CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
147 produits trouvés pour "CXCR"
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Quetmolimab
CAS :<p>Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.59%Couleur et forme :LiquidMasse moléculaire :150 kDaDelmetacin
CAS :<p>Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.</p>Formule :C18H15NO3Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :293.32VUF11207 fumarate
CAS :<p>VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).</p>Formule :C31H39FN2O8Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :586.65Motixafortide TFA(664334-36-5,Free)
<p>Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.</p>Formule :C99H145F4N33O21S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :2273.54LY2510924 acetate(1088715-84-7 free base)
<p>Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.</p>Formule :C64H91N13O13Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :1250.49AMG 487
CAS :<p>AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.</p>Formule :C32H28F3N5O4Degré de pureté :99.82% - 99.89%Couleur et forme :SolidMasse moléculaire :603.59Eldelumab
CAS :<p>Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.</p>Degré de pureté :95%Couleur et forme :LiquidReparixin L-lysine salt
CAS :<p>Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.</p>Formule :C20H35N3O5SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :429.57PF-06835375
CAS :<p>PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).</p>Couleur et forme :LiquidITIC-4F
CAS :<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Formule :C94H78F4N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1499.92ITIC
CAS :<p>"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."</p>Formule :C94H82N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1427.96TC14012
CAS :<p>CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).</p>Formule :C90H140N34O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2066.43CTCE-9908
CAS :<p>CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.</p>Formule :C86H147N27O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1927.27PDE4D inhibitor 1
<p>PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.</p>Couleur et forme :Odour SolidCXCR4 antagonist 2
CAS :<p>CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.</p>Formule :C25H36N6Couleur et forme :SolidMasse moléculaire :420.605CXCR7 modulator 1
CAS :<p>CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.</p>Formule :C48H57F2N7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.07VB-85247
<p>VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.</p>Couleur et forme :Odour SolidBam 12P
CAS :<p>Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.</p>Formule :C62H97N21O16SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1424.64KRH-3955 hydrochloride
CAS :<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09CXCR4 antagonist 1
CAS :<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69AZD4721
CAS :<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55Polyphemusin II-Derived Peptide
CAS :<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42Peptide R
CAS :<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formule :C39H59N13O8S2Couleur et forme :SolidMasse moléculaire :902.1CXCL-CXCR1/2-IN-1
CAS :<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Formule :C14H8Cl2N4O3SDegré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :383.21CXCR2 Probe 1
<p>CXCR2Probe 1 (Compound[18F]16b) is a selective ligand for CXCR2 and serves as a radioactive tracer for PET imaging of neutrophils in inflammatory diseases.</p>Formule :C20H24FN3O4Masse moléculaire :389.17508CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Formule :C13H22N6OSMasse moléculaire :310.15758CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>CXCL8 (54-72)
<p>CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.</p>Formule :C107H173N33O30Masse moléculaire :2400.30261RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Formule :C365H585N105O95S5Masse moléculaire :8119.27766BVT173187
CAS :<p>BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.</p>Formule :C14H10Cl3NO2Couleur et forme :SolidMasse moléculaire :330.59CX4338
CAS :<p>CX4338 is a CXCL8-mediated chemotaxis inhibitor.</p>Formule :C22H24N2OSCouleur et forme :SolidMasse moléculaire :364.50NI-0801
<p>NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.</p>Degré de pureté :97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :Odour LiquidCyclic MKEY
CAS :<p>MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.</p>Formule :C113H174N28O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2532.89TC14012 TFA
<p>TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .</p>Formule :C92H141F3N34O21S2Degré de pureté :96.31%Couleur et forme :SolidMasse moléculaire :2180.44Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Formule :C82H113N22F3O23S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1896.05vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Couleur et forme :Odour SolidSDF-1α (human)
CAS :<p>SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes</p>Formule :C356H578N106O93S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7959.34E70K
<p>E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuate</p>Formule :C108H178N34O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2400.784-Amino-D-phenylalanine
