CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
157 produits trouvés pour "CXCR"
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Motixafortide TFA(664334-36-5,Free)
Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.Formule :C99H145F4N33O21S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :2273.54Quetmolimab
CAS :Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.59%Couleur et forme :LiquidMasse moléculaire :150 kDaVUF11207 fumarate
CAS :VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formule :C31H39FN2O8Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :586.65Ref: TM-T13324
1mg40,00€2mg52,00€5mg84,00€10mg130,00€25mg259,00€50mg447,00€100mg645,00€200mg897,00€1mL*10mM (DMSO)92,00€Delmetacin
CAS :Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.Formule :C18H15NO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :293.32AMG 487
CAS :AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formule :C32H28F3N5O4Degré de pureté :99.82% - 99.89%Couleur et forme :SolidMasse moléculaire :603.59Ref: TM-T10297L
1mg52,00€5mg103,00€10mg148,00€25mg235,00€50mg334,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)138,00€Reparixin L-lysine salt
CAS :Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Formule :C20H35N3O5SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :429.57LY2510924 acetate(1088715-84-7 free base)
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.Formule :C64H91N13O13Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :1250.49Ref: TM-T15805L
1mg159,00€5mg306,00€10mg459,00€25mg750,00€50mg1.026,00€100mg1.415,00€1mL*10mM (DMSO)730,00€SDF-1α (human)
CAS :SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormule :C356H578N106O93S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7959.34vMIP-II (1-21) TFA
vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.Couleur et forme :Odour SolidVUF-11222
CAS :VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formule :C25H31BrINDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :552.33Balixafortide TFA (1051366-32-5 free base)
Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.Formule :C82H113N22F3O23S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1896.05NI-0801
NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.Degré de pureté :97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.81 kDaABX-IL8
ABX-IL8 is a humanized antibody targeting IL-8, capable of interfering with tube formation in human umbilical vein endothelial cells.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :143.94 kDaTC14012
CAS :CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).Formule :C90H140N34O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2066.43ITIC-4F
CAS :ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Formule :C94H78F4N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1499.92CTCE-9908
CAS :CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Formule :C86H147N27O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1927.27PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Couleur et forme :Odour SolidCXCR4 antagonist 2
CAS :CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.Formule :C25H36N6Couleur et forme :SolidMasse moléculaire :420.605TC14012 TFA
TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .Formule :C92H141F3N34O21S2Degré de pureté :96.31%Couleur et forme :SolidMasse moléculaire :2180.44CXCL12 ligand 1
CAS :CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 .Formule :C11H14N4O5S2Couleur et forme :SolidMasse moléculaire :346.38Peptide R54
Peptide R54 (Pep R54; CXCR4 antagonist peptide 19) is an antagonistic polypeptide targeting CXCR4, known for its significant anticancer properties. It inhibits CXCR4-dependent cell migration, epithelial-mesenchymal transition, and the development of lung metastasis, offering better serum stability and higher CXCR4 affinity (IC50=20 nM) compared to the lead compound. Peptide R54 works synergistically with anti-PD-1 therapy to exhibit antitumor effects in vivo, enhancing granzyme activity and reducing Foxp3 cell infiltration. It is useful for research in colon cancer, ovarian cancer, and melanoma.Couleur et forme :Odour SolidPeptide 78
CAS :Peptide 78 is identical to peptide 74 except that serine replaces cysteine. It does not inhibit 72-kDa type IV collagenase.Formule :C62H107N23O21SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1542.74HuMax-IL8
HuMax-IL8 (MDX 018) is a humanized anti-IL-8 monoclonal antibody for the study of metastatic or unresectable solid tumors.Degré de pureté :98.8% (SDS-PAGE); 97.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :Odour LiquidMasse moléculaire :144.82 kDaCyclic MKEY
CAS :MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.Formule :C113H174N28O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2532.89CX4338
CAS :CX4338 is a CXCL8-mediated chemotaxis inhibitor.Formule :C22H24N2OSCouleur et forme :SolidMasse moléculaire :364.50BVT173187
CAS :BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Formule :C14H10Cl3NO2Couleur et forme :SolidMasse moléculaire :330.59RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Formule :C365H585N105O95S5Masse moléculaire :8119.27766CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Formule :C107H173N33O30Masse moléculaire :2400.30261CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Formule :C13H22N6OSMasse moléculaire :310.15758CXCR2 Probe 1
CXCR2Probe 1 (Compound[18F]16b) is a selective ligand for CXCR2 and serves as a radioactive tracer for PET imaging of neutrophils in inflammatory diseases.Formule :C20H24FN3O4Masse moléculaire :389.17508CXCL-CXCR1/2-IN-1
CAS :CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.Formule :C14H8Cl2N4O3SDegré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :383.21ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formule :C25H30N2OSCouleur et forme :SolidMasse moléculaire :406.58Peptide R
CAS :Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formule :C39H59N13O8S2Couleur et forme :SolidMasse moléculaire :902.1Polyphemusin II-Derived Peptide
CAS :T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42CXCR7 modulator 1
CAS :CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Formule :C48H57F2N7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.07Vimnerixin
CAS :Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55CXCR4 antagonist 1
CAS :CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69Bam 12P
CAS :Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.Formule :C62H97N21O16SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1424.64KRH-3955 hydrochloride
CAS :KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Couleur et forme :Odour SolidChemokine Inhibitor Library
A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
Couleur et forme :Odour SolidITIC
CAS :"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formule :C94H82N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1427.96DOTA-CXCR4-L
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancerFormule :C58H78N16O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1223.344-Amino-D-phenylalanine
CAS :4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Formule :C9H12N2O2Couleur et forme :SolidMasse moléculaire :180.2E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFormule :C108H178N34O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2400.78CXCR2 antagonist 8
CAS :CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Formule :C14H13N3O5Couleur et forme :SolidMasse moléculaire :303.27PS372424 hydrochloride
CAS :PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Formule :C33H45ClN6O4Degré de pureté :95.03%Couleur et forme :SolidMasse moléculaire :625.2LY2510924
CAS :LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Formule :C62H88N14O10Couleur et forme :SolidMasse moléculaire :1189.45Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formule :C39H57N13O8S2·xC2HF3O2Couleur et forme :SolidMasse moléculaire :900.08 (free base)Motixafortide
CAS :Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).Formule :C97H144FN33O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2159.52ACT-1004-1239
CAS :ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.
