CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
158 produits trouvés pour "CXCR".
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Delmetacin
CAS :Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.Formule :C18H15NO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :293.32Eldelumab
CAS :Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.Degré de pureté :95%Couleur et forme :Transparent LiquidMasse moléculaire :146.64 kDaLY2510924 acetate(1088715-84-7 free base)
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.Formule :C64H91N13O13Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :1250.49Ref: TM-T15805L
1mg150,00€5mg290,00€10mg434,00€1mL*10mM (DMSO)692,00€25mg710,00€50mg973,00€100mg1.341,00€Reparixin L-lysine salt
CAS :Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Formule :C20H35N3O5SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :429.57VUF11207 fumarate
CAS :VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formule :C31H39FN2O8Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :586.65Ref: TM-T13324
1mg40,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg130,00€25mg259,00€50mg447,00€100mg645,00€200mg897,00€Quetmolimab
CAS :Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.59%Couleur et forme :LiquidMasse moléculaire :150 kDaAMG 487
CAS :AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formule :C32H28F3N5O4Degré de pureté :99.82% - 99.89%Couleur et forme :SolidMasse moléculaire :603.59Ref: TM-T10297L
1mg52,00€5mg103,00€1mL*10mM (DMSO)138,00€10mg148,00€25mg235,00€50mg334,00€100mg528,00€200mg752,00€Motixafortide TFA(664334-36-5,Free)
Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.Formule :C99H145F4N33O21S2Degré de pureté :>99.99%Couleur et forme :White SolidMasse moléculaire :2273.54Polyphemusin II-Derived Peptide
CAS :T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42ITIC
CAS :"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formule :C94H82N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1427.96PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Couleur et forme :Odour SolidCTCE-9908
CAS :CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Formule :C86H147N27O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1927.27ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formule :C25H30N2OSCouleur et forme :SolidMasse moléculaire :406.58PF-06835375
CAS :PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Couleur et forme :LiquidKRH-3955 hydrochloride
CAS :KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09TC14012
CAS :CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).Formule :C90H140N34O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2066.43CXCR4 antagonist 1
CAS :CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Couleur et forme :Odour SolidITIC-4F
CAS :ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Formule :C94H78F4N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1499.92Bam 12P
CAS :Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.Formule :C62H97N21O16SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1424.64
