Nrf2
Nrf2 est un facteur de transcription qui régule l'expression des protéines antioxydantes et des enzymes de détoxification, jouant un rôle crucial dans la défense cellulaire contre le stress oxydatif et l'inflammation. L'activation de la signalisation Nrf2 offre une protection contre diverses maladies, notamment le cancer, la neurodégénérescence et les troubles cardiovasculaires. Les modulateurs de Nrf2 sont explorés pour leurs potentielles applications thérapeutiques dans la réduction des dommages oxydatifs et de l'inflammation. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie Nrf2 de haute qualité pour soutenir vos recherches sur le stress oxydatif, l'inflammation et la prévention des maladies.
84 produits trouvés pour "Nrf2".
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BPK-29
CAS :BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.Formule :C26H32ClN3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470AI-3
CAS :Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFormule :C11H13ClO3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.8WN1316
CAS :WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Formule :C20H26Cl3N5OCouleur et forme :SolidMasse moléculaire :458.81Dihydrolipoic acid
CAS :Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Formule :C8H16O2S2Degré de pureté :97.51%Couleur et forme :Yellow To Orange LiquidMasse moléculaire :208.34K67
CAS :K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Formule :C29H30N2O7S2Degré de pureté :98.43%Couleur et forme :Yellow SolidMasse moléculaire :582.688DDO-7263
CAS :DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Formule :C14H9F2N3ODegré de pureté :99.85%Couleur et forme :White SolidMasse moléculaire :273.2376Nrf2 activator-7
CAS :Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Formule :C35H32N2O11S2Couleur et forme :SolidMasse moléculaire :720.77Nrf2-IN-1
CAS :Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Formule :C21H22ClN3O2Degré de pureté :95.00% - 99.68%Couleur et forme :SolidMasse moléculaire :383.871WRR139
CAS :WRR139 is an NGLY1 inhibitor that impairs Nrf1 processing and sensitizes cancer cells to proteasome inhibitors.Formule :C25H32N2O4SDegré de pureté :99.90%Couleur et forme :White SolidMasse moléculaire :456.6Keap1-Nrf2-IN-16
CAS :Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Formule :C73H114N16O26Couleur et forme :SolidMasse moléculaire :1631.78Keap1-Nrf2-IN-15
CAS :Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFormule :C39H35N3O12S2Couleur et forme :SolidMasse moléculaire :801.84Keap1-IN-1
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.Formule :C17H21Cl2N2O5PS3Couleur et forme :SolidMasse moléculaire :531.434Nrf2-IN-3
CAS :Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Formule :C22H26N4O4SDegré de pureté :97.75%Couleur et forme :SolidMasse moléculaire :442.53Nrf2 degrader 1
CAS :Nrf2 degrader 1 is a PROTAC degrading Nrf2, inhibiting A549 and LK-2 cells (IC₅₀ = 100 nM and 40 nM).Formule :C45H42N6O8SCouleur et forme :SolidMasse moléculaire :826.92CPDT
CAS :CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formule :C6H6S3Couleur et forme :SolidMasse moléculaire :174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formule :C20H17BrO3Couleur et forme :SolidMasse moléculaire :385.25Keap1-Nrf2-IN-3
CAS :Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.Formule :C31H34N6O3Couleur et forme :SolidMasse moléculaire :538.652Keap1-Nrf2-IN-5
CAS :Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formule :C23H30N4O6SCouleur et forme :SolidMasse moléculaire :490.57NFE2L2 activator 3
CAS :NFE2L2 activator 3 (Compound 3) is an activator of NFE2L2/NRF2, specifically enhancing the activity of NAD(P)H:quinone oxidoreductase (NQO1), with an EC50 of less than 1 nM. It is useful for researching respiratory diseases such as chronic obstructive pulmonary disease.Formule :C29H33ClN4O5S2Masse moléculaire :617.18CYP2E1-IN-1
CAS :CYP2E1-IN-1 (Compound 10) is an orally active inhibitor of cytochrome P450 2E1 (CYP2E1) with a dissociation constant (Kd) of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. It alleviates pancreatic damage by activating the Nrf2/HO-1 signaling pathway and inhibiting ROS production. CYP2E1-IN-1 demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing inflammation and oxidative stress in severe acute pancreatitis (SAP). It is suitable for the study of SAP and other inflammation-related conditions.Formule :C6H7NOSMasse moléculaire :141.191