Formule :C27H28F2N6O3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :522.55ATI-2341
CAS :ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Formule :C104H178N26O25S2Couleur et forme :SolidMasse moléculaire :2256.82Alirocumab
CAS :Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.Degré de pureté :95% - 97.1% (SDS-PAGE); 96.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.2 kDaFC131 TFA (606968-52-9 free base)
CAS :FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hivFormule :C38H48F3N11O8Degré de pureté :99.39% - 99.67%Couleur et forme :SolidMasse moléculaire :843.85ATI-2341 acetate(1337878-62-2 free base)
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.Formule :C106H182N26O27S2Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :2316.87Navarixin
CAS :Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFormule :C21H23N3O5Degré de pureté :98% - 99.51%Couleur et forme :SolidMasse moléculaire :397.42Ref: TM-T7130
1mg38,00€5mg80,00€10mg114,00€25mg200,00€50mg299,00€100mg442,00€500mg973,00€1mL*10mM (DMSO)88,00€WZ811
CAS :WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).Formule :C18H18N4Degré de pureté :99.42% - ≥95%Couleur et forme :SolidMasse moléculaire :290.36CTCE 9908 acetate
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.Formule :C88H151N27O25Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :1987.31MSX-127
CAS :MSX-127 elicites positive response in peptide CXCR4.Formule :C16H24N2O4Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :308.37Plerixafor octahydrochloride
CAS :Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Formule :C28H62Cl8N8Degré de pureté :98.01% - 99.79%Couleur et forme :SolidMasse moléculaire :794.46JMS-17-2
CAS :JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Formule :C25H26ClN3ODegré de pureté :98.7% - 99.44%Couleur et forme :SolidMasse moléculaire :419.95Ref: TM-T5849
1mg35,00€5mg78,00€10mg117,00€25mg198,00€50mg310,00€100mg460,00€200mg665,00€1mL*10mM (DMSO)87,00€NUCC-390 dihydrochloride
CAS :NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.Formule :C23H35Cl2N5OCouleur et forme :SolidMasse moléculaire :468.46Decursin
CAS :Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Formule :C19H20O5Degré de pureté :97.22% - 99.91%Couleur et forme :SolidMasse moléculaire :328.36Ref: TM-T3S1416
1mg40,00€5mg84,00€10mg113,00€25mg245,00€50mg439,00€100mg627,00€500mg1.288,00€1mL*10mM (DMSO)93,00€JMS-17-2 hydrochloride
CAS :JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.Formule :C25H27Cl2N3OCouleur et forme :SolidMasse moléculaire :456.41SB-265610
CAS :SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Formule :C14H9BrN6ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :357.16Ref: TM-T16850
1mg52,00€5mg113,00€10mg177,00€25mg356,00€50mg530,00€100mg758,00€500mg1.558,00€1mL*10mM (DMSO)124,00€Danirixin
CAS :Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).Formule :C19H21ClFN3O4SDegré de pureté :99.78% - >99.99%Couleur et forme :SolidMasse moléculaire :441.9Ref: TM-T5193
1mg58,00€5mg105,00€10mg170,00€25mg318,00€50mg505,00€100mg713,00€200mg982,00€1mL*10mM (DMSO)102,00€Nicotinamide N-oxide
CAS :Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Formule :C6H6N2O2Degré de pureté :99.66% - 99.9%Couleur et forme :SolidMasse moléculaire :138.12Elubrixin HCl
CAS :Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Formule :C17H18Cl3FN4O4SCouleur et forme :SolidMasse moléculaire :499.77Mavorixafor trihydrochloride
CAS :Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.Formule :C21H30Cl3N5Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :458.86MSX-130
CAS :MSX-130 is CXCR4 Antagonist.Formule :C36H26N4Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :514.62TAK-779
CAS :TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13Reparixin
CAS :Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formule :C14H21NO3SDegré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :283.39Ref: TM-T4163
5mg48,00€10mg62,00€25mg120,00€50mg187,00€100mg301,00€200mg449,00€1mL*10mM (DMSO)111,00€Baohuoside I
CAS :Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.Formule :C27H30O10Degré de pureté :97.64% - 98.14%Couleur et forme :SolidMasse moléculaire :514.52Ref: TM-T3396
2mg43,00€5mg63,00€10mg92,00€25mg170,00€50mg268,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)123,00€SB225002
