Nrf2
Nrf2 est un facteur de transcription qui régule l'expression des protéines antioxydantes et des enzymes de détoxification, jouant un rôle crucial dans la défense cellulaire contre le stress oxydatif et l'inflammation. L'activation de la signalisation Nrf2 offre une protection contre diverses maladies, notamment le cancer, la neurodégénérescence et les troubles cardiovasculaires. Les modulateurs de Nrf2 sont explorés pour leurs potentielles applications thérapeutiques dans la réduction des dommages oxydatifs et de l'inflammation. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie Nrf2 de haute qualité pour soutenir vos recherches sur le stress oxydatif, l'inflammation et la prévention des maladies.
78 produits trouvés pour "Nrf2"
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NK-252
CAS :<p>NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.</p>Formule :C13H11N5O3Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :285.26AA147
CAS :<p>AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.</p>Formule :C16H17NO2Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :255.31(E/Z)-BCI
CAS :<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formule :C22H23NODegré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :317.42BPK-29 hydrochloride
CAS :<p>"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."</p>Formule :C26H33Cl2N3O3Degré de pureté :99.06%Couleur et forme :SolidMasse moléculaire :506.46Ezetimibe
CAS :<p>Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.</p>Formule :C24H21F2NO3Degré de pureté :97.28% - 99.77%Couleur et forme :SolidMasse moléculaire :409.43Fraxinellone analog 1
<p>Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidative defense system, providing protection against glutamate-mediated excitotoxicity. It induces the expression of antioxidative genes Gpx4, Sod1, and Nqo1. Additionally, Fraxinellone analog 1 exerts neuroprotective effects and modulates oxidative stress and inflammation, making it suitable for research on neurodegenerative diseases.</p>Couleur et forme :Odour SolidNrf2 activator 18
<p>Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 μM. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18 demonstrates anti-inflammatory activity.</p>Formule :C23H24FN3OCouleur et forme :SolidMasse moléculaire :377.45TPNA10168
CAS :<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C9H9ClO2S2Couleur et forme :SolidMasse moléculaire :248.75His-Pro
CAS :<p>His-Pro is a dipeptide consisting of histidyl and proline.</p>Formule :C11H16N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :252.27Nrf2 activator-1
CAS :<p>Nrf2 activator-1 activates Nrf2; used for COPD, asthma, ALI, ARDS, pulmonary fibrosis research.</p>Formule :C30H34N4O6SDegré de pureté :97.8%Couleur et forme :SolidMasse moléculaire :578.68Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Formule :C27H26N2O6Couleur et forme :SolidMasse moléculaire :474.51Butan-1-amine hydrochloride
CAS :<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Formule :C4H12ClNCouleur et forme :SolidMasse moléculaire :109.6Keap1/Nrf2/ARE activator 1
<p>Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.</p>Formule :C19H20O6Couleur et forme :SolidMasse moléculaire :344.12599Eriodictyol-7-O-glucoside
CAS :<p>Eriodictyol-7-O-glucoside, a flavonoid in pistachio skin, activates Nrf2 and protects against Cisplatin toxicity.</p>Formule :C21H22O11Degré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :450.39Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Formule :C13H11ClN2O3SCouleur et forme :SolidMasse moléculaire :310.76Nrf2 degrader 1
CAS :<p>Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].</p>Formule :C45H42N6O8SCouleur et forme :SolidMasse moléculaire :826.92Ac-LDEETGEFL-NH2
CAS :<p>Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor</p>Formule :C48H72N10O19Couleur et forme :SolidMasse moléculaire :1093.144-P-PDOT
CAS :<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Formule :C19H21NODegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :279.3817-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS :<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formule :C22H30O3Couleur et forme :SolidMasse moléculaire :342.479Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Formule :C20H26O4Couleur et forme :SolidMasse moléculaire :330.424TAT 14
CAS :<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Formule :C137H230N48O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3173.59S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formule :C29H30N4O7SCouleur et forme :SolidMasse moléculaire :578.64Keap1-Nrf2-IN-9
CAS :<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Formule :C31H30N2O11S2Couleur et forme :SolidMasse moléculaire :670.71Deacetylgedunin
