CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
147 produits trouvés pour "CXCR"
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rac-NBI-74330
CAS :<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Formule :C32H27F4N5O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :605.58PS372424
CAS :<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Formule :C33H44N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.74AZ10397767
CAS :<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Formule :C15H14ClFN4O2S2Couleur et forme :SolidMasse moléculaire :400.88AMD 3465
CAS :<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Formule :C24H38N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.60SCH 546738
CAS :<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Formule :C23H31Cl2N7ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :492.45GPR35 agonist 1
CAS :<p>GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).</p>Formule :C10H4BrN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.07FC131
CAS :<p>CXCR4 antagonist</p>Formule :C36H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.83SB02024
CAS :<p>SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.</p>Formule :C16H22F3N3O2Couleur et forme :SolidMasse moléculaire :345.36ACT-660602
CAS :<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Formule :C20H20F6N8OSCouleur et forme :SolidMasse moléculaire :534.48IT1t dihydrochloride
CAS :<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Formule :C21H36Cl2N4S2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :479.57Mavorixafor
CAS :<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formule :C21H27N5Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :349.47NUCC-390
CAS :<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Formule :C23H33N5ODegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :395.54AZD8797
CAS :<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Formule :C19H25N5OS2Degré de pureté :98.73% - 99.68%Couleur et forme :SolidMasse moléculaire :403.56Elubrixin
CAS :<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formule :C17H17Cl2FN4O4SDegré de pureté :98.65% - 99.78%Couleur et forme :SolidMasse moléculaire :463.31AZD8309
CAS :<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formule :C15H14F2N4O2S2Degré de pureté :98.35% - 99.67%Couleur et forme :SolidMasse moléculaire :384.42TIQ-15
CAS :<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Formule :C23H32N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.53CXCR4 antagonist 6
CAS :<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5Ladarixin Sodium
CAS :<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Formule :C11H12F3NNaO6S2Couleur et forme :SolidMasse moléculaire :398.32(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59Pentixafor
CAS :<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formule :C60H80N14O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1221.36CXCR4 antagonist 7
CAS :<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33CXCR2 antagonist 2
CAS :<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formule :C17H17FN2O4SCouleur et forme :SolidMasse moléculaire :364.39NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formule :C23H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.46CXCR2-IN-2
CAS :<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9E6130
CAS :<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06CXCR2 antagonist 3
CAS :<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Formule :C17H15FN2O4SCouleur et forme :SolidMasse moléculaire :362.38(R,R)-CXCR2-IN-2
CAS :<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9CXCR2-IN-1
CAS :<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35EMU-116
CAS :<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58CXCR4 modulator-1
CAS :<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49ACT-777991
CAS :<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48(R)-SCH 546738
CAS :<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR4 antagonist 10
CAS :<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52CXCR7 modulator 2
CAS :<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.42CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4Paeoniflorin-6′-O-benzene sulfonate
CAS :<p>Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.</p>Formule :C29H32O13SCouleur et forme :SolidMasse moléculaire :620.622CXCR7 antagonist-1 hydrochloride
CAS :<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formule :C21H20ClFN6OCouleur et forme :SolidMasse moléculaire :426.87CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36SCH 563705
CAS :<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48SLW131
CAS :<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535CCX662
CAS :<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36ACT-672125
CAS :<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59VUF11207 trifluoroacetate salt
CAS :<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609CXCR4-IN-1
CAS :<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54