CAS :<p>4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.</p>Formule :C9H12N2O2Couleur et forme :SolidMasse moléculaire :180.2DOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Formule :C58H78N16O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1223.34Chemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Couleur et forme :Odour SolidVUF-11222
CAS :<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Formule :C25H31BrINDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :552.33LY2510924
CAS :<p>LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).</p>Formule :C62H88N14O10Couleur et forme :SolidMasse moléculaire :1189.45ACT-1004-1239
CAS :<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Formule :C27H28F2N6O3Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :522.55ATI-2341
CAS :<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Formule :C104H178N26O25S2Couleur et forme :SolidMasse moléculaire :2256.82Peptide R TFA
<p>Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.</p>Formule :C39H57N13O8S2·xC2HF3O2Couleur et forme :SolidMasse moléculaire :900.08 (free base)Motixafortide
CAS :<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Formule :C97H144FN33O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2159.52CXCR2 antagonist 8
CAS :<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Formule :C14H13N3O5Couleur et forme :SolidMasse moléculaire :303.27PS372424 hydrochloride
CAS :<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Formule :C33H45ClN6O4Degré de pureté :95.03%Couleur et forme :SolidMasse moléculaire :625.2SRT3109
CAS :<p>SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.</p>Formule :C18H23F2N5O4S2Degré de pureté :99.65% - 99.92%Couleur et forme :SolidMasse moléculaire :475.53MSX-122
CAS :<p>MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).</p>Formule :C16H16N6Degré de pureté :98.31% - 98.94%Couleur et forme :SolidMasse moléculaire :292.34Plerixafor
CAS :<p>Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.</p>Formule :C28H54N8Degré de pureté :99.17% - >99.99%Couleur et forme :SolidMasse moléculaire :502.78UNBS5162
CAS :<p>UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.</p>Formule :C17H18N4O3Degré de pureté :98.37% - 99.97%Couleur et forme :SolidMasse moléculaire :326.35WZ811
CAS :<p>WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).</p>Formule :C18H18N4Degré de pureté :99.42% - ≥95%Couleur et forme :SolidMasse moléculaire :290.36Baohuoside I
CAS :<p>Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.</p>Formule :C27H30O10Degré de pureté :97.64% - 98.14%Couleur et forme :SolidMasse moléculaire :514.52USL311
CAS :<p>USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.</p>Formule :C24H34N6ODegré de pureté :98.46% - 99.56%Couleur et forme :SolidMasse moléculaire :422.57SB225002
CAS :<p>SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.</p>Formule :C13H10BrN3O4Degré de pureté :98.16% - 99.85%Couleur et forme :SolidMasse moléculaire :352.14JMS-17-2
CAS :<p>JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).</p>Formule :C25H26ClN3ODegré de pureté :98.7% - 99.44%Couleur et forme :SolidMasse moléculaire :419.95Reparixin
CAS :<p>Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.</p>Formule :C14H21NO3SDegré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :283.39Mavorixafor trihydrochloride
CAS :<p>Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.</p>Formule :C21H30Cl3N5Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :458.86Navarixin
CAS :<p>Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil</p>Formule :C21H23N3O5Degré de pureté :98% - 99.51%Couleur et forme :SolidMasse moléculaire :397.42MSX-127
CAS :<p>MSX-127 elicites positive response in peptide CXCR4.</p>Formule :C16H24N2O4Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :308.37MSX-130
CAS :<p>MSX-130 is CXCR4 Antagonist.</p>Formule :C36H26N4Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :514.62JMS-17-2 hydrochloride
CAS :<p>JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.</p>Formule :C25H27Cl2N3OCouleur et forme :SolidMasse moléculaire :456.41CTCE 9908 acetate
<p>CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.</p>Formule :C88H151N27O25Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :1987.31ATI-2341 acetate(1337878-62-2 free base)
<p>ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.</p>Formule :C106H182N26O27S2Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :2316.87Elubrixin HCl
CAS :<p>Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.</p>Formule :C17H18Cl3FN4O4SCouleur et forme :SolidMasse moléculaire :499.77NUCC-390 dihydrochloride
CAS :<p>NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.</p>Formule :C23H35Cl2N5OCouleur et forme :SolidMasse moléculaire :468.46Decursin
CAS :<p>Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.</p>Formule :C19H20O5Degré de pureté :97.22% - 99.84%Couleur et forme :SolidMasse moléculaire :328.36FC131 TFA (606968-52-9 free base)
CAS :<p>FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv</p>Formule :C38H48F3N11O8Degré de pureté :99.39% - 99.67%Couleur et forme :SolidMasse moléculaire :843.85AZD-5069
CAS :<p>AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).</p>Formule :C18H22F2N4O5S2Degré de pureté :98.38% - 98.63%Couleur et forme :SolidMasse moléculaire :476.52ML339
CAS :<p>ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.</p>Formule :C26H32ClN3O5Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :502AMD 3465 hexahydrobromide
