Couleur et forme :SolidMasse moléculaire :434.89AZD-4818
CAS :<p>AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formule :C27H32Cl2N2O7Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :567.46Vicriviroc maleate
CAS :<p>Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.</p>Formule :C32H42F3N5O6Degré de pureté :98.16% - 98.37%Couleur et forme :SolidMasse moléculaire :649.7Cenicriviroc
CAS :<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Formule :C41H52N4O4SDegré de pureté :97.87%Couleur et forme :SolidMasse moléculaire :696.94
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