CXCR
Les CXCR sont une sous-famille de GPCR qui se lient aux chimiokines, de petites protéines de signalisation qui guident le déplacement des cellules immunitaires vers les sites d'inflammation, d'infection ou de lésion. Les CXCR jouent des rôles cruciaux dans les réponses immunitaires, la métastase du cancer et les maladies inflammatoires. Les modulateurs des CXCR sont étudiés pour leur potentiel dans le traitement des maladies auto-immunes, du cancer et des affections inflammatoires chroniques. Chez CymitQuimica, nous offrons une gamme de modulateurs de CXCR de haute qualité pour soutenir vos recherches en immunologie, oncologie et inflammation.
158 produits trouvés pour "CXCR"
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LY2510924
CAS :LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Formule :C62H88N14O10Couleur et forme :SolidMasse moléculaire :1189.45CXCR2 antagonist 8
CAS :CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Formule :C14H13N3O5Couleur et forme :SolidMasse moléculaire :303.27ATI-2341
CAS :ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Formule :C104H178N26O25S2Couleur et forme :SolidMasse moléculaire :2256.82Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formule :C39H57N13O8S2·xC2HF3O2Couleur et forme :SolidMasse moléculaire :900.08 (free base)AZD-5069
CAS :AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Formule :C18H22F2N4O5S2Degré de pureté :98.38% - 98.63%Couleur et forme :SolidMasse moléculaire :476.52Ref: TM-T7681
1mg34,00€2mg47,00€5mg66,00€10mg98,00€25mg190,00€50mg295,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)73,00€JMS-17-2
CAS :JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Formule :C25H26ClN3ODegré de pureté :98.7% - 99.44%Couleur et forme :SolidMasse moléculaire :419.95Ref: TM-T5849
1mg35,00€5mg78,00€10mg117,00€25mg198,00€50mg310,00€100mg460,00€200mg665,00€1mL*10mM (DMSO)87,00€WZ811
CAS :WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).Formule :C18H18N4Degré de pureté :99.42% - ≥95%Couleur et forme :SolidMasse moléculaire :290.36Plerixafor octahydrochloride
CAS :Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Formule :C28H62Cl8N8Degré de pureté :98.01% - 99.79%Couleur et forme :SolidMasse moléculaire :794.46MSX-127
CAS :MSX-127 elicites positive response in peptide CXCR4.Formule :C16H24N2O4Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :308.37Navarixin
CAS :Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFormule :C21H23N3O5Degré de pureté :98% - 99.51%Couleur et forme :SolidMasse moléculaire :397.42Ref: TM-T7130
1mg38,00€5mg80,00€10mg114,00€25mg200,00€50mg299,00€100mg442,00€500mg973,00€1mL*10mM (DMSO)88,00€Plerixafor
CAS :Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formule :C28H54N8Degré de pureté :99.17% - >99.99%Couleur et forme :SolidMasse moléculaire :502.78Mavorixafor trihydrochloride
CAS :Mavorixafor trihydrochloride blocks CXCR4 (IC50: 13 nM) and suppresses T-tropic HIV-1 replication (IC50: 1-9 nM). It's orally active.Formule :C21H30Cl3N5Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :458.86Elubrixin HCl
CAS :Elubrixin is a interleukin 8 inhibitor and CXCR2 selective antagonist.Formule :C17H18Cl3FN4O4SCouleur et forme :SolidMasse moléculaire :499.77JMS-17-2 hydrochloride
CAS :JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.Formule :C25H27Cl2N3OCouleur et forme :SolidMasse moléculaire :456.41NUCC-390 dihydrochloride
CAS :NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.Formule :C23H35Cl2N5OCouleur et forme :SolidMasse moléculaire :468.46Decursin
CAS :Decursin: potential antiepileptic, hepatoprotective, anti-cancer, anti-amnesic; affects NOX activation, PKCα/MAPK/NF-κB pathways, AChE.Formule :C19H20O5Degré de pureté :97.22% - 99.91%Couleur et forme :SolidMasse moléculaire :328.36Ref: TM-T3S1416
1mg40,00€5mg84,00€10mg113,00€25mg245,00€50mg439,00€100mg627,00€500mg1.288,00€1mL*10mM (DMSO)93,00€SB-265610
CAS :SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.Formule :C14H9BrN6ODegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :357.16Ref: TM-T16850
1mg52,00€5mg113,00€10mg177,00€25mg356,00€50mg530,00€100mg758,00€500mg1.558,00€1mL*10mM (DMSO)124,00€Danirixin
CAS :Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).Formule :C19H21ClFN3O4SDegré de pureté :99.78% - >99.99%Couleur et forme :SolidMasse moléculaire :441.9Ref: TM-T5193
1mg58,00€5mg105,00€10mg170,00€25mg318,00€50mg505,00€100mg713,00€200mg982,00€1mL*10mM (DMSO)102,00€Nicotinamide N-oxide
CAS :Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Formule :C6H6N2O2Degré de pureté :99.66% - 99.9%Couleur et forme :SolidMasse moléculaire :138.12SB225002
CAS :SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Formule :C13H10BrN3O4Degré de pureté :98.16% - 99.85%Couleur et forme :SolidMasse moléculaire :352.14Ref: TM-T1955
5mg48,00€10mg63,00€25mg120,00€50mg213,00€100mg383,00€200mg585,00€500mg888,00€1mL*10mM (DMSO)50,00€USL311
CAS :USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Formule :C24H34N6ODegré de pureté :98.46% - 99.56%Couleur et forme :SolidMasse moléculaire :422.57Ref: TM-T17208