CAS :<p>AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.</p>Formule :C24H44Br6N6Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :896.07SB-265610
CAS :<p>SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.</p>Formule :C14H9BrN6ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :357.16Danirixin
CAS :<p>Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).</p>Formule :C19H21ClFN3O4SDegré de pureté :99.78% - >99.99%Couleur et forme :SolidMasse moléculaire :441.9SX-682
CAS :<p>SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.</p>Formule :C19H14BF4N3O4SDegré de pureté :98.19% - 99.57%Couleur et forme :SolidMasse moléculaire :467.2Nicotinamide N-oxide
CAS :<p>Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.</p>Formule :C6H6N2O2Degré de pureté :99.66% - 99.9%Couleur et forme :SolidMasse moléculaire :138.12Plerixafor octahydrochloride
CAS :<p>Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.</p>Formule :C28H62Cl8N8Degré de pureté :98.01% - 99.79%Couleur et forme :SolidMasse moléculaire :794.46TAK-779
CAS :<p>TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).</p>Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13AMD-070 hydrochloride
CAS :<p>AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.</p>Formule :C21H28ClN5Degré de pureté :98.38% - 98.57%Couleur et forme :SolidMasse moléculaire :385.93ML 145
CAS :<p>ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)</p>Formule :C24H22N2O5S2Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :482.57HF51116
CAS :<p>HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.</p>Formule :C29H46N8OCouleur et forme :SolidMasse moléculaire :522.73CXCR3 Antagonist 6c
CAS :<p>CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.</p>Formule :C30H32Cl3N5O3Couleur et forme :SolidMasse moléculaire :616.97CXCR4 antagonist 9
CAS :<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Formule :C21H27FN6Couleur et forme :SolidMasse moléculaire :382.48VUF10132
CAS :<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Formule :C19H13BrCl4N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.03AMG 487 (S-enantiomer)
CAS :<p>AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59HF50731
CAS :<p>HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).</p>Formule :C26H46N4Couleur et forme :SolidMasse moléculaire :414.67SRT3190
CAS :<p>SRT3190 is an antagonist of CXCR2.</p>Formule :C18H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.53CXCR4 modulator-2
CAS :<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Formule :C21H32N8O2Couleur et forme :SolidMasse moléculaire :428.53ICT5040
CAS :<p>ICT5040 is a CXCR4 antagonist.</p>Formule :C10H8F3N3OSCouleur et forme :SolidMasse moléculaire :275.25SB-332235
CAS :<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Formule :C13H10Cl3N3O4SCouleur et forme :SolidMasse moléculaire :410.66VUF11211
CAS :<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Formule :C26H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.49TN-14003
CAS :<p>TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.</p>Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42CXCR4 antagonist 8
CAS :<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Formule :C21H26N6Couleur et forme :SolidMasse moléculaire :362.47CXCR4 antagonist 5
CAS :<p>CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.</p>Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5SX-517
CAS :<p>SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.</p>Formule :C19H16BFN2O3SCouleur et forme :SolidMasse moléculaire :382.22KRH-1636
CAS :<p>KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.</p>Formule :C32H37N7O2Couleur et forme :SolidMasse moléculaire :551.68IT1t
CAS :<p>IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.</p>Formule :C21H34N4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.65Burixafor hydrobromide
CAS :<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Formule :C27H52BrN8O3PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :647.644VUF5834
CAS :<p>VUF5834 is a full inverse agonist of CXCR3 N3.35A.</p>Formule :C31H41N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.69rac-NBI-74330
CAS :<p>rac-NBI-74330 is an effective and selective CXCR3 antagonist.</p>Formule :C32H27F4N5O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :605.58PS372424
CAS :<p>PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.</p>Formule :C33H44N6O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :588.74AZ10397767
CAS :<p>AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.</p>Formule :C15H14ClFN4O2S2Couleur et forme :SolidMasse moléculaire :400.88AMD 3465
CAS :<p>AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).</p>Formule :C24H38N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :410.60SCH 546738
CAS :<p>SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.</p>Formule :C23H31Cl2N7ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :492.45GPR35 agonist 1
CAS :<p>GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).</p>Formule :C10H4BrN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :354.07FC131
CAS :<p>CXCR4 antagonist</p>Formule :C36H47N11O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :729.83SB02024
CAS :<p>SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.</p>Formule :C16H22F3N3O2Couleur et forme :SolidMasse moléculaire :345.36ACT-660602
