RCC
Les récepteurs des chimiokines C-C (CCRs) sont un groupe de GPCR qui répondent aux chimiokines, des molécules de signalisation qui guident la migration des cellules immunitaires vers les sites d'inflammation ou d'infection. Les CCR jouent un rôle crucial dans les réponses immunitaires, l'inflammation et le développement de diverses maladies, y compris les troubles auto-immuns et le cancer. La modulation de l'activité des CCR est explorée comme une stratégie thérapeutique pour des affections telles que la polyarthrite rhumatoïde, la sclérose en plaques et l'infection par le VIH. Chez CymitQuimica, nous offrons une gamme de modulateurs de CCR de haute qualité pour soutenir vos recherches en immunologie, inflammation et développement thérapeutique.
136 produits trouvés pour "RCC"
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IPG7236
CAS :<p>IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer</p>Formule :C23H31N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :429.58(1S)-CCR2 antagonist 1
CAS :<p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>Formule :C28H32BrF3N2OCouleur et forme :SolidMasse moléculaire :549.47MLN-3897
CAS :<p>MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.</p>Formule :C30H31ClN2O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :519.03AZD2423
CAS :<p>AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for</p>Formule :C20H29ClFN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.93SB-649701
CAS :<p>SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].</p>Formule :C27H28N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54cis-J-113863
CAS :<p>Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].</p>Formule :C30H37Cl2IN2O2Couleur et forme :SolidMasse moléculaire :655.44PF-04634817
CAS :<p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>Formule :C25H36F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.58(Rac)-PF-4136309(1341224-83-6 Free base)
CAS :<p>PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human</p>Formule :C29H31F3N6O3Couleur et forme :SolidMasse moléculaire :568.59CMPD167
CAS :<p>CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].</p>Formule :C35H47FN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.77RP-23618
CAS :<p>RP-23618 is a non-peptidic antagonist of RANTES.</p>Formule :C30H35N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.76trans-J-113863
CAS :<p>Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].</p>Formule :C30H37Cl2IN2O2Couleur et forme :SolidMasse moléculaire :655.44BMS-639623
CAS :<p>BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.</p>Formule :C25H32FN7O2Couleur et forme :SolidMasse moléculaire :481.57LMD-009
CAS :<p>LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.</p>Formule :C29H33N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.59K777
CAS :<p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).</p>Formule :C32H38N4O4SDegré de pureté :98.43% - 99.14%Couleur et forme :SolidMasse moléculaire :574.73CCR3 antagonist 1
CAS :<p>CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.</p>Formule :C19H21Cl2N3O4S2Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :490.42INCB3344
CAS :<p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>Formule :C29H34F3N3O6Degré de pureté :98% - 98.2%Couleur et forme :SolidMasse moléculaire :577.59CP-865569
CAS :<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Formule :C22H26ClFN2O5SCouleur et forme :SolidMasse moléculaire :484.969Aplaviroc
CAS :<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Formule :C33H43N3O6Degré de pureté :97.98% - 98.26%Couleur et forme :SolidMasse moléculaire :577.71CCR5 antagonist 1
CAS :<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Formule :C39H46ClF2N5O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :738.33CXCR2/CCR7 antagonist-1
CAS :<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formule :C23H27N3O5Couleur et forme :SolidMasse moléculaire :425.48CCR7 Ligand 1
CAS :<p>CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.</p>Formule :C22H29N5O5SCouleur et forme :SolidMasse moléculaire :475.56PF-07054894
CAS :<p>PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.</p>Formule :C24H30N6O4Couleur et forme :SolidMasse moléculaire :466.53Aplaviroc hydrochloride
CAS :<p>Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.</p>Formule :C33H44ClN3O6Couleur et forme :SolidMasse moléculaire :614.17INCB-9471 dihydrochloride
CAS :<p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.</p>Formule :C30H42Cl2F3N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.59CCR1 antagonist 11 hydrochloride
<p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>Couleur et forme :SolidTAK-661
CAS :<p>TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.</p>Formule :C13H21N5O3SCouleur et forme :SolidMasse moléculaire :327.40CP-481715
CAS :<p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>Formule :C26H31FN4O4Couleur et forme :SolidMasse moléculaire :482.55Ophiobolin C
CAS :<p>inhibitor of human CCR5 binding to HIV-1 gp120</p>Formule :C25H38O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.57BAY-3153
CAS :<p>BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .</p>Formule :C25H29Cl2N3O4Couleur et forme :SolidMasse moléculaire :506.42BI 639667
CAS :<p>BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).</p>Formule :C22H18FN5O3SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :451.47CCR1 antagonist 13
CAS :<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Formule :C25H27ClFN3O4Couleur et forme :SolidMasse moléculaire :487.95BMS-741672
CAS :<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Formule :C25H33F3N6O2Couleur et forme :SolidMasse moléculaire :506.56Nifeviroc
CAS :<p>Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.</p>Formule :C33H42N4O6Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :590.71MK-0812
CAS :<p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>Formule :C24H34F3N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :469.54AZD-5672
CAS :<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formule :C32H38F2N2O5S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :632.78BX471 hydrochloride
CAS :<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Formule :C21H25Cl2FN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :471.35