CAS :SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Formule :C13H10BrN3O4Degré de pureté :98.16% - 99.85%Couleur et forme :SolidMasse moléculaire :352.14Ref: TM-T1955
5mg48,00€10mg63,00€25mg120,00€50mg213,00€100mg383,00€200mg585,00€500mg888,00€1mL*10mM (DMSO)50,00€USL311
CAS :USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Formule :C24H34N6ODegré de pureté :98.46% - 99.56%Couleur et forme :SolidMasse moléculaire :422.57Ref: TM-T17208
1mg42,00€5mg88,00€10mg127,00€25mg250,00€50mg393,00€100mg628,00€500mg1.304,00€1mL*10mM (DMSO)87,00€UNBS5162
CAS :UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.Formule :C17H18N4O3Degré de pureté :98.37% - 99.97%Couleur et forme :SolidMasse moléculaire :326.35Ref: TM-T2477
1mg39,00€5mg81,00€10mg116,00€25mg215,00€50mg340,00€100mg540,00€200mg787,00€1mL*10mM (DMSO)89,00€MSX-122
CAS :MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formule :C16H16N6Degré de pureté :98.31% - 98.94%Couleur et forme :SolidMasse moléculaire :292.34AMD 3465 hexahydrobromide
CAS :AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Formule :C24H44Br6N6Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :896.07ML339
CAS :ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
Formule :C26H32ClN3O5Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :502SRT3109
CAS :SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Formule :C18H23F2N5O4S2Degré de pureté :99.65% - 99.92%Couleur et forme :SolidMasse moléculaire :475.53AMD-070 hydrochloride
CAS :AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Formule :C21H28ClN5Degré de pureté :98.38% - 98.57%Couleur et forme :SolidMasse moléculaire :385.93SX-682
CAS :SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Formule :C19H14BF4N3O4SDegré de pureté :98.19% - 99.61%Couleur et forme :SolidMasse moléculaire :467.2AZD-5069
CAS :AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Formule :C18H22F2N4O5S2Degré de pureté :98.38% - 98.63%Couleur et forme :SolidMasse moléculaire :476.52Ref: TM-T7681
1mg34,00€2mg47,00€5mg66,00€10mg98,00€25mg190,00€50mg295,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)73,00€Plerixafor
CAS :Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formule :C28H54N8Degré de pureté :99.17% - >99.99%Couleur et forme :SolidMasse moléculaire :502.78ML 145
CAS :ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)Formule :C24H22N2O5S2Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :482.57Ref: TM-T12074
1mg52,00€5mg100,00€10mg149,00€25mg250,00€50mg408,00€100mg572,00€1mL*10mM (DMSO)109,00€PS372424
CAS :PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.Formule :C33H44N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.74GPR35 agonist 1
CAS :GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).Formule :C10H4BrN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.07GSK812397
CAS :GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Formule :C24H32N6OCouleur et forme :SolidMasse moléculaire :420.55CXCR4 antagonist 9
CAS :CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.Formule :C21H27FN6Couleur et forme :SolidMasse moléculaire :382.48VUF11211
CAS :VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Formule :C26H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.49rac-NBI-74330
CAS :rac-NBI-74330 is an effective and selective CXCR3 antagonist.Formule :C32H27F4N5O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :605.58HF50731
CAS :HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Formule :C26H46N4Couleur et forme :SolidMasse moléculaire :414.67SRT3190
CAS :SRT3190 is an antagonist of CXCR2.Formule :C18H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.53CXCR4 antagonist 5
CAS :CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5ACT-660602
CAS :ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Formule :C20H20F6N8OSCouleur et forme :SolidMasse moléculaire :534.48SB02024
CAS :SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Formule :C16H22F3N3O2Couleur et forme :SolidMasse moléculaire :345.36BC-1485
CAS :BC-1485 is a small molecule inhibitor of FIEL1 that inhibits the degradation of PIAS4 and ameliorates fibrosis in a mouse model.Formule :C19H21N5O5SDegré de pureté :97.03% - 97.15%Couleur et forme :SolidMasse moléculaire :431.47FC131
CAS :CXCR4 antagonistFormule :C36H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.83AZ10397767
CAS :AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.Formule :C15H14ClFN4O2S2Couleur et forme :SolidMasse moléculaire :400.88