CAS :<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formule :C26H32O6Couleur et forme :SolidMasse moléculaire :440.53Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Couleur et forme :Odour SolidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formule :C17H21Cl2N2O5PS3Couleur et forme :SolidMasse moléculaire :531.434Keap1-Nrf2-IN-3
CAS :<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formule :C31H34N6O3Couleur et forme :SolidMasse moléculaire :538.652Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Couleur et forme :Odour SolidMonascin
CAS :<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formule :C21H26O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.43CBR-470-2
CAS :<p>CBR-470-2 activates NRF2 signaling, aiding in glycolysis research.</p>Formule :C12H13Cl2NO6S2Couleur et forme :SolidMasse moléculaire :402.26KI696 isomer
CAS :<p>KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases.</p>Formule :C28H30N4O6SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :550.63ML334
CAS :<p>ML334 (LH601A) is an NRF2 activator that inhibits cardiac fibroblast activation and proliferation ameliorating myocardial infarction-induced cardiac fibrosis.</p>Formule :C26H26N2O5Degré de pureté :98.06% - 98.06%Couleur et forme :SolidMasse moléculaire :446.49I-152
CAS :<p>Bepranemab (UCB 0107) is a humanized IgG monoclonal antibody against tau for the study of Alzheimer's disease (AD) and tau proteinopathies.</p>Formule :C9H16N2O3S2Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :264.37Anti-NFE2L2 Antibody (9K94)
<p>Anti-NFE2L2 Antibody (9K94) is a Mouse antibody targeting NFE2L2. Anti-NFE2L2 Antibody (9K94) can be used in ELISA, WB, IHC, IF, FCM.</p>Degré de pureté :>95%Couleur et forme :Odour LiquidAnti-Phospho-NFE2L2 (Ser40) Antibody (6V851)
<p>Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) is an antibody targeting Phospho-NFE2L2 (Ser40). Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) can be used in ELISA, WB, IHC, IF.</p>Couleur et forme :Odour LiquidAnti-NFE2L2 Antibody (6K859)
<p>Anti-NFE2L2 Antibody (6K859) is an antibody targeting NFE2L2. Anti-NFE2L2 Antibody (6K859) can be used in ELISA, IF.</p>Couleur et forme :Odour LiquidDimethyl fumarate-d6
CAS :<p>Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression.</p>Formule :C6H8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :150.16Artemisitene
CAS :<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formule :C15H20O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :280.32AEM1
CAS :<p>AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.</p>Formule :C20H14FN3O2SDegré de pureté :98.37% - 99.88%Couleur et forme :SolidMasse moléculaire :379.41ML162
CAS :<p>ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.</p>Formule :C23H22Cl2N2O3SDegré de pureté :98.42% - 99.55%Couleur et forme :SolidMasse moléculaire :477.4Diroximel fumarate
CAS :<p>Diroximel fumarate (Diroximel Fumarete), a prodrug of monomethyl fumarate in a controlled-release formulation, rapidly and potently converts to MMF in the body.</p>Formule :C11H13NO6Degré de pureté :99.8% - 99.88%Couleur et forme :SolidMasse moléculaire :255.22Trilobatin
CAS :<p>Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially</p>Formule :C21H24O10Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :436.414-Octyl itaconate
CAS :<p>4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite.</p>Formule :C13H22O4Degré de pureté :99.3% - 99.94%Couleur et forme :SolidMasse moléculaire :242.31Kinsenoside
CAS :<p>Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities.</p>Formule :C10H16O8Degré de pureté :99.2% - >99.99%Couleur et forme :SolidMasse moléculaire :264.23Brusatol
CAS :<p>Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.</p>Formule :C26H32O11Degré de pureté :99.35% - 99.95%Couleur et forme :SolidMasse moléculaire :520.53CBR-470-1
CAS :<p>CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.</p>Formule :C14H20ClNO4S2Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :365.9L-Cystine dihydrochloride
CAS :<p>L-Cystine dihydrochloride, a sulfur-based glutathione precursor, maintains GSH balance, used in cell culture.</p>Formule :C6H14Cl2N2O4S2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :313.22MIND4-17
CAS :<p>MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.</p>Formule :C20H15N5O3SCouleur et forme :SolidMasse moléculaire :405.43Nrf2-Activator-12G
CAS :<p>Nrf2-Activator-12G is a potent Nrf-2 activator.</p>Formule :C15H13ClO3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.78MSU38225
CAS :<p>MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.</p>Formule :C21H19N3Couleur et forme :SolidMasse moléculaire :313.4
