Nrf2
Nrf2 est un facteur de transcription qui régule l'expression des protéines antioxydantes et des enzymes de détoxification, jouant un rôle crucial dans la défense cellulaire contre le stress oxydatif et l'inflammation. L'activation de la signalisation Nrf2 offre une protection contre diverses maladies, notamment le cancer, la neurodégénérescence et les troubles cardiovasculaires. Les modulateurs de Nrf2 sont explorés pour leurs potentielles applications thérapeutiques dans la réduction des dommages oxydatifs et de l'inflammation. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie Nrf2 de haute qualité pour soutenir vos recherches sur le stress oxydatif, l'inflammation et la prévention des maladies.
81 produits trouvés pour "Nrf2"
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WN1316
CAS :WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Formule :C20H26Cl3N5OCouleur et forme :SolidMasse moléculaire :458.81Nrf2 activator-4
CAS :Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.Formule :C23H24ClF3N2O3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :468.9K67
CAS :K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Formule :C29H30N2O7S2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :582.69Keap1-Nrf2-IN-14
CAS :Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Formule :C30H29NO8SCouleur et forme :SolidMasse moléculaire :563.62Keap1-Nrf2-IN-13
CAS :Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.Formule :C28H32N2O10S2Couleur et forme :SolidMasse moléculaire :620.69CDDO-EA
CAS :CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Formule :C33H46N2O3Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :518.73Ref: TM-T10733
1mg80,00€5mg160,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg485,00€50mg693,00€100mg893,00€200mg1.198,00€DDO-7263
CAS :DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Formule :C14H9F2N3ODegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :273.24Keap1-Nrf2-IN-15
CAS :Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFormule :C39H35N3O12S2Couleur et forme :SolidMasse moléculaire :801.84WRR139
CAS :WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1Formule :C25H32N2O4SCouleur et forme :SolidMasse moléculaire :456.6Nrf2-IN-1
CAS :Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Formule :C21H22ClN3O2Degré de pureté :95.00% - 99.68%Couleur et forme :SolidMasse moléculaire :383.87Ref: TM-T12253
1mg71,00€2mg92,00€5mg152,00€10mg207,00€1mL*10mM (DMSO)285,00€25mg344,00€50mg485,00€100mg690,00€200mg888,00€Nrf2 activator-7
CAS :Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Formule :C35H32N2O11S2Couleur et forme :SolidMasse moléculaire :720.77Keap1-Nrf2-IN-16
CAS :Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Formule :C73H114N16O26Couleur et forme :SolidMasse moléculaire :1631.78Keap1-Nrf2-IN-6
Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nMFormule :C30H34N4O8SCouleur et forme :SolidMasse moléculaire :610.68Nrf2-IN-3
CAS :Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Formule :C22H26N4O4SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :442.53Ref: TM-T78841
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg197,00€25mg371,00€50mg512,00€100mg707,00€200mg1.018,00€Nrf2 activator-6
CAS :Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Formule :C31H37ClFN5O5Couleur et forme :SolidMasse moléculaire :614.11Keap1-Nrf2-IN-5
CAS :Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formule :C23H30N4O6SCouleur et forme :SolidMasse moléculaire :490.57CPDT
CAS :CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formule :C6H6S3Couleur et forme :SolidMasse moléculaire :174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formule :C20H17BrO3Couleur et forme :SolidMasse moléculaire :385.25VVD-130037
CAS :VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Formule :C17H17ClN4O2Degré de pureté :99.01% - 99.92%Couleur et forme :SolidMasse moléculaire :344.8KI696
CAS :KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Formule :C28H30N4O6SDegré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :550.63Ref: TM-T11758L
1mg137,00€5mg281,00€1mL*10mM (DMSO)341,00€10mg423,00€25mg707,00€50mg1.018,00€100mg1.468,00€200mg1.963,00€