1mg42,00€5mg88,00€10mg127,00€25mg250,00€50mg393,00€100mg628,00€500mg1.304,00€1mL*10mM (DMSO)87,00€UNBS5162
CAS :UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.Formule :C17H18N4O3Degré de pureté :98.37% - 99.97%Couleur et forme :SolidMasse moléculaire :326.35Ref: TM-T2477
1mg39,00€5mg81,00€10mg116,00€25mg215,00€50mg340,00€100mg540,00€200mg787,00€1mL*10mM (DMSO)89,00€MSX-122
CAS :MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formule :C16H16N6Degré de pureté :98.31% - 98.94%Couleur et forme :SolidMasse moléculaire :292.34AMD 3465 hexahydrobromide
CAS :AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Formule :C24H44Br6N6Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :896.07ML339
CAS :ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.Formule :C26H32ClN3O5Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :502AMD-070 hydrochloride
CAS :AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Formule :C21H28ClN5Degré de pureté :98.38% - 98.57%Couleur et forme :SolidMasse moléculaire :385.93Alirocumab
CAS :Alirocumab is a human monoclonal antibody that inhibits PCSK9. It is produced by recombinant DNA technology in Chinese hamster ovary cell suspension culture.Degré de pureté :95% - 97.1% (SDS-PAGE); 96.1% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :146.2 kDaFC131 TFA (606968-52-9 free base)
CAS :FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hivFormule :C38H48F3N11O8Degré de pureté :99.39% - 99.67%Couleur et forme :SolidMasse moléculaire :843.85ATI-2341 acetate(1337878-62-2 free base)
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.Formule :C106H182N26O27S2Degré de pureté :97.14%Couleur et forme :SolidMasse moléculaire :2316.87CTCE 9908 acetate
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.Formule :C88H151N27O25Degré de pureté :98.47%Couleur et forme :SolidMasse moléculaire :1987.31SX-682
CAS :SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Formule :C19H14BF4N3O4SDegré de pureté :98.19% - 99.61%Couleur et forme :SolidMasse moléculaire :467.2SRT3109
CAS :SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Formule :C18H23F2N5O4S2Degré de pureté :99.65% - 99.92%Couleur et forme :SolidMasse moléculaire :475.53Baohuoside I
CAS :Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.Formule :C27H30O10Degré de pureté :97.64% - 98.14%Couleur et forme :SolidMasse moléculaire :514.52Ref: TM-T3396
2mg43,00€5mg63,00€10mg92,00€25mg170,00€50mg268,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)123,00€Reparixin
CAS :Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.Formule :C14H21NO3SDegré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :283.39Ref: TM-T4163
5mg48,00€10mg62,00€25mg120,00€50mg187,00€100mg301,00€200mg449,00€1mL*10mM (DMSO)111,00€TAK-779
CAS :TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formule :C33H39ClN2O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :531.13MSX-130
CAS :MSX-130 is CXCR4 Antagonist.Formule :C36H26N4Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :514.62ML 145
CAS :ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)Formule :C24H22N2O5S2Degré de pureté :97.74%Couleur et forme :SolidMasse moléculaire :482.57Ref: TM-T12074
1mg52,00€5mg100,00€10mg149,00€25mg250,00€50mg408,00€100mg572,00€1mL*10mM (DMSO)109,00€rac-NBI-74330
CAS :rac-NBI-74330 is an effective and selective CXCR3 antagonist.Formule :C32H27F4N5O3Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :605.58CXCR4 modulator-2
CAS :CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.Formule :C21H32N8O2Couleur et forme :SolidMasse moléculaire :428.53SRT3190
CAS :SRT3190 is an antagonist of CXCR2.Formule :C18H23F2N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.53AMG 487 (S-enantiomer)
CAS :AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist.Formule :C32H28F3N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.59ICT5040
CAS :ICT5040 is a CXCR4 antagonist.Formule :C10H8F3N3OSCouleur et forme :SolidMasse moléculaire :275.25VUF10132
CAS :VUF10132 is a full inverse CXCR3 N3.35A agonist.Formule :C19H13BrCl4N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.03CXCR4 antagonist 9
CAS :CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.Formule :C21H27FN6Couleur et forme :SolidMasse moléculaire :382.48SB-332235
CAS :SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.Formule :C13H10Cl3N3O4SCouleur et forme :SolidMasse moléculaire :410.66VUF5834
CAS :VUF5834 is a full inverse agonist of CXCR3 N3.35A.Formule :C31H41N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.69IT1t
CAS :IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.Formule :C21H34N4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.65CXCR3 Antagonist 6c
CAS :CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.Formule :C30H32Cl3N5O3Couleur et forme :SolidMasse moléculaire :616.97CXCR4 antagonist 5
CAS :CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.Formule :C21H30N6Couleur et forme :SolidMasse moléculaire :366.5ACT-660602
CAS :ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Formule :C20H20F6N8OSCouleur et forme :SolidMasse moléculaire :534.48
