CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
158 produits trouvés pour "CXCR"
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Eldelumab
CAS :Eldelumab (BMS-936557) is an anti-IP-10 IgG 1 monoclonal antibody.Eldelumab has anti-inflammatory activity and is used to study rheumatoid arthritis.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :146.64 kDaVUF11207 fumarate
CAS :VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).Formule :C31H39FN2O8Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :586.65Ref: TM-T13324
1mg40,00€2mg52,00€5mg84,00€10mg130,00€25mg259,00€50mg447,00€100mg645,00€200mg897,00€1mL*10mM (DMSO)92,00€Delmetacin
CAS :Delmetacin: a non-steroidal anti-inflammatory drug with analgesic properties, inhibits CXCR1.Formule :C18H15NO3Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :293.32Quetmolimab
CAS :Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis.Degré de pureté :SDS-PAGE:95% SEC-HPLC:97.59%Couleur et forme :LiquidMasse moléculaire :150 kDaReparixin L-lysine salt
CAS :Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.Formule :C20H35N3O5SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :429.57Motixafortide TFA(664334-36-5,Free)
Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.Formule :C99H145F4N33O21S2Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :2273.54LY2510924 acetate(1088715-84-7 free base)
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.Formule :C64H91N13O13Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :1250.49Ref: TM-T15805L
1mg150,00€5mg290,00€10mg434,00€25mg710,00€50mg973,00€100mg1.341,00€1mL*10mM (DMSO)692,00€AMG 487
CAS :AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.Formule :C32H28F3N5O4Degré de pureté :99.82% - 99.89%Couleur et forme :SolidMasse moléculaire :603.59Ref: TM-T10297L
1mg52,00€5mg103,00€10mg148,00€25mg235,00€50mg334,00€100mg528,00€200mg752,00€1mL*10mM (DMSO)138,00€VB-85247
VB-85247 is a STING agonist that, by activating the STING pathway, induces the upregulation of inflammatory cytokines IFNα/β, TNFα, IL6, and CXCL10, as well as the maturation and activation of dendritic cells. It can lead to the regression of tumors within the bladder and is applicable in bladder cancer research.Couleur et forme :Odour SolidRCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Formule :C365H585N105O95S5Masse moléculaire :8119.27766Cyclic MKEY
CAS :MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.Formule :C113H174N28O34S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2532.89CX4338
CAS :CX4338 is a CXCL8-mediated chemotaxis inhibitor.Formule :C22H24N2OSCouleur et forme :SolidMasse moléculaire :364.50E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFormule :C108H178N34O28Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2400.784-Amino-D-phenylalanine
CAS :4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Formule :C9H12N2O2Couleur et forme :SolidMasse moléculaire :180.2CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
vMIP-II (1-21) TFA
vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.Couleur et forme :Odour SolidCXCR4 antagonist 1
CAS :CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.Formule :C27H43N7Couleur et forme :SolidMasse moléculaire :465.69TC14012
CAS :CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).Formule :C90H140N34O19S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2066.43Chemokine Inhibitor Library
A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;
Couleur et forme :Odour SolidCXCR2 Probe 1
CXCR2Probe 1 (Compound[18F]16b) is a selective ligand for CXCR2 and serves as a radioactive tracer for PET imaging of neutrophils in inflammatory diseases.Formule :C20H24FN3O4Masse moléculaire :389.17508CTCE-9908
CAS :CXCR4 blocker; triggers cell division failure in ovarian cancer, boosts taxol and docetaxel treatment effects, proven in mice.Formule :C86H147N27O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1927.27Balixafortide TFA (1051366-32-5 free base)
Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.Formule :C82H113N22F3O23S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1896.05CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Formule :C107H173N33O30Masse moléculaire :2400.30261ITIC-4F
CAS :ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.Formule :C94H78F4N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1499.92Polyphemusin II-Derived Peptide
CAS :T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formule :C90H141N33O18S2Couleur et forme :SolidMasse moléculaire :2037.42BVT173187
CAS :BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Formule :C14H10Cl3NO2Couleur et forme :SolidMasse moléculaire :330.59Peptide R54