CAS :<p>ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.</p>Formule :C20H20F6N8OSCouleur et forme :SolidMasse moléculaire :534.48IT1t dihydrochloride
CAS :<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Formule :C21H36Cl2N4S2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :479.57Mavorixafor
CAS :<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formule :C21H27N5Degré de pureté :98.56%Couleur et forme :SolidMasse moléculaire :349.47NUCC-390
CAS :<p>NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.</p>Formule :C23H33N5ODegré de pureté :97.08%Couleur et forme :SolidMasse moléculaire :395.54AZD8797
CAS :<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Formule :C19H25N5OS2Degré de pureté :98.73% - 99.68%Couleur et forme :SolidMasse moléculaire :403.56Elubrixin
CAS :<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formule :C17H17Cl2FN4O4SDegré de pureté :98.65% - 99.78%Couleur et forme :SolidMasse moléculaire :463.31AZD8309
CAS :<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formule :C15H14F2N4O2S2Degré de pureté :98.35% - 99.67%Couleur et forme :SolidMasse moléculaire :384.42TIQ-15
CAS :<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Formule :C23H32N4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.53CXCR4 antagonist 6
CAS :<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5Ladarixin Sodium
CAS :<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Formule :C11H12F3NNaO6S2Couleur et forme :SolidMasse moléculaire :398.32(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59Pentixafor
CAS :<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formule :C60H80N14O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1221.36CXCR4 antagonist 7
CAS :<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Formule :C15H17N5O3Couleur et forme :SolidMasse moléculaire :315.33CXCR2 antagonist 2
CAS :<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formule :C17H17FN2O4SCouleur et forme :SolidMasse moléculaire :364.39NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formule :C23H35Cl2N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.46CXCR2-IN-2
CAS :<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9E6130
CAS :<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Formule :C28H37ClF3N3O3Couleur et forme :SolidMasse moléculaire :556.06CXCR2 antagonist 3
CAS :<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Formule :C17H15FN2O4SCouleur et forme :SolidMasse moléculaire :362.38(R,R)-CXCR2-IN-2
CAS :<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Formule :C18H23ClN2O5SCouleur et forme :SolidMasse moléculaire :414.9CXCR2-IN-1
CAS :<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formule :C19H20Cl2FN3O4SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :476.35EMU-116
CAS :<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formule :C25H35N5Couleur et forme :SolidMasse moléculaire :405.58CXCR4 modulator-1
CAS :<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formule :C23H27N5O2Couleur et forme :SolidMasse moléculaire :405.49ACT-777991
CAS :<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formule :C20H20F6N8O2SCouleur et forme :SolidMasse moléculaire :550.48(R)-SCH 546738
CAS :<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formule :C23H31Cl2N7OCouleur et forme :SolidMasse moléculaire :492.45CXCR4 antagonist 10
CAS :<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formule :C18H18N4O4Couleur et forme :SolidMasse moléculaire :354.36CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formule :C22H31N5Couleur et forme :SolidMasse moléculaire :365.52CXCR7 modulator 2
CAS :<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formule :C29H42N6O3Couleur et forme :SolidMasse moléculaire :522.68CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formule :C15H14F2N4OS2Couleur et forme :SolidMasse moléculaire :368.42CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formule :C17H16F2N4OSCouleur et forme :SolidMasse moléculaire :362.4Paeoniflorin-6′-O-benzene sulfonate
CAS :<p>Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.</p>Formule :C29H32O13SCouleur et forme :SolidMasse moléculaire :620.622CXCR7 antagonist-1 hydrochloride
CAS :<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formule :C21H20ClFN6OCouleur et forme :SolidMasse moléculaire :426.87CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formule :C15H14F2N4O2SCouleur et forme :SolidMasse moléculaire :352.36SCH 563705
CAS :<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formule :C23H27N3O5Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :425.48SLW131
CAS :<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535CCX662
CAS :<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Formule :C28H37N5O4SCouleur et forme :SolidMasse moléculaire :539.69CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formule :C14H14F2N6OSCouleur et forme :SolidMasse moléculaire :352.36ACT-672125
CAS :<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Formule :C25H25F3N10O2SCouleur et forme :SolidMasse moléculaire :586.59VUF11207 trifluoroacetate salt
CAS :<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formule :C29H36F4N2O6Couleur et forme :SolidMasse moléculaire :584.609CXCR4-IN-1
CAS :<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formule :C23H32N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.54