Peptide R54 (Pep R54; CXCR4 antagonist peptide 19) is an antagonistic polypeptide targeting CXCR4, known for its significant anticancer properties. It inhibits CXCR4-dependent cell migration, epithelial-mesenchymal transition, and the development of lung metastasis, offering better serum stability and higher CXCR4 affinity (IC50=20 nM) compared to the lead compound. Peptide R54 works synergistically with anti-PD-1 therapy to exhibit antitumor effects in vivo, enhancing granzyme activity and reducing Foxp3 cell infiltration. It is useful for research in colon cancer, ovarian cancer, and melanoma.Couleur et forme :Odour SolidPeptide 78
CAS :Peptide 78 is identical to peptide 74 except that serine replaces cysteine. It does not inhibit 72-kDa type IV collagenase.Formule :C62H107N23O21SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1542.74SDF-1α (human)
CAS :SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormule :C356H578N106O93S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :7959.34HuMax-IL8
HuMax-IL8 (MDX 018) is a humanized anti-IL-8 monoclonal antibody for the study of metastatic or unresectable solid tumors.Degré de pureté :98.8% (SDS-PAGE); 97.4% (SEC-HPLC) - 98.8% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :Odour LiquidMasse moléculaire :144.82 kDaPeptide R
CAS :Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formule :C39H59N13O8S2Couleur et forme :SolidMasse moléculaire :902.1NI-0801
NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.Degré de pureté :97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :144.81 kDaCXCL12 ligand 1
CAS :CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 .Formule :C11H14N4O5S2Couleur et forme :SolidMasse moléculaire :346.38TC14012 TFA
TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .Formule :C92H141F3N34O21S2Degré de pureté :96.31%Couleur et forme :SolidMasse moléculaire :2180.44ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formule :C25H30N2OSCouleur et forme :SolidMasse moléculaire :406.58ABX-IL8
ABX-IL8 is a humanized antibody targeting IL-8, capable of interfering with tube formation in human umbilical vein endothelial cells.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :143.94 kDaKRH-3955 hydrochloride
CAS :KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.Formule :C28H48Cl3N7Couleur et forme :SolidMasse moléculaire :589.09Vimnerixin
CAS :Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Formule :C19H25FN4O5S2Couleur et forme :SolidMasse moléculaire :472.55CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Formule :C13H22N6OSMasse moléculaire :310.15758DOTA-CXCR4-L
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancerFormule :C58H78N16O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1223.34ITIC
CAS :"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formule :C94H82N4O2S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1427.96CXCR7 modulator 1
CAS :CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Formule :C48H57F2N7O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.07VUF-11222
CAS :VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formule :C25H31BrINDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :552.33Bam 12P
CAS :Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla.Formule :C62H97N21O16SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1424.64PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor characterized by high potency (IC50: 8.6 nM) and superior selectivity over other PDE subtypes. This compound inhibits the release of inflammatory cytokines and chemokines. Additionally, PDE4-IN-1 significantly restores the damaged cAMP-CREB signaling pathway, inhibits proliferation, and promotes differentiation to reverse psoriasis formation.Couleur et forme :Odour SolidCXCL-CXCR1/2-IN-1
CAS :CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.Formule :C14H8Cl2N4O3SDegré de pureté :99.4%Couleur et forme :SoildMasse moléculaire :383.21CXCR4 antagonist 2
CAS :CXCR4 antagonist 2 is a CXCR4 antagonist with an IC 50 value of 47 nM.Formule :C25H36N6Couleur et forme :SolidMasse moléculaire :420.605Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formule :C39H57N13O8S2·xC2HF3O2Couleur et forme :SolidMasse moléculaire :900.08 (free base)PS372424 hydrochloride
CAS :PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Formule :C33H45ClN6O4Degré de pureté :95.03%Couleur et forme :SolidMasse moléculaire :625.2LY2510924
CAS :LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Formule :C62H88N14O10Couleur et forme :SolidMasse moléculaire :1189.45
